Kernel alignment for identifying objective criteria from brain MEG recordings in schizophrenia

The current wide access to data from different neuroimaging techniques has permitted to obtain data to explore the possibility of finding objective criteria that can be used for diagnostic purposes. In order to decide which features of the data are relevant for the diagnostic task, we present in this paper a simple method for feature selection based on kernel alignment with the ideal kernel in support vector machines (SVM). The method presented shows state-of-the-art performance while being more efficient than other methods for feature selection in SVM. It is also less prone to overfitting due to the properties of the alignment measure. All these abilities are essential in neuroimaging study, where the number of features representing recordings is usually very large compared with the number of recordings. The method has been applied to a dataset in order to determine objective criteria for the diagnosis of schizophrenia. The dataset analyzed has been obtained from multichannel magnetoencephalogram (MEG) recordings, corresponding to the recordings during the performance of a mismatch negativity (MMN) auditory task by a set of schizophrenia patients and a control group. All signal frequency bands are analyzed (from d (1–4 Hz) to high frequency ¿ (60–200 Hz)) and the signal correlations among the different sensors for these frequencies are used as features.Peer ReviewedPostprint (author's final draft

Effects of customer knowledge management and customer orientation on innovation capacity and marketing results in SMEs: the mediating role of innovation orientation

Managing customer knowledge is a key of source for SMEs. The principal aim of this paper is to provide empirical evidence on the direct effects of two specific strategic resources: customer orientation and customer knowledge management (CKM), on innovation capacity and marketing results in SMEs. The study also examines the role of innovation orientation as a mediator between customer orientation and CKM. For this purpose, a structural model was proposed and tested through an empirical investigation with variance-based structural equation modeling (PLS) using a sample made up of 210 Spanish SMEs. The findings highlight the relevance of CKM and customer orientation as important strategic resources for developing innovation capacity and marketing results, and they confirm the mediation effect of innovation orientation. Empirical evidence supports the importance of customer orientation and CKM in boosting innovation and performance. These findings have important implications for performance in SMEs

Propuesta de sistema de derivación regional de pacientes:una oportunidad para la cooperación sur-sur

Teniendo en cuenta la problemática que muchas veces genera el acceso al sistema público de salud por parte de inmigrantes que carecen de políticas de desarrollo asistencial adecuadas, es necesario, teniendo en cuenta las implicancias del derecho a la salud y de la calidad de vida, generar un sistema regional de derivación de pacientes, el cual, financiado por un fondo dentro del marco de la cooperación sur-sur, permita financiar la atención médica y generar un recupero del gasto

La autonomía del derecho sanitario en la organización institucional de las provincias argentinas

Una vez planteada la autonomía del derecho sanitario en la Argentina, a partir de sentar sus bases, se observará la relación a través de los distintos niveles de gobierno, ya que la existencia de un Estado Federal en la Argentina se traduce en un sistema jurídico multinivel y plurilegislativo en el cual coexisten diversos ordenamientos jurídicos. Por ello resulta necesario conocer el ámbito de competencia específico de cada orden de gobierno y que asuma fundamental importancia la articulación y cooperación en las relaciones intergubernamentales, lo que no está exento de algunas dificultades: ¿En qué consisten los deberes positivos de los distintos órdenes de gobierno, cuál es su alcance y quiénes responden por su cumplimiento? Así como la doctrina ha trabajado muchas cuestiones atinentes a la organización institucional de las provincias argentinas, ha faltado, a nuestro criterio, un estudio transversal en relación con una rama del derecho sumamente importante: el derecho sanitario

Propuesta de sistema de derivación regional de pacientes:una oportunidad para la cooperación sur-sur

Teniendo en cuenta la problemática que muchas veces genera el acceso al sistema público de salud por parte de inmigrantes que carecen de políticas de desarrollo asistencial adecuadas, es necesario, teniendo en cuenta las implicancias del derecho a la salud y de la calidad de vida, generar un sistema regional de derivación de pacientes, el cual, financiado por un fondo dentro del marco de la cooperación sur-sur, permita financiar la atención médica y generar un recupero del gasto

