Trees, homology, and automorphism groups of right-angled Artin groups

We study the homology of an explicit finite-index subgroup of the automorphism group of a partially commutative group, in the case when its defining graph is a tree. More concretely, we give a lower bound on the first Betti number of this subgroup, based on the number and degree of a certain type of vertices, which we call deep. We then use combinatorial methods to analyze the average value of this Betti number, in terms of the size of the defining tree

Fusion of 8He with 206Pb around Coulomb barrier energies

5th International Conference FUSION11The experimental study of the fusion of light neutron-rich nucleus 8He with 206Pb is reported in this work. A fusion stack of 206Pb targets has been used for this study. The most prominent evaporation residue (210Po), which has half-life of 138 days and decays by alpha emission, is populated in the reaction. Radiochemical analysis technique is used to extract the yield of this evaporation residueMinisterio Español de Ciencia e Innovación FPA2007-6307

Estudio de expresión diferencial de genes y distribución de la vinculina en ovario de cerdas

Ponencia publicada en ITEA, vol.104El objetivo de este estudio es analizar las diferencias en la expresión de genes y proteínas en tres estadios reproductivos en cerdas. Con el fin de caracterizar los cambios en los perfiles de expresión, se hibridó RNA de ovario de cerdas en celo, 15 y 45 días de gestación en microchips porcinos. Se detectaron diferencias de expresión en 281 genes (probabilidad posterior <10-11) entre los tres momentos reproductivos analizados en ovario. Uno de estos genes, la vinculina, mostró una expresión 100 veces mayor en celo comparado con 45 días de gestación. Por ello, fue escogido para realizar un análisis de expresión proteica mediante inmunohistoquímica y análisis western blot. Los resultados obtenidos mediante inmunohistoquímica muestran mayor cantidad de vinculina en celo que a 30 días de gestación. Para esta misma proteína, los resultados sugieren la existencia de diferencias significativas entre ovarios de cerdas en celo y a 45 días de gestación mediante la técnica western blotStudy on the differential gene expression and distribution of the vinculin in the ovary of sows The objective of this experiment is to study genes and proteins differing across reproductive stages in swine. RNA from ovary, from sows on heat, 15 and 45 days of pregnancy have been hybridised in porcine oligonucleotide microchips to characterize changes in gene expression profile between different reproductive stages. Expression differences in 281 genes (posterior probability <10-11) have been found between expression at different stages in ovary. One of these genes, vinculin, showed 100 times more expression on heat than at 45 days of pregnancy, so we chose that gene for immunohistochemistry and western blot analysis. On immunohistochemistry we found that ovaries of sows on heat showed stronger vinculin staining than ovaries stroma of sows at 30 days of pregnancy. On western blot, significant differences appeared only between heat and 45 days of pregnancy

Fracturas patológicas en la región de la cadera

Entre 1973 y 1992, fueron tratados en nuestra institución 20 casos de fracturas patológicas a nivel de la cadera, secundarias a metástasis esqueléticas. Se realizó tratamiento quirúrgico mediante osteosíntesis o artroplastias según la localización y la extensión de la lesión. En 8 casos, la fractura fué subcapital, en 6 fué pertrocantérea y en otros 6 casos fué subtrocantérea. En el tratamiento quirúrgico, se recalca la importancia de la fijación interna inmediata con la adición de metilmetacrilato y el uso de la radioterapia postoperatoria. Siempre se obtuvo la mejoría del dolor y un resultado funcional bueno en el 70% de los casos. En 7 casos, aparecieron complicaciones locales. El tratamiento quirúrgico debe ser agresivo en estos pacientes, ya que la rehabilitación inmediata es primordial en su calidad de vida.From 1973 to 1992, 20 cases of pathological fractures around the hip secondary to skeletal metastases were treated in our institution. The surgical treatment was performed by internal fixation or arthroplasty according the location and extension of the lesion. In 8 cases the fracture was located in the femoral neck, 6 cases were intertrochanteric fractures and 6 cases were subtrochanteric fractures. In the surgical management the importance of inmediately internal fixation, with the use of methylnietacrilate and post surgical radiotherapy are justified. Always the pain was relieved and the functional result was good in 70%. In 7 cases were local complications. The surgical treatment should be more agresive in these special patients, because the inmediately rehabilitation is essential in your quality lifes

Synthesis and Characterization of LnAg(WO4)(MoO4)

Polycrystalline LnAg(WO4)(MoO4) powders, with Ln = La to Lu and Y, have been obtained by ceramic method. Rietveld refinement for all compounds reveals that they present tetragonal symmetry, space group I41/a (No. 88), where the Ln3+/Ag+ ions are located in the 4a atomic positions, since the W/Mo are randomly distributed into 4b crystal sites. In these compounds, a and b lattice parameters take values between those corresponding to tungstate and molybdate compounds. A progressive decrease in the lattice parameters is observed in going from La to Lu derivatives as a consequence of the well-known lanthanide contraction

Mass-Up and Decision Peptide-Driven: two open-source applications for MALDI-TOF MS data analysis and protein quantification

Poster presentation at EUBIC Winter School 2017 (10th - 13th January 2017, Sporthotel Semmering, Austria)

Carga del cuidador del paciente con parálisis cerebral moderada-grave: ¿influye el estado nutricional?

