Otoneurologic Evaluation In Children With School Difficulties: Vestibular Function Investigation

According to the literature, child vestibular dysfunctions can considerably affect their ability of communication and school performance. Aim: to study the vestibular function in children with school difficulties and associated symptoms. Case study: Clinical study with transversal cohort. Method: Research subjects were 50 school children between 7 and 12 years old, from a public school of Piracicaba city, during the years 2004 and 2005. The procedure was based on: anamnesis; otorrinolaryngologic evaluation; audiologic evaluation and vestibular evaluation. Results: All children assessed, 62.0% did not have school difficulties and 38.0% had school difficulties. Dizziness was the most common general complaint (36.0%). Migraine was the most common symptom regarding the school environment (50.0%). We found a high rate of normal vestibular condition (74.2%) in children without school difficulties and low normality rate in those with school difficulties (31.6%). All found vestibular alterations, both unilateral and bilateral, had been of peripheral irritative origin, accounting for 68.4% of cases for children with school difficulties and 25.8% for children without school difficulties. Conclusion: Dizziness, nausea, reading and copying difficulties presented a statistically significant relationship between the studied variables. All found vestibular alterations had been of peripheral irritative origin. Data showed a statistically significant relationship among variables. © Revista Brasileira de Otorrinolaringologia. All Rights reserved.736803815Polity, E., (2003) Dificuldade de Ensinagem: Que história é essa? Fonoaudiologia Atual, pp. 60-68Undheim, A.M., Dyslexia and psychosocial factors. A follow-up study of young Norwegian adults with a history of dyslexia in childhood (2003) Nord J Psychiatry, 57, pp. 221-226Mathes, P.G., Denton, C.A., The prevention and identification of reading disability (2002) Semin Pediatr Neurol, 9, pp. 185-191Schirmer, C.R., Fontoura, D.R., Nunes, M.L., Distúrbios da aquisição da linguagem e da aprendizagem. (2004) J Pediatr, 80, pp. 95-103Farias, L.S., Toniolo, I.F., Coser, P.L., P300: Avaliação eletrofisiológica da audição em crianças sem e com repetência escolar. (2004) Rev Bras Otorrinolaringol, 70, pp. 194-199Campos, M.I., Ganança, F.F., Caovilla, H.H., Ganança, M.M., Prevalência de sinais de disfunção vestibular em crianças com vertigem e/ou outros tipos de tontura. RBM-ORL (1996), 3, pp. 165-170Ganança, M.M., Caovilla, H.H., Labirintopatias na infância (1999) Caldas N, Caldas S, Sih T. Otologia e audiologia em pediatria, pp. 277-286. , São Paulo: Revinter;Caovilla, H.H., Ganança, M.M., Munhoz, M.S.L., Silva, M.L.G., Ganança, F.F., Frazza, M.M., Vertigem paroxística benigna da infância (2000) Silva MLG, Munhoz MSL, Ganança MM, Caovolla HH. Quadros clínicos otoneurológicos mais comuns, pp. 109-117. , São Paulo: Atheneu;Lavinsky, L., Abelin, C.A., D'Avila, C., Lavinsky, M., Exame otoneurológico na infância (1999) Caldas N, Caldas S, Sih T. Otologia e audiologia em pediatria, pp. 287-295. , São Paulo: Ed. Revinter;Formigoni, L.G., (1998) A avaliação vestibular na criança, pp. 117-126. , Ganança MM. Vertigem tem cura? São Paulo: Lemos;Frank, J., Levinson, H., Dysmetric dyslexia and dyspraxia (1973) J Am Acad Child Psychiatry, 12, pp. 690-701Quirós JB de. Diagnosis of vestibular disorders in learning disabled. J Learn Desabil 1976;9:50-8Horak, F.G., Shumway-Cook, A., Crowe, T.K., Black, F.O., Vestibular function and motor proficiency of children with impaired hearing, or with learning disability and motor impairment (1988) Dev Med Child Neurol, 30, pp. 64-79Hoyt, C.S., Visual training and reading (1999) Am Orthopt J, 49, pp. 23-23Ganança, M.M., (1989) Da vestibulometria em crianças com distúrbio de linguagem, , Tese de Doutorado] São Paulo: Universidade Federal de São Paulo, UNIFESP, EPM;Glorig, A., Davis, H., Age, noise and hearing loss (1961) Ann Otol (St. Louis), 70, pp. 556-574Mangabeira Albernaz, P., Mangabeira Albernaz, P.L., Mangabeira Albernaz, L.G., Mangabeira, Albernaz Filho, P., (1981) Otorrinolaringologia prática, , 10a Edição. São Paulo: Sarvier;Mangabeira Albernaz, P.L., Ganança, M.M., Caovilla, H.H., Ito, Y.I., Novo, N.F., Juliano, I., Aspectos Clínicos e Terapêuticos das Vertigens (1986) Acta WHO, 5 (SUPL 2), pp. 49-109Caovilla, H.H., Ganança, M.M., Munhoz, M.S.L., Silva, M.L.G., (1999) Equilibriometria Clínica, , São Paulo: Atheneu;Ganança, C.F., Souza, J.A.C., Segatin, L.A., Caovilla, H.H., Ganança, M.M., Limites de normalidade dos parâmetros de avaliação a vectonistagmografia digital neurograff Acta AWHO 2000?2, 105Vieira, S., (2004) Bioestatística: Tópicos avançados, , Rio de Janeiro: Elsevier;Callegari-Jacques, S.M., (2003) Bioestatística: Princípios e aplicações, , Porto Alegre: Artmed

