Red-shifted and pH-responsive imidazole-based Azo Dyes with potent antimicrobial activity

A novel route is described to obtain 2 aminoimidazole azo dyes with unique substituents pattern in the heteroaryl unit that provides halochromic properties, exhibiting vibrant colours that change from magenta to deep blue. Potent antimicrobial properties against infectious yeasts were demonstrated. No cytotoxicity was detected for concentrations lower than 16 μg·mL-1This work wasfunded by European Regional Development Fund and the National Foundation for Science and Technology of Portugal (FCT) under the projects UIDB/00686/2020, UIDP/00264/2020, UIDB/04423/2020, UIDP/04378/2020, UIDB/04378/2020, LA/P/0140/2020, MEDCOR PTDC/CTM-TEX/ 1213/2020, SFRH/BD/137668/2018, and PINFRA/22161/2016

Let there be light...

“Let there be light...” is a project in the scope of the International Year of Light 2015 (IYL 2015) targeted at children of the first school grade. Basically, it comprises nine recreational - scientific workshops that last for approximately 90 minutes. Each workshop is dedicated to a different topic, namely: bioluminescence, mineral observation, the rainbow, light-shadow contrast, battery production, just to name a few, and is designed, in differ- ent approaches, by a distinct team of scientists familiar to the scientific area focused. The activity starts with the dramatized storytelling of a children’s story related to the scientific subject and performed by the team of the public library expert in this area. This moment takes place in an almost magical environment opening the door to the science topic light-related that would be focused later on. In the third part of the workshop, the children are invited to produce plastic works (e.g. drawings, constructions and models) inspired in what they have learned, and that are to be collected in a public exhibition held at the same institution at the end of the project. In the present work, besides the description of the experience, you can find the critical analysis of the activity and the evaluation of the action by all the actors involved (project team and children/teachers that attended the workshops).info:eu-repo/semantics/publishedVersio

Programa de seguimento protocolado de doentes com insuficiência cardíaca : impacto no prognóstico e na qualidade de vida

© 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license.Introduction: Heart failure is associated with high rates of readmission and mortality, and there is a need for measures to improve outcomes. This study aims to assess the impact of the implementation of a protocol-based follow-up program for heart failure patients on readmission and mortality rates and quality of life. Methods: A quasi-experimental study was performed, with a prospective registry of 50 consecutive patients discharged after hospitalization for acute heart failure. The study group was followed by a cardiologist at days 7-10 and the first, third, sixth and 12th month after discharge, with predefined procedures. The control group consisted of patients hospitalized for heart failure prior to implementation of the program and followed on a routine basis. Results: No significant differences were observed between the two groups regarding mean age (67.1±11.2 vs. 65.8±13.4 years, p=0.5), NYHA functional class (p=0.37), or median left ventricular ejection fraction (27% [19.8-35.3] vs. 29% [23.5-40]; p=0.23) at discharge. Mean follow-up after discharge was similar (11±5.3 vs. 10.9±5.5 months, p=0.81). The protocol-based follow-up program was associated with a significant reduction in allcause readmission (26% vs. 60%, p=0.003), heart failure readmission (16% vs. 36%, p=0.032), and mortality (4% vs. 20%, p=0.044). In the study group there was a significant improvement in all quality of life measures (p<0.001). Conclusion: A protocol-based follow-up program for patients with heart failure led to a signif-icant reduction in readmission and mortality rates, and was associated with better quality of life.info:eu-repo/semantics/publishedVersio

Non‐invasive telemonitoring improves outcomes in heart failure with reduced ejection fraction : a study in high‐risk patients

© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Aims: Non-invasive telemonitoring (TM) in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF) may be useful in the early diagnosis of HF decompensation, allowing therapeutic optimization and avoiding re-hospitalization. We describe a TM programme in this population and evaluate its effectiveness during a 12 month period. Methods and results: We conducted a single-centre study of patients discharged from hospital after decompensated HF, allocated into three groups: prospective TM programme, prospective HF protocol follow-up programme (PFP) with no TM facilities, and retrospective propensity-matched usual care (UC). TM effectiveness was assessed by all-cause hospitalizations and mortality; HF-related hospitalization (HFH), days lost to unplanned hospital admissions/death, functional capacity and quality of life (New York Heart Association, Kansas City Cardiomyopathy Questionnaire, 6 min walk test, and plasma N-terminal pro-brain natriuretic peptide) were also evaluated. A total of 125 patients were included [65.9 ± 11.9 years, 32% female, left ventricular ejection fraction 27% (21-32)]. TM was similar to PFP regarding effectiveness; TM reduced all-cause hospitalization and mortality (HR 0.27; 95% CI 0.11-0.71; P < 0.01) and HFH (HR 0.29; 95% CI 0.10-0.89; P < 0.05) as compared with UC. TM reduced the average number of days lost due to unplanned hospital admissions or all-cause death as compared with PFP (5.6 vs. 12.4 days, P < 0.05) and UC (5.6 vs. 48.8 days, P < 0.01). Impact on quality of life was similar between TM and PFP (P = 0.36). Conclusions: In patients with HFrEF and recent HF hospitalization, non-invasive TM reduced 12 month all-cause hospitalization/mortality and HFH as compared with usual care. TM also reduced the number of days lost due to unplanned hospital admission/death as compared with either an optimized protocol-based follow-up programme or usual care.This work was supported by National Health System programme with specific budget attributed to non-invasive TM of HF patients. TM was performed in cooperation with Linde Healthcare®, which had no role in the data interpretation or writing of the report. The corresponding author had full access to all the data in the study and had the final responsibility for the decision to submit for publication.info:eu-repo/semantics/publishedVersio

Portuguese propolis: a source of valuable bioactivities

To FEDER/COMPETE/POCI– Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER-006958 and FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013

A novel case of human visceral leishmaniasis from the urban area of the city of Rio de Janeiro: autochthonous or imported from Spain ?

Submitted by Janaína Nascimento ([email protected]) on 2019-02-07T11:55:47Z No. of bitstreams: 1 ve_Silva_Guilherme_etal_INI_2017.pdf: 476774 bytes, checksum: 117ce9df08684188394f5ff125a0909f (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-02-08T10:52:32Z (GMT) No. of bitstreams: 1 ve_Silva_Guilherme_etal_INI_2017.pdf: 476774 bytes, checksum: 117ce9df08684188394f5ff125a0909f (MD5)Made available in DSpace on 2019-02-08T10:52:32Z (GMT). No. of bitstreams: 1 ve_Silva_Guilherme_etal_INI_2017.pdf: 476774 bytes, checksum: 117ce9df08684188394f5ff125a0909f (MD5) Previous issue date: 2017Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Hospital Universitário Gaffrée e Guinle. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil

Innovative Educational Approach in Healthcare-Associated Infection Prevention and Control. Results of a European Study

Prevent and control healthcare-associated infections (HAIs) is a priority in healthcare assistance, not only due to present COVID-19 pandemic. Annually, around 3.2 million patients are affected by one of these infections and it is estimated that without controlling them, by 2050, 10 million more people could die every year, with especial relevance among elderly with infectious situations representing a third of mortality in people over 65 years old. Higher Education Institutions (HEI) in healthcare area have an important role in this panorama, by preparing students to be future professionals, stimulating them to have an innovative and entrepreneurial approach to today’s real-life challenges. A mixed-methods research was conducted, at European level (in Portugal, Finland, Poland and Spain), to facilitate learning of good practices on HAIs prevention and control while developing innovative solutions. 1475 participants were enrolled, from all partner HEI: 79 professors and mentors were interviewed (individual or focus group), 1326 final year nursing students made a self-report inventory (application of InovSafeCare Scale) and 70 students participated on focus group (agile piloting of the Model). The result of this research is a pedagogical model that mixes dimensions and methods that take nursing students closer to the demands of HAIs prevention and control and capacitates them to transfer knowledge to work settings with an innovative and entrepreneurial perspective – the InovSafeCare Model.info:eu-repo/semantics/publishedVersio

Erratum of Enteropathic arthritis in Brazil: data from the Brazilian registry of spondyloarthritis

Universidade Federal de Minas GeraisInstituto Insper de Educação e PesquisaUniversidade de São Paulo Disciplina de ReumatologiaUniversidade de BrasíliaHospital Geral de GoiâniaUniversidade de CampinasUniversidade Federal do AmazonasPontifícia Universidade CatólicaFaculdade de Medicina de São José do Rio PretoHospital Evangélico de CuritibaUniversidade Federal do Rio de JaneiroUniversidade Federal do ParanáHospital Geral de FortalezaUniversidade Estadual do Rio de JaneiroSanta Casa do Rio de JaneiroSanta Casa de São PauloHospital de BaseUniversidade Federal do Mato Grosso do SulUniversidade Federal de PernambucoUniversidade Federal do Rio Grande do SulFaculdade de Medicina Souza MarquesHospital do Servidor Público EstadualUniversidade de São Paulo Instituto de Ortopedia e TraumatologiaUniversidade Federal de Santa CatarinaUniversidade Federal de São Paulo (UNIFESP)Santa Casa de Belo HorizonteUniversidade Federal do CearáEscola de Medicina e Saúde PúblicaUniversidade Federal do ParáUniversidade Federal do Espírito SantoUNIFESPSciEL

