Evaluación de la fuerza relativa de las extremidades superiores con la plataforma de Bosco

The purpose of the study was to test whether Ergojump contact platform, used to measure the ability of lower limb drive through jumps, was valid to do it on the upper limbs from lying prone making elbow extension starting from the classical position flexion and extension of the arms and forearms at 90 degrees. A study was conducted of correlation between records of the platform (Φ= 1) and an electromyograph. Has also reliability analysis (e) experimental measure different plans that made the study variables, obtaining optimal results.El propósito del estudio fue comprobar si la Plataforma de contacto Ergojump, utilizada para medir la capacidad de impulsión de las extremidades inferiores a través de saltos, era válida  para hacerlo sobre las extremidades superiores realizando desde tumbado prono una extensión de codos partiendo de la posición clásica de flexo-extensión de brazos y antebrazos de 90 grados. Se realizó un estudio de correlación entre los registros de la  plataforma (Φ=1) y un electromiógrafo. También se ha realizado análisis de la fiabilidad (e) experimental de los distintos planes de medida que conformaban las distintas variables de estudio, obteniendo óptimos resultados

The Representation of Queer Teen Identities in Sex Education (Netflix, 2019-)

This article provides an analysis of the representation of LGBTIQ+ teen identities in the first two seasons of ‘Sex Education’ (Netflix, 2019-). Utilising a methodology of analysis anchored in Queer Theory and in the concept of intersectionality, we will study the construction of those characters whose gender expression and/or sexual orientation defy the limits established by cisheteronormativity, as well as those whose desires (whether straight or not) do not fit within what Western societies understand as «normal», since we consider the rejection of the norm as a constitutive element of queerness. The main objectives are a.) to determine which images, knowledge and epistemological constructions regarding sexogenic diversity are disseminated by the show; and b.) to define which discourses are articulated regarding queer (non)identities and the violence suffered by LGBTIQ+ people

Research on nonlinear and quantum optics at the photonics and quantum information group of the University of Valladolid

We outline the main research lines in Nonlinear and Quantum Optics of the Group of Photonics and Quantum Information at the University of Valladolid. These works focus on Optical Solitons, Quantum Information using Photonic Technologies and the development of new materials for Nonlinar Optics. The investigations on optical solitons cover both temporal solitons in dispersion managed fiber links and nonparaxial spatial solitons as described by the Nonlinear Helmholtz Equation. Within the Quantum Information research lines of the group, the studies address new photonic schemes for quantum computation and the multiplexing of quantum data. The investigations of the group are, to a large extent, based on intensive and parallel computations. Some associated numerical techniques for the development of the activities described are briefly sketched

Human Interaction in Learning Ecosystems based on Open Source Solutions

Technological ecosystems are software solutions based on the integration of heterogeneous software components through information flows in order to provide a set of services that each component separately does not offer, as well as to improve the user experience. In particular, the learning ecosystems are technological ecosystems focused on learning and knowledge management in different contexts such as educational institutions or companies. The ecosystem metaphor comes from biology field and it has transferred to technology field to highlight the evolving component of software. Taking into account the definitions of natural ecosystems, a technological ecosystem is a set of people and software components that play the role of organisms; a series of elements that allow the ecosystem works (hardware, networks, etc.); and a set of information flows that establish the relationships between the software components, and between these and the people involved in the ecosystem. Human factor has a main role in the definition and development of this kind of solutions. In previous works, a metamodel has been defined and validated to support Model-Driven Development of learning ecosystems based on Open Source software, but the interaction in the learning ecosystem should be defined in order to complete the proposal to improve the development process of technological ecosystems. This paper presents the definition and modelling of the human interaction in learning ecosystem

Depredatory impact of free-roaming dogs (Canis lupus familiaris) on Mediterranean deer in southern Spain: implications for the human-wolf conflict.

