New methods for the estimation of Takagi-Sugeno model based extended Kalman filter and its applications to optimal control for nonlinear systems

This paper describes new approaches to improve the local and global approximation (matching) and modeling capability of Takagi–Sugeno (T-S) fuzzy model. The main aim is obtaining high function approximation accuracy and fast convergence. The main problem encountered is that T-S identification method cannot be applied when the membership functions are overlapped by pairs. This restricts the application of the T-S method because this type of membership function has been widely used during the last 2 decades in the stability, controller design of fuzzy systems and is popular in industrial control applications. The approach developed here can be considered as a generalized version of T-S identification method with optimized performance in approximating nonlinear functions. We propose a noniterative method through weighting of parameters approach and an iterative algorithm by applying the extended Kalman filter, based on the same idea of parameters’ weighting. We show that the Kalman filter is an effective tool in the identification of T-S fuzzy model. A fuzzy controller based linear quadratic regulator is proposed in order to show the effectiveness of the estimation method developed here in control applications. An illustrative example of an inverted pendulum is chosen to evaluate the robustness and remarkable performance of the proposed method locally and globally in comparison with the original T-S model. Simulation results indicate the potential, simplicity, and generality of the algorithm. An illustrative example is chosen to evaluate the robustness. In this paper, we prove that these algorithms converge very fast, thereby making them very practical to use

Capturing coevolutionary signals in repeat proteins

The analysis of correlations of amino acid occurrences in globular proteins has led to the development of statistical tools that can identify native contacts -- portions of the chains that come to close distance in folded structural ensembles. Here we introduce a statistical coupling analysis for repeat proteins -- natural systems for which the identification of domains remains challenging. We show that the inherent translational symmetry of repeat protein sequences introduces a strong bias in the pair correlations at precisely the length scale of the repeat-unit. Equalizing for this bias reveals true co-evolutionary signals from which local native-contacts can be identified. Importantly, parameter values obtained for all other interactions are not significantly affected by the equalization. We quantify the robustness of the procedure and assign confidence levels to the interactions, identifying the minimum number of sequences needed to extract evolutionary information in several repeat protein families. The overall procedure can be used to reconstruct the interactions at long distances, identifying the characteristics of the strongest couplings in each family, and can be applied to any system that appears translationally symmetric

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

et al.Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem cell compartments. To evaluate this hypothesis, we examined the number and functional competence of stem cells in Zmpste24 -null progeroid mice, which exhibit nuclear lamina defects. We show that Zmpste24 deficiency causes an alteration in the number and proliferative capacity of epidermal stem cells. These changes are associated with an aberrant nuclear architecture of bulge cells and an increase in apoptosis of their supporting cells in the hair bulb region. These alterations are rescued in Zmpste24 -/- Lmna+/- mutant mice, which do not manifest progeroid symptoms. We also report that molecular signaling pathways implicated in the regulation of stem cell behavior, such as Wnt and microphthalmia transcription factor, are altered in Zmpste24-/- mice. These findings establish a link between age-related nuclear envelope defects and stem cell dysfunction.This work was supported by grants from Ministerio de Educacion y Ciencia (Spain), Fundación Lilly, Fundación La Caixa, Fundación M. Botín, and the European Union. I. Flores is a Ramón y Cajal senior scientist. M.A. Blasco´s laboratory is funded by the Ministerio de Ciencia y Tecnologia (Spain), the regional government of Madrid, the European Union, and Josef Steiner Cancer Research Award 2003. The Instituto Universitario de Oncología is supported by Obra Social Cajastur.Peer Reviewe

HI asymmetry in the isolated galaxy CIG 85 (UGC 1547)

We present the results from the Giant Metrewave Radio Telescope (GMRT) interferometric HI and 20 cm radio continuum observations of CIG 85, an isolated asymmetric galaxy from the AMIGA (Analysis of the Interstellar Medium of Isolated GAlaxies) sample. Despite being an isolated galaxy, CIG 85 showed an appreciable optical and HI spectral asymmetry and therefore was an excellent candidate for resolved HI studies to understand the reasons giving rise to asymmetries in isolated galaxies. The galaxy was imaged in HI and 20 cm radio continuum using the GMRT. For a detailed discussion of the results we also made use of multi-wavelength data from archival SDSS, GALEX and Halpha imaging. We find the HI in CIG 85 to have a clumpy, asymmetric distribution which in the NW part is correlated with optical tail like features, but the HI velocity field displays a relatively regular rotation pattern. Evaluating all the observational evidence, we come to a conclusion that CIG 85 is most likely a case of a disturbed spiral galaxy which now appears to have the morphology of an irregular galaxy. Although it is currently isolated from major companions, the observational evidence is consistent with HI asymmetries, a highly disturbed optical disk and recent increase in star formation having been caused by a minor merger, remnants of which are now projected in front of the optical disk. If this is correct, the companion will be fully accreted by CIG 85 in the near future.Comment: 10 pages, 9 figures, accepted in A&

