Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors

[Cu(thp)4][PF6] (HydroCuP) is a phosphino copper(I) complex highly soluble and stable in physiological media that has been developed as a possible viable alternative to platinum-based drugs for anticancer therapy. HydroCuP potently inhibited the growth of human cancer cells derived from solid tumors by inducing endoplasmatic reticulum (ER) stress thus leading to cell death through paraptosis with a preferential efficacy against cancer rather than non-cancer cells. Aim of the present study was to assess the therapeutic potential of HydroCuP in vivo, in syngenic and xenograft murine models of solid tumors by triggering the Unfolded Protein Response (UPR) pathway. With respect to platinum drugs, HydroCuP induced a markedly higher reduction of tumor growth associated with minimal animal toxicity. In human colorectal cancer xenografts, chemotherapy with HydroCuP was extremely effective in both oxaliplatin-sensitive and resistant models. The favorable in vivo tolerability of HydroCuP was also correlated to an encouraging biodistribution profile. Additionally, no signs of drug-related neurotoxicity and nephrotoxicity were observed. Altogether, these results demonstrate that HydroCuP appears worth of further investigation to evaluate its therapeutic activity towards a broad spectrum of solid malignancies

Estudio de mercado para proyecto de hotel ecoturístico en la playa Los Cocos, Lago Cocibolca, Granada, Nicaragua

Tesis (Licenciatura en Turismo y Administracion Hotelera)--Universidad Americana, Managua, 2004El presente estudio tiene la finalidad de conocer los atractivos turisticos que posee la ciudad de Granada para asi diagnosticar la demanda vs. la oferta demostrando la viabilidad de ofertar y promocionar un hotel Ecoturistico en la costa del Gran Lago Cocibolca

Shape Sensing of Plate and Shell Structures Undergoing Large Displacements Using the Inverse Finite Element Method

The inverse Finite Element Method (iFEM) is applied to reconstruct the displacement field of a shell structure which undergoes large deformations using discreet strain measurements as the prescribed data. The iFEM computations are carried out using an incremental procedure where at each load step, the incremental strains are used to evaluate the incremental displacements which in turn update the geometry of the deformed structure. The efficacy of the proposed approach to predict large displacements is examined using two case studies involving a cantilevered wing-shaped plate and a clamped plate. The incremental iFEM procedure is demonstrated to be sufficiently accurate in terms of reproducing the correct nonlinear character of the load-displacement curve even when a reduced number of strain sensors is used. Therefore, this approach may have important implications for real-time monitoring of aerospace structures that undergo large displacements

Evaluación del contenido proteico en variedades de arveja

El objetivo de este estudio ha sido evaluar la potencialidad comercial de las variedades desarrolladas por INTA y la FCA UNR en comparación con las disponibles en el mercado, contemplando tanto el comportamiento en la producción primaria como la calidad industrial de los granos producidos. Para este último punto, se propuso evaluar la composición y el comportamiento de solubilidad de las proteínas, dado que es un parámetro importante previo a la producción de aislados proteicos.EEA OliverosFil: Espósito, María Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Accoroni, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros. Laboratorio de Agroindustria; Argentin

In search of feasting in tawantinsuyu: an analisis of the evidence from a discard Sector at el Shincal de Quimivil

El Shincal de Quimivil es considerado un sitio inkaico de gran importancia dentro del Kollasuyu, y es distinguible, dadas sus características, de otros sitios inka del NOA. Cuenta con más de un centenar de estructuras arquitectónicas residenciales y públicas, y en sus inmediaciones se hallan numerosas obras de infraestructura de riego y de cultivo, además de morteros múltiples. Estos últimos se han vinculado con la preparación de grandes cantidades de comida y bebida en momentos de ocupación inkaica en la región. La articulación de estos elementos y las grandes dimensiones de la plaza central sugieren la afluencia de personas en momentos festivos. En este trabajo se considera al estudio de la cerámica como factor particularmente significativo para dilucidar este tipo de eventos y las relaciones sociales en las que se estructuran. El análisis minucioso del conjunto cerámico recolectado en un sector definido como "zona de descarte" nos lleva a comprender aspectos de la estructura sociopolítica inkaica en un sitio plenamente articulado al Tawantinsuyu, con una dinámica propia particular que incluye, a través de las festividades, la emergencia de un espacio social para abordar la representación y manipulación de las relaciones políticas."El Shincal de Quimivil" is considered an Inka site of great importance within the Kollasuyu sector of Tawantinsuyu as it has specific characteristics that distinguish it from other late Imperial sites in Northwest Argentina. It contains over a hundred residential and public structures and, within its surroundings, their exist many irrigation structures for farming and multiple grinding mortars. These components are likely related to the preparation of large quantities of food and drink during the Inka period. The articulation of these elements, as well as the size of the central plaza, suggests that the people involved in the state-related festivities were quite affluent. In this paper the study of the associated ceramics is considered to be particularly important in elucidating such events and social relations at this site. A thorough analysis of the ceramic assemblage recovered from the sector defined as the "discard area" provides insight into various aspects of Inka sociopolitical structure at a site that was fully situated within the imperial fold of Tawantinsuyu. The study suggests that the feasting context created a particular social space and local dynamic within which the representation and manipulation of political relationships took place.Fil: Giovannetti, Marco Antonio. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Cientifico de Arqueologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata; ArgentinaFil: Spina, Josefina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Arqueologia; ArgentinaFil: Paez, Maria Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Cientifico de Arqueologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata; ArgentinaFil: Cochero, Gregoria. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Cientifico de Arqueologia; ArgentinaFil: Rossi, Ariadna. Universidad Nacional de La Plata; ArgentinaFil: Esposito, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Arqueologia; Argentin

