Search for an infrared counterpart of IGR J16358-4756

We report here on near infrared observations of the field around IGR J16358-4756. The source belongs to the new class of highly absorbed X-ray binaries discovered by IBIS/INTEGRAL. Our primary goal was to identify the infrared counterpart of the source, previously suggested to be a LMXB and then further reclassified as a HMXB. We have made use of Chandra observations of the source in order to better constrain the number of possible counterparts. Using the differential photometry technique, in observations spanning a timescale of 1 month, we found no long term variability in our observations. This is compatible, and we suggest here, that the source is a HMXB.Comment: 5 pages, 2 figures, all styles included; to be published in: "The Transient Milky Way: a perspective for MIRAX", eds. F. D'Amico, J. Braga, and R. E. Rothschild, AIP Conference Proceeding

Accretion-powered Millisecond Pulsar Outbursts

The population of accretion-powered millisecond pulsars has grown rapidly over the last four years, with the discovery of six new examples to bring the total sample to seven. While the first six discovered are transients active for a few weeks every two or more years, the most recently-discovered source HETE J1900.1-2455, has been active for more than 8 months. We summarise the transient behaviour of the population to estimate long-term time-averaged fluxes, and equate these fluxes to the expected mass transfer rate driven by gravitational radiation in order to constrain the distances. We also estimate an upper limit of 6 kpc to the distance of IGR J00291+5934 based on the non-detection of bursts from this source.Comment: 5 pages, 2 figures, to be published in: "The Transient Milky Way: a perspective for MIRAX", eds. F. D'Amico, J. Braga & R. Rothschild, AIP Conf. Pro

What can we learn from long term monitoring of X-ray bursters?

The last few years have seen the discovery of a number of new aspects of Type I X-ray bursts: the extremely energetic and long duration superbursts, intermediate duration bursts at low luminosities, mHz QPOs, and burst oscillations. These discoveries promise a new understanding of nuclear burning on accreting neutron stars, and offer a chance to use observations to probe neutron star properties. I discuss what we can learn from future long term monitoring with MIRAX.Comment: 5 pages, 2 figures, to be published in: "The Transient Milky Way: a perspective for MIRAX", eds. F. D'Amico, J. Braga & R. Rothschild, AIP Conf. Pro

One for All—A Highly Efficient and Versatile Method for Fluorescent Immunostaining in Fish Embryos

Background: For the detection and sub-cellular (co)-localization of proteins in the context of the tissue or organism immunostaining in whole mount preparations or on sections is still the best approach. So far, each antibody required its own fixation and antigen retrieval protocol so that optimizing immunostaining turned out to be tedious and time consuming. Methodology/Principal Finding: Here we present a novel method to efficiently retrieve the antigen in a widely applicable standard protocol, facilitating fluorescent immunostaining of both cryosections and whole mount preparations in zebrafish (Danio rerio) and medaka (Oryzias latipes). Conclusions/Significance: Our method overcomes the loss of sections and damage of tissue and cell morphology, and allows parallel immunostaining in multiple colors, co-immunostaining with fluorescent proteins in transgenic fish lines and in combination with whole mount in situ hybridization

Présence de chimiorécepteurs sur l'aile des tsé-tsé (Diptera : Glossinidae)

Cette note signale pour la première fois l'existence de chimiorécepteurs sur les ailes des mouches tsé-tsé. Ceux-ci sont principalement localisés sur le milieu de la nervure costale. Leur morphologie est comparable à celle des chimiorécepteurs observés sur les pattes. Leur nombre ne différe pas entre les sexes comme pour les pattes, mais entre les espèces. Ceci suggère un rôle dans la perception chimique proche de l'environnement, par rapport aux chimiorécepteurs des pattes qui semblent impliqués dans le comportement sexuel. L'étude a été conduite sur six espèces ou sous-espèces de glossines. (Résumé d'auteur

Osteosarcoma microenvironment: whole-slide imaging and optimized antigen detection overcome major limitations in immunohistochemical quantification.