The central parsecs of M87: jet emission and an elusive accretion disc

We present the first simultaneous spectral energy distribution (SED) of M87 core at a scale of 0.4 arcsec ($\sim 32\, \rm{pc}$) across the electromagnetic spectrum. Two separate, quiescent, and active states are sampled that are characterized by a similar featureless SED of power-law form, and that are thus remarkably different from that of a canonical active galactic nuclei (AGN) or a radiatively inefficient accretion source. We show that the emission from a jet gives an excellent representation of the core of M87 core covering ten orders of magnitude in frequency for both the active and the quiescent phases. The inferred total jet power is, however, one to two orders of magnitude lower than the jet mechanical power reported in the literature. The maximum luminosity of a thin accretion disc allowed by the data yields an accretion rate of $< 6 \times 10^{-5}\, \rm{M_\odot \, yr^{-1}}$, assuming 10% efficiency. This power suffices to explain M87 radiative luminosity at the jet-frame, it is however two to three order of magnitude below that required to account for the jet's kinetic power. The simplest explanation is variability, which requires the core power of M87 to have been two to three orders of magnitude higher in the last 200 yr. Alternatively, an extra source of power may derive from black hole spin. Based on the strict upper limit on the accretion rate, such spin power extraction requires an efficiency an order of magnitude higher than predicted from magnetohydrodynamic simulations, currently in the few hundred per cent range.Comment: 18 pages, 6 figures. Accepted for publication in MNRA

Patterns of resistance to antibiotics in Enterococcus spp isolated from raw milk tank of dairy farms; a risk for animal and public health?

Antimicrobial resistant microorganisms are responsible of emerging infections in both, humans and animals which represent a health challenge, especially in public health due to the possible spreading of this resistance from animals to humans. According to this idea, a study was carried out on raw milk tank from twenty four dairy herds with the objective to detect the prevalence of Enterococcus spp, a bacteria inhabitant of the animal and human environment. Antibiotic resistance patterns and phenotypes of the isolated strains were studied in order to evaluate their potential role in the transmission of the antimicrobial resistance to humans and also to other animals from milk production environment. E. faecium was the most prevalent microorganism while E. faecalis was the second one. The level of Enterococcus spp strains with resistance to the antibiotics used in veterinary medicine were medium-high while the level of resistance to some reference antibiotics in human medicine (glicopeptides) was low but in most of the strains the value was in the limit of the cut-off point. Multidrug resistance (more than three classes of antibiotics tested) was detected in the majority of the isolated strains. While no resistant phenotypes were identified according to the MIC studies and vanA phenotype was not detected, some strains presented MIC values near this vanA phenotype. These results suggested that implementation of antimicrobial resistant microorganisms surveillance programs in raw milk tank of dairy herds could contribute to define future animal treatments at farm level and to identify the animal and public health risks of antimicrobial resistance transmission associated to milk production

Chemistry in isolation: High CCH/HCO+ line ratio in the AMIGA galaxy CIG 638

Multi-molecule observations towards an increasing variety of galaxies have been showing that the relative molecular abundances are affected by the type of activity. However, these studies are biased towards bright active galaxies, which are typically in interaction. We study the molecular composition of one of the most isolated galaxies in the local Universe where the physical and chemical properties of their molecular clouds have been determined by intrinsic mechanisms. We present 3 mm broad band observations of the galaxy CIG 638, extracted from the AMIGA sample of isolated galaxies. The emission of the J=1-0 transitions of CCH, HCN, HCO+, and HNC are detected. Integrated intensity ratios between these line are compared with similar observations from the literature towards active galaxies including starburst galaxies (SB), active galactic nuclei (AGN), luminous infrared galaxies (LIRG), and GMCs in M33. A significantly high ratio of CCH with respect to HCN, HCO+, and HNC is found towards CIG 638 when compared with all other galaxies where these species have been detected. This points to either an overabundance of CCH or to a relative lack of dense molecular gas as supported by the low HCN/CO ratio, or both. The data suggest that the CIG 638 is naturally a less perturbed galaxy where a lower fraction of dense molecular gas, as well as a more even distribution could explain the measured ratios. In this scenario the dense gas tracers would be naturally dimmer, while the UV enhanced CCH, would be overproduced in a less shielded medium.Comment: Letter accepted for publication in A&

