Meningkatkan Kreativitas Dengan Pelatihan Bahan Keras Dengan Teknik Anyaman Bagi Siswa SMPK Trimulia HITS

Sesuai dengan kurikulum 2013 revisi 2016 salah satu Kompetensi Dasar siswa-siswi SMP di bidang kerajinan adalah memahami pengetahuan tentang jenis, sifat, karakter dan teknik pengolahan bahan olahan (kali ini menggunakan Busa Eva).SMPK Trimulia HITS mengajukan permohonan pelatihan untuk memperluas wawasan bagi guru maupun siswa tentang alternatif pengolahan bahan keras.  Dengan demikian tim FSRD mencari ide kriya dengan struktur sekaligus finishing yang tergabung dari dua material , tidak sekedar hanya menempelkan satu material di atas material lainnya. Materi yang diusulkan adalah busa eva, karena mudah untuk dipotong, dimanipulasi dengan cara ditekuk , dilengkungkan dan dapat dengan mudah dijahit. Adapun kriya yang diajarkan selalu berusaha memasukkan unsur-unsur kriya tradisional Indonesia , dalam hal ini adalah anyaman. Unsur menganyam akan dimasukkan untuk memperkuat pertemuan dua material antara busa eva dan benang yang dijalin atau dianyam membentuk tekstil. Pelatihan ini diharapkan dapat menumbuhkan kreativitas peserta didalam bidang seni dan mendukung perkembangan motorik peserta

Yeast as a Model System to Study Tau Biology

Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease. In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanisms of tau toxicity remain unanswered. In this paper we will highlight some of the processes involved in tau biology and pathology, focusing on tau phosphorylation and the interplay with oxidative stress. In addition, we will introduce the development of a human tau-expressing yeast model, and discuss some crucial results obtained in this model, highlighting its potential in the elucidation of cellular processes leading to tau toxicity

Valoración Ambiental Programa de Gestión Ambiental del Banco de Material “WAPI” Proyecto“Mejoramiento o del Camino La Esperanza-WAPÍ TRAMO I: EST. 0+000 – EST. 15+200 TRAMO II: EST. 15+200 – EST. 32+000

El presente trabajo se registra dentro de la línea de investigación de la Facultad de Ciencias Económicas, Departamento de Economía Agrícola, y en el cual se abordan las directrices que inciden para realizar una evaluación ambiental. El proyecto en estudio es la Valoración Ambiental para la explotación de un banco de materiales, localizado en las afueras del poblado de Wapí del Municipio del Rama de la Región Autónoma de la Costa Caribe Sur, del Proyecto Mejoramiento del Camino La Esperanza – Wapí 32 Km, el cual es de categoría III por ser un proyecto que presenta impactos moderados al medio ambiente. El documento contiene las características generales del proyecto, el marco legal, la identificación de los factores y evaluación de los mismos en cuanto al nivel de impacto que estos causan sobre el medio ambiente durante las diferentes actividades en la fase de construcción, operación y cierre. Así mismo se propone el Programa de Gestión Ambiental (PGA) siguiendo todos los requerimientos y requisitos del Decreto No. 20-2017, que se denomina Sistema de Evaluación Ambiental de Permisos y Autorizaciones para el Uso Sostenible de los Recursos Naturales

SURFICIAL GEOLOGY OF YORK COLLEGE CAMPUS (QUEENS) AND MONTAUK POINT (LONG ISLAND): AN OPEN ACCESS TO GEOSCIENCE EDUCATION

