The Hybrid Legal Geographies of a War Crimes Court

This paper explores the implications of understanding war crime trials as hybrid legal spaces. Drawing on twelve months of residential fieldwork in the Court of Bosnia and Herzegovina, Sarajevo, it examines the circulation of evidence, the choreography of the court room and the nature and possibilities for legal observation. Analyzing hybrid legal geographies foregrounds the material and embodied nature of trials, illuminating the forms of comportment, categorization and exclusion through which law establishes its legitimacy. Rather than emphasizing separation and distance, the lens of hybridity illuminates the multiple ways in which war crimes trials are grounded in the social and political context of present day Bosnia and Herzegovina. Consequently this analysis traces the disjuncture between the imagined geographies of legal jurisdiction and the material and embodied spaces of trial practices. In conclusion we argue that the establishment of the Court of Bosnia and Herzegovina illustrates the tensions that emerge when an institution of trial justice is used to strengthen the coherence of a post-conflict state.This paper is based on research funded by the Economic and Social Research Council (RES-061-25-0479).This is the accepted manuscript. The final version is available from http://www.tandfonline.com/doi/abs/10.1080/00045608.2014.892365

The blind men and the AML elephant:can we feel the progress?

The pharmacological therapy of non-promyelocytic acute myeloid leukemia (AML) has remained unchanged for over 40 years with an anthracycline–cytarabine combination forming the backbone of induction treatments. Nevertheless, the survival of younger patients has increased due to improved management of the toxicity of therapies including stem cell transplantation. Older patients and those with infirmity that precludes treatment-intensification have, however, not benefited from improvements in supportive care and continue to experience poor outcomes. An increased understanding of the genomic heterogeneity of AML raises the possibility of treatment-stratification to improve prognosis. Thus, efforts to identify agents with non-conventional anti-leukemic effects have paralleled those aiming to optimize leukemia cell-kill with conventional chemotherapy, resulting in a number of randomized controlled trials (RCT). In the last 18 months, RCTs investigating the effects of vosaroxin, azacitidine and gemtuzumab ozogamycin and daunorubicin dose have been reported with some studies indicating a statistically significant survival benefit with the investigational agent compared with standard therapy and potentially, a new era in AML therapeutics. Given the increasing costs of cancer care, a review of these studies, with particular attention to the magnitude of clinical benefit with the newer agents would be useful, especially for physicians treating patients in single-payer health systems

A Roma European crisis road-map: a holistic answer to a complex problem

This contribution explores the adequacy of EU action with regard to the Roma. The expulsion of large numbers of Roma individuals, accompanied by other discriminatory practices and forms of hostility, exclusion and violence against the Roma across Europe, has brought the attention of the media and policy makers to Roma issues to a greater extent than ever before during the last decade. The range of problems still afflicting the lives of many Roma individuals nowadays is extremely wide, well researched and profusely documented. This contribution leaves aside issues related to free movement and EU citizenship, thus moving the debate beyond the narrow framework of the ‘migrant Roma’. This contribution considers the wide range of relevant EU competences in this field, and assesses how comprehensive and appropriate the EU’s approach to Roma issues is. The analysis combines legal instruments, policy papers, and case law, draws from legal and non-legal literature, and integrates considerations of a social, economic and cultural nature. In the process, this contribution considers themes that cut across several strands of the EU’s Roma policy, including fundamental rights, intercultural sensitivity, the limits of the ‘integration model’, and issues of enforcement, monitoring and funding. The logical narrative developed puts together the key jigsaw pieces that currently contribute to an EU Roma policy, and clearly identifies the limitations of the present state of affairs. Finally, this contribution interrogates the trends underlying the development of the EU Roma policy and puts forward a range of recommendations

Recommendations from the European Working Group for Value Assessment and Funding Processes in Rare Diseases (ORPH-VAL)

