Two-meson cloud contribution to the baryon antidecuplet self-energy

We study the self-energy of the SU(3) antidecuplet coming from two-meson virtual clouds. Assuming that the exotic Theta+ belongs to an antidecuplet representation with N(1710) as nucleon partner, we derive effective Lagrangians that describe the decay of N(1710) into N pi pi with two pions in s- or p-wave. It is found that the self-energies for all members of the antidecuplet are attractive, and the larger strangeness particle is more bound. From two-meson cloud, we obtain about 20 % of the empirical mass splitting between states with different strangeness.Comment: 4 pages, 2 figures, 1 table, Talk given at the 10th International Conference on Baryons (Baryons04), Palaiseau (France), October 25-29, 200

Efectividad de la terapia combinada a dosis fijas en una cohorte de hipertensos no controlados con monoterapia

ObjetivoEvaluar la efectividad de lisinoprilhidroclorotiazida a dosis fijas en el control de la presión arterial en hipertensos tratados con monoterapia y mal controlados.DiseñoEstudio observacional, prospectivo.EmplazamientoAtención primaria.ParticipantesCiento noventa y nueve médicos de atención primaria que incluyeron a 931 pacientes (56,7% mujeres), con edad media de 62,0 ± 10,3 años. Finalizaron el estudio 915 pacientes (98%) que se incluyeron en el análisis.Mediciones principalesSe siguieron las recomendaciones de la OMS/SIH en la medición de la presión arterial y el diagnóstico de mal control. Además, se evaluaron presión del pulso, índice de masa corporal y parámetros analíticos básicos. Se realizaron 4 visitas durante 6 meses de seguimiento.ResultadosLisinopril-hidroclorotiazida (20/12,5mg) disminuyó significativamente la PAS (24,6 ± 3,5mmHg) y la PAD (14,3 ± 0,7mmHg) (p < 0,001). El control de la presión arterial aumentó hasta el 52,8% (p < 0,001). La edad fue la única variable que influyó en el control de la presión arterial (OR, 0,81; IC del 95%, 0,71-0,92%; p = 0,001). La presión del pulso disminuyó 10,4 ± 4,3mmHg (p < 0,001). A las 24 semanas de tratamiento, se observó una mejoría en el perfil glucémico y lipídico, y de la HbA1c en los diabéticos.ConclusionesEn atención primaria, lisinopril-hidroclorotiazida (20/12,5mg), controló la presión arterial del 52,8% los de hipertensos mal controlados con monoterapia. Además, disminuyó la presión del pulso y mejoró el perfil lipídico y el glucémico.ObjectiveTo evaluate the effectiveness of the fixed dose of a lisinoprilhydrochlorothiazide combination treatment in the control of blood pressure, in poorly controlled high blood pressure people, treated with monotherapy.DesignProspective observational study.SettingPrimary care frame.Participants931 patients (56.7% women) with an average age of 62.0±10.3 years, were included by 199 primary care physicians. 915 patients (98%) ended the study and finally they were included for the statistical analysis.Main measurementsOMS/SIH recommendations on blood pressure measurement and diagnose of poor control were followed. Pulse pressure, body mass index and basic clinical analyses were assessed. Four continuation visits were made during six months.ResultsLisinopril–hidrochlorothiazide (20/12.5mg) reduced significantly SBP (24.6±3.5mm Hg) and DBP (14,3±0.7mm Hg) (P<.001). Blood pressure control was only influenced by age (OR, 0.81; 95% CI, 0.71-0.92; P=.001). Pulse pressure was reduced in 10.4±4.3mm Hg (P<.001). After 24 weeks of treatment, glycemic and lipidic profiles showed an improvement, as well as HbA1c in diabetic people.ConclusionsIn Primary care, a 52.8% of poorly controlled with monotherapy high blood pressure people were controlled by a combination of lisinoprilhydrochlorothiazide (20/12.5mg). In addition, pulse pressure was decreased and both lipid and glucose blood profiles improved

Designing Soil-Nailed Walls Using the Amherst Wall Considering Problematic Issues during Execution and Service Life

