The display makes a difference: A mobile eye tracking study on the perception of art before and after a museum’s rearrangement

There is increasing awareness that the perception of art is affected by the way it is presented. In 2018, the Austrian Gallery Belvedere redisplayed its permanent collection. Our multi-disciplinary team seized this opportunity to investigate the viewing behavior of specific artworks both before and after the museum’s rearrangement. In contrast to previous mobile eye tracking (MET) studies in museums, this study benefits from the comparison of two realistic display conditions (without any research interference), an unconstrained study design (working with regular museum visitors), and a large data sample (comprising 259 participants). We employed a mixed-method approach that combined mobile eye tracking, subjective mapping (a drawing task in conjunction with an open interview), and a questionnaire in order to relate gaze patterns to processes of meaning-making. Our results show that the new display made a difference in that it 1) generally increased the viewing times of the artworks; 2) clearly extended the reading times of labels; and 3) deepened visitors’ engagement with the artworks in their exhibition reflections. In contrast, interest in specific artworks and art form preferences proved to be robust and independent of presentation modes

Canakinumab for Treatment of Adult-Onset Still's Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial

Background: Inhibition of interleukin (IL)-1 represents a promising treatment option in adult-onset Still's disease (AOSD). Objective: To investigate the efficacy and safety of canakinumab in patients with AOSD and active joint involvement by means of a multicentre, double-blind, randomised, placebo-controlled trial. Methods Patients with AOSD and active joint involvement (tender and swollen joint counts of >= 4 each) were treated with canakinumab (4 mg/kg, maximum 300 mg subcutaneous every 4 weeks) or placebo. The primary endpoint was the proportion of patients with a clinically relevant reduction in disease activity at week 12 as determined by the change in disease activity score (Delta DAS28>1.2). Results At enrolment, patients had high active disease with a mean DAS28(ESR) of 5.4 in the canakinumab and 5.3 in the placebo group, respectively. In the intention-to-treat analysis, 12 patients (67%) in the canakinumab group and 7 patients (41%) in the placebo group fulfilled the primary outcome criterion (p=0.18). In the per-protocol analysis, significantly higher American College of Rheumatology (ACR) 30% (61% vs 20%, p=0.033), ACR 50% (50% vs 6.7%, p=0.009) and ACR 70% (28% vs 0%, p=0.049) response rates were observed in the canakinumab group compared with the placebo group. Two patients in the canakinumab group experienced a serious adverse event. Conclusion Although the study was terminated prematurely and the primary endpoint was not achieved, treatment with canakinumab led to an improvement of several outcome measures in AOSD. The overall safety findings were consistent with the known profile of canakinumab. Thus, our data support indication for IL-1 inhibition with canakinumab in AOSD

Capturing Aesthetic Experiences With Installation Art: An Empirical Assessment of Emotion, Evaluations, and Mobile Eye Tracking in Olafur Eliasson’s “Baroque, Baroque!”

Installation art is one of the most important and provocative developments in the visual arts during the last half century and has become a key focus of artists and of contemporary museums. It is also seen as particularly challenging or even disliked by many viewers, and—due to its unique in situ, immersive setting—is equally regarded as difficult or even beyond the grasp of present methods in empirical aesthetic psychology. In this paper, we introduce an exploratory study with installation art, utilizing a collection of techniques to capture the eclectic, the embodied, and often the emotionally-charged viewing experience. We present results from an investigation of two pieces, both part of Olafur Eliasson’s exhibition “Baroque, Baroque” held at the Belvedere museum in Vienna. These were assessed by pre- and post-viewing questionnaires focusing on emotion, meaning-making, and appraisals, in tandem with mobile eye tracking to consider viewers’ attention to both installed artworks and/or to the museum environment. The data showed differences in participants’ emotional states, appraisals, and visual exploration, which together paint a picture of the aesthetic reactions to the works. These differences also showed how viewers’ appraisal strategies, meaning making, and physical actions facilitated relatively more or less deep engagement with, and enjoyment of, the art. The results are discussed in terms of their implications for museum studies, art education, and theory in empirical aesthetics

The Process of Replication Target Selection in Psychology: What to Consider?

Increased execution of replication studies contributes to the effort to restore credibility of empirical research. However, a second generation of problems arises: the number of potential replication targets is at a serious mismatch with available resources. Given limited resources, replication target selection should be well justified, systematic, and transparently communicated. At present the discussion on what to consider when selecting a replication target is limited to theoretical discussion, self-reported justifications, and a few formalized suggestions. In this Registered Report, we proposed a study involving the scientific community to create a list of considerations for consultation when selecting a replication target in psychology. We employed a modified Delphi approach. First, we constructed a preliminary list of considerations. Second, we surveyed psychologists who previously selected a replication target with regards to their considerations. Third, we incorporated the results into the preliminary list of considerations and sent the updated list to a group of individuals knowledgeable about concerns regarding replication target selection. Over the course of several rounds, we established consensus regarding what to consider when selecting a replication target

The process of replication target selection in psychology: what to consider?