Enteropathic arthritis in Brazil: data from the brazilian registry of spondyloarthritis

Inflammatory bowel diseases (Crohn's disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis. METHODS: Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied. Laboratory and radiographic examinations were performed. The aim of this study is to compare the clinical, epidemiological, genetic, imaging, treatment and prognosis characteristics of patients with enteropathic arthritis with other types of spondyloarthritis in a large Brazilian cohort. RESULTS: A total of 3.2% of patients were classified as having enteroarthritis, 2.5% had spondylitis and 0.7%, arthritis (peripheral predominance). The subgroup of individuals with enteroarthritis had a higher prevalence in women (P < 0.001), lower incidence of inflammatory axial pain (P < 0.001) and enthesitis (P = 0.004). HLA-B27 was less frequent in the group with enteroarthritis (P = 0.001), even when considering only those with the pure axial form. There was a lower prevalence of radiographic sacroiliitis (P = 0.009) and lower radiographic score (BASRI) (P = 0.006) when compared to patients with other types of spondyloarthritis. They also used more corticosteroids (P < 0.001) and sulfasalazine (P < 0.001) and less non-steroidal anti-inflammatory drugs (P < 0.001) and methotrexate (P = 0.001). CONCLUSION: There were differences between patients with enteroarthritis and other types of spondyloarthritis, especially higher prevalence of females, lower frequency of HLA-B27, associated with less severe axial involvement.As doenças inflamatórias intestinais (doença de Crohn e retocolite ulcerativa) apresentam manifestações extraintestinais em um quarto dos pacientes, sendo a mais comum a artrite enteropática. MÉTODOS: Estudo prospectivo, observacional e multicêntrico, realizado com pacientes de 29 centros de referência participantes do Registro Brasileiro de Espondiloartrites (RBE), que se incorpora ao grupo RESPONDIA (Registro Ibero-americano de Espondiloartrites). Dados demográficos e clínicos de 1472 pacientes foram colhidos, e aplicaram-se questionários padronizados de avaliação de mobilidade axial, de qualidade de vida, de envolvimento entesítico, de atividade de doença e de capacidade funcional. Exames laboratoriais e radiográficos foram realizados. Objetivamos, neste presente artigo, comparar as características clínicas, epidemiológicas, genéticas, imagenológicas, de tratamento e prognóstico de enteroartríticos com os outros espondiloartríticos nesta grande coorte brasileira. RESULTADOS: Foram classificados como enteroartrite 3,2% dos pacientes, sendo que 2,5% tinham espondilite e 0,7%, artrite (predomínio periférico). O subgrupo de indivíduos com enteroartrite apresentava maior prevalência de mulheres (P < 0,001), menor incidência de dor axial inflamatória (P < 0,001) e de entesite (P = 0,004). O HLA-B27 foi menos frequente no grupo de enteroartríticos (P = 0,001), mesmo se considerado apenas aqueles com a forma axial pura. Houve menor prevalência de sacroiliíte radiológica (P = 0,009) e também menor escore radiográfico (BASRI) (P = 0,006) quando comparado aos pacientes com as demais espondiloartrites. Também fizeram mais uso de corticosteroides (P < 0,001) e sulfassalasina (P < 0,001) e menor uso de anti-inflamatórios não hormonais (P < 0,001) e metotrexato (P = 0,001). CONCLUSÃO: Foram encontradas diferenças entre as enteroartrites e as demais espondiloartrites, principalmente maior prevalência do sexo feminino, menor frequência do HLA-B27, associados a uma menor gravidade do acometimento axial.Universidade Federal de Minas GeraisInstituto Insper de Educação e PesquisaUniversidade de São PauloUniversidade de BrasíliaHospital Geral de GoiâniaUniversidade de CampinasUniversidade Federal do AmazonasPontifícia Universidade CatólicaFaculdade de Medicina de São José do Rio PretoHospital Evangélico de CuritibaUniversidade Federal do Rio de JaneiroUniversidade Federal do ParanáHospital Geral de FortalezaUniversidade Estadual do Rio de JaneiroSanta Casa do Rio de JaneiroSanta Casa de São PauloHospital de BaseUniversidade Federal do Mato Grosso do SulUniversidade Federal de PernambucoUniversidade Federal do Rio Grande do SulFaculdade de Medicina Souza MarquesHospital do Servidor Público EstadualUniversidade de São Paulo Instituto de Ortopedia e TraumatologiaUniversidade Federal de Santa CatarinaUniversidade Federal de São Paulo (UNIFESP)Santa Casa de Belo HorizonteUniversidade Federal do CearáEscola de Medicina e Saúde PúblicaUniversidade Federal do ParáUniversidade Federal do Espírito SantoUNIFESPSciEL

Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort

Objective To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) and compare them with a group of adult-onset (≥ 16 years) SpA patients. Patients and methods Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE – Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset<16 years (JOSpA group) and age at onset ≥ 16 years (AOSpA group). Results Among the 1,424 patients, 235 presented disease onset before 16 years (16.5%). The clinical and epidemiologic variables associated with JOSpA were male gender (p<0.001), lower limb arthritis (p=0.001), enthesitis (p=0.008), anterior uveitis (p=0.041) and positive HLA-B27 (p=0.017), associated with lower scores of disease activity (Bath Ankylosing Spondylitis Disease Activity Index – BASDAI; p=0.007) and functionality (Bath Ankylosing Spondylitis Functional Index – BASFI; p=0.036). Cutaneous psoriasis (p<0.001), inflammatory bowel disease (p=0.023), dactylitis (p=0.024) and nail involvement (p=0.004) were more frequent in patients with adult-onset SpA. Conclusions Patients with JOSpA in this large Brazilian cohort were characterized predominantly by male gender, peripheral involvement (arthritis and enthesitis), positive HLA-B27 and lower disease scores.Objetivo Analisar as características clínicas e epidemiológicas das espondiloartrites (EpA) de início juvenil (< 16 anos) e compará-las com um grupo de pacientes com EspA de início na vida adulta (≥ 16 anos). Pacientes e métodos Coorte prospectiva, observacional e multicêntrica com 1.424 pacientes com diagnóstico de EspA de acordo com o European Spondyloarthropathy Study Group (ESSG) submetidos a um protocolo comum de investigação e recrutados em 29 centros de referência participantes do Registro Brasileiro de Espondiloartrites (RBE). Os pacientes foram divididos em dois grupos: idade no início<16 anos (grupo EspAiJ) e idade no início ≥ 16 anos. Resultados Entre os 1.424 pacientes, 235 manifestaram o início da doença antes dos 16 anos (16,5%). As variáveis clínicas e epidemiológicas associadas com a EspAiJ foram: gênero masculino (p<0,001), artrite em membro inferior (p=0,001), entesite (p=0,008), uveíte anterior (p=0,041) e HLA-B27 positivo (p=0,017), em associação com escores mais baixos de atividade da doença (Bath Ankylosing Spondylitis Disease Activity Index – BASDAI; p=0,007) e de capacidade funcional (Bath Ankylosing Spondylitis Functional Index – BASFI; p=0,036). A psoríase cutânea (p<0,001), a doença inflamatória intestinal (p=0,023), a dactilite (p=0,024) e o envolvimento ungueal (p=0,004) foram mais frequentes em pacientes com EspA de início na vida adulta. Conclusões Nessa grande coorte brasileira, os pacientes com EspAiJ se caracterizavam predominantemente pelo gênero masculino, envolvimento periférico (artrite e entesite), HLA-B27 positivo e escores de doença mais baixos.Universidade Federal de PernambucoInsper Instituto de Educação e PesquisaUniversidade de São Paulo Faculdade de Medicina Divisão de ReumatologiaUniversidade de BrasíliaHospital Geral de GoiâniaUniversidade de CampinasUniversidade Federal do AmazonasPontifícia Universidade CatólicaHospital Evangélico de CuritibaUniversidade Federal do Rio de JaneiroUniversidade Estadual do Rio de JaneiroFaculdade de Medicina de São José do Rio PretoUniversidade Federal do ParanáHospital Geral de FortalezaSanta Casa do Rio de JaneiroSanta Casa de São PauloHospital de Base do Distrito FederalUniversidade Federal do Mato Grosso do SulUniversidade Federal do Rio Grande do SulFaculdade de Medicina Souza MarquesHospital do Servidor Público EstadualUniversidade de São Paulo Instituto de Ortopedia e TraumatologiaUniversidade Federal de Santa CatarinaUniversidade Federal de São Paulo (UNIFESP)Santa Casa de Belo HorizonteUniversidade Federal de Minas GeraisUniversidade Federal do CearáEscola de Medicina e Saúde PúblicaUniversidade Federal do ParáUniversidade Federal do Espírito SantoUNIFESPSciEL