Effects of Osteopathic Visceral Treatment in Patients with Gastroesophageal Reflux: A Randomized Controlled Trial

Osteopathic manual treatment has been recommended as a non-pharmacological therapy for Gastroesophageal Reflux Disease (GERD). However, to date, no study has supported the effectiveness of this intervention with respect to the symptoms of the disease. Our goal was to assess the effect of an osteopathic manual technique for the lower esophageal sphincter on GERD symptoms, cervical mobility and on the C4 spinous process pressure pain threshold (PPTs). Methods: A randomized, double-blind placebo-controlled trial was performed. Sixty subjects suffering from GERD participated in this study and were randomly assigned to either an experimental group (EG) (n = 29), who received the osteopathic technique for the lower esophageal sphincter, or to a control group (CG) (n = 31), who received a manual contact, which mimicked the osteopathic technique without exerting any therapeutic force. Randomization was computer-generated, with allocation concealed by sequentially numbered, opaque, sealed envelopes. The GerdQ questionnaire was used to assess symptom changes the week after intervention. Cervical Range of Motion (CROM) and algometer were used to evaluate cervical mobility and PPTs before and after both treatments. Before-after between groups comparison (t-test) was used for statistical analysis of the outcome, with two measurement points (GerdQ), while repeated-measures ANOVA was used for those outcomes with four measurement points (CROM and PPT). Results: The application of the osteopathic manual treatment in subjects with GERD produced a significant improvement in symptoms one week after the intervention (p = 0.005) with a between-groups difference of 1.49 points in GerdQ score (95% CI: 0.47-2.49). PPT C4 improved in the EG after the treatment (p = 0.034; eta(2) = 0.048) (between-groups difference 8.78 Newton/cm(2); 95% CI: 0.48-17.09). CROM also increased in the EG compared to the CG (p < 0.001; eta(2) = 0.108) (between-groups difference 33.89 degrees; 95% CI: 15.17-52.61). Conclusions: The manual osteopathic technique produces an improvement in GERD symptoms one week after treatment, cervical mobility, and PPTs. This may mean that osteopathic treatment is useful for improving symptoms of GERD

