989 research outputs found

    A data-driven network approach for characterization of political parties’ ideology dynamics

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    This is the final published version. Available from SpringerOpen via the DOI in this record.All datasets used in this work are freely available at http://www.tse.jus.br/eleicoes/estatisticas/(in Portuguese). Intermediary files and code are available upon request to the corresponding author.Political ideology is a major social phenomena that plays a crucial role in the formation and dynamics of ideologically-aligned social groups. This alignment gives rise to some of the most powerful social structures in modern democracies, the political parties. Due to the influence and importance of political parties in society, estimating their ideology is an active topic in political science research. However ideology is a very subjective phenomena and existing quantitative methods for ideology estimation are susceptible to a variety estimation issues, specially when applied in multi-partisan systems. In this work, we developed a data-driven network model for political ideology estimation based on partisan relationships established from party-switching politicians. The model is applied to the Brazilian case and yields results consistent with existing literature in the Brazilian political scenario while addressing data scarcity issues in existing methodologies.Science Without Borders program (CAPES, Brazil)National Science Foundation (NSF)Army Research Offic

    Designing a shipboard line transect survey to estimate cetacean abundance off the Azores archipelago

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    Management schemes dedicated to the conservation of wildlife populations rely on the effective monitoring of population size, and this may require the accurate and precise estimation of this parameter. Line transect distance sampling can be an effective approach for estimating abundance. Little information is available regarding cetacean abundance in the Azores. This paper had two aims: 1) to design a line transect shipboard survey to estimate the absolute abundance of the most common cetaceans off the Azores; and 2) to provide a set of potential survey effort scenarios to policy makers and environmental managers. Three survey scenarios are assessed, and one detailed survey design is presented. A total of 8,800 km of survey effort is recommended; at this level the expected coefficient of variation of estimates is less than 0.3 for most species. However, if logistic constraints prevent this, at least 5,000 km of survey effort should be used to achieve minimum sample size requirements; this is estimated to take 36 days of effort. It is also recommended to conduct a pilot survey. This would provide more detailed information that could be used to improve the survey design of what would be the first survey of this magnitude ever to be implemented in the Azores

    In situ modification of nanostructure configuration through the manipulation of hydrogen bonded amphiphile self-association

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    Herein, we report the synthesis of a novel amphiphilic salt containing a number of hydrogen bond donating (HBD) and accepting (HBA) functionalities. This amphiphile has been shown to self-associate via hydrogen bond formation in a DMSO solution, confirmed through a combination of NMR, UV-Vis and dynamic light scattering and supported by X-ray diffraction studies. The combination of different HBD and HBA functionalities within the amphiphile structure gives rise to a variety of competitive, self-associative hydrogen bonding modes that result in the formation of ‘frustrated’ hydrogen bonded nanostructures. These nanostructures can be altered through the addition of competitive HBD arrays and/or HBA anionic guests. The addition of these competitive species modifies the type of self-associative hydrogen bonding modes present between the amphiphilic molecules, triggering the in situ formation of novel hydrogen bonded nanostructures

    EDUCAÇÃO EM DIREITOS HUMANOS COMO COMBATE AO RACISMO ESTRUTURAL

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    Este estudo traz uma análise acerca do tema racismo estrutural, direcionando reflexões sobre direitos humanos e a importância de inclusão no currículo escolar da educação sobre direitos humanos, valorizando e enfatizando os princípios constitucionais da igualdade e repúdio ao racismo, buscando o respeito à diversidade e às diferenças. Nesse contexto, objetivamos apresentar os conceitos de igualdade formal e material, qual corrobora para a compreensão acerca de inserção de políticas públicas específicas para negros, em decorrência da reparação à dívida histórica, a compreensão sobre o racismo estrutural e os contornos deste na sociedade, até os dias atuais e, por fim, a relevância de uma educação antirracista. Justifica-se a presente pesquisa, em razão da importância do tema nos dias correntes, após diversos movimentos sociais contra o racismo, devendo a educação também se mover nesse sentido, promovendo reflexões e conscientização sobre o assunto, mudando a cultura racista intrincada em nosso país, desde o período colonial. Dessa feita, para alcançar nossos objetivos, usamos a metodologia bibliográfica, com enfoque qualitativo, com instrumentos legislativos, além de artigos científicos e livros. Aponta-se, portanto, a necessidade de desmistificar os estigmas raciais perpetuados pela história e reformar uma nova cultura que consolide o direito de todos, que promova nova mentalidade, vivências de valores de igualdade, solidariedade, tolerância e respeito, e repúdio a qualquer tipo de discriminação

    In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine

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    BACKGROUND: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S. haematobium is the most prevalent, causing the chronic parasitic disease schistosomiasis that still represents a major problem of public health in many regions of the world and especially in tropical areas, leading to serious manifestations and mortality in developing countries. Since the 1970s, praziquantel (PZQ) is the drug of choice for the treatment of schistosomiasis, but concerns about relying on a single drug to treat millions of people, and the potential appearance of drug resistance, make identification of alternative schistosomiasis chemotherapies a high priority. Alkylphospholipid analogs (APLs), together with their prototypic molecule edelfosine (EDLF), are a family of synthetic antineoplastic compounds that show additional pharmacological actions, including antiparasitic activities against several protozoan parasites. METHODOLOGY/PRINCIPAL FINDINGS: We found APLs ranked edelfosine> perifosine> erucylphosphocholine> miltefosine for their in vitro schistosomicidal activity against adult S. mansoni worms. Edelfosine accumulated mainly in the worm tegument, and led to tegumental alterations, membrane permeabilization, motility impairment, blockade of male-female pairing as well as induction of apoptosis-like processes in cells in the close vicinity to the tegument. Edelfosine oral treatment also showed in vivo schistosomicidal activity and decreased significantly the egg burden in the liver, a key event in schistosomiasis. CONCLUSIONS/SIGNIFICANCE: Our data show that edelfosine is the most potent APL in killing S. mansoni adult worms in vitro. Edelfosine schistosomicidal activity seems to depend on its action on the tegumental structure, leading to tegumental damage, membrane permeabilization and apoptosis-like cell death. Oral administration of edelfosine diminished worm and egg burdens in S. mansoni-infected CD1 mice. Here we report that edelfosine showed promising antischistosomal properties in vitro and in vivo

    Chiral properties of discrete Joyce and Hestenes equations

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    This paper concerns the question of how chirality is realized for discrete counterparts of the Dirac-K\"{a}hler equation in the Hestenes and Joyce forms. It is shown that left and right chiral states for these discrete equations can be described with the aid of some projectors on a space of discrete forms. The proposed discrete model admits a chiral symmetry. We construct discrete analogues of spin operators, describe spin eigenstates for a discrete Joyce equation, and also discuss chirality.Comment: 14 pages, conference pape

    Decentralized ellipsoidal state estimation for linear model predictive control of an irrigation canal

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    A centralized linear MPC is used to stabilize an irrigation system whose operation is represented by an integrator-delay model. Since not all the state variables can be measured, a decentralized ellipsoidal estimation strategy is proposed. This approach keeps the quality of a centralized estimation and reduces significantly the computation time for the systems considered. An adaptation of Test Canal 1, developed by the ASCE Task Committee on Canal Automation Algorithms, is used as a case study to show the performance of the proposed methodology.Fil: Rodriguez Aguilar, Leandro Pedro Faustino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Maestre, J. M.. Universidad de Sevilla. Escuela Técnica Superior de Ingeniería; EspañaFil: Camacho, E. F.. Universidad de Sevilla. Escuela Técnica Superior de Ingeniería; EspañaFil: Sanchez, Mabel Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentin
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