To evaluate compositional and textural differences among the samples collected from York College (YC) campus (Queens), Montauk Point (MP) and Hither Hills (HH), Long Island, emphasis is given to the general geologic setting, overall grain size distribution, and relative abundances of light and heavy mineral assemblages. Geologic setting encompasses outwash plains (York College), fluvioglacial and glacial (Montauk Point) and beach and dune complex (Hither Hills). YC samples were collected from depth ranging 40 cm to 250 cm and are mostly an assortment of medium to coarse sand, granule to cobble sized, minor silt, and clay. Presence of low angle cross bedding was noted within the sandy unit located around 150 cm from the surface and melt-water dominated transport can also be associated with this feature. MP sand samples largely collected from the beach were mostly free of finer fraction and preponderance of coarse-sand sized grains is highly noticeable. Scattered presence of purple sand often containing garnet, magnetite, rutile, monazite, and tourmaline is suggestive of hydraulic sorting due to wave action and provenance of purple sand is presumed to be intermediate to mafic clasts associated with coastal bluff. Magnetite abundances within the purple sand range from 5% to 20%. HH sands are representative of both beach and dune complex and showing prominent cross bedding with foresets accentuated by heavy minerals. Dominant grain size is medium to fine-grained and well sorted sand. Subtle differences in terms of mineral assemblages including quartz, feldspar, muscovite, biotite, garnet, zircon, monazite, rutile, and tourmaline within the YC, MP, and HH samples suggest slight variation of the source rock composition and overall grain size trends also point to a particular sedimentary environment of deposition. These locations are easily accessible and form a great field geology sites for understanding surficial geology of Queens and Long Island and recent glacial activity that sculptured the landscapes. K9-16 earth science students can greatly benefit by having this opportunity located close to the urban setting of New York. Department of Education Grant titled Enhancing Talents of African American Students funded this research project

Sintomas depressivos e distúrbios motores axiais em indivíduos com doença de Parkinson : um estudo transversal

Background: Depression is an important nonmotor symptom of Parkinson's disease (PD) and has been associated with the motor symptoms in these individuals. Objectives: To determine whether there are relationships between depressive symptoms and abnormalities in axial postural alignment and axial motor deficits, especially postural instability, and trunk rigidity in PD. Methods: In this cross-sectional study, 65 individuals were evaluated using the Beck Depression Inventory-II (BDI-II) for the analysis of depressive symptoms and underwent a postural assessment of head, trunk, and hip sagittal alignment through computerized photogrammetry. The MDS-UPDRS was used to assess clinical aspects of PD, the Trunk Mobility Scale was used to assess axial rigidity, and the MiniBESTest to assess balance. To determine the relationship between depressive symptoms and postural alignment, multiple linear regression analysis was performed. Results: The participants with depressive symptoms had more severe motor deficits as well as greater trunk rigidity and worse postural instability (p < 0.05). When the postural angles were compared between men and women using Student's t-test, it was found that men had greater flexion angles of the head (p = 0.003) and trunk (p = 0.017). Using multiple linear regression analysis corrected for the age and sex of the participants, we verified that the anterior trunk inclination was significantly larger in the PD population with depressive symptoms (R2 = 0.453, β = 0.116, and p = 0.045). Conclusion: PD individuals with depressive symptoms have more severe flexed trunk posture, mainly in older men. Additionally, more severe depressive symptoms are associated with worsening postural instability, trunk rigidity and motor deficits in this population.Antecedentes: A depressão é um sintoma não motor importante da doença de Parkinson (DP) e tem sido associada aos sintomas motores nesses indivíduos. Objetivos: Determinar se existem relações entre sintomas depressivos e anormalidades no alinhamento postural axial e déficits motores axiais, especialmente instabilidade postural e rigidez de tronco na DP. Métodos: Neste estudo transversal, 65 indivíduos foram avaliados pelo BDI-II para análise de sintomas depressivos e submetidos à avaliação postural do alinhamento sagital de cabeça, tronco e quadril por meio de fotogrametria computadorizada. A MDS-UPDRS avaliou os aspectos clínicos, TMS avaliou rigidez axial e o MiniBESTest equilíbrio. Para determinar a relação entre sintomas depressivos e alinhamento postural, realizou-se uma análise de regressão linear múltipla. Resultados: Os participantes com sintomas depressivos apresentaram déficits motores mais graves, bem como maior rigidez de tronco e pior instabilidade postural (p < 0,05). Quando comparados os ângulos posturais entre homens e mulheres pelo teste t de Student, verificou-se que os homens apresentaram maiores graus de flexão da cabeça (p = 0,003) e do tronco (p = 0,017). Por meio da análise de regressão linear múltipla corrigida para a idade e sexo dos participantes, verificamos que a inclinação anterior do tronco foi significativamente maior nos indivíduos com DP com sintomas depressivos do que sem sintomas depressivos (R2 = 0,453, β = 0,116 e p = 0,045) Conclusão: Indivíduos com DP com sintomas depressivos apresentam postura de tronco flexionado mais severa, principalmente em homens mais idosos. