Monte Carlo method applied to the mechanical dating of the Turin Shroud

Alternative dating methods to radiocarbon have been recently developed to study the Turin Shroud (TS), the linen sheet that according to the tradition enveloped the dead body of Jesus Christ; among them, a mechanical one is based on the study of five mechanical parameters in reference to the breaking strength, the Young modulus and the loss factor. This method tests single TS linen fibers using a machine, built in for the purpose, capable to measure the stress-stain parameters during loading cycles. These parameters have been already shown to be dependent on the age of the linen under test, and a preliminary result has been obtained: the TS date is 400 A.D. \ub1400 years at 95% confidence level. A companion paper has combined this mechanical result with two chemical ones, coming from Raman and FT-IR spectra, and the combined result is 90 AD \ub1200 years at 95% confidence level, thus confirming the compatibility of the age of the TS with the period in which Jesus Crist lived in Palestine. As the evaluation of the uncertainty propagation is not simple in the case of the mechanical parameters, this paper tries to furnish a more reliable result applying the Monte Carlo method to the mechanical parameters directly measured. The obtained mechanical age of the TS of 279 A.D. \ub1216 years at 95% confidence level is compatible with the previous results, but with an uncertainty almost halved

A Blockchain-based traceability system in Agri-Food SME: case study of a traditional bakery

In this paper we present a blockchain based system for the supply chain management of a particular Italian bread. Goal of the system is to guarantee a transparent and auditable traceability of the Carasau bread where each actor of the supply chain can verify the quality of the products and the conformity to the normative about the hygienic-sanitary conditions along the chain. To realize this system we relied on the Blockchain and the Internet of Thing technologies in order to provide a trustless environment, in which trust is placed in cryptography, in mathematical operations and on the network, and not in public or private companies. Thanks to the use of digital technologies the system aims to reduce the data entry errors and the risk of tampering. Our system is designed so that along the supply chain, the nodes equipped with several sensors directly communicate their data to Raspberry Pi units that elaborate and transmit them to Interplanetary File System and to the Ethereum Blockchain. Furthermore, we designed ad hoc Radio Frequency Identification and Near Field communication tags to shortly supply the proposed system with information about the products and batches. The dedicated RFID tags robustness during on-bread operation was numerically tested. The system will easily allow end consumers to have a transparent view on the whole journey from raw material to purchased final product and a supervisory authority to perform online inspections on the products’ quality and on the good working practices

11C-choline vs. 18F-FDG PET/CT in assessing bone involvement in patients with multiple myeloma

<p>Abstract</p> <p>Background</p> <p>Multiple Myeloma (MM) is a B cell neoplasm causing lytic or osteopenic bone abnormalities. Whole body skeletal survey (WBSS), Magnetic resonance (MR) and ¹⁸F-FDG PET/CT are imaging techniques routinely used for the evaluation of bone involvement in MM patients.</p> <p>Aim</p> <p>As MM bone lesions may present low ¹⁸F-FDG uptake; the aim of this study was to assess the possible added value and limitations of ¹¹C-Choline to that of ¹⁸F-FDG PET/CT in patients affected with MM.</p> <p>Methods</p> <p>Ten patients affected with MM underwent a standard ¹¹C-Choline PET/CT and an ¹⁸F-FDG PET/CT within one week. The results of the two scans were compared in terms of number, sites and SUV_maxof lesions.</p> <p>Results</p> <p>Four patients (40%) had a negative concordant ¹¹C-Choline and ¹⁸F-FDG PET/CT scans. Two patients (20%) had a positive ¹¹C-Choline and ¹⁸F-FDG PET/CT scans that identified the same number and sites of bone lesions. The remaining four patients (40%) had a positive ¹¹C-Choline and ¹⁸F-FDG PET/CT scan, but the two exams identified different number of lesions. Choline showed a mean SUV_maxof 5 while FDG showed a mean SUV_maxof 3.8 (P = 0.042). Overall, ¹¹C-Choline PET/CT scans detected 37 bone lesions and ¹⁸F-FDG PET/CT scans detected 22 bone lesions but the difference was not significant (P = 0.8).</p> <p>Conclusion</p> <p>According to these preliminary data, ¹¹C-Choline PET/CT appears to be more sensitive than ¹⁸F-FDG PET/CT for the detection of bony myelomatous lesions. If these data are confirmed in larger series of patients, ¹¹C-Choline may be considered a more appropriate functional imaging in association with MRI for MM bone staging.</p

Landslide-Induced Damage Probability Estimation Coupling InSAR and Field Survey Data by Fragility Curves