International audienceAbstractRare diseases are an important public health issue with high unmet need. The introduction of the EU Regulation on orphan medicinal products (OMP) has been successful in stimulating investment in the research and development of OMPs. Despite this advancement, patients do not have universal access to these new medicines. There are many factors that affect OMP uptake, but one of the most important is the difficulty of making pricing and reimbursement (P&R) decisions in rare diseases. Until now, there has been little consensus on the most appropriate assessment criteria, perspective or appraisal process. This paper proposes nine principles to help improve the consistency of OMP P&R assessment in Europe and ensure that value assessment, pricing and funding processes reflect the specificities of rare diseases and contribute to both the sustainability of healthcare systems and the sustainability of innovation in this field. These recommendations are the output of the European Working Group for Value Assessment and Funding Processes in Rare Diseases (ORPH-VAL), a collaboration between rare disease experts, patient representatives, academics, health technology assessment (HTA) practitioners, politicians and industry representatives. ORPH-VAL reached its recommendations through careful consideration of existing OMP P&R literature and through a wide consultation with expert stakeholders, including payers, regulators and patients. The principles cover four areas: OMP decision criteria, OMP decision process, OMP sustainable funding systems and European co-ordination. This paper also presents a guide to the core elements of value relevant to OMPs that should be consistently considered in all OMP appraisals. The principles outlined in this paper may be helpful in drawing together an emerging consensus on this topic and identifying areas where consistency in payer approach could be achievable and beneficial. All stakeholders have an obligation to work together to ensure that the promise of OMP’s is realised

Military business and the business of the military

Contrary to dominant approaches that locate the causes for military entrepreneurialism in eastern Democratic Republic of the Congo predominantly in criminal military elites, this article highlights the importance of the Congolese military’s (FARDC) civilian context for understanding military revenue-generation. It analyses how the latter is shaped by structures of domination, signification and legitimisation that drive and are driven by the FARDC’s governance, private protection and security practices. It argues that these practices contribute to bestowing a degree of legitimacy on both the FARDC’s position of power and some of its revenue-generation activities. Furthermore, by emphasising that the FARDC’s regulatory and protection practices are partly the product of popular demands and the routine actions of civilians, the article contends that the causes of military revenue-generation are co-located in the military’s civilian environment. In this manner, it offers a more nuanced conceptualisation of military entrepreneurialism, thus opening up new perspectives on policy interventions in this area

Primary recovery factor as a function of production rate: implications for conventional reservoirs with different drive mechanisms

This study evaluates the dependency of production rate on the recovery of hydrocarbon from conventional reservoirs using MBAL simulator. The results indicated that the recoveries are sensitive to the production rate in almost all hydrocarbon reservoirs. It was also found that the recovery of volumetric gas drive reservoirs is not impacted by the production rate. In fact, any increase in the production rate improves gas recovery in weak and strong water drive reservoirs. Moreover, increasing the production rate in oil reservoirs decreases the recovery with a significant effect observed in the weak water drive reservoirs. The results of this study demonstrate the need for implementing an effective reservoir management in order to obtain a maximum recovery

Tratamiento con agonistas dopaminérgicos en la enfermedad de Parkinson: consenso de expertos españoles sobre su uso en diferentes situaciones clínicas