Introducción: Los pacientes con parálisis cerebral moderada-grave precisan de sus cuidadores para realizar las actividades básicas de la vida diaria (ABVD). Objetivos: Describir la presencia de comorbilidades, la percepción de dificultad de los cuidadores para las ABVD y analizar la influencia del grado de afectación motora, el estado nutricional y otras alteraciones neurológicas. Métodos: Estudio transversal y observacional. Se estudió a pacientes con parálisis cerebral grados III-IV-V según el Sistema de Clasificación de la Función Motora Gruesa (GMFCS). Se registraron las comorbilidades y se estudió la composición corporal mediante antropometría y bioimpedanciometría. Además, se hizo una encuesta de carga del cuidador sobre ABVD (10 ítems que exploran las diferentes actuaciones: higiene, vestido, transferencias, sueño y alimentación). Se estudió qué variables influyen más en la percepción de dificultad para las ABVD. Resultados: Muestra de 69 pacientes (50,7% mujeres, edad media de 10,46 ± 0,4 años), con los siguientes grados de GMFCS: grado III 36,2% (N = 25), grado IV 29,0% (N = 20) y grado V 34,8% (N = 24). Se halló relación entre la puntuación de carga del cuidador y el grado GMFCS (p = 0,003) y la discapacidad intelectual (p < 0,001). Además, independientemente del grado de GMFCS y de la discapacidad intelectual, existe mayor dificultad para las ABVD en relación con valores más bajos en peso (Z) (p = 0,028), masa grasa (kg) (p = 0,035), masa grasa (%) (p = 0,094) e índice de masa corporal (Z) (p = 0,086). Conclusiones: Además del grado de afectación motora y de la discapacidad intelectual, el estado nutricional es uno de los factores modificables que influyen en la dificultad del cuidador para realizar las ABVD en los pacientes con parálisis cerebral

The U(1)-Higgs Model: Critical Behaviour in the Confinig-Higgs region

We study numerically the critical properties of the U(1)-Higgs lattice model, with fixed Higgs modulus, in the region of small gauge coupling where the Higgs and Confining phases merge. We find evidence of a first order transition line that ends in a second order point. By means of a rotation in parameter space we introduce thermodynamic magnitudes and critical exponents in close resemblance with simple models that show analogous critical behaviour. The measured data allow us to fit the critical exponents finding values in agreement with the mean field prediction. The location of the critical point and the slope of the first order line are accurately given.Comment: 21 text pages. 12 postscript figures available on reques

Cost-effectiveness of midostaurin in the treatment of acute myeloid leukemia with the FLT3 mutation in Spain

The addition of midostaurin to standard chemotherapy (cytarabine and daunorubicin) has shown significant improvements in the survival of patients with acute myeloid leukemia with the FLT3 mutation (FLT3-AML). The objective of this study was to determine whether this intervention would be cost-effective in Spain. A partitioned survival model with five health states was developed (diagnosis and induction, complete remission, no complete remission, transplantation and death). A lifetime time horizon and the Spanish National Health System perspective were adopted. During the first three years, permanence in the different health states was determined according to the results of the RATIFY study. In successive years, the death rates of the Spanish population adjusted by a factor to reflect long-term disease-related mortality were used. Utilities were obtained from the literature. Pharmacological costs (first and second line) and the costs of other health resources (hospitalizations, visits and tests) were included. The robustness of the model was evaluated by deterministic and probabilistic sensitivity analyses. The addition of midostaurin resulted in 1.46 life years gained (LYG) and 1.23 quality-adjusted life years (QALY) gained and implied an additional cost of € 47,955, resulting in an incremental cost-effectiveness ratio (ICER) of € 32,854/LYG and an incremental cost-utility ratio of € 38,985/QALY. In the univariate sensitivity analysis, the threshold of € 50,000/QALY was not exceeded in any case; taking into consideration potential discounts of 20-40% in the PVL of midostaurin the ICER would be below € 30,000/QALY, a commonly accepted threshold in Spain. In the probabilistic analysis, when the threshold was € 50,000/QALY, midostaurin was cost-effective in 82.3% of simulations. According to our modeling, midostaurin, in combination with standard chemotherapy, could be an efficient alternative for the treatment of FLT3-AML in Spain. © 2019 Arenaza et al