Increased execution of replication studies contributes to the effort to restore credibility of empirical research. However, a second generation of problems arises: the number of potential replication targets is at a serious mismatch with available resources. Given limited resources, replication target selection should be well-justified, systematic and transparently communicated. At present the discussion on what to consider when selecting a replication target is limited to theoretical discussion, self-reported justifications and a few formalized suggestions. In this Registered Report, we proposed a study involving the scientific community to create a list of considerations for consultation when selecting a replication target in psychology. We employed a modified Delphi approach. First, we constructed a preliminary list of considerations. Second, we surveyed psychologists who previously selected a replication target with regards to their considerations. Third, we incorporated the results into the preliminary list of considerations and sent the updated list to a group of individuals knowledgeable about concerns regarding replication target selection. Over the course of several rounds, we established consensus regarding what to consider when selecting a replication target. The resulting checklist can be used for transparently communicating the rationale for selecting studies for replication

The German National Registry of Primary Immunodeficiencies (2012-2017)

Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment

Looking on the Bright Side: Replicating the Association between Brightness and Positivity

The present study is a pre-registered replication of a study by Specker et al. (2018) that tests the hypothesis that brightness of colors is associated with positivity. Our results showed an implicit association between brightness and positivity in both Study 1 and Study 2, however, an explicit association between brightness and positivity was only found in Study 2, thereby replicating 3 out of 4 effects. To investigate these effects in more detail, we present a meta-analysis of both the original and the replication study. This indicated a large effect 1.31 [1.12, 1.51]. In addition, we used meta-analysis to assess potential moderators of the effect, in particular stimulus type (chromatic vs. achromatic) and measure type (implicit vs. explicit). This indicated that the effect is stronger when measured implicitly than when measured explicitly and that the effect is stronger when achromatic stimuli are used. In sum, we take these findings to indicate that there is a strong and replicable association between brightness and positivity. These findings offer researchers interested in the effect concrete tools when designing a study investigating the effect with regard to effect size estimates for power analysis as well as stimulus and measurement design

Dispersion matters: Diagnostics and control data computer simulation in Concealed Information Test studies.

Binary classification has numerous applications. For one, lie detection methods typically aim to classify each tested person either as "liar" or as "truthteller" based on the given test results. To infer practical implications, as well as to compare different methods, it is essential to assess the diagnostic efficiency, such as demonstrating the number of correctly classified persons. However, this is not always straightforward. In Concealed Information Tests (CITs), the key predictor value (probe-irrelevant difference) for "truthtellers" is always similar (zero on average), and "liars" are always distinguished by a larger value (i.e., a larger number resulting from the CIT test, as compared to the zero baseline). Thereby, in general, the larger predictor values a given CIT method obtains for "liars" on average, the better this method is assumed to be. This has indeed been assumed in countless studies, and therefore, when comparing the classification efficiencies of two different designs, the mean difference of "liar" predictor values in the two designs were simply compared to each other (hence not collecting "truthteller" data to spare resources). We show, based on the meta-data of 12 different experimental designs collected in response time-based CIT studies, that differences in dispersion (i.e., variance in the data, e.g. the extent of random deviations from the zero average in case of "truthtellers") can substantially influence classification efficiency-to the point that, in extreme cases, one design may even be superior in classification despite having a larger mean "liar" predictor value. However, we also introduce a computer simulation procedure to estimate classification efficiency in the absence of "truthteller" data, and validate this procedure via a meta-analysis comparing outcomes based on empirical data versus simulated data

Do You See What I See? an Investigation of the Aesthetic Experience in the Laboratory and Museum

Two studies examined people\u27s aesthetic experiences of art in the laboratory and the museum. The theoretical framework guiding the research was based on the Mirror Model of Art (Tinio, 2013), which proposes that the process of artistic creation and artistic reception mirror each other. Study 1 used a think-aloud protocol to assess people\u27s natural and spontaneous reactions while looking at art. Study 2 examined whether presenting information about an artwork in a certain order (lower-order to higherorder information or higher-order to lower-order information) enhances aspects of the aesthetic experience and retention of information about art. Studies 1 and 2 were each conducted both in a laboratory and in a museum. The results replicate those of previous research that showed that the aesthetic experience of art is enhanced in the museum as compared with the laboratory setting. In addition, the results show that the effects of presenting information in a certain order (lower-order to higher-order information) depend on the context of presentation: museum visitors were better able to remember information about art than laboratory participants. Overall, the findings suggest that the Mirror Model is a good representation of how people naturally process art, but that certain aspects of the model could be optimized