Landslides are considered to be one of the main natural geohazards causing relevant economic damages and social effects worldwide. Italy is one of the countries worldwide most affected by landslides; in the Region of Tuscany alone, more than 100,000 phenomena are known and mapped. The possibility to recognize, investigate, and monitor these phenomena play a key role to avoid further occurrences and consequences. The number of applications of Advanced Differential Interferometric Synthetic Aperture Radar (A-DInSAR) analysis for landslides monitoring and mapping greatly increased in the last decades thanks to the technological advances and the development of advanced processing algorithms. In this work, landslide-induced damage on structures recognized and classified by field survey and velocity of displacement re-projected along the steepest slope were combined in order to extract fragility curves for the hamlets of Patigno and Coloretta, in the Zeri municipality (Tuscany, northern Italy). Images using ERS1/2, ENVISAT, COSMO-SkyMed (CSK) and Sentinel-1 SAR (Synthetic Aperture Radar) were employed to investigate an approximate 25 years of deformation affecting both hamlets. Three field surveys were conducted for recognizing, identifying, and classifying the landslide-induced damage on structures and infrastructures. At the end, the damage probability maps were designed by means of the use of the fragility curves between Sentinel-1 velocities and recorded levels of damage. The results were conceived to be useful for the local authorities and civil protection authorities to improve the land managing and, more generally, for planning mitigation strategies.This work has been carried out within the project founded and supported by the Regional government of Tuscany, under the agreement “Monitoring ground deformation in the Tuscany Region with satellite radar data”. Roberto Tomás was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), the State Agency of Research (AEI) and European Funds for Regional Development (FEDER), under projects TEC2017-85244-C2-1-P and PRX17/00439

Proof of concept study on coronary microvascular function in low flow low gradient aortic stenosis

ObjectivesWe hypothesised that low flow low gradient aortic stenosis (LFLGAS) is associated with more severe coronary microvascular dysfunction (CMD) compared with normal-flow high-gradient aortic stenosis (NFHGAS) and that CMD is related to reduced cardiac performance. MethodsInvasive CMD assessment was performed in 41 consecutive patients with isolated severe aortic stenosis with unobstructed coronary arteries undergoing transcatheter aortic valve implantation (TAVI). The index of microcirculatory resistance (IMR), resistive reserve ratio (RRR) and coronary flow reserve (CFR) were measured in the left anterior descending artery before and after TAVI. Speckle tracking echocardiography was performed to assess cardiac function at baseline and repeated at 6 months. ResultsIMR was significantly higher in patients with LFLGAS compared with patients with NFHGAS (24.1 (14.6 to 39.1) vs 12.8 (8.6 to 19.2), p=0.002), while RRR was significantly lower (1.4 (1.1 to 2.1) vs 2.6 (1.5 to 3.3), p=0.020). No significant differences were observed in CFR between the two groups. High IMR was associated with low stroke volume index, low cardiac output and reduced peak atrial longitudinal strain (PALS). TAVI determined no significant variation in microvascular function (IMR: 16.0 (10.4 to 26.1) vs 16.6 (10.2 to 25.6), p=0.403) and in PALS (15.9 (9.9 to 26.5) vs 20.1 (12.3 to 26.7), p=0.222). Conversely, left ventricular (LV) global longitudinal strain increased after TAVI (-13.2 (8.4 to 16.6) vs -15.1 (9.4 to 17.8), p=0.047). In LFLGAS, LV systolic function recovered after TAVI in patients with preserved microvascular function but not in patients with CMD. ConclusionsCMD is more severe in patients with LFLGAS compared with NFHGAS and is associated with low-flow state, left atrial dysfunction and reduced cardiac performance

Evolutive Unification in Composite Active Galactic Nuclei

In this paper we explore an evolutionary Unified scenario involving super massive black hole and starburst with outflow, that seems capable of explaining most of the observational properties of at least part of AGNs. Our suggestion is explored inside the expectations of the Starburst model close associated with the AGN where the NLR, BLR and BAL region are produced in part by the outflow process with shells and in compact supernova remnants. The outflow process in BAL QSOs with extreme IR and Fe II emission is studied. In addition, the Fe II poblem regarding the BLR of AGN is analysed. Neither the correlations between the BAL, IR emission, FeII intensity and the intrinsic properties of the AGN are clearly understood. We suggest here that the behaviour of the BAL, IR and FeII emission in AGNs can be understood inside an evolutionary and composite model for AGNs. In our model, strong BAL systems and Fe II emission are present (and intense) in young IR objects. Orientation/ obscuration effects take the role of a second parameter providing the segregation between Sy1/Sy2 and BLRG/NLRG.Comment: 14 pages, 6 figures (submitted MNRAS