Existing and potential use of Orton Bradley Park, Charteris Bay, New Zealand

Orton Bradley Park (OBP) is a private farm park located 25 kilometres south east of Christchurch in the Lyttelton Harbour basin. The Park is marketed as offering peaceful picnic, BBQ and camping areas, heritage buildings and agricultural relics, as well as extensive walking tracks through regenerating native forest, commercial forest and farmland. Over its forty years of operation, little visitor profile data has been collected, so documented evidence of the Park’s use and users is limited. Despite this lack of information on visitation, recent development proposals have been suggested for the Park, which include family-friendly mountain bike tracks, a café, plant nursery, dog exercise area, historic tours and year-round basic camping facilities. To help evaluate the appropriateness of the proposed Park developments, the purpose of this study was to better understand OBP’s current and potential visitor use and markets in order for the Orton Bradley Park Board to make informed choices about future development and marketing

A bibliographical review of research completed by Nepali students at Lincoln University, New Zealand (1956 - 2022)

Not long after the summiting of Everest in May 1953, Bidur Kumar Thapa, the first recorded Nepali student arrived at the then Lincoln Agricultural College, supported by the Colombo Plan. He graduated in 1956 with a Masters of Agricultural Science with Honours in Soil Science under the supervision of Dr Walker, and went on to publish his findings on grassland soils in the Journal of Soil Science, in 1959. Thapa’s work laid the foundation and pathway for future students from Nepal. In the following years, more than fifty Nepali research students have been recorded in the Lincoln University archives as completing a range of research-based qualifications from across the University, and in many instances going on to publish findings in scholarly journals. This annotated bibliography sets out to collate, review and curate their collective research efforts spanning almost seventy years

The Tourism Adaptation Classification (TAC) framework: An application to New Zealand's Glacier country

Alongside growing awareness of the significance of environmental change for glacier regions, and their tourism-dependent communities, is the realization of the need to adapt to changing conditions. Such adaptation is necessary for tourism operators, managers, and planners as well as the visitors themselves, and is part of building resilient tourism systems. This paper presents a conceptual framework for understanding the possible stages of adaptation in glacier tourism destinations. The Tourism Adaptation Classification (TAC) framework aligns three stages of adaptation (resilience, transition, and transformation) against adaptation strategies implemented by tourism stakeholders and identifies specific characteristics. Using a desk-based case study approach, the framework is illustrated with reference to Glacier Country in New Zealand's Westland/Tai Poutini National Park in relation to three core dimensions of the tourism system: tourism planning and governance; tourism business and operations; and visitor experience

Resveratrol-Induced Suppression of C-type Natriuretic Peptide Associates With Increased Vertebral Bone Density in Postmenopausal Women

C-type natriuretic peptide (CNP) is a paracrine growth factor essential in driving endochondral bone growth in mammals including humans. Despite evidence from animal experiments and tissues that CNP signaling stimulates osteoblast proliferation and osteoclast activity, whether CNP participates in bone remodeling in the mature skeleton is unknown. Using stored plasma samples from a previous randomized controlled clinical trial (RESHAW) of resveratrol supplementation in postmenopausal women exhibiting mild osteopenia, we have studied changes in plasma aminoterminal proCNP (NTproCNP) and concurrent change in bone turnover markers of formation (osteocalcin [OC] and alkaline phosphatase [ALP]) and resorption (C-terminal telopeptide type 1 collagen [CTX]) with bone mineral density (BMD) over a 2-year period of study in 125 subjects. In year one, subjects received placebo or resveratrol, switching to resveratrol or placebo, respectively, in year two. Across all time points, there were no significant associations of NTproCNP with CTX, ALP, or OC. During year one, plasma NTproCNP declined significantly in both groups. In the crossover comparison, analysis of change within individuals showed that, compared with placebo, NTproCNP declined after resveratrol (p = 0.011) and ALP increased (p = 0.008), whereas CTX and OC were unchanged. Inverse association of NTproCNP (r = −0.31; p = 0.025) and positive association of OC (r = 0.32, p = 0.022) with BMD at the lumbar spine were identified after resveratrol but not found after placebo. Decline in NTproCNP was independently associated with resveratrol treatment. This is the first evidence that CNP is modulated during a period of increasing BMD in postmenopausal women. Further study of NTproCNP and associations with drivers of bone formation or resorption can be expected to clarify CNP's role during other interventions directed to bone health in adults. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research

Food security in a COVID-impacted tourism destination: A case study of Queenstown, New Zealand