Fatty acid profile of lamb meat from two portuguese autochthonous breeds

In Portugal, sheep and goat meat production accounts for 2.8% of the total meat production in the country; and it is capable of supplying approximately 82% of the domestic demand (INE, 2015). Churra-Galega-Bragançana (CGB) and Bordaleira-entre-Douro-e-Minho (BEDM) are two native breeds of the north of Portugal, classified as endangered lamb breeds. These breeds are exploited for meat production, the former in the Atlantic bio-region and the latter in the Mediterranean area. Production factors, such as breed, have a great influence on nutritional aspects related with the content and quality of fat and fatty acid profile (Frank et al., 2016), which are considered important quality indicators that have a great influence on consumer acceptability (Andersen et al., 2005), especially nowadays as consumers have become increasingly concerned about health and the relationship between meat consumption and saturated fatty acids (Leroy and De Smet, 2019). These autochthonous breeds constitute an important genetic heritage that must be preserved, so assessing their fatty acid profile will allow a correct characterization of these breeds and their products.info:eu-repo/semantics/publishedVersio

Recuperação de área degradada com sistema agroflorestal no Vale do Rio Doce, Minas Gerais.

O Vale do Rio Doce, MG, apresenta um histórico de ocupação e uso do solo que favorece a degradação ambiental, em que predominam pastagens sob o uso constante de queimadas. Os sistemas agroflorestais têm se mostrado eficientes na recuperação de áreas degradadas. Neste estudo foram avaliados os efeitos de um sistema agroflorestal na recuperação do solo em área degradada por pastagem na comunidade de Ilha Funda,Município de Periquito, Minas Gerais. A implantação do sistema se deu em 1994 e está sendo conduzido segundo os princípios agroecológicos, potencializando a regeneração natural e a sucessão de espécies. Em 1998, foram coletadas amostras de solo na área em recuperação e em duas áreas adjacentes: uma área degradada, que se encontrava em condições semelhantes às da área em recuperação no início do processo, e outra ocupada por pastagem. Foram determinados atributos químicos do solo e realizada a caracterização da matéria orgânica. O solo da área em recuperação com sistema agroflorestal mostrou-se em melhores condições do que o solo sob pastagem e o da área degradada, apresentando maior dinâmica do carbono orgânico e maior disponibilidade de nutrientes. Embora o teor de carbono orgânico total apresentado pelo solo sob pastagem tenha sido maior que nas demais condições avaliadas, o solo do sistema agroflorestal já está se igualando ao da pastagem no acúmulo das formas mais estáveis de carbono e apresentando maior dinâmica das frações orgânicas menos estáveis. Este estudo comprovou a eficiência dos sistemas agroflorestais, conduzidos segundo os princípios agroecológicos, na recuperação de áreas degradadas

Thimet oligopeptidase (EC 3.4.24.15) key functions suggested by knockout mice phenotype characterization

Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1(-/-)) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies per litter similar to C57BL/6 wild type mice (WT). In specific brain regions, THOP1(-/-) exhibit altered mRNA expression of proteasome beta5, serotonin 5HT2a receptor and dopamine D2 receptor, but not of neurolysin (NLN). Peptidomic analysis identifies differences in intracellular peptide ratios between THOP1(-/-) and WT mice, which may affect normal cellular functioning. In an experimental model of multiple sclerosis THOP1(-/-) mice present worse clinical behavior scores compared to WT mice, corroborating its possible involvement in neurodegenerative diseases. THOP1(-/-) mice also exhibit better survival and improved behavior in a sepsis model, but also a greater peripheral pain sensitivity measured in the hot plate test after bradykinin administration in the paw. THOP1(-/-) mice show depressive-like behavior, as well as attention and memory retention deficits. Altogether, these results reveal a role of THOP1 on specific behaviors, immune-stimulated neurodegeneration, and infection-induced inflammation

Azimuthal asymmetries of charged hadrons produced by high-energy muons scattered off longitudinally polarised deuterons

Azimuthal asymmetries in semi-inclusive production of positive (h^+) and negative hadrons (h^-) have been measured by scattering 160 GeV muons off longitudinally polarised deuterons at CERN. The asymmetries were decomposed in several terms according to their expected modulation in the azimuthal angle phi of the outgoing hadron. Each term receives contributions from one or several spin and transverse-momentum-dependent parton distribution and fragmentation functions. The amplitudes of all phi-modulation terms of the hadron asymmetries integrated over the kinematic variables are found to be consistent with zero within statistical errors, while the constant terms are nonzero and equal for h^+ and h^- within the statistical errors. The dependencies of the phi-modulated terms versus the Bjorken momentum fraction x, the hadron fractional momentum z, and the hadron transverse momentum p_h^T were studied. The x dependence of the constant terms for both positive and negative hadrons is in agreement with the longitudinal double-spin hadron asymmetries, measured in semi-inclusive deep-inelastic scattering. The x dependence of the sin phi-modulation term is less pronounced than that in the corresponding HERMES data. All other dependencies of the phi-modulation amplitudes are consistent with zero within the statistical errors.Comment: 12 pages, 11 Figures; revision 1 signs in Eq 5 corrected, polishe

Effects on short term outcome of non-invasive ventilation use in the emergency department to treat patients with acute heart failure: A propensity score-based analysis of the EAHFE Registry

Objective: To assess the effects of non-invasive ventilation (NIV) in emergency department (ED) patients with acute heart failure (AHF) on short term outcomes. Methods: Patients from the EAHFE Registry (a multicenter, observational, multipurpose, cohort-designed database including consecutive AHF patients in 41 Spanish EDs) were grouped based on NIV treatment (NIV+ and NIV–groups). Using propensity score (PS) methodology, we identified two subgroups of patients matched by 38 covariates and compared regarding 30-day survival (primary outcome). Interaction was investigated for age, sex, ischemic cardiomyopathy, chronic obstructive pulmonary disease, AHF precipitated by an acute coronary syndrome (ACS), AHF classified as hypertensive or acute pulmonary edema (APE), and systolic blood pressure (SBP). Secondary outcomes were intensive care unit (ICU) admission; mechanical ventilation; in-hospital, 3-day and 7-day mortality; and prolonged hospitalization (>7 days). Results: Of 11, 152 patients from the EAHFE (age (SD): 80 (10) years; 55.5% women), 718 (6.4%) were NIV+ and had a higher 30-day mortality (HR = 2.229; 95%CI = 1.861–2.670) (p 85 years, p < 0.001), AHF associated with ACS (p = 0.045), and SBP < 100 mmHg (p < 0.001). No significant differences were found in the secondary endpoints except for more prolonged hospitalizations in NIV+ patients (OR = 1.445; 95%CI = 1.122–1.862) (p = 0.004). Conclusion: The use of NIV to treat AHF in ED is not associated with improved mortality outcomes and should be cautious in old patients and those with ACS and hypotension

Influence of the length of hospitalisation in post-discharge outcomes in patients with acute heart failure: Results of the LOHRCA study

Objective: To investigate the relationship between length of hospitalisation (LOH) and post-discharge outcomes in acute heart failure (AHF) patients and to ascertain whether there are different patterns according to department of initial hospitalisation. Methods: Consecutive AHF patients hospitalised in 41 Spanish centres were grouped based on the LOH (15 days). Outcomes were defined as 90-day post-discharge all-cause mortality, AHF readmissions, and the combination of both. Hazard ratios (HRs), adjusted by chronic conditions and severity of decompensation, were calculated for groups with LOH >6 days vs. LOH <6 days (reference), and stratified by hospitalisation in cardiology, internal medicine, geriatrics, or short-stay units. Results: We included 8563 patients (mean age: 80 (SD = 10) years, 55.5% women), with a median LOH of 7 days (IQR 4–11): 2934 (34.3%) had a LOH 15 days. The 90-day post-discharge mortality was 11.4%, readmission 32.2%, and combined endpoint 37.4%. Mortality was increased by 36.5% (95%CI = 13.0–64.9) when LOH was 11–15 days, and by 72.0% (95%CI = 42.6–107.5) when >15 days. Conversely, no differences were found in readmission risk, and the combined endpoint only increased 21.6% (95%CI = 8.4–36.4) for LOH >15 days. Stratified analysis by hospitalisation departments rendered similar post-discharge outcomes, with all exhibiting increased mortality for LOH >15 days and no significant increments in readmission risk. Conclusions: Short hospitalisations are not associated with worse outcomes. While post-discharge readmissions are not affected by LOH, mortality risk increases as the LOH lengthens. These findings were similar across hospitalisation departments