Dentin wettability enhancement for three irrigating solutions and their effect on push out bond strength of gutta percha / AH Plus

Background: The aim of this study was to investigate the effect of wettability enhancement for 17% EDTA, 2.5% sodium hypochlorite and 7% maleic acid solutions on push out bond strength of gutta percha /AH Plus to root dentin. Materials and Methods: One hundred and eight extracted single rooted human lower premolars were instrumented up to Protaper Universal F5 then irrigated with 3ml of 2.5% NaOCl after each file. Irrigants were prepared and a pilot study for determination of Tween 80 concentration yielding the lowest surface tension value in every solution was conducted. Samples were randomly divided into a control group and two experimental groups (17% EDTA and 7% Maleate), further split into eight subgroups (n=12), according to Tween 80 implementation sequence. Roots were obturated using gutta percha and AH plus by lateral condensation. Bond strength was measured by push out test. Mode of failure was then evaluated quantitatively by stereomicroscopy. Data were statistically analyzed using one way ANOVA followed by Tukey-Kramer for multiple comparisons. Results: Control group showed the lowest values. Maleic acid subgroups showed significantly higher overall values than EDTA subgroups ( P <0.05). Protocols implementing surfactant containing NaOCl showed significantly lower values than plain counterparts. Failure pattern was predominantly cohesive for plain regimens and the ones implementing Tween 80 in maleic acid solutions with plain NaOCl. Conclusions: Tween 80 addition to demineralizing irrigants increased the bond strength values. Surfactant containing NaOCl solutions yielded lower bond strength than plain one

Lessons in cat herding: methods used for managing a large international collaborative engineering project, the Ariel mission payload

The Ariel space mission will characterize spectroscopically the atmospheres of a large and diverse sample of hundreds of exoplanets.. Ariel is an ESA Medium class science mission (M4) with a spacecraft bus developed by industry under contract to ESA, and a Payload provided by a consortium of national funding agencies in ESA member states, plus contributions from NASA, the CSA and JAXA. With the payload being provided by a consortium of scientific institutes and industrial partners funded through their respective European national funding agencies, and additional contributions provided by ESA, NASA, CSA and JAXA, the coordination and management of this team is vital to the successful delivery of the mission. This paper will describe how we have tailored the standard systems engineering approaches taken for space instrumentation and implemented these in the large consortium structure. This has been done in order to try to maximise the efficiency of the consortium work and to allow as close to a seamless flow of information as possible. We outline the key tools being deployed by the payload management, systems engineering and product assurance teams in the consortium

The electrical design of the thermal control systems of the all-aluminum ARIEL telescope

The Atmospheric Remote-sensing InfraRed Large-survey (ARIEL) is a medium-class mission of the European Space Agency whose launch is planned by late 2029 whose aim is to study the composition of exoplanet atmospheres, their formation and evolution. The ARIEL’s target will be a sample of about 1000 planets observed with one or more of the following methods: transit, eclipse and phase-curve spectroscopy, at both visible and infrared wavelengths simultaneously. The scientific payload is composed by a reflective telescope having a 1m-class primary mirror, built in solid aluminum, and two focal-plane instruments: 1. FGS (Fine Guidance System), performing photometry in visible light and low resolution spectrometry over three bands (from 0.8 to 1.95 µm) 2. AIRS (ARIEL InfraRed Spectrometer) that will perform infrared spectrometry in two wavelength ranges between 1.95 and 7.8 µm. This paper depicts the status of the TA (Telescope Assembly) electric section whose purpose is to deploy sensors, managed by the Telescope Control Unit, for the precise monitoring of the Telescope’s temperatures and the decontamination system, used to avoid the contamination of the optical surfaces (mirrors in primis)

The instrument control unit of the AIRS instrument on-board the ARIEL mission: design status after PDR

ARIEL (Atmospheric Remote-sensing InfraRed Large-survey) is the fourth medium-class mission (M4) of the European Space Agency, part of the Cosmic Vision program, whose launch is planned by late 2029. ARIEL aims to study the composition of exoplanet atmospheres, their formation and evolution. The ARIEL’s target will be a sample of about 1000 planets observed with one or more of the following methods: transit, eclipse and phase-curve spectroscopy, in both visible and infrared light. The scientific payload is composed by a reflective telescope having a 1m-class elliptical primary mirror, built in solid Aluminum, and two focal-plane instruments: FGS and AIRS. FGS (Fine Guidance System)3 has the double purpose of performing photometry (0.50-0.55 µm) and low resolution spectrometry over three bands (from 0.8 to 1.95 µm) and, simultaneously, to provide data to the spacecraft AOCS (Attitude and Orbit Control System). AIRS (ARIEL InfraRed Spectrometer) instrument will perform IR spectrometry in two wavelength ranges: between 1.95 and 3.9 µm (with a spectral resolution R > 100) and between 3.9 and 7.8 µm with a spectral resolution R > 30. This paper provides the status of the ICU (Instrument Control Unit), an electronic box whose purpose is to command and supply power to the AIRS warm front-end (as well as acquire science data from its two channels) and to command and control the TCU (Telescope Control Unit)

The Ariel mission: a mission of the European Space Agency for the characterization of exoplanets

Ariel, part of the European Space Agency's (ESA) Cosmic Vision science program, is an innovative medium-class mission designed for atmospheric remote sensing of exoplanets. It is the first mission solely dedicated to investigating the atmospheres of more than 500 transiting exoplanets, ranging from gas giants to super-Earths, using a combination of transit photometry and spectroscopy. The mission's primary goal is to analyze these exoplanets' chemical composition and thermal structures, paving the way for large-scale, comparative planetology. Ariel is scheduled for launch in 2029 aboard Ariane 6.2. It will operate from an orbit around the Sun-Earth system's second Lagrange point. The mission has a nominal lifetime of four years, with the potential for a two-year extension. The spacecraft comprises two main modules: the Service Module (SVM) and the Payload Module (PLM). The SVM manages platform elements, including attitude control, power, data handling, and communication systems. The PLM incorporates an all-aluminium cryogenic telescope with two scientific instruments, the Ariel IR Spectrometer (AIRS) and the Fine Guidance System (FGS). The Operational Ground Segment consists of ground stations and the Mission Operation Centre (MOC) located at ESOC, responsible for the operations of the spacecraft and instruments. The Science Ground Segment (SGS) consists of the Science Operation Centre (SOC), located at ESAC, along with the Instrument Operations and Science Data Centre (IOSDC) provided by the Ariel Mission Consortium (AMC). The SGS will perform the science mission planning as well as processing of the data to generate the mission data products and provision of the Ariel mission archive for the user community. While ESA holds overall responsibility for Ariel, the Ariel Mission Consortium is responsible for the procurement of the payload units, as well as managing the IOSDC. This collaborative effort aims to unlock the mysteries of exoplanetary atmospheres and deepen our understanding of these distant worlds

FEA testing the pre-flight Ariel primary mirror

Ariel (Atmospheric Remote-sensing Infrared Exoplanet Large-survey) is an ESA M class mission aimed at the study of exoplanets. The satellite will orbit in the lagrangian point L2 and will survey a sample of 1000 exoplanets simultaneously in visible and infrared wavelengths. The challenging scientific goal of Ariel implies unprecedented engineering efforts to satisfy the severe requirements coming from the science in terms of accuracy. The most important specification – an all-Aluminum telescope – requires very accurate design of the primary mirror (M1), a novel, off-set paraboloid honeycomb mirror with ribs, edge, and reflective surface. To validate such a mirror, some tests were carried out on a prototype – namely Pathfinder Telescope Mirror (PTM) – built specifically for this purpose. These tests, carried out at the Centre Spatial de Liège in Belgium – revealed an unexpected deformation of the reflecting surface exceeding a peek-to-valley of 1µm. Consequently, the test had to be re-run, to identify systematic errors and correct the setting for future tests on the final prototype M1. To avoid the very expensive procedure of developing a new prototype and testing it both at room and cryogenic temperatures, it was decided to carry out some numerical simulations. These analyses allowed first to recognize and understand the reasoning behind the faults occurred during the testing phase, and later to apply the obtained knowledge to a new M1 design to set a defined guideline for future testing campaigns

The telescope assembly of the Ariel space mission: an updated overview

Ariel (Atmospheric Remote-Sensing Infrared Exoplanet Large Survey) is the adopted M4 mission in the framework of the ESA “Cosmic Vision” program. Its purpose is to survey the atmospheres of known exoplanets through transit spectroscopy. The launch is scheduled for 2029. The scientific payload consists of an off-axis, unobscured Cassegrain telescope feeding a set of photometers and spectrometers in the waveband 0.5-7.8 µm and operating at cryogenic temperatures (55 K). The Telescope Assembly is based on an innovative fully aluminium design to tolerate thermal variations to avoid impacts on the optical performance; it consists of a primary parabolic mirror with an elliptical aperture of 1.1 m (the major axis), followed by a hyperbolic secondary that is mounted on a refocusing system, a parabolic re-collimating tertiary and a flat folding mirror directing the output beam parallel to the optical bench. An innovative mounting system based on 3 flexure hinges supports the primary mirror on one of the optical bench sides. The instrument bay on the other side of the optical bench houses the Ariel IR Spectrometer (AIRS) and the Fine Guidance System / NIR Spectrometer (FGS/NIRSpec). The Telescope Assembly is in phase B2 towards the Critical Design Review; the fabrication of the structural and engineering models has started; some components, i.e., the primary mirror and its mounting system are undergoing further qualification activities. This paper aims to update the scientific community on the progress concerning the development, manufacturing and qualification activity of the ARIEL Telescope Assembly

The Ariel payload design post-PDR

The Ariel space mission will characterize spectroscopically the atmospheres of a large and diverse sample of hundreds of exoplanets. Through the study of targets with a wide range of planetary parameters (mass, density, equilibrium temperature) and host star types the origin for the diversity observed in known exoplanets will be better understood. Ariel is an ESA Medium class science mission (M4) with a spacecraft bus developed by industry under contract to ESA, and a Payload provided by a consortium of national funding agencies in ESA member states, plus contributions from NASA, the CSA and JAXA. The payload is based on a 1-meter class telescope operated at below 60K, built all in Aluminium, which feeds two science instruments. A multi-channel photometer and low-resolution spectrometer instrument (the FGS, Fine Guidance System instrument) operating from 0.5 – 1.95 microns in wavelength provides both guidance information for stabilizing the spacecraft pointing as well as vital scientific information from spectroscopy in the near-infrared and photometry in the visible channels. The Ariel InfraRed Spectrometer (AIRS) instrument provides medium resolution spectroscopy from 1.95 – 7.8 microns wavelength coverage over two instrument channels. Supporting subsystems provide the necessary mechanical, thermal and electronics support to the cryogenic payload. This paper presents the overall picture of the payload for the Ariel mission. The payload tightly integrates the design and analysis of the various payload elements (including for example the integrated STOP analysis of the Telescope and Common Optics) in order to allow the exacting photometric stability requirements for the mission to be met. The Ariel payload has passed through the Preliminary Design Review (completed in Q2 2023) and is now developing and building prototype models of the Telescope, Instruments and Subsystems (details of which will be provided in other contributions to this conference). This paper will present the current status of the development work and outline the future plans to complete the build and verification of the integrated payload

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely