analysis of hmds self assembled monolayer effect on trap density in pc70bm n type thin film transistors through admittance studies

Abstract In this work, n-type organic thin film transistors (OTFTs) were fabricated in the bottom-gate bottom-contact configuration, depositing a fullerene-derived semiconductor (PC 70 BM) by drop-casting technique on SiO 2 substrates treated with a self-assembled monolayer, namely the HMDS. The influence of the deposition temperature of the HMDS on the device performance was investigated, using three different temperatures. The relationship between the properties of the resulting semiconductor films and the electrical characteristics of the transistors was evaluated through admittance measurements. The frequency response of the devices vs. the bias was interpreted applying an electrical equivalent circuit to model the properties of the semiconductor and of the transistor conductive channel. The proposed model shows the critical role played by the quality of the insulator-semiconductor interface on the traps density in the semiconductor, and therefore on the increase of the mobility and on the reduction of the threshold voltage of the transistors

A retrospective analysis of pegylated liposomal doxorubicin in ovarian cancer: Do we still need it?

Background: Ovarian cancer (OC) is the sixth most common cancer in women. Currently, carboplatin/ paclitaxel bevacizumab is the cornerstone of front-line treatment. Conversely, the therapeutic options for recurrent or progressive disease are not well defined. For platinum-sensitive patients the best therapeutic approach is still a re-challenge with a platinum-based regimen. Pegylated liposomal doxorubicin (PLD), is considered one of the most active therapeutic options for recurrent or progressive OC. In this retrospective mono-institutional analysis, we evaluated the impact of PLD on the outcome of OC patients. Patients and methods: We performed the retrospective study on a cohort of 108 patients with histologically confirmed serous papillary OC, followed at our Institution between 2001 and 2011. 80 patients were in stage III/IV and 55 of them received a second-line treatment. Thirty patients were treated with PLD. Both groups (PLD-treated versus PLD-untreated) underwent a median of 3 treatment lines and were prognostically balanced. The median follow-up was 60 months. Survival endpoints, toxicity and correlations between patients' baseline characteristics and treatment efficacy were evaluated. Results: Patients who had undergone PLD treatment (PLD group) showed a median overall survival (OS) of 45 months as compared to 65 months of patients not treated with PLD (PLD-free group) (HR 2.50 [0.95-6.67; p = 0.06]). Moreover, the median progression-free survival was 6 months in the PLD group versus 10 months in the PLD-free group (HR 1.75 [0.94-3.34; p = 0.07]). The overall objective response rate in II line treatment was 43% (13% in PLD group versus 57% in PLD-free group). Furthermore, we investigated survival endpoints in platinum-refractory patients who received PLD at least once during the course of disease. No OS advantage was achieved by PLD administration when compared to other therapeutic options (30 versus 32 months; HR 1.16 [0.31-4.34; p = 0.81]). No difference in term of toxicity was observed among different groups. Conclusions: No evidence of superiority if PLD was compared to alternative agents was found in this analysis, particularly in the platinum-refractory setting. Our findings indicate a modest therapeutic activity of PLD in OC. Analysis of cost/benefit of PLD in OC is eagerly awaited

pc70bm n type thin film transistors influence of hmds deposition temperature on the devices properties

This study investigates the influence of the deposition temperature of hexamethyldisilazane (HMDS) on the performances of organic thin film transistors (OTFTs) using the [6,6]-phenyl-C71-butyric acid methyl ester (PC70BM) as semiconductor. N-type OTFTs have been fabricated using this fullerene derivative, deposited from solution by drop casting technique on HMDS self-assembled monolayer (SAM) deposited at three different temperatures, 7 °C, 25 °C and 60 °C, in order to evaluate the influence of these deposition conditions on the morphology of PC70BM films and on the electrical responses of fullerene derivative-based OTFTs. The effect of the treatments of the surfaces was observed through contact angle measurements. AFM imaging of the deposited material has been used to analyse its structure and morphology. The transistors performances have been evaluated through I vs. V static characterization and parameters extraction. Contact angle vs. HMDS deposition temperature shows the minimum value at 60 °C, instead here field effect mobility presents a maximum. It has been observed that the lower hydrophobicity of the surface of the SAM induces the formation of more homogeneous surface of the PC70BM film, resulting in an increase of the OTFTs performances

Coerced Hospital Admission and Symptom Change-A Prospective Observational Multi-Centre Study

PMCID: PMC3227658 Freely available online via CCplosone.org

“New” cyanobacterial blooms are not new: two centuries of lake production are related to ice cover and land use

Recent cyanobacterial blooms in otherwise unproductive lakes may be warning signs of impending eutrophication in lakes important for recreation and drinking water, but little is known of their historical precedence or mechanisms of regulation. Here, we examined long-term sedimentary records of both general and taxon-specific trophic proxies from seven lakes of varying productivity in the northeastern United States to investigate their relationship to historical in-lake, watershed, and climatic drivers of trophic status. Analysis of fossil pigments (carotenoids and chlorophylls) revealed variable patterns of past primary production across lakes over two centuries despite broadly similar changes in regional climate and land use. Sediment abundance of the cyanobacterium Gloeotrichia, a large, toxic, nitrogen-fixing taxon common in recent blooms in this region, revealed that this was not a new taxon in the phytoplankton communities but rather had been present for centuries. Histories of Gloeotrichia abundance differed strikingly across lakes and were not consistently associated with most other sediment proxies of trophic status. Changes in ice cover most often coincided with changes in fossil pigments, and changes in watershed land use were often related to changes in Gloeotrichia abundance, although no single climatic or land-use factor was associated with proxy changes across all seven lakes. The degree to which changes in lake sediment records co-occurred with changes in the timing of ice-out or agricultural land use was negatively correlated with the ratio of watershed area to lake area. Thus, both climate and land management appeared to play key roles in regulation of primary production in these lakes, although the manner in which these factors influenced lakes was mediated by catchment morphometry. Improved understanding of the past interactions between climate change, land use, landscape setting, and water quality underscores the complexity of mechanisms regulating lake and cyanobacterial production and highlights the necessity of considering these interactions—rather than searching for a singular mechanism—when evaluating the causes of ongoing changes in low-nutrient lakes

Evidence for a vortex-glass transition in superconducting Ba(Fe0.9_{0.9}Co0.1_{0.1})2_{2}As2_{2}

Measurements of magneto-resistivity and magnetic susceptibility were performed on single crystals of superconducting Ba(Fe$_{0.9}$Co$_{0.1}$)$_{2}$As$_{2}$ close to the conditions of optimal doping. The high quality of the investigated samples allows us to reveal a dynamic scaling behaviour associated with a vortex-glass phase transition in the limit of weak degree of quenched disorder. Accordingly, the dissipative component of the ac susceptibility is well reproduced within the framework of Havriliak-Negami relaxation, assuming a critical power-law divergence for the characteristic correlation time $\tau$ of the vortex dynamics. Remarkably, the random disorder introduced by the Fe$_{1-x}$Co$_{x}$ chemical substitution is found to act on the vortices as a much weaker quenched disorder than previously reported for cuprate superconductors such as, e.g., Y$_{1-x}$Pr$_{x}$Ba$_{2}$Cu$_{3}$O$_{7-\delta}$.Comment: 10 pages, 8 figure

Solar neutrino detection in a large volume double-phase liquid argon experiment

Precision measurements of solar neutrinos emitted by specific nuclear reaction chains in the Sun are of great interest for developing an improved understanding of star formation and evolution. Given the expected neutrino fluxes and known detection reactions, such measurements require detectors capable of collecting neutrino-electron scattering data in exposures on the order of 1 ktonne yr, with good energy resolution and extremely low background. Two-phase liquid argon time projection chambers (LAr TPCs) are under development for direct Dark Matter WIMP searches, which possess very large sensitive mass, high scintillation light yield, good energy resolution, and good spatial resolution in all three cartesian directions. While enabling Dark Matter searches with sensitivity extending to the "neutrino floor" (given by the rate of nuclear recoil events from solar neutrino coherent scattering), such detectors could also enable precision measurements of solar neutrino fluxes using the neutrino-electron elastic scattering events. Modeling results are presented for the cosmogenic and radiogenic backgrounds affecting solar neutrino detection in a 300 tonne (100 tonne fiducial) LAr TPC operating at LNGS depth (3,800 meters of water equivalent). The results show that such a detector could measure the CNO neutrino rate with ~15% precision, and significantly improve the precision of the 7Be and pep neutrino rates compared to the currently available results from the Borexino organic liquid scintillator detector.Comment: 21 pages, 7 figures, 6 table

Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial

Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often causes lack of effectiveness of many psychotropic drugs. Thus, efforts should be made to improve adherence to pharmacological treatments in patients with these disorders. Methods: In this paper, based on the LIFESTYLE randomized, controlled multicentric trial, we aim to: 1) assess the level of adherence in a real-world sample of patients with severe mental disorders; 2) evaluate differences in treatment adherence according to patients’ socio-demographic and clinical characteristics; 3) evaluate the impact of an innovative psychosocial intervention, on patients’ adherence to treatments. The Lifestyle Psychosocial Group Intervention consists of group sessions, focused on different lifestyle behaviours, including healthy diet; physical activity; smoking habits; medication adherence; risky behaviours; and regular circadian rhythms. At end of each session a 20-min moderate physical activity is performed by the whole group. Results: The sample consists of 402 patients, mainly female (57.1%, N = 229), with a mean age of 45.6 years (±11.8). Less than 40% of patients reported a good adherence to pharmacological treatments. Adherence to treatments was not influenced by gender, age, diagnosis and duration of illness. At the end of the intervention, patients receiving the experimental intervention reported a significant improvement in the levels of adherence to treatments (T0: 35.8% vs. T3: 47.6%, p < 0.005). Patients practicing moderate physical activity reported a two-point improvement in the levels of adherence [odds ratio (OR): 1,542; 95% confidence intervals (CI): 1,157–2,055; p < 0.001], even after controlling for several confounding factors. Discussion: The experimental lifestyle intervention, which can be easily implemented in the routine clinical practice of mental health centres, was effective in improving adherence to pharmacological treatments

Precise 3D track reconstruction algorithm for the ICARUS T600 liquid argon time projection chamber detector

Liquid Argon Time Projection Chamber (LAr TPC) detectors offer charged particle imaging capability with remarkable spatial resolution. Precise event reconstruction procedures are critical in order to fully exploit the potential of this technology. In this paper we present a new, general approach of three-dimensional reconstruction for the LAr TPC with a practical application to track reconstruction. The efficiency of the method is evaluated on a sample of simulated tracks. We present also the application of the method to the analysis of real data tracks collected during the ICARUS T600 detector operation with the CNGS neutrino beam.Comment: Submitted to Advances in High Energy Physic

Observation of the Dependence of Scintillation from Nuclear Recoils in Liquid Argon on Drift Field

We have exposed a dual-phase Liquid Argon Time Projection Chamber (LAr-TPC) to a low energy pulsed narrowband neutron beam, produced at the Notre Dame Institute for Structure and Nuclear Astrophysics to study the scintillation light yield of recoiling nuclei in a LAr-TPC. A liquid scintillation counter was arranged to detect and identify neutrons scattered in the LAr-TPC target and to select the energy of the recoiling nuclei. We report the observation of a significant dependence on drift field of liquid argon scintillation from nuclear recoils of 11 keV. This observation is important because, to date, estimates of the sensitivity of noble liquid TPC dark matter searches are based on the assumption that electric field has only a small effect on the light yield from nuclear recoils.Comment: v3 updated to reflect published version, including a set of plots for 49.9 keV dat