A ~ 12 kpc HI extension and other HI asymmetries in the isolated galaxy CIG 340 (IC 2487)

HI kinematic asymmetries are common in late-type galaxies irrespective of environment, although the amplitudes are strikingly low in isolated galaxies. As part of our studies of the HI morphology and kinematics in isolated late-type galaxies we have chosen several very isolated galaxies from the AMIGA sample for HI mapping. Here we present GMRT 21-cm HI line mapping of CIG 340 which was selected because its integrated HI spectrum has a very symmetric profile, Aflux = 1.03. Optical images of the galaxy hinted at a warped disk in contrast to the symmetric integrated HI spectrum profile. Our aim is to determine the extent to which the optical asymmetry is reflected in the resolved HI morphology and kinematics. GMRT observations reveal significant HI morphological asymmetries in CIG 340 despite it's overall symmetric optical form and highly symmetric HI spectrum. The most notable HI features are: 1) a warp in the HI disk (with an optical counterpart), 2) the HI north/south flux ratio = 1.32 is much larger than expected from the integrated HI spectrum profile and 3) a ~ 45" (12 kpc) HI extension, containing ~ 6% of the detected HI mass on the northern side of the disk. We conclude that in isolated galaxies a highly symmetric HI spectrum can mask significant HI morphological asymmetries. The northern HI extension appears to be the result of a recent perturbation (10^8 yr), possibly by a satellite which is now disrupted or projected within the disk. This study provides an important step in our ongoing program to determine the predominant source of HI asymmetries in isolated galaxies. For CIG 340 the isolation from major companions, symmetric HI spectrum, optical morphology and interaction timescales have allowed us to narrow the possible causes the HI asymmetries and identify tests to further constrain the source of the asymmetries.Comment: 10 page

New Optimal Approach for the Identification of Takagi-Sugeno Fuzzy Model

A novel optimal method is developed to improve the identification and estimation of Takagi-Sugeno (TS) fuzzy model. The idea comes from the fact that the main drawback of T-S model is that it can not be applied when the membership functions are overlapped by pairs. This limits the application of the T-S model because this type of membership function has been widely used in the stability and controller design of fuzzy systems. It is also very popular in industrial control applications. The method presented here can be considered as a generalized version of T-S fuzzy model with optimized performance in approximating nonlinear functions. Various examples are chosen to show the high function approximation accuracy and fast convergence obtained by applying the proposed method in approximating nonlinear systems locally and globally in comparison with the original T-S model

Tests of star formation metrics in the low metallicity galaxy NGC 5253 using ALMA observations of H30α\alpha line emission

We use Atacama Large Millimeter/submillimeter Array (ALMA) observations of H30$\alpha$ (231.90 GHz) emission from the low metallicity dwarf galaxy NGC 5253 to measure the star formation rate (SFR) within the galaxy and to test the reliability of SFRs derived from other commonly-used metrics. The H30$\alpha$ emission, which originates mainly from the central starburst, yields a photoionizing photon production rate of (1.9$\pm$0.3)$\times$10$^{52}$ s$^{-1}$ and an SFR of 0.087$\pm$0.013 M$_\odot$ yr$^{-1}$ based on conversions that account for the low metallicity of the galaxy and for stellar rotation. Among the other star formation metrics we examined, the SFR calculated from the total infrared flux was statistically equivalent to the values from the H30$\alpha$ data. The SFR based on previously-published versions of the H$\alpha$ flux that were extinction corrected using Pa$\alpha$ and Pa$\beta$ lines were lower than but also statistically similar to the H30$\alpha$ value. The mid-infrared (22 $\mu$m) flux density and the composite star formation tracer based on H$\alpha$ and mid-infrared emission give SFRs that were significantly higher because the dust emission appears unusually hot compared to typical spiral galaxies. Conversely, the 70 and 160 $\mu$m flux densities yielded SFR lower than the H30$\alpha$ value, although the SFRs from the 70 $\mu$m and H30$\alpha$ data were within 1-2$\sigma$ of each other. While further analysis on a broader range of galaxies are needed, these results are instructive of the best and worst methods to use when measuring SFR in low metallicity dwarf galaxies like NGC 5253.Comment: 14 pages, 5 figures, accepted for publication in MNRA