Feral dogs (Canis lupus familiaris) are efficient wild ungulate hunters in many parts of the world. This has not been confirmed in Mediterranean ecosystems. However, if feral dogs can predate upon wild Mediterranean ungulates, they can also do so upon livestock. Therefore, to more realistically understand human-wolf conflict in areas where wolves and feral dogs overlap, the possible role of the latter taking domestic prey should be considered. . During a 6-month study period, we carried out daily observations of a pack of medium-sized dogs, where they were the only large-bodied carnivore capable of killing ungulates, in a fenced estate in southern Spain. The estate contained sizeable populations of red deer, fallow deer and mouflons, but no livestock. We described feral dog predation patterns and depredatory impact. We found that dogs predated upon a total of 57 ungulates killed; fallow deer (47%) red deer (37%), and mouflon (16%). Red deer adults were the least frequent prey, but dogs killed significantly more females and fawns of red and fallow deer. Mouflons were attacked indistinctly. Our results suggest that dogs in our study exhibited a kill pattern similar to Iberian wolves. Therefore, in areas where wolves and feral dogs coexist, a significant proportion of livestock predation could be falsely attributed to the wild canid. In addition, the presence of feral dogs may be a cause of risk in big game hunting estates

Distribution of melanopsin positive neurons in pigmented and albino mice: evidence for melanopsin interneurons in the mouse retina.

Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their distribution is slightly different: while in pigmented mice ipRGCs are more abundant in the temporal retina, in albinos the ipRGCs are more abundant in superior retina. In both strains, ipRGCs are located in the retinal periphery, in the areas of lower Brn3a(+)RGC density. Both strains also contain displaced ipRGCs (d-ipRGCs) in the inner nuclear layer (INL) that account for 14% of total ipRGCs in pigmented mice and 5% in albinos. Tracing from both superior colliculli shows that 98% (pigmented) and 97% (albino) of the total ipRGCs, become retrogradely labeled, while double immunodetection of melanopsin and Brn3a confirms that few ipRGCs express this transcription factor in mice. Rather surprisingly, application of a retrograde tracer to the optic nerve (ON) labels all ipRGCs, except for a sub-population of the d-ipRGCs (14% in pigmented and 28% in albino, respectively) and melanopsin positive cells residing in the ciliary marginal zone (CMZ) of the retina. In the CMZ, between 20% (pigmented) and 24% (albino) of the melanopsin positive cells are unlabeled by the tracer and we suggest that this may be because they fail to send an axon into the ON. As such, this study provides the first evidence for a population of melanopsin interneurons in the mammalian retina

Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

Prior to its total synthesis, a new vanadium coordination compound, called TSAG0101, was computationally designed to inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B). The PTP1B acts as a negative regulator of insulin signaling by blocking the active site where phosphate hydrolysis of the insulin receptor takes place. TSAG001, [VVO2(OH)(picolinamide)], was characterized by infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy; IR: ν/cm−1 3,570 (NH), 1,627 (C=O, coordinated), 1,417 (C−N), 970/842 (O=V=O), 727 δ. (pyridine ring); 13C NMR: 5 bands between 122 and 151 ppm and carbonyl C shifted to 180 ppm; and 1H NMR: 4 broad bands from 7.6 to 8.2 ppm and NH2 shifted to 8.8 ppm. In aqueous solution, in presence or absence of sodium citrate as a biologically relevant and ubiquitous chelator, TSAG0101 undergoes neither ligand exchange nor reduction of its central vanadium atom during 24 hours. TSAG0101 shows blood glucose lowering effects in rats but it produced no alteration of basal- or glucose-induced insulin secretion on β cells during in vitro tests, all of which excludes a direct mechanism evidencing the extrapancreatic nature of its activity. The lethal dose (LD50) of TSAG0101 was determined in Wistar mice yielding a value of 412 mg/kg. This value is one of the highest among vanadium compounds and classifies it as a mild toxicity agent when compared with literature data. Due to its nonsubstituted, small-sized scaffold design, its remarkable complex stability, and low toxicity; TSAG0101 should be considered as an innovative insulin-mimetic principle with promising properties and, therefore, could become a new lead compound for potential nonpeptide PTP1B inhibitors in antidiabetic drug research. In view of the present work, the inhibitory concentration (IC50) and extended solution stability will be tested

Actividad antioxidante de los alcaloides de Bocconia arborea. Estudio sobre seis métodos de análisis

Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridinealkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods.The isolated alkaloids 6-acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidativeactivity on thiocyanate assays, free radical scavenging activity, b-carotene bleaching method, and deoxyribose assay. Allalkaloids exhibited significant antioxidant activities in linoleic acid and b-carotene. Although afforded protection againstthe damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavengingeffects on the 1,1-diphenyl-2-picrylhydrazyl radicals.El fraccionamiento de la actividad antioxidante dirigida por actividad, junto con el análisis químico, llevaron alaislamiento de tres alcaloides de benzofenantridina del extracto de metanol de la corteza de Bocconia arborea. Laidentificación se basó en métodos espectroscópicos. Se analizó la actividad antioxidante de los alcaloides aislados 6-acetonildihidroqueleritrina, queleritrina y dihidroqueleritrina en ensayos de tiocianato, la actividad de barrido delos radicales libres, el método de decoloración del b-caroteno y el ensayo de la desoxirribosa. Todos los alcaloidesmostraron actividad antioxidante significativa en ácido linoleico y b-caroteno. Además de conceder protección frentea la desoxirribosa, la peroxidación liposómica y los lípidos microsomiales de la peroxidación, también presentaronefectos de barrido en los radicales de 1,1-difenil-2-picrilhidrazi

The effect of beta-tricalcium phosphate on mechanical and thermal performances of poly(lactic acid)

Orthophosphates are bioactive crystals with similar structure, in terms of elemental composition and crystal nature, to human bone. In this work, biocomposite materials were prepared with poly(lactic acid) (PLA) as matrix, and betatricalcium phosphate (b-TCP) as osteoconductive filler by extrusion-compounding followed by conventional injection molding. The b-TCP load content was varied in the 10 40 wt% range and the influence of the b-TCP load on mechanical performance of PLA/b-TCP composites was evaluated. Mechanical properties of composites were obtained by standardized tensile, flexural, impact, and hardness tests. Thermal analysis of composites was carried out by means of differential scanning calorimetry; degradation at high temperatures was studied by thermogravimetric analysis; and the effect of the b-TCP load on dynamical response of composites was studied by mechanical thermal analysis in torsion mode. The bestbalanced properties were obtained for PLA composites containing 30 wt% b-TCP with a remarkable increase in the Young s modulus. These materials offer interesting properties to be used as base materials for medical applications such as interference screws due to high stiffness and mechanical resistance.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by "Conselleria d'Educacio, Cultura i Esport" - Generalitat Valenciana ref: GV/2014/008.Ferri Azor, JM.; Gisbert, I.; García Sanoguera, D.; Reig Pérez, MJ.; Balart Gimeno, RA. (2016). The effect of beta-tricalcium phosphate on mechanical and thermal performances of poly(lactic acid). Journal of Composite Materials. 50(30):4189-4198. https://doi.org/10.1177/0021998316636205S41894198503

Stir Casting Routes for Processing Metal Matrix Syntactic Foams: A Scoping Review

Metal matrix syntactic foams (MMSFs) are advanced lightweight materials constituted by a metallic matrix and a dispersion of hollow/porous fillers. Physical and mechanical properties can be fitted regarding matrix and filler properties and processing parameters. Their properties make them potential materials for sectors where density is a limiting parameter, such as transport, marine, defense, aerospace, and engineering applications. MMSFs are mainly manufactured by powder metallurgy, infiltration, and stir casting techniques. This study focuses on the current stir casting approaches and on the advances and deficiencies, providing processing parameters and comparative analyses on porosity and mechanical properties. PRISMA approaches were followed to favor traceability and reproducibility of the study. Stir casting techniques are low-cost, industrially scalable approaches, but they exhibit critical limitations: buoyancy of fillers, corrosion of processing equipment, premature solidification of molten metal during mixing, cracking of fillers, heterogeneous distribution, and limited incorporation of fillers. Six different approaches were identified; four focus on limiting buoyancy, cracking, heterogeneous distribution of fillers, and excessive oxidation of sensitive matrix alloys to oxygen. These improvements favor reaching the maximum porosity of 54%, increasing the fillers size from a few microns to 45 mm, reducing residual porosity by ±4%, synthesizing bimodal MMSFs, and reaching maximum incorporation of 74 vol%.</jats:p