The abstraction transition taxonomy: developing desired learning outcomes through the lens of situated cognition

We report on a post-hoc analysis of introductory programming lecture materials. The purpose of this analysis is to identify what knowledge and skills we are asking students to acquire, as situated in the activity, tools, and culture of what programmers do and how they think. The specific materials analyzed are the 133 Peer Instruction questions used in lecture to support cognitive apprenticeship -- honoring the situated nature of knowledge. We propose an Abstraction Transition Taxonomy for classifying the kinds of knowing and practices we engage students in as we seek to apprentice them into the programming world. We find students are asked to answer questions expressed using three levels of abstraction: English, CS Speak, and Code. Moreover, many questions involve asking students to transition between levels of abstraction within the context of a computational problem. Finally, by applying our taxonomy in classifying a range of introductory programming exams, we find that summative assessments (including our own) tend to emphasize a small range of the skills fostered in students during the formative/apprenticeship phase

Atividade citocromo C oxidase em espermatozoide bovinos.

A enzima citrocromo C oxidase participa do metabolismo energético dos espermatozoides, podendo sua atividade ser quantificada por método citoquímico em uma variedade de espécies de animal. Atividade enzimática e estabelecimento de coeficientes de correlação com diversas caracteristicas do semen e da fertilidade.Resumo

Comprimento da peça intermediária de espermatozóides bovinos e suas relações com características do sêmen e fertilidade.

Visando identificar preditores de fertilidade em touros, foram estimados os coeficientes de correlacao do comprimento da peca intermediária (CPI) dos espermatozóides com características físicas e metabolicas do semem e fertilidade. Utilizaram-se amostras de sêmen de 50 touros mestiços, submetidos a teste de progenie. O CPI foi determinados em 40 espermatozóides de cada touro por um sistema de analise de imagens (Videoplan). alem das características físicas antes e após a congelacao, foram verificados a velocidade do consumo de oxigênio e o índice de atividade citoquímica do semem desses touros. Os coeficientes de correlacao entre o CPI e os resultados da avaliações física e metabolicas do sêmen e fertilidade foram baixos e nao significativos (P>0,05), não sendo o CPI considerado como um bom indicador da fertilidade

Three centuries of Slovakian drought dynamics

Tree-ring data from Slovakia are used to reconstruct decadal-scale fluctuations of the self-calibrated Palmer Drought Severity Index (scPDSI) over 1744-2006. The ring width chronology correlates at 0.58 (annual) and 0.88 (decadal) with regional-scale (48-50°N and 18-20°E) summer (June-August) scPDSI variations (1901-2002). Driest and wettest years common to the tree-ring and target data are 1947, 1948, 1964, and 1916, 1927, 1938, 1941, respectively. The model indicates decadal-scale drought ~1780-1810, 1850-1870, 1940-1960, and during the late twentieth century. The wettest period occurred ~1745-1775. Instrumental measurements and documentary evidence allow the reconstructed drought extremes to be verified and also provide additional insights on associated synoptic drivers and socioeconomic impacts. Comparison of anomalous dry conditions with European-scale fields of 500hPa geopotential height retains positive pressure anomalies centered over Central Europe leading to atmospheric stability, subsidence and dry conditions. Negative mid-tropospheric geopotential height anomalies over Western Europe are connected with anomalous wet conditions over Slovakia. Nine existing, annually resolved hydro-climatic reconstructions from Central Europe, which were herein considered for comparison with the Slovakian findings, reveal significant high- to low-frequency coherency among the majority of records. Differences between the Slovakian and the other reconstructions are most evident at the end of the nineteenth centur

A 3,500-year tree-ring record of annual precipitation on the northeastern Tibetan Plateau

An annually resolved and absolutely dated ring-width chronology spanning 4,500 y has been constructed using subfossil, archaeological, and living-tree juniper samples from the northeastern Tibetan Plateau. The chronology represents changing mean annual precipitation and is most reliable after 1500 B.C. Reconstructed precipitation for this period displays a trend toward more moist conditions: the last 10-, 25-, and 50-y periods all appear to be the wettest in at least three and a half millennia. Notable historical dry periods occurred in the 4th century BCE and in the second half of the 15th century CE. The driest individual year reconstructed (since 1500 B.C.) is 1048 B.C., whereas the wettest is 2010. Precipitation variability in this region appears not to be associated with inferred changes in Asian monsoon intensity during recent millennia. The chronology displays a statistical association with the multidecadal and longer-term variability of reconstructed mean Northern Hemisphere temperatures over the last two millennia. This suggests that any further large-scale warming might be associated with even greater moisture supply in this region

Neonatal exposure to monosodium glutamate results in dysmorphology of orofacial lower motor neurons

Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and is stored and released by both neurons and astrocytes. Despite the important role of glutamate as a neurotransmitter, high levels of extracellular glutamate can result in excitotoxicity and apoptosis. Monosodium glutamate (MSG) is a naturally occurring sodium salt of glutamic acid that is used as a flavour enhancer in many processed foods. Neonatal exposure to MSG has been shown to result in neurodegeneration in several forebrain regions, characterised by neuronal loss and neuroendocrine abnormalities. However, the brainstem effects of neonatal MSG exposure have not been investigated. It is therefore hypothesized that MSG exposure during the early postnatal period would impact brainstem lower motor neurons involved in feeding behaviour. The effect of neonatal MSG exposure on brainstem lower motor neurons was investigated by exposing rat pups to either 4 mg/g MSG or saline from postnatal day (P) 4 through 10. On P28, brains were preserved by vascular perfusion with fixative, frozen sectioned and stained for Nïssl substance. The number, size and shape of brainstem motor neurons were compared between MSG and saline-exposed animals. MSG exposure had no impact on the total number of neurons in the nuclei examined. However, MSG exposure was associated with a significant increase in the number of round somata in both the trigeminal and facial nuclei. Furthermore, MSG exposure resulted in significantly smaller neurons in all motor nuclei examined. These results suggest that neonatal exposure to MSG impacts the development of brainstem lower motor neurons which may impact feeding and swallowing behaviours in young animals.

Last millennium northern hemisphere summer temperatures from tree rings: Part I: The long term context

Large-scale millennial length Northern Hemisphere (NH) temperature reconstructions have been progressively improved over the last 20 years as new datasets have been developed. This paper, and its companion (Part II, Anchukaitis et al. in prep), details the latest tree-ring (TR) based NH land air temperature reconstruction from a temporal and spatial perspective. This work is the first product of a consortium called N-TREND (Northern Hemisphere Tree-Ring Network Development) which brings together dendroclimatologists to identify a collective strategy for improving large-scale summer temperature reconstructions. The new reconstruction, N-TREND2015, utilises 54 records, a significant expansion compared with previous TR studies, and yields an improved reconstruction with stronger statistical calibration metrics. N-TREND2015 is relatively insensitive to the compositing method and spatial weighting used and validation metrics indicate that the new record portrays reasonable coherence with large scale summer temperatures and is robust at all time-scales from 918 to 2004 where at least 3 TR records exist from each major continental mass. N-TREND2015 indicates a longer and warmer medieval period (∼900–1170) than portrayed by previous TR NH reconstructions and by the CMIP5 model ensemble, but with better overall agreement between records for the last 600 years. Future dendroclimatic projects should focus on developing new long records from data-sparse regions such as North America and eastern Eurasia as well as ensuring the measurement of parameters related to latewood density to complement ring-width records which can improve local based calibration substantially

Temperature-sensitive Tien Shan tree ring chronologies show multi-centennial growth trends

Two millennia-length juniper ring width chronologies, processed to preserve multi-centennial growth trends, are presented for the Alai Range of the western Tien Shan in Kirghizia. The chronologies average the information from seven near-timberline sampling sites, and likely reflect summer temperature variation. For comparison, chronologies are also built using standard dendrochronological techniques. We briefly discuss some qualities of these "inter-decadal” records, and show the low frequency components removed by the standardization process include a long-term negative trend in the first half of the last millennium and a long-term positive trend since about AD 1800. The multi-centennial scale Alai Range chronologies, where these trends are retained, are both systematically biased (but in an opposite sense) in their low frequency domains. Nevertheless, they represent the best constraints and estimates of long-term summer temperature variation, and reflect the Medieval Warm Period, the Little Ice Age, and a period of warming since about the middle of the nineteenth centur

Radial Growth of Qilian Juniper on the Northeast Tibetan Plateau and Potential Climate Associations

There is controversy regarding the limiting climatic factor for tree radial growth at the alpine treeline on the northeastern Tibetan Plateau. In this study, we collected 594 increment cores from 331 trees, grouped within four altitude belts spanning the range 3550 to 4020 m.a.s.l. on a single hillside. We have developed four equivalent ring-width chronologies and shown that there are no significant differences in their growth-climate responses during 1956 to 2011 or in their longer-term growth patterns during the period AD 1110–2011. The main climate influence on radial growth is shown to be precipitation variability. Missing ring analysis shows that tree radial growth at the uppermost treeline location is more sensitive to climate variation than that at other elevations, and poor tree radial growth is particularly linked to the occurrence of serious drought events. Hence water limitation, rather than temperature stress, plays the pivotal role in controlling the radial growth of Sabina przewalskii Kom. at the treeline in this region. This finding contradicts any generalisation that tree-ring chronologies from high-elevation treeline environments are mostly indicators of temperature changes