Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial

Objective: To compare the behavioural side effects associated with two commonly used antiepilepsy drugs--phenobarbital and carbamazepine--in children in Bangladesh. Design: Prospective randomised controlled single centre trial. Setting: Specialist children's hospital in Dhaka, Bangladesh. Participants: 108 children aged 2-15 with generalised tonic-clonic (n=51) or partial and secondary generalised seizures (n=57). Main outcome measures: Seizure control and behavioural side effects. Results: 91 children were followed up for 12 months. Six required a change of antiepilepsy drug. Side effects were compared in 85 children. In the last quarter of the 12 month follow-up, 71 children were seizure free after one year's treatment. Thirty two in the phenobarbital group and 39 in the carbamazepine group had no seizures in 74 and 102 days after randomisation, respectively. Ten children had increased behavioural problems, which were unacceptable in four (one in the phenobarbital group and three in the carbamazepine group). Independent t tests, however, showed no difference between the two trial drugs. Conclusion: There was no excess in behavioural side effects with phenobarbital in children with epilepsy in a country with limited resources

ALIGNING ASSESSMENT WITH OUTCOME BASED ASSESSMENT: AN EMPIRICAL STUDY ON UNDERGRADUATE COURSE ON FUNDAMENTALS OF STATISTICS

Since the Institution of Engineers, Bangladesh (IEB) has made Outcome Based Assessment (OBA) compulsory towards program accreditation it has been one of the vital interests of most engineering departments in Bangladesh. When considering the mapping of the Course outcome (CO) to Program Outcomes (PO) implementation of the OBA may not be an easy task. This paper reports the analysis procedure of the CO and PO achievement for an B.Sc. course on Fundamentals of Statistics, a subject, which is part of curriculum of Electrical & Electronics Engineering and Computer Science and Engineering at Eastern University, Bangladesh. As a sum, this paper contributes complete process and an example investigation for Outcome Based Valuation starting from course curriculum progress to its CO-PO achievement based on definite criteria.  Article visualizations

The ship-breaking industry of Bangladesh: an exploration of the accountability of shipping companies

This thesis explores the social and environmental information disclosure practices of shipping companies, with specific reference to how they account for the lifecycle of ships under their control. This thesis sheds light on the working conditions, violations of human rights, and ecological damage within the ship-breaking yards of Chittagong, Bangladesh. The thesis has two interrelated sections. The first section explores the social and environmental disclosure practices of the top ten global shipping companies for a particular year. The second section explores the disclosure practices of some of the identified shipping companies that supplied their ships for dismantling to the ship yards of Chittagong, Bangladesh. Both sections utilise annual report content analysis. For the purposes of measurement, an index called ‘Ship recycling related information disclosure index’ (SRIDI) has been used and the unit of analysis is the frequency of disclosures. The thesis also developed an ‘accountability model’ to evaluate the accountability demonstrated by the shipping companies. The thesis finds that the extent of disclosures of social and environmental information, including ship recycle-related information by the global top ten shipping companies, is relatively high for some of the organisations. However, the disclosures made by the identified shipping companies that are alleged to supply the end-of-life ships to Bangladesh seem to be lower than the global top ten shipping companies. The thesis finds no information from either the global shipping companies or from the identified shipping companies annual report that specifically states where the ships actually go at the end of their lifecycle. This implies that the shipping companies avoid mentioning the final destination for their end-of-life ships to avoid potential criticism for dumping them in the ship-breaking yards of developing countries, an act which might negatively impact their reputation as well as ‘brands’. This also implies that although shipping companies that allegedly supply their end-of-life ships to Bangladesh should be accountable for their actions. However this does not appear to be the case. This thesis used a normative theoretical perspective and applied ‘accountability model’ to analyse the findings. The first part of the thesis was accepted as a paper in the AFAANZ conference 2012 held in Melbourne and was presented in a concurrent session by the researcher

Bacterial Isolates and Antimicrobial Susceptibility in Children with Acute Diarrhea at Ibn Sina Medical College, Bangladesh

Backround: Infectious diarrhea is one of common cause of children diarrhea causing mortality and morbidity worldwide. This study was performed to identify the common bacteria and their antimicrobial susceptibility in children with diarrhea. Methods: A retrospective study was conducted from April 2014 to March 2016 at IBN SINA Medical College Hospital, Bangladesh. Stool samples were cultured on MacConkey agar and blood agar. A standard biochemical procedure was used for full identification of bacterial isolates. Antimicrobial susceptibility tests were done on Mueller-Hinton agar by using disc diffusion method. Data were entered and analyzed by using SPSS version 20 and a p-value of < 0.05 was considered statistically significant. Results: A total of 186 stool samples were tested for bacterial isolation and 55 (29.57%) cases were found to have bacterial isolates. From the total bacterial isolates, the predominant isolate was E. coli 39 (70.91%) followed by Salmonella 9 (16.36%) and Shigella Spp.7 (12.73%). As much as 84.62% E. coli were resistant to co-trimoxazole and cefuroxime while 92.31% E. coli were sensitive to amikacin and 71.79% were sensitive to cefepime and gentamicin. Salmonella were 100% sensitive to cefepime, ceftriaxone, cefixime, ceftazidime, and ciprofloxacin. Shigella were 85.71% sensitive to amikacin and cefepime. Conclusion: The results show that E. coli were the most frequently isolated pathogen in children. The majority of the bacterial isolates were resistant to multiple antibiotics. Hence, antibiotics susceptibility test is mandatory before prescribing any antibiotics

Estimation of swine movement network at farm level in the US from the Census of Agriculture data