[EN] Soil nailing is a technique commonly used as a temporary or permanent earth-retention system in soft soils. Habitually, the design of a soil nailing focuses on its performance at failure and computing a safety factor, thus neglecting ground deformations. In this study, an analysis and a comparison of the convenience of the use of the limit-equilibrium method and the FEM for designing a soil nailing were conducted. The assessment considered both the suitability of an easy and fast design process and the necessity to take into account such issues as ground deformations to avoid problematic consequences that can arise during the execution phase and service life. For performing the analyses, a numerical study of the Amherst wall, a full-scale soil-nailed wall built to be an experimental test in the last years of the twentieth century, was carried out. A two-step process for designing soil-nailed walls is proposed. The first step involves the use of limit-equilibrium methods to define the main parameters. The second step deals with the development of a finite-element model to consider ground deformations and determine nail forces. An approach based on the use the Mohr-Coulomb model for simulating materials more similar to granular soils and the hardening soil model for simulating materials more similar to cohesive soils is also presented as an answer for the numerical modeling of soil-nailed walls in ground situations where the soil is neither purely cohesive nor purely granular.Garzón-Roca, J.; Capa-Guachon, VE.; Torrijo, F.; Company Rodríguez, J. (2019). Designing Soil-Nailed Walls Using the Amherst Wall Considering Problematic Issues during Execution and Service Life. International Journal of Geomechanics. 19(7):1-14. https://doi.org/10.1061/(ASCE)GM.1943-5622.0001453S11419

Measures to evaluate quality of care in renal cancer: results of a Delphi study in Spain.

Purpose: To review current measures for renal cancer care and develop a comprehensive and updated list of measures for their practical use. Methods: The study was developed by Fundación ECO, a Spanish foundation aiming to improve oncology quality of care. A systematic literature review was carried out to identify measures and knowledge gaps. A scientific committee composed of 9 experts reviewed the literature findings and added measures. A preliminary list of 42 measures was evaluated with the Delphi method to gather feedback from 47 medical oncology experts in Spain. Experts scored the appropriateness of the measures and ranked their priority in 2 consecutive online surveys. The scientific committee reviewed the Delphi results and developed the measures. A technical group from Universidad Francisco de Vitoria conducted and oversaw the Delphi method. Results: The Delphi method led to consensus on all 42 measures. The scientific committee used a prioritisation matrix to select 25 of these measures for evaluating quality of care in renal cancer. These measures regarded structure, process, and outcome and covered general management, diagnosis, treatment, follow-up, and evaluation of health outcomes. Easy-to-use index cards were developed for all 25 measures, including their definition, formula, acceptable level of attainment, and rationale. Conclusions: This manuscript aims to provide healthcare professionals with expert- and evidence-based measures that are useful for evaluating quality of care in renal cancer and cover all aspects and stages.pre-print451 K

Determining major factors controlling phosphorus removal by promising adsorbents used for lake restoration: a linear mixed model approach

Phosphorus (P) removal from lake/drainage waters by novel adsorbents may be affected by competitive substances naturally present in the aqueous media. Up to date, the effect of interfering substances has been studied basically on simple matrices (single-factor effects) or by applying unsuitable statistical approaches when using natural lake water. In this study, we determined major factors controlling P removal efficiency in 20 aquatic ecosystems in the southeast Spain by using linear mixed models. Two non-magnetic -CFH-12® and Phoslock®- and two magnetic materials -hydrous lanthanum oxide loaded silica-coated magnetite (Fe-Si-La) and commercial zero-valent iron particles (FeHQ)- were tested to remove P at two adsorbent dosages. Results showed that the type of adsorbent, the adsorbent dosage and color of water (indicative of humic substances) are major factors controlling P removal efficiency. Differences in physico-chemical properties (i.e. surface charge or specific surface), composition and structure explain differences in maximum P adsorption capacity and performance of the adsorbents when competitive ions are present. The highest P removal efficiency, independently on whether the adsorbent dosage was low or high, were 85-100% for Phoslock and CFH-12®, 70-100% for Fe-Si-La and 0-15% for FeHQ. The low dosage of FeHQ, compared to previous studies, explained its low P removal efficiency. Although non-magnetic materials were the most efficient, magnetic adsorbents (especially Fe-Si-La) could be proposed for P removal as they can be recovered along with P and be reused, potentially making them more profitable in a long-term period.This work was supported by Junta de Andalucía project P10-RNM-6630 [Proyectos de Excelencia, Spain]; MINECO CTM 2013-46951-R project; and MAT 2016-78778-R project [Spain]. Authors would also like to thank Fernando Ortega for helping in the sampling procedure

Prediction of Reverse Remodeling at Cardiac MR Imaging Soon after First ST-Segment-Elevation Myocardial Infarction: Results of a Large Prospective Registry

[EN] Conclusion: Assessment of infarct size and MVO with cardiac MR imaging soon after STEMI enables one to make a decision in the prediction of reverse remodeling. (C) RSNA, 2015Supported by the Instituto de Salud Carlos III and FEDER (grant PI1400271) and the Generalitat Valenciana (grant PROMETEO/2013/007).Bodi, V.; Monmeneu, J.; Ortiz-Perez, J.; López-Lereu, M.; Bonanad, C.; Husser, O.; Minana, G.... (2016). Prediction of Reverse Remodeling at Cardiac MR Imaging Soon after First ST-Segment-Elevation Myocardial Infarction: Results of a Large Prospective Registry. Radiology. 278(1):54-63. https://doi.org/10.1148/radiol.2015142674S5463278

Methylglyoxal Produced by Amyloid- Peptide-Induced Nitrotyrosination of Triosephosphate Isomerase Triggers Neuronal Death in Alzheimer’s Disease

Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the triosephosphate isomerase (TPI) enzyme which regulates glycolytic flow, and its efficiency decreased when it is nitrotyrosinated. The main aims of this study were to analyze the impact of TPI nitrotyrosination on cell viability and to identify the mechanism behind this effect. In human neuroblastoma cells (SH-SY5Y), we evaluated the effects of Aβ42 oligomers on TPI nitrotyrosination. We found an increased production of methylglyoxal (MG), a toxic byproduct of the inefficient nitro-TPI function. The proapoptotic effects of Aβ42 oligomers, such as decreasing the protective Bcl2 and increasing the proapoptotic caspase-3 and Bax, were prevented with a MG chelator. Moreover, we used a double mutant TPI (Y165F and Y209F) to mimic nitrosative modifications due to Aβ action. Neuroblastoma cells transfected with the double mutant TPI consistently triggered MG production and a decrease in cell viability due to apoptotic mechanisms. Our data show for the first time that MG is playing a key role in the neuronal death induced by Aβ oligomers. This occurs because of TPI nitrotyrosination, which affects both tyrosines associated with the catalytic center

Ethylene and phloem signals are involved in the regulation of responses to Fe and P deficiencies in roots of strategy I plants

Iron (Fe) and phosphorus (P) are two essential mineral nutrients whose acquisition by plants presents important environmental and economic implications. Both elements are abundant in most soils but scarcely available to plants. To prevent Fe or P deficiency dicot plants initiate morphological and physiological responses in their roots aimed to specifically acquire these elements. The existence of common signals in Fe and P deficiency pathways suggests the signaling factors must act in conjunction with distinct nutrient-specific signals in order to confer tolerance to each deficiency. Previous works have shown the existence of cross talk between responses to Fe and P deficiency, but details of the associated signaling pathways remain unclear. Herein, the impact of foliar application of either P or Fe on P and Fe responses was studied in P- or Fe-deficient plants of Arabidopsis thaliana, including mutants exhibiting altered Fe or P homeostasis. Ferric reductase and acid phosphatase activities in roots were determined as well as the expression of genes related to P and Fe acquisition. The results obtained showed that Fe deficiency induces the expression of P acquisition genes and phosphatase activity, whereas P deficiency induces the expression of Fe acquisition genes and ferric reductase activity, although only transitorily. Importantly, these responses were reversed upon foliar application of either Fe or P on nutrient-starved plants. Taken together, the results reveal interactions between P- and Fe-related phloem signals originating in the shoots that likely interact with hormones in the roots to initiate adaptive mechanisms to tolerate deficiency of each nutrient

Different resource allocation strategies result from selection for litter size at weaning in rabbit does