Amistad y cooperación en las fronteras argentinochilenas: el caso de los “Hielos Continentales” o “Campo de Hielo Sur”. Una propuesta de soberanía compartida y “sustentable

From the literature review and technical analysis regarding the concept and the legal and political influence exerted by the “friendship” in international relations, it will be seek to implement that “corpus” to the consideration of Argentine-Chilean overall bilateral ties, and referred specifically to the issue of “Southern Ice Field” or “Continental Ice”, and finally outline a proposal for the exercise, after being met a number of paces of shared sovereignty in that geographical area, in the form of international condominium, considering that despite the 1998 Treaty was signed, to date it has not been possible to demarcate a part of the territory covered by the agreement, a fact that conspires against the sustainability of the area under discussion, obstructing the matrix of “strategic friendship” that the parties opened in 1984, to resolve the conflict of the Beagle.A partir de la revisión bibliográfica y el análisis técnico respecto al concepto y la influencia jurídica y política que ejerce la “amistad” en las relaciones internacionales, se procurará aplicar ese “corpus” al examen de los vínculos bilaterales argentino-chilenos en general, y concretamente a la denominada cuestión de “Campo de Hielo Sur” o “Hielos Continentales”, para esbozar finalmente una propuesta para el ejercicio-luego de cumplirse una serie de pasos- de soberanía compartida en dicho espacio geográfico, bajo la modalidad del condominio internacional, teniendo en cuenta que, pese a haberse firmado el Tratado de 1998, a la fecha no se ha podido demarcar una parte del territorio comprendido por el acuerdo, hecho que conspira contra la sustentabilidad de la zona bajo discusión y que obstruye la matriz de “amistad estratégica” que las partes inauguraron en 1984, al resolver el conflicto del Beagle

Kernel alignment for identifying objective criteria from brain MEG recordings in schizophrenia

The current wide access to data from different neuroimaging techniques has permitted to obtain data to explore the possibility of finding objective criteria that can be used for diagnostic purposes. In order to decide which features of the data are relevant for the diagnostic task, we present in this paper a simple method for feature selection based on kernel alignment with the ideal kernel in support vector machines (SVM). The method presented shows state-of-the-art performance while being more efficient than other methods for feature selection in SVM. It is also less prone to overfitting due to the properties of the alignment measure. All these abilities are essential in neuroimaging study, where the number of features representing recordings is usually very large compared with the number of recordings. The method has been applied to a dataset in order to determine objective criteria for the diagnosis of schizophrenia. The dataset analyzed has been obtained from multichannel magnetoencephalogram (MEG) recordings, corresponding to the recordings during the performance of a mismatch negativity (MMN) auditory task by a set of schizophrenia patients and a control group. All signal frequency bands are analyzed (from d (1–4 Hz) to high frequency ¿ (60–200 Hz)) and the signal correlations among the different sensors for these frequencies are used as features.Peer Reviewe

Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008

Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertension. A MedDiet rich in OO and OO per se has been shown to improve cardiovascular risk factors, such as lipid profiles, blood pressure, postprandial hyperlipidemia, endothelial dysfunction, oxidative stress, and antithrombotic profiles. Some of these beneficial effects can be attributed to the OO minor components. Therefore, the definition of the MedDiet should include OO. Phenolic compounds in OO have shown antioxidant and anti-inflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Observational studies from Mediterranean cohorts have suggested that dietary MUFA may be protective against age-related cognitive decline and Alzheimer's disease. Recent studies consistently support the concept that the OO-rich MedDiet is compatible with healthier aging and increased longevity. In countries where the population adheres to the MedDiet, such as Spain, Greece and Italy, and OO is the principal source of fat, rates of cancer incidence are lower than in northern European countries. Experimental and human cellular studies have provided new evidence on the potential protective effect of OO on cancer. Furthermore, results of case-control and cohort studies suggest that MUFA intake including OO is associated with a reduction in cancer risk (mainly breast, colorectal and prostate cancers).CIBEROBN is an initiative of ISCIII and CEAS Foundation, Spain.Peer reviewe