BACKGROUND: In osteosarcoma survival rates could not be improved over the last 30 years. Novel biomarkers are warranted to allow risk stratification of patients for more individual treatment following initial diagnosis. Although previous studies of the tumor microenvironment have identified promising candidates, novel biomarkers have not been translated into routine histopathology. Substantial difficulties regarding immunohistochemical detection and quantification of antigens in decalcified and heterogeneous osteosarcoma might largely explain this translational short-coming. Furthermore, we hypothesized that conventional hot spot analysis is often not representative for the whole section when applied to heterogeneous tissues like osteosarcoma. We aimed to overcome these difficulties for major biomarkers of the immunovascular microenvironment. METHODS: Immunohistochemistry was systematically optimized for cell surface (CD31, CD8) and intracellular antigens (FOXP3) including evaluation of 200 different antigen retrieval conditions. Distribution patterns of these antigens were analyzed in formalin-fixed and paraffin-embedded samples from 120 high-grade central osteosarcoma biopsies and computer-assisted whole-slide analysis was compared with conventional quantification methods including hot spot analysis. RESULTS: More than 96% of osteosarcoma samples were positive for all antigens after optimization of immunohistochemistry. In contrast, standard immunohistochemistry retrieved false negative results in 35-65% of decalcified osteosarcoma specimens. Standard hot spot analysis was applicable for homogeneous distributed FOXP3+ and CD8+ cells. However, heterogeneous distribution of vascular CD31 did not allow reliable quantification with hot spot analysis in 85% of all samples. Computer-assisted whole-slide analysis of total CD31- immunoreactive area proved as the most appropriate quantification method. CONCLUSION: Standard staining and quantification procedures are not applicable in decalcified formalin-fixed and paraffin-embedded samples for major parameters of the immunovascular microenvironment in osteosarcoma. Whole-slide imaging and optimized antigen retrieval overcome these limitations

Importance of Spin-Orbit Interaction for the Electron Spin Relaxation in Organic Semiconductors

Despite the great interest organic spintronics has recently attracted, there is only a partial understanding of the fundamental physics behind electron spin relaxation in organic semiconductors. Mechanisms based on hyperfine interaction have been demonstrated, but the role of the spin-orbit interaction remains elusive. Here, we report muon spin spectroscopy and time-resolved photoluminescence measurements on two series of molecular semiconductors in which the strength of the spin-orbit interaction has been systematically modified with a targeted chemical substitution of different atoms at a particular molecular site. We find that the spin-orbit interaction is a significant source of electron spin relaxation in these materials

Modelling and Measuring the Irrational behaviour of Agents in Financial Markets: Discovering the Psychological Soliton

Following a Geometrical Brownian Motion extension into an Irrational Fractional Brownian Motion model, we re-examine agent behaviour reacting to time dependent news on the log-returns thereby modifying a financial market evolution. We specifically discuss the role of financial news or economic information positive or negative feedback of such irrational (or contrarian) agents upon the price evolution. We observe a kink-like effect reminiscent of soliton behaviour, suggesting how analysts' forecasts errors induce stock prices to adjust accordingly, thereby proposing a measure of the irrational force in a market.Comment: 14 pages, 5 figures, 33 references; prepared for a special issue of Chaos, Solitons & Fractal

Managing Tsetse Transmitted Trypanosomosis by Insecticide Treated Nets - an Affordable and Sustainable Method for Resource Poor Pig Farmers in Ghana

An outbreak of tsetse-transmitted trypanosomiasis resulted in more than 50% losses of domestic pigs in the Eastern Region of Ghana (source: Veterinary Services, Accra; April 2007). In a control trial from May 4th–October 10th 2007, the efficacy of insecticide-treated mosquito fences to control tsetse was assessed. Two villages were selected – one serving as control with 14 pigsties and one experimental village where 24 pigsties were protected with insecticide treated mosquito fences. The 100 cm high, 150denier polyester fences with 100 mg/m2 deltamethrin and a UV protector were attached to surrounding timber poles and planks. Bi-monthly monitoring of tsetse densities with 10 geo-referenced bi-conical traps per village showed a reduction of more than 90% in the protected village within two months. Further reductions exceeding 95% were recorded during subsequent months. The tsetse population in the control village was not affected, only displaying seasonal variations. Fifty pigs from each village were ear-tagged and given a single curative treatment with diminazene aceturate (3.5 mg/kg bw) after their blood samples had been taken. The initial trypanosome prevalence amounted to 76% and 72% of protected and control animals, respectively, and decreased to 16% in protected as opposed to 84% in control pigs three months after intervention. After six months 8% of the protected pigs were infected contrasting with 60% in the control group