263 research outputs found
Dexmedetomidine Clearance Decreases with Increasing Drug Exposure:Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics
Background: Numerous pharmacokinetic models have been published aiming at more accurate and safer dosing of dexmedetomidine. The vast majority of the developed models underpredict the measured plasma concentrations with respect to the target concentration, especially at plasma concentrations higher than those used in the original studies. The aim of this article was to develop a dexmedetomidine pharmacokinetic model in healthy adults emphasizing linear versus nonlinear kinetics. Methods: The data of two previously published clinical trials with stepwise increasing dexmedetomidine target-controlled infusion were pooled to build a pharmacokinetic model using the NONMEM software package (ICON Development Solutions, USA). Data from 48 healthy subjects, included in a stratified manner, were utilized to build the model. Results: A three-compartment mamillary model with nonlinear elimination from the central compartment was superior to a model assuming linear pharmacokinetics. Covariates included in the final model were age, sex, and total body weight. Cardiac output did not explain between-subject or within-subject variability in dexmedetomidine clearance. The results of a simulation study based on the final model showed that at concentrations up to 2 ng center dot ml(-1), the predicted dexmedetomidine plasma concentrations were similar between the currently available Hannivoort model assuming linear pharmacokinetics and the nonlinear model developed in this study. At higher simulated plasma concentrations, exposure increased nonlinearly with target concentration due to the decreasing dexmedetomidine clearance with increasing plasma concentrations. Simulations also show that currently approved dosing regimens in the intensive care unit may potentially lead to higher-than-expected dexmedetomidine plasma concentrations. Conclusions: This study developed a nonlinear three-compartment pharmacokinetic model that accurately described dexmedetomidine plasma concentrations. Dexmedetomidine may be safely administered up to target-controlled infusion targets under 2 ng center dot ml(-1) using the Hannivoort model, which assumed linear pharmacokinetics. Consideration should be taken during long-term administration and during an initial loading dose when following the dosing strategies of the current guidelines
Observation of the Dependence of Scintillation from Nuclear Recoils in Liquid Argon on Drift Field
We have exposed a dual-phase Liquid Argon Time Projection Chamber (LAr-TPC)
to a low energy pulsed narrowband neutron beam, produced at the Notre Dame
Institute for Structure and Nuclear Astrophysics to study the scintillation
light yield of recoiling nuclei in a LAr-TPC. A liquid scintillation counter
was arranged to detect and identify neutrons scattered in the LAr-TPC target
and to select the energy of the recoiling nuclei.
We report the observation of a significant dependence on drift field of
liquid argon scintillation from nuclear recoils of 11 keV. This observation is
important because, to date, estimates of the sensitivity of noble liquid TPC
dark matter searches are based on the assumption that electric field has only a
small effect on the light yield from nuclear recoils.Comment: v3 updated to reflect published version, including a set of plots for
49.9 keV dat
A Study of the Residual 39Ar Content in Argon from Underground Sources
The discovery of argon from underground sources with significantly less 39Ar
than atmospheric argon was an important step in the development of
direct-detection dark matter experiments using argon as the active target. We
report on the design and operation of a low background detector with a single
phase liquid argon target that was built to study the 39Ar content of the
underground argon. Underground argon from the Kinder Morgan CO2 plant in
Cortez, Colorado was determined to have less than 0.65% of the 39Ar activity in
atmospheric argon.Comment: 21 pages, 10 figure
Snowmass CF1 Summary: WIMP Dark Matter Direct Detection
As part of the Snowmass process, the Cosmic Frontier WIMP Direct Detection
subgroup (CF1) has drawn on input from the Cosmic Frontier and the broader
Particle Physics community to produce this document. The charge to CF1 was (a)
to summarize the current status and projected sensitivity of WIMP direct
detection experiments worldwide, (b) motivate WIMP dark matter searches over a
broad parameter space by examining a spectrum of WIMP models, (c) establish a
community consensus on the type of experimental program required to explore
that parameter space, and (d) identify the common infrastructure required to
practically meet those goals.Comment: Snowmass CF1 Final Summary Report: 47 pages and 28 figures with a 5
page appendix on instrumentation R&
Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors
We report on the first measurement of 39Ar in argon from underground natural
gas reservoirs. The gas stored in the US National Helium Reserve was found to
contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be
<=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon
(39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National
Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most
important backgrounds in argon detectors for WIMP dark matter searches. The
findings reported demonstrate the possibility of constructing large multi-ton
argon detectors with low radioactivity suitable for WIMP dark matter searches.Comment: 6 pages, 2 figures, 2 table
Measurement of the solar 8B neutrino rate with a liquid scintillator target and 3 MeV energy threshold in the Borexino detector
We report the measurement of electron neutrino elastic scattering from 8B
solar neutrinos with 3 MeV energy threshold by the Borexino detector in Gran
Sasso (Italy). The rate of solar neutrino-induced electron scattering events
above this energy in Borexino is 0.217 +- 0.038 (stat) +- 0.008 (syst) cpd/100
t, which corresponds to the equivalent unoscillated flux of (2.4 +- 0.4 (stat)
+- 0.1 (syst))x10^6 cm^-2 s^-1, in good agreement with measurements from SNO
and SuperKamiokaNDE. Assuming the 8B neutrino flux predicted by the high
metallicity Standard Solar Model, the average 8B neutrino survival probability
above 3 MeV is measured to be 0.29+-0.10. The survival probabilities for 7Be
and 8B neutrinos as measured by Borexino differ by 1.9 sigma. These results are
consistent with the prediction of the MSW-LMA solution of a transition in the
solar electron neutrino survival probability between the low energy
vacuum-driven and the high-energy matter-enhanced solar neutrino oscillation
regimes.Comment: 10 pages, 8 figures, 6 table
Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun
The Sun is fueled by a series of nuclear reactions that produce the energy
that makes it shine. The primary reaction is the fusion of two protons into a
deuteron, a positron and a neutrino. These neutrinos constitute the vast
majority of neutrinos reaching Earth, providing us with key information about
what goes on at the core of our star. Several experiments have now confirmed
the observation of neutrino oscillations by detecting neutrinos from secondary
nuclear processes in the Sun; this is the first direct spectral measurement of
the neutrinos from the keystone proton-proton fusion. This observation is a
crucial step towards the completion of the spectroscopy of pp-chain neutrinos,
as well as further validation of the LMA-MSW model of neutrino oscillations.Comment: Proceedings from NOW (Neutrino Oscillation Workshop) 201
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