PROSPECTANDO O NÍVEL DE CONCENTRAÇÃO DA INDÚSTRIA DE TRANSFORMAÇÃO CAPIXABA

Este artigo tem como objetivo principal mensurar o nível de concentração industrial da indústria de transformação capixaba, para o período 2002-2012, fazendo uso dos índices de concentração (Razão de Concentração, Hirchsman-Herfindahl e o Coeficiente de Entropia de Theil). A principal fonte de dados utilizada nesta pesquisa foi a Relação Anual de Informações Sociais (RAIS), do Ministério do Trabalho e Emprego (MTE), que informa anualmente por meio do Cadastro Geral de Empregados e Desempregados (CAGED) o número de vínculos empregatícios (variável utilizada na mensuração dos índices de concentração) por setor da atividade econômica. Os resultados mostraram uma razoável concentração no setor estudado, com uma reversão dessa concentração no final do período analisado

Early selection in Theobroma grandiflorum, aiming at tolerance to hypoxia

Abstract Cupuassu (Theobroma grandiflorum)-based agroforestry system (AFS) can be used for restoration of vegetation around springs and riparian forests of water sources (rivers, streams, lakes etc.), subject to constant flooding. The objectives of this work were to study the relations between morphophysiological traits when flooding occurs, determining the most important to assess genotypes’ tolerance, and evaluate the ability of cupuassu genotypes to express alternative phenotypes and grow efficiently, in order to select materials capable of sustaining hypoxic conditions. The trial was carried out in a greenhouse, in a completely randomized design with a 16 x 2 (16 progenies and two water regimes) factorial scheme and four replications. Treatments started six months after the seedlings were transplanted. 15 traits related to vegetative development, biomass accumulation and physiology were measured for the experimental evaluation. Correlations and principal components were estimated to study the traits’ interrelationships and identify the most important to assist progeny selection. The results revealed that, among the evaluated traits, ten were sufficient to explain the variability within the population and four were elected as the most relevant to select the best progenies. 75% of the genotypes showed tolerance to partial flooding and based on performance and plasticity, we selected G174, G48 and G56 for a broader spectrum and G44, G47 and G51 for hypoxic conditions only. The promising evidence pointed out here will need to be corroborated with field tests, so that the cupuassu tree can be recommended in the recovery of environments subject to hypoxia

Detection of potential safety signals related to the use of remdesivir and tocilizumab in the COVID era during pregnancy, resorting to open data from the FDA adverse event reporting system (FAERS)

Background: The in-hospital treatment for COVID-19 may include medicines from various therapeutic classes, such as antiviral remdesivir and immunosuppressant tocilizumab. Safety data for these medicines are based on controlled clinical trials and case reports, limiting the knowledge about less frequent, rare or unique population adverse events excluded from clinical trials.Objective: This study aims at analyzing the reports of Adverse Drug Events (ADEs) related to these two medicines, focusing on events in pregnant women and foetuses.Methods: Data from the open-access FDA Adverse Event Reporting System (FAERS) from 2020 to 2022 were used to create a dashboard on the Grafana platform to ease querying and analyzing report events. Potential safety signals were generated using the ROR disproportionality measure.Results: Remdesivir was notified as the primary suspect in 7,147 reports and tocilizumab in 19,602. Three hundred and three potential safety signals were identified for remdesivir, of which six were related to pregnant women and foetuses (including abortion and foetal deaths). Tocilizumab accumulated 578 potential safety signals, and three of them were associated with this population (including neonatal death).Discussion: None of the possible signals generated for this population were found in the product labels. According to the NIH and the WHO protocols, both medicines are recommended for pregnant women hospitalized with COVID-19.Conclusion: Despite the known limitations of working with open data from spontaneous reporting systems (e.g., absence of certain clinical data, underreporting, a tendency to report severe events and recent medicines) and disproportionality analysis, the findings suggest concerning associations that need to be confirmed or rejected in subsequent clinical studies

FREQUÊNCIA DE SARCOPENIA EM IDOSOS SUBMETIDOS À CIRURGIA CARDÍACA

Introdução: A sarcopenia é definida como a perda da massa muscular esquelética associada à idade, que resulta em diminuiçãoda força e capacidade aeróbica e, portanto, da capacidade funcional. Em Unidades de Terapia Intensiva (UTI) cirúrgicas a fraquezamuscular pode prolongar a permanência na UTI e a hospitalização. Objetivo: Investigar a frequência de sarcopenia em idosossubmetidos à cirurgia cardíaca. Métodos: Estudo transversal, prospectivo e quantitativo. Para avaliar comorbidades foiutilizado o índice Comorbidade-Idade de Charlson (ICIC), e o teste Timed Up and Go (TUG) para avaliar o desempenho físico. Asavaliações foram realizadas no período pré-operatório e no 6º dia pós-operatório, e os dados comparados entre eles. Para avaliara normalidade da amostra foi utilizado o teste de Shapiro-Wilk. As variáveis quantitativas estão expressas como média edesvio padrão. Para as variáveis de desfecho utilizou-se os testes de Wilcoxon e t de Student pareado. Resultados: Os pacientestinham idade média de 69 ± 6 anos. A frequência de sarcopenia foi de 5% nos dois momentos da avaliação. Os valores da forçade preensão palmar (FPP) (p=0,004), do teste de velocidade de marcha de seis metros (TVM6) (p=0,001) e o teste TUG (p=0,001),apresentaram redução entre os períodos avaliados. Conclusão: Os resultados demonstraram que a frequência de sarcopeniaem idosos submetidos à cirurgia cardíaca foi baixa, entretanto, encontrou-se redução da FPP e do desempenho físico.Palavras-chave: Sarcopenia. Idoso. Unidade de Terapia Intensiva. Cirurgia Cardíaca

