Dynamic association between perfusion and white matter integrity across time since injury in Veterans with history of TBI.

ObjectiveCerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Although both CBF and white matter microstructural alterations have been observed within the context of traumatic brain injury (TBI), the degree to which these pathological changes relate to one another and whether this association is altered by time since injury have not been examined. The current study therefore sought to clarify associations between resting CBF and white matter microstructure post-TBI.Methods37 veterans with history of mild or moderate TBI (mmTBI) underwent neuroimaging and completed health and psychiatric symptom questionnaires. Resting CBF was measured with multiphase pseudocontinuous arterial spin labeling (MPPCASL), and white matter microstructural integrity was measured with diffusion tensor imaging (DTI). The cingulate cortex and cingulum bundle were selected as a priori regions of interest for the ASL and DTI data, respectively, given the known vulnerability of these regions to TBI.ResultsRegression analyses controlling for age, sex, and posttraumatic stress disorder (PTSD) symptoms revealed a significant time since injury × resting CBF interaction for the left cingulum (p < 0.005). Decreased CBF was significantly associated with reduced cingulum fractional anisotropy (FA) in the chronic phase; however, no such association was observed for participants with less remote TBI.ConclusionsOur results showed that reduced CBF was associated with poorer white matter integrity in those who were further removed from their brain injury. Findings provide preliminary evidence of a possible dynamic association between CBF and white matter microstructure that warrants additional consideration within the context of the negative long-term clinical outcomes frequently observed in those with history of TBI. Additional cross-disciplinary studies integrating multiple imaging modalities (e.g., DTI, ASL) and refined neuropsychiatric assessment are needed to better understand the nature, temporal course, and dynamic association between brain changes and clinical outcomes post-injury

Effect of Low Strain Rate on Formability of Aluminium Alloy

Effect of low strain rate on formability of aluminium alloy 2014 by means of torsion test was performed. The presented experimental results exhibit decrease of the ductility with increase and decrease of ε and T, respectively, and optimal values of , ε T are thus obtained

The contingent roles of perceived budget fairness, budget goal commitment and vertical information sharing in driving work performance

Drawing on equity theory, social exchange theory and goal setting theory, the purpose of this paper is to investigate the contingencies on the link between employees’ budgetary participation and their work performance. Specifically, this study addresses the research questions: whether vertical information sharing and budget goal commitment mediate the relationship between employees’ budgetary participation and their work performance; and whether employees’ perceived budget fairness can strengthen the positive effects of budgetary participation on vertical information sharing and budget goal commitment

Molecular dysfunction and phenotypic derangement in diabetic cardiomyopathy

The high incidence and poor prognosis of heart failure (HF) patients affected with diabetes (DM) is in part related to a specific cardiac remodeling currently recognized as diabetic cardiomyopathy (DCM). This cardiac frame occurs regardless of the presence of coronary artery diseases (CAD) and it can account for 15-20% of the total diabetic population. The pathogenesis of DCM remains controversial, and several molecular and cellular alterations including myocardial hypertrophy, interstitial fibrosis, oxidative stress and vascular inflammation, have been postulated. The main cardio-vascular alterations associated with hyperglycemia comprise endothelial dysfunction, adverse effects of circulating free fatty acids (FFA) and increased systemic inflammation. High glucose concentrations lead to a loss of mitochondrial networks, increased reactive oxygen species (ROS), endothelial nitric oxide synthase (eNOS) activation and a reduction in cGMP production related to protein kinase G (PKG) activity. Current mechanisms enhance the collagen deposition with subsequent increased myocardial stiffness. Several concerns regarding the exact role of DCM in HF development such as having an appearance as either dilated or as a concentric phenotype and whether diabetes could be considered a causal factor or a comorbidity in HF, remain to be clarified. In this review, we sought to explain the different DCM subtypes and the underlying pathophysiological mechanisms. Therefore, the traditional and new molecular and signal alterations and their relationship with macroscopic structural abnormalities are described

Uma estratégia para auxiliar a identificação de portfólios por meio de mineração de textos.

Neste trabalho utilizou-se uma estratégia com base em mineração de textos para fornecer uma indicação dos atuais portfólios da Embrapa Informática Agropecuária. Para tanto, utilizaram-se, como dados, os projetos liderados por essa unidade nos últimos anos, de 2004 a 2010. A esses dados aplicou-se um processo de extração semiautomática do conhecimento, utilizando vocabulário controlado, filtragem estatística de atributos, agrupamento hierárquico de documentos, descrição única dos agrupamentos e várias interações usuários do processo. Os resultados obtidos foram satisfatórios, tendo passado apenas por validação subjetiva, mostrando que o processo pode ser aplicado a dados semelhantes.bitstream/item/56719/1/Livro-BolPesq28.pd

X-ray follow-ups of XSSJ12270-4859: a low-mass X-ray binary with gamma ray FERMI-LAT association

XSSJ1227.0-4859 is a peculiar, hard X-ray source recently positionally associated to the Fermi-LAT source 1FGLJ1227.9-4852/2FGLJ1227.7-4853. Multi-wavelength observations have added information on this source, indicating a low-luminosity low-mass X-ray binary (LMXB), but its nature is still unclear. To progress in our understanding, we present new X-ray data from a monitoring campaign performed in 2011 with the XMM-Newton, RXTE, and Swift satellites and combine them with new gamma-ray data from the Fermi and AGILE satellites. We complement the study with simultaneous near-UV photometry from XMM-Newton and with previous UV/optical and near-IR data. The X-ray history of XSSJ1227.0-4859 over 7yr shows a persistent and rather stable low-luminosity (~6x10^33 d_{1\,kpc}^2 erg/s) source, with flares and dips being peculiar and permanent characteristics. The associated Fermi-LAT source 2FGLJ1227.7-4853 is also stable over an overlapping period of 4.7\,yr. Searches for X-ray fast pulsations down to msec give upper limits to pulse fractional amplitudes of 15-25% that do not rule out a fast spinning pulsar. The combined UV/optical/near-IR spectrum reveals a hot component at ~13\,kK and a cool one at ~4.6\,kK. The latter would suggest a late-type K2-K5 companion star, a distance range of1.4--3.6kpc and an orbital period of 7--9 h. A near-UV variability (>6\,h) also suggests a longer orbital period than previously estimated. The analysis shows that the X-ray and UV/optical/near-IR emissions are more compatible with an accretion-powered compact object than with a rotational powered pulsar. The X-ray to UV bolometric luminosity ratio could be consistent with a binary hosting a neutron star, but the uncertainties in the radio data may also allow an LMXB black hole with a compact jet. In this case it would be the first associated with a high-energy gamma-ray source.Comment: 17 pages, 14 figures, 1 table; Accepted for publication in Astronomy & Astrophysics Main Journa

"Double trouble” or digenic disorder in Complex I deficiency

Complex I (CI) deficiency is a defect of OXPHOS caused by mutations in the mitochondrial or nuclear genomes. To date disease-causing mutations have been reported in all mitochondrial-encoded subunits and 22 nuclear genes. In about 50% of the patients no mutations are found, suggesting that undiscovered factors are an important cause of disease. In this study we report a consanguineous family from Southern Portugal with three affected children presenting with CI deficiency and 3-methylglutaconic aciduria type IV