332 research outputs found
Recommended from our members
Austria in the COVID-19 Pandemic - Citizens' Satisfaction with Crisis Measures and Communication
Background: We assess satisfaction about various aspects of the 2020 COVID-19 crisis for a representative sample of 1798 respondents living in Austria. Survey questions were added to a previously planned data collection, based on concrete questions discussed at a BKA Clearing Board meeting (Tuesday, 14.04.2020: Subarbeitsgruppe Psycho-Soziale-Effekte im Rahmen von "COVID-19 / Future Operations").
Findings: Overall, people living in Austria are satisfied with the various crisis management elements of the COVID-19 pandemic, as answers are mainly at the positive side of the response scale that ranges from -3 (Very unsatisfied) to +3 (Very satisfied). Citizens are most satisfied with how well they implement the measures of the federal government themselves (and/or their employer) to overcome the Corona crisis, and about how they are able to comply with these measures. In contrast, they are least satisfied with how national media report on the measures (Newspapers, TV, etc.). Splitting-up satisfaction evaluations for gender, age, region, level of education, occupation, or sector of employment does show no or some small (but no substantial) differences for particular subgroups. We can observe an age effect for satisfaction on how others deal with the government's COVID-19 measures. This means: the older people are, the more satisfied they are about how others comply with the COVID-19 measures. Self-employed respondents are least satisfied with how the government is dealing with the crisis and communicating the measures. Students are most satisfied about that. However, it has to be noted that this data is from 17 April to 29 April (2020), which is just before loosening, in a second round, many of the restrictions on small businesses
Steigerung der Energieeffizienz einer integrierten Heimnetzwerkinfrastruktur
Zur Realisierung von Applikationen aus den Bereichen Smart Home, Ambient Assisted Living und E-Health ist es notwendig, eine Vielzahl von kleinen ressourcenbeschränkten Systemen zu vernetzen. Dazu eignen sich drahtlose Kommunikationslösungen mit niedrigen Datenraten und energiesparender Arbeitsweise. Damit erhalten neben den bereits weitverbreiteten hochratigen Technologien, wie WLAN, PLC und Ethernet, niederratige Kommunikationstechnologien Einzug in den Heimbereich. Eine intelligente Kombination und Interaktion zwischen beiden Netzwerken verspricht vielfältige Vorteile. Wenn z.B. zunehmend Switches, Access Points oder Mediengeräte mit niederratigen Schnittstellen ausgestattet werden, erhalten diese nicht nur Zugriff auf Heimautomatisierungsgeräte, sondern können auch über diese energiesparende Schnittstelle untereinander kommunizieren. Ein solches dediziertes Signalisierungsnetzwerk kann dazu dienen, das hochratige Netzwerk zu parametrisieren. In diesem Beitrag wird ein Verfahren vorgestellt, das über die niederratige Technologie Informationen über benötigte und nicht benötigte hochratige Schnittstellen austauscht. Unbenutzte Schnittstellen werden gezielt abgeschaltet. Mit Hilfe von Simulationen wird gezeigt, dass solche Verfahren erhebliche Energieeinsparungen der Heimnetzwerkinfrastruktur ermöglichen
Recommended from our members
COVID-19 Pandemie in Österreich – Zufriedenheit der Bürger*innen mit Maßnahmen und Kommunikation
Wir bewerten die Zufriedenheit mit verschiedenen Aspekten der COVID-19-Krise 2020 für eine repräsentative Stichprobe von 1798 in Österreich lebenden Befragten. Eine zuvor geplante Datenerhebung wurde um Erhebungsfragen ergänzt, die auf konkreten Fragen basieren, die in einer Sitzung des BKA-Clearing Boards (Dienstag, 14.04.2020: Subarbeitsgruppe Psycho-Soziale-Effekte im Rahmen von "COVID-19 / Future Operations").