This study examined the effect of long-term selection of a maternal rabbit line, solely for a reproductive criterion, on the ability of female rabbits to deal with constrained environmental conditions. Female rabbits from generations 16 and 36 (n = 72 and 79, respectively) of a line founded and selected to increase litter size at weaning were compared simultaneously. Female rabbits were subjected to normal (NC), nutritional (NF) or heat (HC) challenging conditions from 1st to 3rd parturition. Animals in NC and NF were housed at normal room temperatures (18°C to 25°C) and respectively fed with control (11.6 MJ digestible energy (DE)/kg dry matter (DM), 126 g digestible protein (DP)/kg DM, and 168 g of ADF/kg DM) or low-energy fibrous diets (9.1 MJ DE/kg DM, 104 g DP/kg DM and 266 g ADF/kg DM), whereas those housed in HC were subjected to high room temperatures (25°C to 35°C) and the control diet. The litter size was lower for female rabbits housed in both NF and HC environments, but the extent and timing where this reduction took place differed between generations. In challenging conditions (NF and HC), the average reduction in the reproductive performance of female rabbits from generation 16, compared with NC, was &#8722;2.26 (P<0.05) and &#8722;0.51 kits born alive at 2nd and 3rd parturition, respectively. However, under these challenging conditions, the reproductive performance of female rabbits from generation 36 was less affected at 2nd parturition (&#8722;1.25 kits born alive), but showed a greater reduction at the 3rd parturition (&#8722;3.53 kits born alive; P<0.05) compared with NC. The results also showed differences between generations in digestible energy intake, milk yield and accretion, and use of body reserves throughout lactation in NC, HC and NF, which together indicate that there were different resource allocation strategies in the animals from the different generations. Selection to increase litter size at weaning led to increased reproductive robustness at the onset of an environmental constraint, but failure to sustain the reproductive liability when the challenge was maintained in the long term. This response could be directly related to the shortterm environmental fluctuations (less severe) that frequently occur in the environment where this line has been selected.The authors thank Professor Enrique Blas Ferrer for his valuable comments on the initial version of this document, Juan Carlos Moreno for his help in conducting the trial at the experimental farm, and the Ministry of Economy and Competitiveness (Project: AGL2011-30170-C02-01) for economic support.Savietto, D.; Cervera Fras, MC.; Ródenas Martínez, L.; Martínez Paredes, EM.; Baselga Izquierdo, M.; García Diego, FJ.; Larsen, T.... (2014). Different resource allocation strategies result from selection for litter size at weaning in rabbit does. Animal. 8(4):618-628. https://doi.org/10.1017/S1751731113002437S61862884García-Diego, F.-J., Pascual, J. J., & Marco, F. (2011). Technical Note: Design of a large variable temperature chamber for heat stress studies in rabbits. 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Effect of lucerne-based diets on performance of reproductive rabbit does at two temperatures. Animal Science, 76(2), 283-295. doi:10.1017/s1357729800053534Fernández-Carmona, J., Cervera, C., Sabater, C., & Blas, E. (1995). Effect of diet composition on the production of rabbit breeding does housed in a traditional building and at 30°C. Animal Feed Science and Technology, 52(3-4), 289-297. doi:10.1016/0377-8401(94)00715-lHarano, Y., Ohtsuki, M., Ida, M., Kojima, H., Harada, M., Okanishi, T., … Shigeta, Y. (1985). Direct automated assay method for serum or urine levels of ketone bodies. Clinica Chimica Acta, 151(2), 177-183. doi:10.1016/0009-8981(85)90321-3Dauncey, M. J. (1990). Thyroid hormones and thermogenesis. Proceedings of the Nutrition Society, 49(2), 203-215. doi:10.1079/pns19900024Savietto, D., Blas, E., Cervera, C., Baselga, M., Friggens, N. C., Larsen, T., & Pascual, J. J. (2012). Digestive efficiency in rabbit does according to environment and genetic type. World Rabbit Science, 20(3). doi:10.4995/wrs.2012.1152Falconer, D. S. (1990). Selection in different environments: effects on environmental sensitivity (reaction norm) and on mean performance. Genetical Research, 56(1), 57-70. doi:10.1017/s0016672300028883Vicente, J., & García-Ximénez, F. (1993). Effects of strain and embryo transfer model (embryos from one versus two donor does/recipient) on results of cryopreservation in rabbit. Reproduction Nutrition Development, 33(1), 5-13. doi:10.1051/rnd:19930101Quiniou, N., Renaudeau, D., Dubois, S., & Noblet, J. (2000). Influence of high ambient temperatures on food intake and feeding behaviour of multiparous lactating sows. Animal Science, 70(3), 471-479. doi:10.1017/s1357729800051821Theilgaard, P., Sánchez, J. P., Pascual, J. J., Friggens, N. C., & Baselga, M. (2006). Effect of body fatness and selection for prolificacy on survival of rabbit does assessed using a cryopreserved control population. Livestock Science, 103(1-2), 65-73. doi:10.1016/j.livsci.2006.01.007Brecchia, G., Bonanno, A., Galeati, G., Federici, C., Maranesi, M., Gobbetti, A., … Boiti, C. (2006). Hormonal and metabolic adaptation to fasting: Effects on the hypothalamic–pituitary–ovarian axis and reproductive performance of rabbit does. Domestic Animal Endocrinology, 31(2), 105-122. doi:10.1016/j.domaniend.2005.09.006Piles, M., Garreau, H., Rafel, O., Larzul, C., Ramon, J., & Ducrocq, V. (2006). Survival analysis in two lines of rabbits selected for reproductive traits1. Journal of Animal Science, 84(7), 1658-1665. doi:10.2527/jas.2005-678Sanchez, J. P., Baselga, M., & Ducrocq, V. (2006). Genetic and environmental correlations between longevity and litter size in rabbits. Journal of Animal Breeding and Genetics, 123(3), 180-185. doi:10.1111/j.1439-0388.2006.00590.xQuevedo, F., Cervera, C., Blas, E., Baselga, M., & Pascual, J. J. (2006). Long-term effect of selection for litter size and feeding programme on the performance of reproductive rabbit does 2. Lactation and growing period. Animal Science, 82(5), 751-762. doi:10.1079/asc200688Vicente, J. S., & García-Ximénez, F. (1996). Direct transfer of vitrified rabbit embryos. Theriogenology, 45(4), 811-815. doi:10.1016/0093-691x(96)00010-6Coureaud, G., Fortun-Lamothe, L., Langlois, D., & Schaal, B. (2007). The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability. animal, 1(7), 1026-1032. doi:10.1017/s1751731107000389Rommers, J. M., Boiti, C., Brecchia, G., Meijerhof, R., Noordhuizen, J. P. T. M., Decuypere, E., & Kemp, B. (2004). Metabolic adaptation and hormonal regulation in young rabbit does during long-term caloric restriction and subsequent compensatory growth. Animal Science, 79(2), 255-264. doi:10.1017/s1357729800090111Piles, M., García, M. L., Rafel, O., Ramon, J., & Baselga, M. (2006). Genetics of litter size in three maternal lines of rabbits: Repeatability versus multiple-trait models. Journal of Animal Science, 84(9), 2309-2315. doi:10.2527/jas.2005-622Garcı́a, M. L., & Baselga, M. (2002). Estimation of genetic response to selection in litter size of rabbits using a cryopreserved control population. Livestock Production Science, 74(1), 45-53. doi:10.1016/s0301-6226(01)00280-9Cervera, C., & Carmona, J. F. (s. f.). Nutrition and the climatic environment. Nutrition of the rabbit, 267-284. doi:10.1079/9781845936693.0267Nicodemus, N., Redondo, R., Pérez-Alba, L., Carabaño, R., De Blas, J. C., & García, J. (2010). Effect of level of fibre and type of grinding on the performance of rabbit does and their litters during the first three lactations. Livestock Science, 129(1-3), 186-193. doi:10.1016/j.livsci.2010.01.023Theilgaard, P., Sánchez, J., Pascual, J., Berg, P., Friggens, N. C., & Baselga, M. (2007). Late reproductive senescence in a rabbit line hyper selected for reproductive longevity, and its association with body reserves. Genetics Selection Evolution, 39(2), 207. doi:10.1186/1297-9686-39-2-207Martínez-Paredes, E., Ródenas, L., Martínez-Vallespín, B., Cervera, C., Blas, E., Brecchia, G., … Pascual, J. J. (2012). Effects of feeding programme on the performance and energy balance of nulliparous rabbit does. animal, 6(7), 1086-1095. doi:10.1017/s1751731111002643Baselga M 2004. Genetic improvement of meat rabbits. Programmes and diffusion. In Proceedings of 8th World Rabbit Science Congress, 5–7 September 2004, Puebla, Mexico, pp. 1–13