A Quasi-linear Diffusion Model for Resonant Wave–Particle Instability in Homogeneous Plasma

In this paper, we develop a model to describe the generalized wave-particle instability in a quasi-neutral plasma. We analyze the quasi-linear diffusion equation for particles by expressing an arbitrary unstable and resonant wave mode as a Gaussian wave packet, allowing for an arbitrary direction of propagation with respect to the background magnetic field. We show that the localized energy density of the Gaussian wave packet determines the velocity-space range in which the dominant wave-particle instability and counteracting damping contributions are effective. Moreover, we derive a relation describing the diffusive trajectories of resonant particles in velocity space under the action of such an interplay between the wave-particle instability and damping. For the numerical computation of our theoretical model, we develop a mathematical approach based on the Crank-Nicolson scheme to solve the full quasi-linear diffusion equation. Our numerical analysis solves the time evolution of the velocity distribution function under the action of a dominant wave-particle instability and counteracting damping and shows a good agreement with our theoretical description. As an application, we use our model to study the oblique fast-magnetosonic/whistler instability, which is proposed as a scattering mechanism for strahl electrons in the solar wind. In addition, we numerically solve the full Fokker-Planck equation to compute the time evolution of the electron-strahl distribution function under the action of Coulomb collisions with core electrons and protons after the collisionless action of the oblique fast-magnetosonic/whistler instability

Solar cycle variations of the Cluster spacecraft potential and its use for electron density estimations

International audience[1] A sunlit conductive spacecraft, immersed in tenuous plasma, will attain a positive potential relative to the ambient plasma. This potential is primarily governed by solar irradiation, which causes escape of photoelectrons from the surface of the spacecraft, and the electrons in the ambient plasma providing the return current. In this paper we combine potential measurements from the Cluster satellites with measurements of extreme ultraviolet radiation from the TIMED satellite to establish a relation between solar radiation and spacecraft charging from solar maximum to solar minimum. We then use this relation to derive an improved method for determination of the current balance of the spacecraft. By calibration with other instruments we thereafter derive the plasma density. The results show that this method can provide information about plasma densities in the polar cap and magnetotail lobe regions where other measurements have limitations

The gamma-ray giant flare from SGR1806-20: Evidence for crustal cracking via initial timescales

We report here on serendipitous observations of the intense gamma-ray flare from SGR 1806-20 that occured on 27 December 2004. Unique data from the Cluster and Double Star-2 satellites, designed to study the Earth's magnetosphere, provide the first observational evidence of three separate timescales within the early (first 100ms) phases of this class of events. These observations reveal that, in addition to the initial very steep (<0.25ms) X-ray onset, there is firstly a 4.9ms exponential rise timescale followed by a continued exponential rise in intensity on a timescale of 70ms. These three timescales are a prominent feature of current theoretical models including the timescale (several ms) for fracture propagation in the crust of the neutron star.Comment: 10 pages including 2 figures Ap J Letters in press, May 200

Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration.

BACKGROUND: Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to support breast cancer progression is poorly understood. RESULTS: Here, we show that co-culture of breast cancer cells with adipocytes revealed cancer cell-stimulated depletion of adipocyte triacylglycerol. Adipocyte-derived free fatty acids were transferred to breast cancer cells, driving fatty acid metabolism via increased CPT1A and electron transport chain complex protein levels, resulting in increased proliferation and migration. Notably, fatty acid transfer to breast cancer cells was enhanced from "obese" adipocytes, concomitant with increased stimulation of cancer cell proliferation and migration. This adipocyte-stimulated breast cancer cell proliferation was dependent on lipolytic processes since HSL/ATGL knockdown attenuated cancer cell responses. CONCLUSIONS: These findings highlight a novel and potentially important role for adipocyte lipolysis in the provision of metabolic substrates to breast cancer cells, thereby supporting cancer progression

