1,013 research outputs found
International outbreak of Salmonella Oranienburg due to German chocolate
BACKGROUND: This report describes a large international chocolate-associated Salmonella outbreak originating from Germany. METHODS: We conducted epidemiologic investigations including a case-control study, and food safety investigations. Salmonella (S.) Oranienburg isolates were subtyped by the use of pulsed-field gel electrophoresis (PFGE). RESULTS: From 1 October 2001 through 24 March 2002, an estimated excess of 439 S. Oranienburg notifications was registered in Germany. Simultaneously, an increase in S. Oranienburg infections was noted in other European countries in the Enter-net surveillance network. In a multistate matched case-control study in Germany, daily consumption of chocolate (matched odds ratio [MOR]: 4.8; 95% confidence interval [CI]: 1.3–26.5), having shopped at a large chain of discount grocery stores (MOR: 4.2; CI: 1.2–23.0), and consumption of chocolate purchased there (MOR: 5.0; CI: 1.1–47.0) were associated with illness. Subsequently, two brands from the same company, one exclusively produced for that chain, tested positive for S. Oranienburg. In two other European countries and in Canada chocolate from company A was ascertained that also contained S. Oranienburg. Isolates from humans and from chocolates had indistinguishable PFGE profiles. No source or point of contamination was identified. Epidemiological identification of chocolate as a vehicle of infections required two months, and was facilitated by proxy measures. CONCLUSIONS: Despite the use of improved production technologies, the chocolate industry continues to carry a small risk of manufacturing Salmonella-containing products. Particularly in diffuse outbreak-settings, clear associations with surrogates of exposure should suffice to trigger public health action. Networks such as Enter-net have become invaluable for facilitating rapid and appropriate management of international outbreaks
Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection.
BackgroundHIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis. Higher levels of ET-1 predict disease severity and mortality in other forms of PAH, and endothelin receptor antagonists are central to treatment, including in HIV-associated PAH. The direct relationship between ET-1 and PAH in HIV-infected individuals is not well described.MethodsWe measured ET-1 and estimated pulmonary artery systolic pressure (PASP) with transthoracic echocardiography (TTE) in 106 HIV-infected individuals. Participants with a PASP ≥ 30 mmHg (n = 65) underwent right heart catheterization (RHC) to definitively diagnose PAH. We conducted multivariable analysis to identify factors associated with PAH.ResultsAmong 106 HIV-infected participants, 80% were male, the median age was 52 years and 77% were on antiretroviral therapy. ET-1 was significantly associated with higher values of PASP [14% per 0.1 pg/mL increase in ET-1, p = 0.05] and PASP ≥ 30 mmHg [PR (prevalence ratio) = 1.24, p = 0.012] on TTE after multivariable adjustment for PAH risk factors. Similarly, among the 65 individuals who underwent RHC, ET-1 was significantly associated with higher values of mean pulmonary artery pressure and PAH (34%, p = 0.003 and PR = 2.43, p = 0.032, respectively) in the multivariable analyses.ConclusionsHigher levels of ET-1 are independently associated with HIV-associated PAH as hemodynamically assessed by RHC. Our findings suggest that excessive ET-1 production in the setting of HIV infection impairs pulmonary endothelial function and contributes to the development of PAH
Dynamics on expanding spaces: modeling the emergence of novelties
Novelties are part of our daily lives. We constantly adopt new technologies,
conceive new ideas, meet new people, experiment with new situations.
Occasionally, we as individuals, in a complicated cognitive and sometimes
fortuitous process, come up with something that is not only new to us, but to
our entire society so that what is a personal novelty can turn into an
innovation at a global level. Innovations occur throughout social, biological
and technological systems and, though we perceive them as a very natural
ingredient of our human experience, little is known about the processes
determining their emergence. Still the statistical occurrence of innovations
shows striking regularities that represent a starting point to get a deeper
insight in the whole phenomenology. This paper represents a small step in that
direction, focusing on reviewing the scientific attempts to effectively model
the emergence of the new and its regularities, with an emphasis on more recent
contributions: from the plain Simon's model tracing back to the 1950s, to the
newest model of Polya's urn with triggering of one novelty by another. What
seems to be key in the successful modelling schemes proposed so far is the idea
of looking at evolution as a path in a complex space, physical, conceptual,
biological, technological, whose structure and topology get continuously
reshaped and expanded by the occurrence of the new. Mathematically it is very
interesting to look at the consequences of the interplay between the "actual"
and the "possible" and this is the aim of this short review.Comment: 25 pages, 10 figure
Ochronosis of hip joint; a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Non-Fermi-liquid d-wave metal phase of strongly interacting electrons
Developing a theoretical framework for conducting electronic fluids
qualitatively distinct from those described by Landau's Fermi-liquid theory is
of central importance to many outstanding problems in condensed matter physics.
One such problem is that, above the transition temperature and near optimal
doping, high-transition-temperature copper-oxide superconductors exhibit
`strange metal' behaviour that is inconsistent with being a traditional Landau
Fermi liquid. Indeed, a microscopic theory of a strange-metal quantum phase
could shed new light on the interesting low-temperature behaviour in the
pseudogap regime and on the d-wave superconductor itself. Here we present a
theory for a specific example of a strange metal---the 'd-wave metal'. Using
variational wavefunctions, gauge theoretic arguments, and ultimately
large-scale density matrix renormalization group calculations, we show that
this remarkable quantum phase is the ground state of a reasonable microscopic
Hamiltonian---the usual t-J model with electron kinetic energy and two-spin
exchange supplemented with a frustrated electron `ring-exchange' term,
which we here examine extensively on the square lattice two-leg ladder. These
findings constitute an explicit theoretical example of a genuine
non-Fermi-liquid metal existing as the ground state of a realistic model.Comment: 22 pages, 12 figures: 6 pages, 7 figures of main text + 16 pages, 5
figures of Supplementary Information; this is approximately the version
published in Nature, minus various subedits in the main tex
Modelling avalanches in martensites
Solids subject to continuous changes of temperature or mechanical load often
exhibit discontinuous avalanche-like responses. For instance, avalanche
dynamics have been observed during plastic deformation, fracture, domain
switching in ferroic materials or martensitic transformations. The statistical
analysis of avalanches reveals a very complex scenario with a distinctive lack
of characteristic scales. Much effort has been devoted in the last decades to
understand the origin and ubiquity of scale-free behaviour in solids and many
other systems. This chapter reviews some efforts to understand the
characteristics of avalanches in martensites through mathematical modelling.Comment: Chapter in the book "Avalanches in Functional Materials and
Geophysics", edited by E. K. H. Salje, A. Saxena, and A. Planes. The final
publication is available at Springer via
http://dx.doi.org/10.1007/978-3-319-45612-6_
Niche as a determinant of word fate in online groups
Patterns of word use both reflect and influence a myriad of human activities
and interactions. Like other entities that are reproduced and evolve, words
rise or decline depending upon a complex interplay between {their intrinsic
properties and the environments in which they function}. Using Internet
discussion communities as model systems, we define the concept of a word niche
as the relationship between the word and the characteristic features of the
environments in which it is used. We develop a method to quantify two important
aspects of the size of the word niche: the range of individuals using the word
and the range of topics it is used to discuss. Controlling for word frequency,
we show that these aspects of the word niche are strong determinants of changes
in word frequency. Previous studies have already indicated that word frequency
itself is a correlate of word success at historical time scales. Our analysis
of changes in word frequencies over time reveals that the relative sizes of
word niches are far more important than word frequencies in the dynamics of the
entire vocabulary at shorter time scales, as the language adapts to new
concepts and social groupings. We also distinguish endogenous versus exogenous
factors as additional contributors to the fates of words, and demonstrate the
force of this distinction in the rise of novel words. Our results indicate that
short-term nonstationarity in word statistics is strongly driven by individual
proclivities, including inclinations to provide novel information and to
project a distinctive social identity.Comment: Supporting Information is available here:
http://www.plosone.org/article/fetchSingleRepresentation.action?uri=info:doi/10.1371/journal.pone.0019009.s00
How victim age affects the context and timing of child sexual abuse: applying the routine activities approach to the first sexual abuse incident
The aim of this study was to examine from the routine activities approach how victim age might help to explain the timing, context and nature of offenders’ first known contact sexual abuse incident. One-hundred adult male child sexual abusers (M = 45.8 years, SD = 12.2; range = 20–84) were surveyed about the first time they had sexual contact with a child. Afternoon and early evening (between 3 pm and 9 pm) was the most common time in which sexual contact first occurred. Most incidents occurred in a home. Two-thirds of incidents occurred when another person was in close proximity, usually elsewhere in the home. Older victims were more likely to be sexually abused by someone outside their families and in the later hours of the day compared to younger victims. Proximity of another person (adult and/or child) appeared to have little effect on offenders’ decisions to abuse, although it had some impact on the level of intrusion and duration of these incidents. Overall, the findings lend support to the application of the routine activities approach for considering how contextual risk factors (i.e., the timing and relationship context) change as children age, and raise questions about how to best conceptualize guardianship in the context of child sexual abuse. These factors should be key considerations when devising and implementing sexual abuse prevention strategies and for informing theory development
The smaller vesicomyid bivalves in the genus Isorropodon (Bivalvia, Vesicomyidae, Pliocardiinae) also harbour chemoautotrophic symbionts
Species of Isorropodon are vesicomyid bivalves for which little information is available regarding host phylogeny and bacterial symbioses. In this study we investigated the symbioses in three Isorropodon species from three cold seep areas: Isorropodon bigoti (Gulf of Guinea), Isorropodon megadesmus (Gulf of Cadiz) and Isorropodon perplexum (Eastern Mediterranean). Analysis of bacterial 16S ribosomal RNA gene sequences demonstrated that each vesicomyid species harbours a single symbiont phylotype, that symbionts from the three species cluster together, and that they are closely related to other known vesicomyid symbionts. These results are confirmed by other marker genes (encoding 23S rRNA and APS reductase) and by fluorescence in situ hybridization. Due to their extended depth range and transoceanic distribution Isorropodon species are interesting examples to further study evolutionary processes in bivalve hosts and their associated symbionts
Phylogeny and Diversification Patterns among Vesicomyid Bivalves
Vesicomyid bivalves are among the most abundant and diverse symbiotic taxa in chemosynthetic-based ecosystems: more than 100 different vesicomyid species have been described so far. In the present study, we investigated the phylogenetic positioning of recently described vesicomyid species from the Gulf of Guinea and their western Atlantic and Pacific counterparts using mitochondrial DNA sequence data. The maximum-likelihood (ML) tree provided limited support for the recent taxonomic revision of vesicomyids based on morphological criteria; nevertheless, most of the newly sequenced specimens did not cluster with their morphological conspecifics. Moreover, the observed lack of geographic clustering suggests the occurrence of independent radiations followed by worldwide dispersal. Ancestral character state reconstruction showed a significant correlation between the characters “depth” and “habitat” and the reconstructed ML phylogeny suggesting possible recurrent events of ‘stepwise speciation’ from shallow to deep waters in different ocean basins. This is consistent with genus or species bathymetric segregation observed from recent taxonomic studies. Altogether, our results highlight the need for ongoing re-evaluation of the morphological characters used to identify vesicomyid bivalves
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