711 research outputs found
Fisiologia e fisiopatologia della insufficienza venosa cerebrospinale: proposta di nuovi criteri diagnostici
Background: The physiological meccanisms thath influence the venous drainage of the extracranial venous system could be investigated by ecoDoppler sonography.
The alterations of phsyological meccanism of extracranial venous drainage
rappresents the physiopathological substract of CCSVI.
Patients with SM have shown to have a higher prevalence of CCSVI.
Objective: to study the physiology and physiopatology of the venous drainage trough the extracranial venous system using ecoDoppler sonography and to propose new criteria to define a condition of CCSVI
Methods: Extracranial ECD were carried out in 126 enrolled subjects (63 healthy control and 63 subjects with multiple sclerosis matched by gender and age).
Prevalence rates for CCSVI were calculated using Zamboni criteria and using two new criteria (Giugular Respiratory Index and Giugular Subclavian Index) based on physiology of extracranial venous drainage.
Results: CCSVI prevalence using Zamboni criteria was 63% in SM and 44% in HC (P 0,03*), the prevalence using new criteria was 44% and 36% in SM ( respectively for GRI and GSI) and 9% and 3% in HC (P <0,0001 ****).
Conclusions: our findings are consistent with an increased prevalence of CCSVI in MS with modest sensitivity and specificity using Zamboni criteria and with high specificity using new criteria (Giugular Respiratory Index a nd Giugular Subclavian Index). Our findings point against CCSVI having a primary causative role in the development of MS
A Tool to Analyze the Reading Behavior of the Users in a Mobile Digital Publishing Platform
Abstract. In their daily activities, users interact multiple times with mobile applications. This generates huge amounts of data related to these interactions that, when filtered and analyzed, would give insights on the behavior of the users while using an application. In this paper, we consider a real-world mobile digital publishing platform, named Viewerplus, which enables a digital, augmented fruition of content from traditional magazines. The objective is to develop a tool that allows the human editors to analyze the reading behavior of the users, by providing analytics that show how the users read magazine issues (i.e., how they browse an issue and move inside the app, which portions of an issue are most frequently read and which frequency, and which topics are of interest for the users during a reading session). The tool has been developed by employing a dataset extracted from the reading sessions of a magazine of an important international publisher. In this work we also employ the dataset to present a preliminary study of the user reading behavior
Effects of metformin and exercise training, alone or in association, on cardio-pulmonary performance and quality of life in insulin resistance patients
BACKGROUND:
Metformin (MET) therapy exerts positive effects improving glucose tolerance and preventing the evolution toward diabetes in insulin resistant patients. It has been shown that adding MET to exercise training does not improve insulin sensitivity. The aim of this study was to determine the effect of MET and exercise training alone or in combination on maximal aerobic capacity and, as a secondary end-point on quality of life indexes in individuals with insulin resistance.
METHODS:
75 insulin resistant patients were enrolled and subsequently assigned to MET (M), MET with exercise training (MEx), and exercise training alone (Ex). 12-weeks of supervised exercise-training program was carried out in both Ex and MEx groups. Cardiopulmonary exercise test and SF-36 to evaluate Health-Related Quality of Life (HRQoL) was performed at basal and after 12-weeks of treatment.
RESULTS:
Cardiopulmonary exercise test showed a significant increase of peak VO2 in Ex and MEx whereas M showed no improvement of peak VO2 (â VO2 [CI 95%] Ex +0.26 [0.47 to 0.05] l/min; â VO2 MEx +0.19 [0.33 to 0.05] l/min; â VO2 M -0.09 [-0.03 to -0.15] l/min; M vs E pâ<â0.01; M vs MEx pâ<â0.01; MEx vs Ex pâ=âns). SF-36 highlighted a significant increase in general QoL index in the MEx (58.3â±â19 vs 77.3â±â16; pâ<â0.01) and Ex (62.1â±â17 vs 73.7â±â12; pâ<â0.005) groups.
CONCLUSIONS:
We evidenced that cardiopulmonary negative effects showed by MET therapy may be counterbalanced with the combination of exercise training. Given that exercise training associated with MET produced similar effects to exercise training alone in terms of maximal aerobic capacity and HRQoL, programmed exercise training remains the first choice therapy in insulin resistant patients
Biodiversity of Sardinian marine caves: sponge fauna = BiodiversitĂ delle grotte marine della Sardegna: la fauna a poriferi
This paper focuses on a faunistic study on sponges from three submerged caves of the Marine Protected Area of Capo Caccia-Isola Piana. Results contribute to the assessment of biodiversity of the scarcely known Sardinian Sea
Effects of metformin and exercise training, alone or in combination, on cardiac function in individuals with insulin resistance
Introduction: In patients affected by insulin resistance (IR), metformin (MET) therapy has been shown to exert its positive effects by improving glucose tolerance and preventing the evolution to diabetes. Recently, it was shown that the addition of metformin to physical training did not improve sensitivity to insulin or peak oxygen consumption (peak VO2). The purpose of this study was to establish the effect of metformin and exercise, separately or in combination, on systolic left ventricular (LV) function in individuals with IR.
Methods: Seventy-five patients with IR were enrolled and subsequently assigned to MET, combination MET and exercise, or exercise alone. The LV systolic and diastolic functions were evaluated with standard echocardiography tissue Doppler imaging (TDI) and speckle tracking echocardiography at baseline and after 12 weeks of treatment.
Results: MET, administered alone or in association with exercise, improved longitudinal LV function, as evidenced by an increase in systolic (S) wave on TDI, alongside increases in longitudinal global strain and strain rate in comparison to the group undergoing physical training alone. The traditional echocardiographic parameters showed no statistically significant differences among the three groups before or after the different cycles of therapy.
Conclusions: Treatment with MET, either with or without exercise, but not exercise alone, produced a significant increase in global longitudinal LV systolic function at rest. These findings validate the observation that the use of MET alone or in association with exercise has a crucial role to counteract the negative effects of IR on cardiovascular function
Quantum numbers of the state and orbital angular momentum in its decay
Angular correlations in decays, with , and , are used to measure
orbital angular momentum contributions and to determine the value of
the meson. The data correspond to an integrated luminosity of 3.0
fb of proton-proton collisions collected with the LHCb detector. This
determination, for the first time performed without assuming a value for the
orbital angular momentum, confirms the quantum numbers to be .
The is found to decay predominantly through S wave and an upper limit
of at C.L. is set on the fraction of D wave.Comment: 16 pages, 4 figure
Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires
The production of tt⟠, W+bb⟠and W+cc⟠is studied in the forward region of protonâproton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fbâ1 . The W bosons are reconstructed in the decays WââÎœ , where â denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of , and is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 0.02 \mbox{fb}^{-1}. The bosons are reconstructed in the decays , where denotes muon or electron, while the and quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
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