TRATAMENTOS ALTERNATIVOS DAS LESÕES POR HABRONEMOSE – BREVE ESTUDO

Cutaneous habronemosis is a pathology that affects several species of animals, including horses. It is caused by the nematodes of the genus Habronema spp. and Draschia megastoma, where the adult worms of these species release eggs in the feces of horses, since these turn into larvae and are ingested by the flies of the species Stomoxys calcitranse and Musca Doméstica. These contaminated flies deposit their larvae in open wounds or humid regions, presenting a predilection for the eyes and lips. The presumptive diagnosis is given by the history of lesions that are difficult to heal, which is confirmed by histopathological examination or even scraping of the lesion. Despite the higher frequency of conventional treatments, healing has a long period and there is a possibility of parasitic resistance and relapses. Therefore, some professionals opt for new therapies and new drugs, in order to have a better result and not develop resistance to certain drugs. In view of this, this article aims to present a brief study bringing several therapeutic ways to treat cutaneous habronemosis.A habronemose cutânea é uma patologia que acomete diversas espécies de animais, entre elas os equinos. É causada pelos nematódeos do gênero Habronema spp. e Draschia megastoma, onde os vermes adultos dessas espécies liberam ovos nas fezes dos equinos, uma vez que esses se transformam em larvas e são ingeridos pelas moscas da espécie Stomoxys calcitranse e Musca Doméstica. Essas moscas contaminadas, depositam suas larvas em feridas abertas ou regiões úmidas, apresentando predileção pelos olhos e lábios. O diagnóstico presuntivo se dar pelo histórico de lesões de difícil cicatrização, o qual é confirmado através do exame histopatológico ou até raspado da lesão. Apesar da maior frequência dos tratamentos convencionais, a cicatrização tem um período demorado e há possibilidade de resistência parasitária e recidivas. Logo, alguns profissionais optam por novas terapias e novos fármacos, afim de ter um melhor resultado e não desenvolver resistência a certos fármacos. Diante disso, o presente artigo tem o objetivo de apresentar um breve estudo trazendo diversas formas terapêuticas para tratar a habronemose cutânea.&nbsp

ESTUDO COMPARATIVO DE BIOMATERIAIS TIPO XENOENXERTO E ENXERTO ALOPLÁSTICO PARA CIRURGIA RECONSTRUTIVA ALVEOLAR COM TÉCNICA DE SINUS LIFT COM JANELA LATERAL

The materials that we can use as grafting material can have different origins, which in turn conditions their different properties and behaviors. Depending on their ability to interact with the surrounding bone, they can be classified as bioinert or bioactive materials. Bioactive materials are capable of stimulating the formation of bone tissue, bonding directly to the bone, thus forming a strong and unique interface between bone and biomaterial. The graft material, on the other hand, must be biocompatible and resorbable to be integrated into the newly formed bone, which is structurally similar to bone, osteoconductive and, if possible, also osteoinductive and osteogenic. When we work on the bone regeneration process, we must also take its structure into account.Os materiais que podemos utilizar como material de enxerto podem ter origens diversas, o que por sua vez condiciona as suas diferentes propriedades e comportamentos. Dependendo da sua capacidade de interagir com o osso circundante, podem ser classificados como materiais bioinertes ou bioativos. Os materiais bioativos são capazes de estimular a formação de tecido ósseo, unindo-se diretamente ao osso, formando assim uma interface forte e única entre osso e biomaterial. O material de enxerto, por outro lado, deve ser biocompatível e reabsorvido para ser integrado ao osso neoformado, que é estruturalmente semelhante ao osso, osteocondutor e, se possível, também osteoindutor e osteogênico. Quando atuamos no processo de regeneração óssea devemos também levar em consideração a sua estrutura

Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells

This work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. ReisParacoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, a disease that affects 10 million individuals in Latin America. This report depicts the results of the analysis of 6,022 assembled groups from mycelium and yeast phase expressed sequence tags, covering about 80% of the estimated genome of this dimorphic, thermo-regulated fungus. The data provide a comprehensive view of the fungal metabolism, including overexpressed transcripts, stage-specific genes, and also those that are up- or down-regulated as assessed by in silico electronic subtraction and cDNA microarrays. Also, a significant differential expression pattern in mycelium and yeast cells was detected, which was confirmed by Northern blot analysis, providing insights into differential metabolic adaptations. The overall transcriptome analysis provided information about sequences related to the cell cycle, stress response, drug resistance, and signal transduction pathways of the pathogen. Novel P. brasiliensis genes have been identified, probably corresponding to proteins that should be addressed as virulence factor candidates and potential new drug targets

A list of land plants of Parque Nacional do Caparaó, Brazil, highlights the presence of sampling gaps within this protected area

Brazilian protected areas are essential for plant conservation in the Atlantic Forest domain, one of the 36 global biodiversity hotspots. A major challenge for improving conservation actions is to know the plant richness, protected by these areas. Online databases offer an accessible way to build plant species lists and to provide relevant information about biodiversity. A list of land plants of “Parque Nacional do Caparaó” (PNC) was previously built using online databases and published on the website "Catálogo de Plantas das Unidades de Conservação do Brasil." Here, we provide and discuss additional information about plant species richness, endemism and conservation in the PNC that could not be included in the List. We documented 1,791 species of land plants as occurring in PNC, of which 63 are cited as threatened (CR, EN or VU) by the Brazilian National Red List, seven as data deficient (DD) and five as priorities for conservation. Fifity-one species were possible new ocurrences for ES and MG states

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio