Camellia sinensis (Theaceae) en la Argentina : naturalización y usos locales

Sobre la base de ejemplares recolectados en las provincias de Misiones y Corrientes (Argentina) se cita por primera vez al té como una especie naturalizada en el país. La especie es descripta e ilustrada y además se dan a conocer sus usos locales.Camellia sinensis (Theaceae) in Argentina: Naturalization and local uses. By means of herbarium specimens collected in Misiones and Corrientes provinces (Argentina), the tea is mentioned for the first time as a naturalized plant in our country. The species is described and illustrated. Local uses of this species are also mentioned.Fil: Keller, Hector Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); ArgentinaFil: Delucchi, Gustavo. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Romero, Héctor F.. Universidad Nacional de Misiones. Facultad de Ciencias Forestales; Argentin

Noncooperative and Cooperative Transmission Schemes with Precoding and Beamforming

The next generation mobile networks are expected to provide multimedia applications with a high quality of service. On the other hand, interference among multiple base stations (BS) that co-exist in the same location limits the capacity of wireless networks. In conventional wireless networks, the base stations do not cooperate with each other. The BSs transmit individually to their respective mobile stations (MS) and treat the transmission from other BSs as interference. An alternative to this structure is a network cooperation structure. Here, BSs cooperate with other BSs to simultaneously transmit to their respective MSs using the same frequency band at a given time slot. By doing this, we significantly increase the capacity of the networks. This thesis presents novel research results on a noncooperative transmission scheme and a cooperative transmission scheme for multi-user multiple-input-multiple-output orthogonal frequency division multiplexing (MIMO-OFDM). We first consider the performance limit of a noncooperative transmission scheme. Here, we propose a method to reduce the interference and increase the throughput of orthogonal frequency division multiplexing (OFDM) systems in co-working wireless local area networks (WLANs) by using joint adaptive multiple antennas(AMA) and adaptive modulation (AM) with acknowledgement (ACK) Eigen-steering. The calculation of AMA and AM are performed at the receiver. The AMA is used to suppress interference and to maximize the signal-to-interference-plus-noise ratio (SINR). The AM scheme is used to allocate OFDM sub-carriers, power, and modulation mode subject to the constraints of power, discrete modulation, and the bit error rate (BER). The transmit weights, the allocation of power, and the allocation of sub-carriers are obtained at the transmitter using ACK Eigen-steering. The derivations of AMA, AM, and ACK Eigen-steering are shown. The performance of joint AMA and AM for various AMA configurations is evaluated through the simulations of BER and spectral efficiency (SE) against SIR. To improve the performance of the system further, we propose a practical cooperative transmission scheme to mitigate against the interference in co-working WLANs. Here, we consider a network coordination among BSs. We employ Tomlinson Harashima precoding (THP), joint transmit-receive beamforming based on SINR (signal-to-interference-plus-noise-ratio) maximization, and an adaptive precoding order to eliminate co-working interference and achieve bit error rate (BER) fairness among different users. We also consider the design of the system when partial channel state information (CSI) (where each user only knows its own CSI) and full CSI (where each user knows CSI of all users) are available at the receiver respectively. We prove analytically and by simulation that the performance of our proposed scheme will not be degraded under partial CSI. The simulation results show that the proposed scheme considerably outperforms both the existing noncooperative and cooperative transmission schemes. A method to design a spectrally efficient cooperative downlink transmission scheme employing precoding and beamforming is also proposed. The algorithm eliminates the interference and achieves symbol error rate (SER) fairness among different users. To eliminate the interference, Tomlinson Harashima precoding (THP) is used to cancel part of the interference while the transmit-receive antenna weights cancel the remaining one. A new novel iterative method is applied to generate the transmit-receive antenna weights. To achieve SER fairness among different users and further improve the performance of MIMO systems, we develop algorithms that provide equal SINR across all users and order the users so that the minimum SINR for each user is maximized. The simulation results show that the proposed scheme considerably outperforms existing cooperative transmission schemes in terms of the SER performance and complexity and approaches an interference free performance under the same configuration. We could improve the performance of the proposed interference cancellation further. This is because the proposed interference cancellation does not consider receiver noise when calculating the transmit-receive weight antennas. In addition, the proposed scheme mentioned above is designed specifically for a single-stream multi-user transmission. Here, we employ THP precoding and an iterative method based on the uplink-downlink duality principle to generate the transmit-receive antenna weights. The algorithm provides an equal SINR across all users. A simpler method is then proposed by trading off the complexity with a slight performance degradation. The proposed methods are extended to also work when the receiver does not have complete Channel State Informations (CSIs). A new method of setting the user precoding order, which has a much lower complexity than the VBLAST type ordering scheme but with almost the same performance, is also proposed. The simulation results show that the proposed schemes considerably outperform existing cooperative transmission schemes in terms of SER performance and approach an interference free performance. In all the cooperative transmission schemes proposed above, we use THP to cancel part of the interference. In this thesis, we also consider an alternative approach that bypasses the use of THP. The task of cancelling the interference from other users now lies solely within the transmit-receive antenna weights. We consider multiuser Gaussian broadcast channels with multiple antennas at both transmitter and receivers. An iterative multiple beamforming (IMB) algorithm is proposed, which is flexible in the antenna configuration and performs well in low to moderate data rates. Its capacity and bit error rate performance are compared with the ones achieved by the traditional zero-forcing method

Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials

BACKGROUND: Heterogeneity in Acute Respiratory Distress Syndrome (ARDS), as a consequence of its non-specific definition, has led to a multitude of negative randomised controlled trials (RCTs). Investigators have sought to identify heterogeneity of treatment effect (HTE) in RCTs using clustering algorithms. We evaluated the proficiency of several commonly-used machine-learning algorithms to identify clusters where HTE may be detected. METHODS: Five unsupervised: Latent class analysis (LCA), K-means, partition around medoids, hierarchical, and spectral clustering; and four supervised algorithms: model-based recursive partitioning, Causal Forest (CF), and X-learner with Random Forest (XL-RF) and Bayesian Additive Regression Trees were individually applied to three prior ARDS RCTs. Clinical data and research protein biomarkers were used as partitioning variables, with the latter excluded for secondary analyses. For a clustering schema, HTE was evaluated based on the interaction term of treatment group and cluster with day-90 mortality as the dependent variable. FINDINGS: No single algorithm identified clusters with significant HTE in all three trials. LCA, XL-RF, and CF identified HTE most frequently (2/3 RCTs). Important partitioning variables in the unsupervised approaches were consistent across algorithms and RCTs. In supervised models, important partitioning variables varied between algorithms and across RCTs. In algorithms where clusters demonstrated HTE in the same trial, patients frequently interchanged clusters from treatment-benefit to treatment-harm clusters across algorithms. LCA aside, results from all other algorithms were subject to significant alteration in cluster composition and HTE with random seed change. Removing research biomarkers as partitioning variables greatly reduced the chances of detecting HTE across all algorithms. INTERPRETATION: Machine-learning algorithms were inconsistent in their abilities to identify clusters with significant HTE. Protein biomarkers were essential in identifying clusters with HTE. Investigations using machine-learning approaches to identify clusters to seek HTE require cautious interpretation. FUNDING: NIGMS R35 GM142992 (PS), NHLBI R35 HL140026 (CSC); NIGMS R01 GM123193, Department of Defense W81XWH-21-1-0009, NIA R21 AG068720, NIDA R01 DA051464 (MMC)

Evaluation of Externality Costs in Life-Cycle Optimization of Municipal Solid Waste Management Systems

The development of sustainable solid waste management (SWM) systems requires consideration of both economic and environmental impacts. Societal life-cycle costing (S-LCC) provides a quantitative framework to estimate both economic and environmental impacts, by including “budget costs” and “externality costs”. Budget costs include market goods and services (economic impact), whereas externality costs include effects outside the economic system (e.g., environmental impact). This study demonstrates the applicability of S-LCC to SWM life-cycle optimization through a case study based on an average suburban U.S. county of 500 000 people generating 320 000 Mg of waste annually. Estimated externality costs are based on emissions of CO₂, CH₄, N₂O, PM_2.5, PM₁₀, NO_<i>x</i>, SO₂, VOC, CO, NH₃, Hg, Pb, Cd, Cr (VI), Ni, As, and dioxins. The results indicate that incorporating S-LCC into optimized SWM strategy development encourages the use of a mixed waste material recovery facility with residues going to incineration, and separated organics to anaerobic digestion. Results are sensitive to waste composition, energy mix and recycling rates. Most of the externality costs stem from SO₂, NO_<i>x</i>, PM_2.5, CH₄, fossil CO₂, and NH₃ emissions. S-LCC proved to be a valuable tool for policy analysis, but additional data on key externality costs such as organic compounds emissions to water would improve future analyses

Growth, blood metabolites and hormones in calves fed diets with different amounts of energy and protein during the pre- or post-weaning periods