The Stability of the Electron Strahl against the Oblique Fast-magnetosonic/Whistler Instability in the Inner Heliosphere

We analyze the micro-kinetic stability of the electron strahl in the solar wind depending on heliocentric distance. The oblique fast-magnetosonic/whistler (FM/W) instability has emerged in the literature as a key candidate mechanism for the effective scattering of the electron strahl into the electron halo population. Using data from the Parker Solar Probe (PSP) and Helios, we compare the measured strahl properties with the analytical thresholds for the oblique FM/W instability in the low- and high-β ∥c regimes, where β ∥c is the ratio of the core parallel thermal pressure to the magnetic pressure. Our PSP and Helios data show that the electron strahl is on average stable against the oblique FM/W instability in the inner heliosphere. Our analysis suggests that the instability, if at all, can only be excited sporadically and on short timescales. We discuss the caveats of our analysis and potential alternative explanations for the observed scattering of the electron strahl in the solar wind. Furthermore, we recommend the numerical evaluation of the stability of individual distributions in the future to account for any uncertainties in the validity of the analytical expressions for the instability thresholds

The Kinetic Expansion of Solar-wind Electrons: Transport Theory and Predictions for the Very Inner Heliosphere

We propose a transport theory for the kinetic evolution of solar-wind electrons in the heliosphere. We derive a gyro-averaged kinetic transport equation that accounts for the spherical expansion of the solar wind and the geometry of the Parker spiral magnetic field. To solve our three-dimensional kinetic equation, we develop a mathematical approach that combines the Crank–Nicolson scheme in velocity space and a finite-difference Euler scheme in configuration space. We initialize our model with isotropic electron distribution functions and calculate the kinetic expansion at heliocentric distances from 5 to 20 solar radii. In our kinetic model, the electrons evolve mainly through the combination of ballistic particle streaming, the magnetic mirror force, and the electric field. By applying fits to our numerical results, we quantify the parameters of the electron strahl and the core part of the electron velocity distributions. The strahl fit parameters show that the density of the electron strahl is around 7% of the total electron density at a distance of 20 solar radii, the strahl bulk velocity and strahl temperature parallel to the background magnetic field stay approximately constant beyond a distance of 15 solar radii, and β∥s (i.e., the ratio of the strahl parallel thermal pressure to the magnetic pressure) is approximately constant with heliocentric distance at a value of about 0.02. We compare our results with data measured by the Parker Solar Probe. Furthermore, we provide theoretical evidence that the electron strahl is not scattered by the oblique fast-magnetosonic/whistler instability in the near-Sun environment

Cluster in the Auroral Acceleration Region

Due to a fortuitous evolution of the Cluster orbit, the Cluster spacecraft penetrated for the first time in its mission the heart of Earth's auroral acceleration region (AAR) in December 2009 and January 2010. During this time a special AAR campaign was carried out by the various Cluster instrument teams with special support from ESA and NASA facilities. We present some of the first multi-spacecraft observations of the waves, particles and fields made during that campaign. The Cluster spacecraft configuration during these AAR passages was such that it allowed us to explore the differences in the signatures of waves, particles, and fields on the various spacecraft in ways not possible with single spacecraft. For example, one spacecraft was more poleward than the other three (C2), one was at higher altitude (C1), and one of them (0) followed another (C4) through the AAR on approximately the same track but delayed by three minutes. Their separations were generally on the order of a few thousand km or less and occasionally two of them were lying along the same magnetic field line. We will show some of the first analyses of the data obtained during the AAR campaign, where upward and downward current regions, and the waves specifically associated with those regions, as well as the auroral cavities, were observed similarly and differently on the various spacecraft, helping us to explore the spatial, as well as the temporal, aspects of processes occurring in the AAR

Genome-Wide Association Study and Functional Characterization Identifies Candidate Genes for Insulin-Stimulated Glucose Uptake

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in \u3e55,000 participants from three ancestry groups. We identified ten new loci (P \u3c 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits