527 research outputs found
Falando em amamentação
Anais do 35º Seminário de Extensão Universitária da Região Sul - Área temática: SaúdeOs benefícios do aleitamento materno exclusivo nos primeiros seis
meses de vida do bebê são muitos, porém, segundo o Ministério da Saúde as taxas
de aleitamento materno no Brasil, em especial as de amamentação exclusiva, estão
bastante aquém do recomendado. Uma das possíveis causas, além da falta de
conhecimento desses benefícios, é a falta de orientação adequada quando há
dúvidas e dificuldades em amamentar. Assim, o projeto de extensão “Falando em
Amamentação”, desenvolvido pela UFCSPA, além de trazer informações sobre a
importância do aleitamento materno, busca também orientar gestantes e puérperas
da rede pública de Porto Alegre quanto aos cuidados com a mama, durante e após a
gestação, à pega correta, posições para a amamentação e a higienização oral do
bebê. O projeto acontece semanalmente com grupos de gestantes, a partir da
orientação dialogada em grupo, elucidação de dúvidas e material ilustrativo, e
individualmente com puérperas no alojamento conjunto de uma maternidade de
Porto Alegre. Até o momento, no ano de 2017, foram orientadas cerca de 110
gestantes e 165 puérperas. Observamos dúvidas principalmente em relação à
eficiência do leite materno exclusivo, aos cuidados com a mama durante a
amamentação e a pega e posição correta para a amamentaçã
Análise da prevalência e fatores associados à incontinência urinária entre idosos do Município de São Paulo, Brasil: Estudo SABE (Saúde, Bem-Estar e Envelhecimento)
To investigate the prevalence of urinary incontinence among elderly people living in São Paulo, Brazil and their associated risk factors. The Pan-American Health Organization and World Health Organization coordinated a multicenter study named Health, Wellbeing and Aging (SABE Study) in elderly people (over 60 years old) living in seven countries in Latin America and the Caribbean. In Brazil, the study was carried out in São Paulo in the year 2000. The total Brazilian sample included 2,143 people. The prevalence of self reported urinary incontinence was 11.8% among men and 26.2% for women. It was verified that among those reporting urinary incontinence, 37% also reported stroke and 34% depression. It was found that the greater the dependence that the elderly people presented, the greater the prevalence of urinary incontinence. The associated factors found were depression (odds ratio = 2.49), female (2.42), advanced age (2.35), important functional limitation (2.01). Urinary incontinence is a highly prevalent symptom among the elderly population of the municipality of São Paulo, especially among women. The adoption of preventive measures can reduce the negative effects of urinary incontinence.Investigar a prevalência de incontinência urinária entre idosos de São Paulo, Brasil, e fatores associados e de risco. A Organização Pan-Americana da Saúde e a Organização Mundial da Saúde coordenaram estudo multicêntrico denominado Saúde, Bem-Estar e Envelhecimento (Estudo SABE) em pessoas idosas (60 anos ou mais) que vivem em sete países da América Latina e Caribe. No Brasil, o estudo populacional foi realizado no Município de São Paulo no ano 2000. A amostra total brasileira foi de 2.143 pessoas. A prevalência da incontinência urinária auto-referida foi de 11,8% entre homens e 26,2% entre mulheres. Verificou-se que entre aqueles que relataram incontinência urinária, 37% também relataram acidente vascular cerebral e 34%, depressão. Observou-se que quanto maior a dependência do idoso, maior era a prevalência de incontinência urinária. Os fatores associados encontrados foram depressão (OR = 2,49), sexo feminino (2,42), idade avançada (2,35), limitação funcional (2,01). Incontinência urinária é um sintoma altamente prevalente entre a população idosa do Município de São Paulo, especialmente entre as mulheres. A adoção de medidas preventivas pode reduzir os efeitos negativos da incontinência urinária
Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism
Altered phase-relationship between peripheral oscillators and environmental time in Cry1 or Cry2 deficient mouse models for early and late chronotypes
The mammalian circadian system is composed of a light-entrainable central clock in the suprachiasmatic nuclei (SCN) of the brain and peripheral clocks in virtually any other tissue. It allows the organism to optimally adjust metabolic, physiological and behavioral functions to the physiological needs it will have at specific time of the day. According to the resonance theory, such rhythms are only advantageous to an organism when in tune with the environment, which is illustrated by the adverse health effects originating from chronic circadian disruption by jetlag and shift work. Using short-period Cry1 and long-period Cry2 deficient mice as models for morningness and eveningness, respectively, we explored the effect of chronotype on the phase relationship between the central SCN clock and peripheral clocks in other organs. Whereas the behavioral activity patterns and circadian gene expression in the SCN of light-entrained Cry1-/- and Cry2-/- mice largely overlapped with that of wild type mice, expression of clock and clock controlled genes in liver, kidney, small intestine, and skin was shown to be markedly phase-advanced or phase-delayed, respectively. Likewise, circadian rhythms in urinary corticosterone were shown to display a significantly altered phase relationship similar to that of gene expression in peripheral tissues. We show that the daily dissonance between peripheral clocks and the environment did not affect the lifespan of Cry1-/- or Cry2-/- mice. Nonetheless, the phase-shifted peripheral clocks in light-entrained mice with morningness and eveningness-like phenotypes may have implications for personalized preventive and therapeutic (i.e. chronomodulation-based) health care for people with early and late chron
Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock
The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms. Interestingly, the animal circadian clock proteins CRYPTOCHROME (CRY), PERIOD (PER) and TIMELESS (TIM) are strongly conserved at the amino acid level through evolution. Within this evolutionary frame, TIM represents a fascinating puzzle. While Drosophila contains two paralogs, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively, mammals contain only one TIM homolog. Whereas TIM has been shown to regulate replication termination and cell cycle progression, its functional link to the circadian clock is under debate. Here we show that RNAi-mediated knockdown of TIM in NIH3T3 and U2OS cells shortens the period by 1 hour and diminishes DNA damage-dependent phase advancing. Furthermore, we reveal that the N-terminus of TIM is sufficient for interaction with CRY1 and CHK1 as well for homodimerization, and the C-terminus is necessary for nuclear localization. Interestingly
The Jang equation reduction of the spacetime positive energy theorem in dimensions less than eight
We extend the Jang equation proof of the positive energy theorem due to R.
Schoen and S.-T. Yau from dimension to dimensions . This
requires us to address several technical difficulties that are not present when
. The regularity and decay assumptions for the initial data sets to which
our argument applies are weaker than those of R. Schoen and S.-T. Yau. In
recent joint work with L.-H. Huang, D. Lee, and R. Schoen we have given a
different proof of the full positive mass theorem in dimensions .
We pointed out that this theorem can alternatively be derived from our density
argument and the positive energy theorem of the present paper.Comment: All comments welcome! Final version to appear in Comm. Math. Phy
miRNAs in serum exosomes for differential diagnosis of brain metastases
Circulating miRNAs are increasingly studied and proposed as tumor markers with the aim of investigating their role in monitoring the response to therapy as well as the natural evolution of primary or secondary brain tumors. This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR-124-3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs. A total of 105 patients with BMs from primary lung or breast cancer, or melanoma underwent neurosurgery or radiosurgery treatment, and 91 patients with HGGs were enrolled, along with 30 healthy controls. A significant increase in miR-21 expression in serum exosomes was observed in both HGGs and BMs compared with healthy controls; on the other hand, miR-124-3p was significantly decreased in BMs, and it was increased in HGGs. After the surgical or radiosurgical treatment of patients with BMs, a significant reduction in miR-21 was noted with both types of treatments. This study identified a signature of exosomal miRNAs that could be useful as a noninvasive complementary analysis both in the differential diagnosis of BMs from glial tumors and in providing information on tumor evolution over time
Dimerization and nuclear entry of mPER proteins in mammalian cells
Nuclear entry of circadian oscillatory gene products is a key step for the
generation of a 24-hr cycle of the biological clock. We have examined
nuclear import of clock proteins of the mammalian period gene family and
the effect of serum shock, which induces a synchronous clock in cultured
cells. Previously, mCRY1 and mCRY2 have been found to complex with PER
proteins leading to nuclear import. Here we report that nuclear
translocation of mPER1 and mPER2 (1) involves physical interactions with
mPER3, (2) is accelerated by serum treatment, and (3) still occurs in
mCry1/mCry2 double-deficient cells lacking a functional biological clock.
Moreover, nuclear localization of endogenous mPER1 was observed in
cultured mCry1/mCry2 double-deficient cells as well as in the liver and
the suprachiasmatic nuclei (SCN) of mCry1/mCry2 double-mutant mice. This
indicates that nuclear translocation of at least mPER1 also can occur
under physiological conditions (i.e., in the intact mouse) in the absence
of any CRY protein. The mPER3 amino acid sequence predicts the presence of
a cytoplasmic localization domain (CLD) and a nuclear localization signal
(NLS). Deletion analysis suggests that the interplay of the CLD and NLS
proposed to regulate nuclear entry of PER in Drosophila is conserved in
mammals, but with the novel twist that mPER3 can act as the dimerizing
partner
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