Insgesamt sind in Österreich lebende Menschen zufrieden mit den abgefragten Aspekten der COVID-19 Krise: Sämtliche Mittelwerte liegen im positiven Bereich der Skala (also über 0 auf der Skala von -3 bis +3). Die größte Zufriedenheit zeigen die Befragten mit sich selbst im Umgang mit der von Regierung und Arbeitgeber\*in gesetzten Maßnahmen zur Bewältigung der Krise. Das betrifft sowohl die Umsetzung als auch die Einhaltung der Maßnahmen durch die Befragten. Im Gegensatz dazu ist die Zufriedenheit am geringsten, wenn es um die Befolgung der Maßnahmen durch Nachbarn und andere Bürger\*innen sowie um die Berichterstattung über die Maßnahmen in den österreichischen Medien geht. Die Schichtung nach Geschlecht, Alter, Bundesland, Bildungsabschluss, Beruf oder beruflichem Sektor zeigt geringe, aber keine bedeutenden Unterschiede zwischen den jeweiligen Untergruppen. Die Splittung nach Altersgruppen zeigt, dass je älter die Befragten sind, desto zufriedener sind sie mit der Befolgung der COVIC-19 Maßnahmen durch andere (Mit)Bürger*innen / die Bevölkerung. Mit der Regierung, sowohl hinsichtlich des Umgangs mit der Krise als auch die Kommunikation der Maßnahmen betreffend, sind Selbstständige am wenigsten und Studierende am meisten zufrieden. Zu beachten ist allerdings, dass die Datensammlung vor der zweiten Lockerung der Restriktionen für (kleine) Unternehmen durchgeführt wurde
The role of membrane lipids in the induction of macrophage apoptosis by microparticles
Microparticles are membrane-derived vesicles that are released from cells during activation or cell death. These particles can serve as mediators of intercellular cross-talk and induce a variety of cellular responses. Previous studies have shown that macrophages undergo apoptosis after phagocytosing microparticles. Here, we have addressed the hypothesis that microparticles trigger this process via lipid pathways. In these experiments, microparticles induced apoptosis in primary macrophage cells or cell lines (RAW 264.7 or U937) with up to a 5-fold increase. Preincubation of macrophages with phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)BP) reduced the microparticle-induced apoptosis in a dose-dependent manner. PtdIns(3,5)BP is a specific inhibitor of the acid sphingomyelinase and thus can block the generation of pro-apoptotic ceramides. Similarly, the pre-incubation of macrophages with PtdIns(3,5)BP prevented microparticle-induced upregulation of caspase 8, which is a major target molecule of ceramide action in the apoptosis pathway. PtdIns(3,5)BP, however, had no effect on the spontaneous rate of apoptosis. To evaluate further signaling pathways induced by microparticles, the extracellular signal regulated kinase (ERK-) 1 was investigated. This kinase plays a role in activating phospholipases A2 which cleaves membrane phospholipids into arachidonic acid; microparticles have been suggested to be a preferred substrate for phospholipases A2. As shown in our experiments, microparticles strongly increased the amount of phosphorylated ERK1/2 in RAW 264.7 macrophages in a time-dependent manner, peaking 15 min after co-incubation. Addition of PD98059, a specific inhibitor of ERK1, prevented the increase in apoptosis of RAW 264.7 macrophages. Together, these data suggest that microparticles perturb lipid homeostasis of macrophages and thereby induce apoptosis. These results emphasize the importance of biolipids in the cellular cross-talk of immune cells. Based on the fact that in clinical situations with excessive cell death such as malignancies, autoimmune diseases and following chemotherapies high levels of circulating microparticles might modulate phagocytosing cells, a suppression of the immune response might occur due to loss of macrophage
Rhizosphere Organic Anions Play a Minor Role in Improving Crop Species' Ability to Take Up Residual Phosphorus (P) in Agricultural Soils Low in P Availability
Many arable lands have accumulated large reserves of residual phosphorus (P) and a relatively large proportion of soil P is less available for uptake by plants. Root released organic anions are widely documented as a key physiological strategy to enhance P availability, while limited information has been generated on the contribution of rhizosphere organic anions to P utilization by crops grown in agricultural soils that are low in available P and high in extractable Ca, Al, and Fe. We studied the role of rhizosphere organic anions in P uptake from residual P in four common crops Triticum aestivum, Avena sativa, Solanum tuberosum, and Brassica napus in low- and high-P availability agricultural soils from long-term fertilization field trials in a mini-rhizotron experiment with four replications. Malate was generally the dominant organic anion. More rhizosphere citrate was detected in low P soils than in high P soil. B. napus showed 74–103% increase of malate in low P loam, compared with clay loam. A. sativa had the greatest rhizosphere citrate concentration in all soils (5.3–15.2 μmol g−1 root DW). A. sativa also showed the highest level of root colonization by arbuscular mycorrhizal fungi (AMF; 36 and 40%), the greatest root mass ratio (0.51 and 0.66) in the low-P clay loam and loam respectively, and the greatest total P uptake (5.92 mg P/mini-rhizotron) in the low-P loam. B. napus had 15–44% more rhizosphere acid phosphatase (APase) activity, ~0.1–0.4 units lower rhizosphere pH than other species, the greatest increase in rhizosphere water-soluble P in the low-P soils, and the greatest total P uptake in the low-P clay loam. Shoot P content was mainly explained by rhizosphere APase activity, water-soluble P and pH within low P soils across species. Within species, P uptake was mainly linked to rhizosphere water soluble P, APase, and pH in low P soils. The effects of rhizosphere organic anions varied among species and they appeared to play minor roles in improving P availability and uptake
Highly Efficient Genome Modification of Cultured Primordial Germ Cells with Lentiviral Vectors to Generate Transgenic Songbirds
Ultra-bright single photon source based on an atomically thin material
Solid-state single photon sources are central building blocks in quantum
communication networks and on-chip quantum information processing. Atomically
thin crystals were established as possible candidates to emit non-classical
states of light, however, the performance of monolayer-based single photon
sources has so far been lacking behind state-of-the-art devices based on volume
crystals. Here, we implement a single photon source based on an atomically thin
sheet of WSe2 coupled to a spectrally tunable optical cavity. It is
characterized by a high single photon purity with a value as low
as and a record-high first lens brightness of linearly
polarized photons as large as . Interestingly, the high
performance of our devices allows us to observe genuine quantum interference
phenomena in a Hong-Ou-Mandel experiment. Our results demonstrate that open
cavities and two-dimensional materials constitute an excellent platform for
ultra-bright quantum light sources: the unique properties of such
two-dimensional materials and the versatility of open cavities open an
inspiring avenue for novel quantum optoelectronic devices.Comment: 12 pages, 7 figure
Wildfire selectivity for land cover type: does size matter ?