This report outlines the food (in)security situation in Queenstown, New Zealand in the context of its COVID-affected tourism downturn. It is illustrative of the global pandemic’s disruption to the tourism-dependent town and the ways in which this impacted food security within the community. The project used interview data from 13 interviewees each active in the Queenstown community in food welfare, social support, or local government. Supplementary data was gathered via a desk-based document and media search. Community-based food welfare providers reported high demand for food parcels largely due to COVID-19-related income reductions and job losses. Food welfare demand was strong from the commencement of the nationwide lockdown in March 2020, and remained relatively consistent in subsequent months as national borders remained closed to international visitors. Interviewees reported high numbers of migrants accessing food welfare as the result of tourism job losses, reduced shifts, and loss of access to meals they had received in hospitality roles previously. Many of these migrants were ineligible for government support. COVID-19 food security issues have been exacerbated by high demand for housing and high density living, which has reduced the amount of land available for home vegetable planting. This is limiting own food production and access to affordable high-nutrition foods. Reliance on the food welfare sector as a long term strategy is not sustainable if food security is the goal, however the array of community groups that offer food welfare may be able to proactively bolster food security, concurrent with their food welfare operations, and so enable food welfare recipients to transition to less vulnerability and greater food security in the future. Our findings caution against sectoral ‘self-sufficiency’ because high degrees of independence within sectors can translate to vulnerability in the face of disruption. Inter-sectoral integration – particularly within the agriculture, food and tourism sectors – is one avenue by which each sector could become more resilient. Further research in this area could identify pathways for building resilience

Minor Abnormalities of Testis Development in Mice Lacking the Gene Encoding the MAPK Signalling Component, MAP3K1

In mammals, the Y chromosome is a dominant male determinant, causing the bipotential gonad to develop as a testis. Recently, cases of familial and spontaneous 46,XY disorders of sex development (DSD) have been attributed to mutations in the human gene encoding mitogen-activated protein kinase kinase kinase 1, MAP3K1, a component of the mitogen-activated protein kinase (MAPK) signal transduction pathway. In individuals harbouring heterozygous mutations in MAP3K1, dysregulation of MAPK signalling was observed in lymphoblastoid cell lines, suggesting a causal role for these mutations in disrupting XY sexual development. Mice lacking the cognate gene, Map3k1, are viable and exhibit the eyes open at birth (EOB) phenotype on a mixed genetic background, but on the C57BL/6J genetic background most mice die at around 14.5 dpc due to a failure of erythropoiesis in the fetal liver. However, no systematic examination of sexual development in Map3k1-deficient mice has been described, an omission that is especially relevant in the case of C57BL/6J, a genetic background that is sensitized to disruptions to testis determination. Here, we report that on a mixed genetic background mice lacking Map3k1 are fertile and exhibit no overt abnormalities of testis development. On C57BL/6J, significant non-viability is observed with very few animals surviving to adulthood. However, an examination of development in Map3k1-deficient XY embryos on this genetic background revealed no significant defects in testis determination, although minor abnormalities were observed, including an increase in gonadal length. Based on these observations, we conclude that MAP3K1 is not required for mouse testis determination. We discuss the significance of these data for the functional interpretation of sex-reversing MAP3K1 mutations in humans

EVIDENCE AGAINST AN INTERACTION OF ANGIOTENSIN II WITH THE SYMPATHETIC NERVOUS SYSTEM IN MAN

Animal experiments indicate that angiotensin II can, under some circumstances stimulate the sympathetic nervous system at a number of different sites. In order to determine whether such a relationship of the renin-angiotensin and sympathetic nervous system exists in man, we increased (by intravenous infusion), or decreased (by administering the oral converting enzyme inhibitor captopril) circulating angiotensin II levels and monitored plasma adrenaline and nor-adrenaline responses. Angiotensin II infusions did not increase plasma catechol-amines, and lowering of angiotensin II by captopril treatment in patients with severe hypertension or congestive heart failure failed to alter plasma adrenaline or nor-adrenaline levels. Whether physiological levels of angiotensin II are capable of interacting directly with the sympathetic nervous system in man remains to be demonstrated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73600/1/j.1365-2265.1981.tb00684.x.pd

Looking beyond limitations: Electric vehicle use in New Zealand holidays

EVs are often described as inadequate for long distance holiday trips, and yet increasing numbers of drivers are travelling on holiday in EVs. We talked to 34 New Zealand EV drivers about their experiences of taking an EV on holiday. Although participants did talk about some of the widely reported difficulties or limitations of EV travel (including range, charging, towing, and access to the backcountry), we focus here on less widely reported experiences of actual (and usually successful) holiday trips. A feeling of being adventurous or pioneering, the freedoms associated with driving an EV, and the different sensations, feelings, and driving styles involved in EV travel all feature in this engaging summary of what we found