Evaluación de la estabilidad en el tiempo del contenido proteico en variedades de arveja

El objetivo del presente trabajo ha sido evaluar la estabilidad del contenido proteico de las variedades desarrolladas por INTA y la Facultad de Ciencias Agrarias de la Universidad Nacional de Rosario y las disponibles en el mercado, contemplando tanto el comportamiento en la producción primaria como la calidad industrial de los granos producidos a la hora de producir aislados proteicos.EEA OliverosFil: Accoroni, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros. Laboratorio de Agroindustria; ArgentinaFil: Magnano, Luciana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Espósito, María Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; Argentin

Situación actual y prospectivas de la arveja

Este trabajo tiene como objetivo analizar la situación actual de la arveja en Argentina, respecto a su producción, exportación y procesamiento, y a su vez, evaluar la potencialidad para el desarrollo del sector en el futuro.EEA OliverosFil: Accoroni, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Espósito, María Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Prieto, Gabriel María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros. Agencia de Extensión Rural Arroyo Seco; Argentin

Bidirectional Modulation of Neuronal Cells Electrical and Mechanical Properties Through Pristine and Functionalized Graphene Substrates

[Abstract] In recent years, the quest for surface modifications to promote neuronal cell interfacing and modulation has risen. This course is justified by the requirements of emerging technological and medical approaches attempting to effectively interact with central nervous system cells, as in the case of brain-machine interfaces or neuroprosthetic. In that regard, the remarkable cytocompatibility and ease of chemical functionalization characterizing surface-immobilized graphene-based nanomaterials (GBNs) make them increasingly appealing for these purposes. Here, we compared the (morpho)mechanical and functional adaptation of rat primary hippocampal neurons when interfaced with surfaces covered with pristine single-layer graphene (pSLG) and phenylacetic acid-functionalized single-layer graphene (fSLG). Our results confirmed the intrinsic ability of glass-supported single-layer graphene to boost neuronal activity highlighting, conversely, the downturn inducible by the surface insertion of phenylacetic acid moieties. fSLG-interfaced neurons showed a significant reduction in spontaneous postsynaptic currents (PSCs), coupled to reduced cell stiffness and altered focal adhesion organization compared to control samples. Overall, we have here demonstrated that graphene substrates, both pristine and functionalized, could be alternatively used to intrinsically promote or depress neuronal activity in primary hippocampal cultures.This work was funded by the European Union’s Horizon 2020 Research and Innovation Program under the Grant Agreements 785219 and 881603 of the Graphene Flagship. DS acknowledges the support of the European Union’s Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no. 838902. MP as the recipient of the AXA Bionanotechnology Chair, is grateful to the AXA Research Fund for financial support. This work was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency-grant no. MDM-2017- 0720. AC thanks Xunta de Galicia for his research grant Atracción de Talento (no. ED431H 2020/17). GR acknowledges funding from RYC-2016-21412. HH acknowledges funding from Juan de la Cierva – Incorporación no. IJC-2018-037396-IXunta de Galicia; ED431H 2020/1

Relacion Entre La Densidad Óptima Agronomica Y El Número De Granos Por Planta En Maíz (Zea Maysl.)

The density of sowing (D) is one of the main management practices that influences the yield (Y) of corn. There exists a density value in which the yield is maximum (OPD), depending on the environment, the genotype and its interaction. The objectives of this project were: i-To determine the OPD for two corn genotypes in different productive environments; ii- Analyze the relationship between the number of kernel fixed per plant (KNP) and its plant growing rate (PGR) to different environments and genotypes iii- Determine the KNP that is related to the OPD for two corn genotypes. Three experiments were carried out in different locations (L) of Córdoba (Argentina) during 2013/14, comparing 2 genotypes (G) in 2 management zones (MZ). The statistical design was random blocks, with a factorial arrangement of subdivided plots, with L, MZ and G being the primary, secondary and tertiary factors, respectively. In addition, 5 D were planted to obtain the relationships that estimate OPD, PGR, KNP and Y. The results indicate that OPD was affected by L; the relationship between PGR and KNP was not modified by the environment, but by G. The PGR coincident with the OPD was modified by the G interaction: L. The OPD the PGR was between 2.74 to 4.81 g d -1 , which were associated with the NGP that varied only between 509 and 603 grains p-1