We investigated the effects of diets differing in energy and protein concentrations given during pre- and post-weaning on hormone and metabolite levels in association to parameters of growth. Sixteen Aberdeen Angus calves four-day-old were allocated in individual pens during 105 days in a randomized complete design. Animals consumed ad libitum various diets differing in proportion of energy and protein (A: 80% of concentrate, 20% alfalfa hay; B: 60% concentrate, 40% of alfalfa hay; C: 40% concentrate, 60% alfalfa hay, and D: 20% concentrate, 80% alfalfa hay). Also, calves consumed milk substitute up to 60-day-old day. Serum growth hormone and cortisol levels were not altered with diet changes (P > 0.05) neither during the pre- nor the post-weaning periods. Plasma insulin concentration average daily intake, glucose and thyroid hormone levels, and concentrations of ammonia nitrogen and propionic acid were greater (P < 0.01) for diets having higher than lower energy and protein levels during the post-weaning but not during the pre-weaning period. These results suggest inclusion of higher amounts of concentrate in the diet of weaned calves.Fil: Fernández, H. T.. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Busso, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; ArgentinaFil: Laborde, Hugo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; ArgentinaFil: Torrea, M. B.. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Fernández, L. M.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: López, G. H.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Delucchi, F.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: García, B. N.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentin

Sentient Spaces: Intelligent Totem Use Case in the ECSEL FRACTAL Project

The objective of the FRACTAL project is to create a novel approach to reliable edge computing. The FRACTAL computing node will be the building block of scalable Internet of Things (from Low Computing to High Computing Edge Nodes). The node will also have the capability of learning how to improve its performance against the uncertainty of the environment. In such a context, this paper presents in detail one of the key use cases: an Internet-of-Things solution, represented by intelligent totems for advertisement and wayfinding services, within advanced ICT-based shopping malls conceived as a sentient space. The paper outlines the reference scenario and provides an overview of the architecture and the functionality of the demonstrator, as well as a roadmap for its development and evaluation

Replication-induced DNA secondary structures drive fork uncoupling and breakage

Sequences that form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play various physiological roles. However, they can also interfere with replication and threaten genome stability. Multiple lines of evidence suggest G4s inhibit replication, but the underlying mechanism remains unclear. Moreover, evidence of how iMs affect the replisome is lacking. Here, we reconstitute replication of physiologically derived structure-forming sequences to find that a single G4 or iM arrest DNA replication. Direct single-molecule structure detection within solid-state nanopores reveals structures form as a consequence of replication. Combined genetic and biophysical characterisation establishes that structure stability and probability of structure formation are key determinants of replisome arrest. Mechanistically, replication arrest is caused by impaired synthesis, resulting in helicase-polymerase uncoupling. Significantly, iMs also induce breakage of nascent DNA. Finally, stalled forks are only rescued by a specialised helicase, Pif1, but not Rrm3, Sgs1, Chl1 or Hrq1. Altogether, we provide a mechanism for quadruplex structure formation and resolution during replication and highlight G4s and iMs as endogenous sources of replication stress

The risk stratification of adverse neonatal outcomes in women with gestational diabetes (STRONG) study

Aims: To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. Methods: Observational, retrospective, multicenter study involving consecutive women with GDM. To identify distinct and homogeneous subgroups of women at a higher risk, the RECursive Partitioning and AMalgamation (RECPAM) method was used. Overall, 2736 pregnancies complicated by GDM were analyzed. The main outcome measure was the occurrence of adverse neonatal outcomes in pregnancies complicated by GDM. Results: Among study participants (median age 36.8 years, pre-gestational BMI 24.8 kg/m2), six miscarriages, one neonatal death, but no maternal death was recorded. The occurrence of the cumulative adverse outcome (OR 2.48, 95% CI 1.59–3.87), large for gestational age (OR 3.99, 95% CI 2.40–6.63), fetal malformation (OR 2.66, 95% CI 1.00–7.18), and respiratory distress (OR 4.33, 95% CI 1.33–14.12) was associated with previous macrosomia. Large for gestational age was also associated with obesity (OR 1.46, 95% CI 1.00–2.15). Small for gestational age was associated with first trimester glucose levels (OR 1.96, 95% CI 1.04–3.69). Neonatal hypoglycemia was associated with overweight (OR 1.52, 95% CI 1.02–2.27) and obesity (OR 1.62, 95% CI 1.04–2.51). The RECPAM analysis identified high-risk subgroups mainly characterized by high pre-pregnancy BMI (OR 1.68, 95% CI 1.21–2.33 for obese; OR 1.38 95% CI 1.03–1.87 for overweight). Conclusions: A deep investigation on the factors associated with adverse neonatal outcomes requires a risk stratification. In particular, great attention must be paid to the prevention and treatment of obesity