Background: Different types of therapies were proven effective for the medical management of motor and non-motor symptoms in Parkinson's disease (PD). We aimed to gain consensus on the dopamine agonist (DA) therapy use in different clinical scenarios of Parkinson's disease (PD) patients. Methods: This consensus study was based on the nominal group technique. Initially, a consensus group comprising 12 expert neurologists in the PD field identified the topics to be addressed and elaborated different evidence-based preliminary statements. Next, a panel of 48 Spanish neurologists expressed their opinion on an internet-based systematic voting program. Finally, initial ideas were reviewed and rewritten according to panel contribution and were ranked by the consensus group using a Likert-type scale. The analysis of data was carried out by using a combination of both qualitative and quantitative methods. The consensus was achieved if the statement reached ≥ 3.5 points in the voting process. Results: The consensus group produced 76 real-world recommendations. The topics addressed included 12 statements related to DA therapy in early PD, 20 statements concerning DA treatment strategy in patients with motor complications, 11 statements associated with DA drugs and their side effects, and 33 statements regarding DA therapy in specific clinical scenarios. The consensus group did not reach a consensus on 15 statements. Conclusion: The findings from this consensus method represent an exploratory step to help clinicians and patients in the appropriate use of DA in different stages and clinical situations of PD.Antecedentes: Se demostró la efectividad de diferentes tipos de terapias para el tratamiento médico de los síntomas motores y no motores en la enfermedad de Parkinson (EP). Nos propusimos lograr un consenso sobre el uso de la terapia con agonistas dopaminérgicos (DA) en diferentes escenarios clínicos de pacientes con enfermedad de Parkinson (EP). Métodos: Este estudio de consenso se basó en la técnica de grupo nominal. Inicialmente, un Grupo de Consenso formado por 12 neurólogos expertos en el campo de la EP identificó los temas a tratar y elaboró diferentes declaraciones preliminares basadas en la evidencia. A continuación, un panel de 48 neurólogos españoles ? expresó su opinión en un programa de votación sistemática a través de Internet. Finalmente, las ideas iniciales fueron revisadas y reescritas de acuerdo con la contribución del panel y fueron clasificadas por el grupo de Consenso utilizando una escala tipo Likert. El análisis de los datos se llevó a cabo mediante una combinación de métodos cualitativos y cuantitativos. El consenso se alcanzaba si la afirmación alcanzaba ≥3,5 puntos en el proceso de votación. Resultados: El Grupo de Consenso elaboró 76 recomendaciones para el mundo real. Los temas abordados incluyeron 12 afirmaciones relacionadas con la terapia con DA en la EP temprana, 20 afirmaciones relativas a la estrategia de tratamiento con DA en pacientes con complicaciones motoras, 11 afirmaciones asociadas con los fármacos DA y sus efectos secundarios, y 33 afirmaciones relativas a la terapia con DA en escenarios clínicos específicos. El Grupo de Consenso no llegó a un consenso en 15 afirmaciones. Conclusiones: Los resultados de este método de consenso representan un paso exploratorio para ayudar a clínicos y pacientes en el uso apropiado de la DA en diferentes estadios y situaciones clínicas de la EP.Funding: This study was funded by the Chair of Epilepsy and Movement Disorders UFV-UCB. Acknowledgement: We thank the neurologists who participated in phase 1 for their disinterested collaboration. We thank the Epilepsy and Movement Disorders UFV-UCB Chair for supporting this initiative. We thank Irene Santamaría of the Francisco de Vitoria University for the technical coordination work of this study

Risk factors for traumatic and non-traumatic lower limb pain among preadolescents: a population-based study of Finnish schoolchildren

BACKGROUND: The child's lower limb is the most commonly reported musculoskeletal location with pain and also the most commonly injured site in sports. Some potential risk factors have been studied, but the results are inconsistent. We hypothesized that distinction of traumatic from non-traumatic pain would provide a clearer picture of these factors. The aim of this study is to assess factors associated with lower extremity pain and its impact on preadolescents in a population-based cohort. METHODS: A structured pain questionnaire was completed by 1756 schoolchildren of third and fifth grades to assess musculoskeletal pain, psychosomatic symptoms, subjective disabilities, school absence and frequency of exercise. In addition, hypermobility and physical fitness were measured. RESULTS: The knee was the most common site of pain followed by the ankle-foot and thigh. Of the children who reported pain in their lower extremity, approximately 70% reported at least one disability and 19 % reported school absence attributed to their pain during the previous three-month period. Children with traumatic pain had a higher subjective disability index than those with non-traumatic pain (P = 0.02). Age less than 11 years, headache, abdominal pain, depressive feelings, day tiredness, and vigorous exercise were more common in children with lower limb pain than those free of it. In the stratified analysis, younger age was related to both traumatic and non-traumatic pain groups. Vigorous exercise was positively associated with traumatic pain, while subjects with non-traumatic pain had more frequent psychosomatic symptoms. CONCLUSION: Risk factors and consequences of traumatic and non-traumatic lower limb pain are not similar. Traumatic lower limb pain is associated with practicing vigorous exercise and high level of physical fitness, while non-traumatic pain is more correlated with psychosomatic symptoms. These differences might be one of the reasons for the discrepancy of previous research conclusions. The two conditions need to be treated as different disorders in future studies