3,720 research outputs found
PIH3 ANÁLISE DO IMPACTO ORÇAMENTARIO DO CATETER COM BALÃO DE SILICONE PARA ABLAÇÃO TERMICA ENDOMETRIAL (THERMACHOICE®) VERSUS HISTERECTOMIA NO TRATAMENTO DE PACIENTES COM MENORRAGIA DE ETIOLOGIA BENIGNA PÓS-FALHA AO TRATAMENTO FARMACOLÓGICO, NA PERSPECTIVA DO PAGADOR PRIVADO, NO BRASIL
Distinguishing mild cognitive impairment from healthy aging and Alzheimer's disease: the contribution of the INECO Frontal Screening (IFS)
Executive functions are affected differently in healthy aging, Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), and evaluating them is important for differential diagnosis. The INECO Frontal Screening (IFS) is a brief neuropsychological screening tool, developed to assess executive dysfunction in neurodegenerative disorders.GoalsWe aimed to examine whether and how MCI patients can be differentiated from cognitively healthy controls (HC) and mild to moderate AD patients based on IFS performance. We also explored how IFS scores are associated with age, years of education, and depressive/anxious symptoms (as assessed by the Hospital Anxiety and Depression Scale).MethodIFS total scores were compared between 26 HC, 32 MCI and 21 mild to moderate AD patients. The three groups were matched for age and education. The Area Under the Curve (AUC) was analyzed and optimal cut-offs were determined.ResultsHealthy participants had higher IFS scores than both clinical groups, and MCI patients had higher scores than AD patients. IFS showed high diagnostic accuracy for the detection of MCI (AUC = .89, p < .001) and AD (AUC = .99, p < .001), and for the differentiation between the clinical groups (AUC = .76, p < .001). We provide optimal cut-offs for the identification of MCI and AD and for their differentiation. We also found that, in general, higher education predicted higher IFS scores (no associations with age and depressive/anxious symptoms were observed). Altogether, these findings indicate that evaluating executive functions with the IFS can be valuable for the identification of MCI, a high-risk group for dementia, and for differentiating this condition from healthy aging and AD
Benefícios dos Ativadores Seletivos dos Recetores de Vitamina D em Doentes Transplantados Renais
Severe chronic kidney disease may lead to disturbances, such as hyperphosphatemia, increased secretion
of fibroblast growth factor -23 (FGF -23) and vitamin D deficiency. These may increase plasmatic levels of
parathyroid hormone, and decrease plasmatic levels of calcium. Altogether, these may contribute to the
development of secondary hyperparathyroidism, and to abnormalities in mineral metabolism. Kidney transplantation is the best option to improve longevity and quality of life in end -stage chronic kidney disease
patients. Vitamin D deficiency has been associated with cardiovascular disease, which is the leading cause
of death in chronic kidney disease. Therefore, diagnosing this deficiency may be pivotal for minimizing
mortality in chronic kidney disease, because pharmacological treatments for this deficiency may be prescribed.
Calcitriol is indicated for the treatment of vitamin D deficiency, both in chronic kidney disease and
in kidney transplanted patients. However, calcitriol may increase the plasmatic levels of calcium and phosphorous, which can lead to vascular calcifications, that have been associated with cardiovascular mortality.
Selective vitamin D receptor activators are indicated for the treatment of vitamin D deficiency in chronic
kidney disease. These have the advantage of being associated with lower increases of plasmatic levels of
calcium and phosphorous. These drugs also seem to have additional effects that may minimise patient
morbidity and mortality, especially due to potentially reducing cardiovascular events. Unfortunately, there
are few studies about the use of these drugs in kidney transplanted patients. Here we present a review about the physiology of vitamin D, the consequences of its deficiency in chronic kidney disease and in
kidney transplanted patients, and about the diagnosis and treatment of this deficiency. Finally, we discuss
the new line of research about the efficacy and safety of selective vitamin D receptor activators in kidney
transplanted patients
Degradation of all-inkjet-printed organic thin-film transistors with TIPS-pentacene under processes applied in textile manufacturing
Printed electronics represent an alternative solution for the manufacturing of low-temperature and large
area flexible electronics. The use of inkjet printing is showing major advantages when compared to other
established printing technologies such as, gravure, screen or offset printing, allowing the reduction of
manufacturing costs due to its efficient material usage and the direct-writing approach without
requirement of any masks. However, several technological restrictions for printed electronics can hinder
its application potential, e.g. the device stability under atmospheric or even more stringent conditions.
Here, we study the influence of specific mechanical, chemical, and temperature treatments usually
appearing in manufacturing processes for textiles on the electrical performance of all-inkjet-printed organic thin-film transistors (OTFTs). Therefore, OTFTs where manufactured with silver electrodes,
a UV curable dielectric, and 6,13-bis(triisopropylsilylethynyl) pentance (TIPS-pentacene) as the active
semiconductor layer. All the layers were deposited using inkjet printing. After electrical characterization
of the printed OTFTs, a simple encapsulation method was applied followed by the degradation study
allowing a comparison of the electrical performance of treated and not treated OTFTs. Industrial
calendering, dyeing, washing and stentering were selected as typical textile processes and treatment
methods for the printed OTFTs. It is shown that the all-inkjet-printed OTFTs fabricated in this work are
functional after their submission to the textiles processes but with degradation in the electrical
performance, exhibiting higher degradation in the OTFTs with shorter channel lengths (L=10 μm).This work was supported by FEDER through the COMPETE Program and by the Portuguese
Foundation for Science and Technology (FCT) in the framework of the Strategic Project PEST
C/FIS/UI607/2014 and the project PTDC/CTM-NAN/121038/2010. Enrico Sowade was financially
supported by the European Commission within the Framework FP7-ICT (grant agreement number
287682, project acronym TDK4PE). The authors also thank for the support by the project Matepro –
Optimizing Materials and Processes”, ref. NORTE-07-0124-FEDER-000037”, co-funded by the
“Programa Operacional Regional do Norte” (ON.2 – O Novo Norte), under the “Quadro de Referência
Estratégico Nacional” (QREN), through the “Fundo Europeu de Desenvolvimento Regional” (FEDER).
Hélder Castro thanks for the support of the FCT under the grant SFRH/BDE/33350/2008
Perfil fermentativo das silagens de seis genótipos de sorgo (Sorghum bicolor (L.) Moench): digestibilidade IN VITRO da matéria seca (DIVMS).
Simulation Mechanism with 2 Degrees of Freedom
This article discusses the historical analysis of the development of simulators applied to aviation. From the development with the application of the first necessity, at the beginning of the 20th century, to the nowadays technology. Today the technology is used in several fields, justifying the increasing business investment destined to the sector, such as training, recycling, development and entertainment. Its advantage, compared to the real model, is the lower cost and greater security. Some simulator mechanisms were studied in order to select one that meets practical USAge demands, and, in the end, a mechanism design is presented, aiming at the future construction and study of the different systems of a simulator in practice
The Association between Socioeconomic Characteristics and Consumption of Food Items among Brazilian Industry Workers
Background. Dietary pattern plays a causative role in the rising of noncommunicable diseases. The SESI (Serviço Social da Indústria) study was designed to evaluate risk factors for noncommunicable diseases. We aimed to describe food items consumed by Brazilian workers and to assess their association with socioeconomic status. Methods. Cross-sectional study was carried out among Brazilian industrial workers, selected by multistage sampling, from 157 companies. Interviews were conducted at the work place using standardized forms. Results. 4818 workers were interviewed, aged 35.4 ± 10.7 years, 76.5% were men. The workers had an average of 8.7 ± 4.1 years of schooling and 25.4 ± 4.1 kg/m2 of BMI. Men and individuals with less than high school education were less likely to consume dairy products, fruits, and vegetables daily, even after control for confounding factors. Men consumed rice and beans daily more often than women. In comparison to workers aged 50–76 years, those under 30 years old consumed less fruits and green leafy vegetables daily. Conclusion. The food items consumed by Brazilian workers show that there are insufficient consumption according to the guidelines of healthy foods, particularly of dairy products, vegetables, and fruits
Shedding light into the Chimaeridae taxonomy: the complete mitochondrial genome of the cartilaginous fish Hydrolagus mirabilis (Collett, 1904) (Holocephali: Chimaeridae)
Cartilaginous fish are fascinating taxa, present in the folklore and art of many different cultures. Moreover, they display several unique anatomical, physiological, molecular, and behavioral characteristics making them extremely interesting from a biological perspective. Nevertheless, some crucial knowledge gaps remain, including phylogenetic relationships among extant species. Here, we produced the complete mitogenome sequence of the large-eyed rabbitfish, Hydrolagus mirabilis (Chimaeriformes). The complete mitogenome is 19,435 bp long and shows the same overall content, i.e. 13 protein-coding genes, 22 transfer RNA, and two ribosomal RNA genes, as all other examined Chondrichthyan mitogenomes. Phylogenetic reconstructions including 12 Holocephalan and three outgroup Elasmobranch mitogenomes place the H. mirabilis within the family Chimaeridae but revealed paraphyletic Hydrolagus and Chimaera, in line with a previous study, highlighting the importance for collecting additional molecular data to improve phylogenetic reconstruction in this group of vertebrates.Versión del edito
Anomalous Roughening in Experiments of Interfaces in Hele-Shaw Flows with Strong Quenched Disorder
We report experimental evidences of anomalous kinetic roughening in the
stable displacement of an oil-air interface in a Hele-Shaw cell with strong
quenched disorder. The disorder consists on a random modulation of the gap
spacing transverse to the growth direction (tracks). We have performed
experiments varying average interface velocity and gap spacing, and measured
the scaling exponents. We have obtained beta=0.50, beta*=0.25, alpha=1.0,
alpha_l=0.5, and z=2. When there is no fluid injection, the interface is driven
solely by capillary forces, and a higher value of beta around beta=0.65 is
measured. The presence of multiscaling and the particular morphology of the
interfaces, characterized by high slopes that follow a L\'evy distribution,
confirms the existence of anomalous scaling. From a detailed study of the
motion of the oil--air interface we show that the anomaly is a consequence of
different local velocities over tracks plus the coupling in the motion between
neighboring tracks. The anomaly disappears at high interface velocities, weak
capillary forces, or when the disorder is not sufficiently persistent in the
growth direction. We have also observed the absence of scaling when the
disorder is very strong or when a regular modulation of the gap spacing is
introduced.Comment: 14 pages, 17 figure
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