Citation: Moon, S. A., Ferdousi, T., Self, A., & Scoglio, C. M. (2019). Estimation of swine movement network at farm level in the US from the Census of Agriculture data. Scientific Reports, 9(1), 6237. https://doi.org/10.1038/s41598-019-42616-wSwine movement networks among farms/operations are an important source of information to understand and prevent the spread of diseases, nearly nonexistent in the United States. An understanding of the movement networks can help the policymakers in planning effective disease control measures. The objectives of this work are: (1) estimate swine movement probabilities at the county level from comprehensive anonymous inventory and sales data published by the United States Department of Agriculture - National Agriculture Statistics Service database, (2) develop a network based on those estimated probabilities, and (3) analyze that network using network science metrics. First, we use a probabilistic approach based on the maximum information entropy method to estimate the movement probabilities among different swine populations. Then, we create a swine movement network using the estimated probabilities for the counties of the central agricultural district of Iowa. The analysis of this network has found evidence of the small-world phenomenon. Our study suggests that the US swine industry may be vulnerable to infectious disease outbreaks because of the small-world structure of its movement network. Our system is easily adaptable to estimate movement networks for other sets of data, farm animal production systems, and geographic regions

Understanding the role of sexual transmission in the spread of ZIKA virus using an individual-based interconnected population model

Citation: Tanver, F., Lee, C., Mcvey, D., & Scoglio, S. (2018). Understanding the role of sexual transmission in the spread of ZIKA virus using an individual-based interconnected population model. Pre-Print, Unpublished Manuscript.Zika virus has affected the world as a long-term threat. Modeling its transmission is important in order to facilitate forecasts and control measures. We propose a novel node-based interconnected population model to simulate both vectored and sexual transmission of Zika virus. Using a sexual contact network, we incorporate heterogeneous mixing in the host population with stochastic transmission for realistic predictions. We also incorporate climatic variations in our model, which affect the mosquito vector population and consequently the arbovirus transmission. We perform extensive simulations to understand the effects of sexual transmission rate and network topology on the spreading of infections. Sexual transmission contributes to the epidemic spread and under certain conditions, can sustain it up to several months without vectors. This can potentially lead to recurrences once the mosquitoes overwinter. We also find that sexual transmission can have a stronger effect when vectored transmission is relatively weaker due to climatic conditions. Our results show that vectored and sexual transmission affect the disease dynamics differently

Understanding the survival of Zika virus in a vector interconnected sexual contact network

Citation: Ferdousi, T., Cohnstaedt, L. W., McVey, D. S., & Scoglio, C. M. (2019). Understanding the survival of Zika virus in a vector interconnected sexual contact network. Scientific Reports, 9(1), 7253. https://doi.org/10.1038/s41598-019-43651-3The recent outbreaks of the insect-vectored Zika virus have demonstrated its potential to be sexually transmitted, which complicates modeling and our understanding of disease dynamics. Autochthonous outbreaks in the US mainland may be a consequence of both modes of transmission, which affect the outbreak size, duration, and virus persistence. We propose a novel individual-based interconnected network model that incorporates both insect-vectored and sexual transmission of this pathogen. This model interconnects a homogeneous mosquito vector population with a heterogeneous human host contact network. The model incorporates the seasonal variation of mosquito abundance and characterizes host dynamics based on age group and gender in order to produce realistic projections. We use a sexual contact network which is generated on the basis of real world sexual behavior data. Our findings suggest that for a high relative transmissibility of asymptomatic hosts, Zika virus shows a high probability of sustaining in the human population for up to 3 months without the presence of mosquito vectors. Zika outbreaks are strongly affected by the large proportion of asymptomatic individuals and their relative transmissibility. The outbreak size is also affected by the time of the year when the pathogen is introduced. Although sexual transmission has a relatively low contribution in determining the epidemic size, it plays a role in sustaining the epidemic and creating potential endemic scenarios

Corneal Confocal Microscopy Detects Small Fibre Neuropathy in Patients with Upper Gastrointestinal Cancer and Nerve Regeneration in Chemotherapy Induced Peripheral Neuropathy.

Published onlineThere are multiple neurological complications of cancer and its treatment. This study assessed the utility of the novel non-invasive ophthalmic technique of corneal confocal microscopy in identifying neuropathy in patients with upper gastrointestinal cancer before and after platinum based chemotherapy. In this study, 21 subjects with upper gastrointestinal (oesophageal or gastric) cancer and 21 healthy control subjects underwent assessment of neuropathy using the neuropathy disability score, quantitative sensory testing for vibration perception threshold, warm and cold sensation thresholds, cold and heat induced pain thresholds, nerve conduction studies and corneal confocal microscopy. Patients with gastro-oesophageal cancer had higher heat induced pain (P = 0.04) and warm sensation (P = 0.03) thresholds with a significantly reduced sural sensory (P<0.01) and peroneal motor (P<0.01) nerve conduction velocity, corneal nerve fibre density (CNFD), nerve branch density (CNBD) and nerve fibre length (CNFL) (P<0.0001). Furthermore, CNFD correlated significantly with the time from presentation with symptoms to commencing chemotherapy (r = -0.54, P = 0.02), and CNFL (r = -0.8, P<0.0001) and CNBD (r = 0.63, P = 0.003) were related to the severity of lymph node involvement. After the 3rd cycle of chemotherapy, there was no change in any measure of neuropathy, except for a significant increase in CNFL (P = 0.003). Corneal confocal microscopy detects a small fibre neuropathy in this cohort of patients with upper gastrointestinal cancer, which was related to disease severity. Furthermore, the increase in CNFL after the chemotherapy may indicate nerve regeneration

Mathematical catastrophe revisited

Volume 2, Issue 1, January 200