Previous research has shown that fires burn certain land cover types disproportionally to their abundance. We used quantile
regression to study land cover proneness to fire as a function of fire size, under the hypothesis that they are inversely
related, for all land cover types. Using five years of fire perimeters, we estimated conditional quantile functions for lower
(avoidance) and upper (preference) quantiles of fire selectivity for five land cover types - annual crops, evergreen oak
woodlands, eucalypt forests, pine forests and shrublands. The slope of significant regression quantiles describes the rate of
change in fire selectivity (avoidance or preference) as a function of fire size. We used Monte-Carlo methods to randomly
permutate fires in order to obtain a distribution of fire selectivity due to chance. This distribution was used to test the null
hypotheses that 1) mean fire selectivity does not differ from that obtained by randomly relocating observed fire perimeters;
2) that land cover proneness to fire does not vary with fire size. Our results show that land cover proneness to fire is higher
for shrublands and pine forests than for annual crops and evergreen oak woodlands. As fire size increases, selectivity
decreases for all land cover types tested. Moreover, the rate of change in selectivity with fire size is higher for preference
than for avoidance. Comparison between observed and randomized data led us to reject both null hypotheses tested
(a = 0.05) and to conclude it is very unlikely the observed values of fire selectivity and change in selectivity with fire size are
due to chance.Funding: This paper was supported by the Fundação para a Ciência e Tecnologia Ph.D. Grant SFRH/BD/40398/2007. JMCP participated in this research under the
framework of research projects ‘‘Forest fire under climate, social and economic changes in Europe, the Mediterranean and other fire-affected areas of the world
(FUME)’’, EC FP7 Grant Agreement No. 243888. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the
manuscrip
Personal preference, experience, intuition and school of surgery dominate the use of wound drainage in dermatosurgery
Hintergrund
Die Verwendung von Drainagesystemen in der Dermatochirurgie erfolgt bislang ohne evidenzbasierte Daten. Indikationen, Komplikationen und Kontraindikationen werden traditionell von Operateur zu Operateur weitergegeben, sind jedoch bisher nicht definiert.
Methodik
Es wurde eine internetbasierte Umfrage erstellt und unter den Mitgliedern der DGDC e. V. (Deutsche Gesellschaft für Dermatochirurgie e. V.) ausgesandt. Abgefragt wurden das allgemeine Behandlungsverhalten im deutschsprachigen Raum in Bezug auf die Anwendung der Wunddrainage nach dermatologischen Operationen sowie die Nutzungsgewohnheiten und Erfahrungen der Kollegen mit Drainage-assoziierten Komplikationen.
Ergebnisse
Es haben 12,73 % der angeschriebenen DGDC-Mitglieder den Fragebogen beantwortet. Drainagen werden überwiegend im klinischen Umfeld eingesetzt, es werden alle abgefragten Drainagesysteme verwendet. Ausmaß und Komplexität des Eingriffs sind die wesentlichen Kriterien bei der Indikationsstellung. Der Einsatz von Drainagen ist abhängig vom Alter des Teilnehmers und erfolgt mehrheitlich bei Patienten, bei denen Komplikationen im postoperativen Verlauf erwartet werden (Adipositas, Nikotinabusus, Diabetiker).
Diskussion
Zusammenfassend verwendet die Mehrzahl der Teilnehmer Wunddrainagen und dies mehrheitlich intuitiv. Einheitliche fixe evidenzbasierte Parameter rund um die Verwendung von Wunddrainagen fehlen. Bei der Beurteilung der Notwendigkeit einer Wunddrainage scheint ein individuell unterschiedlich ausgeprägtes Sicherheitsbedürfnis bei den einen und „eminenzbasiertes“ Handeln bei den anderen Dermatochirurgen eine große Rolle zu spielen.Background
The use of drainage systems in dermatosurgery has so far been carried out without evidence-based data. The indications, complications and contraindications are traditionally passed on from surgeon to surgeon but have so far not been defined.
Method
An Internet-based survey was created and sent out to members of the German Society for Dermatosurgery (DGDC). The questions were on the general treatment approach in German language countries with reference to the use of wound drainage following dermatological operations as well as the utilization habits and experiences with drainage-associated complications.
Results
Of the DGDC members contacted 12.73% completed the questionnaire. Drainages were predominantly used in the clinical environment and all drainage systems in question were used. The extent and complexity of the intervention were essential criteria when evaluating the indications. The use of drainages was dependent on the age of the participant and mostly carried out in patients where complications in the postoperative course were to be expected (e.g. obesity, nicotine use, diabetes).
Conclusion
In summary, the majority of the participants used wound drainages and mostly intuitively. Uniform and fixed evidence-based parameters for the use of wound drainages are lacking. In the assessment of the necessity for a wound drainage, an individually expressed need of safety seems to play a large role for some dermatosurgeons and an eminence-based action for others
- …
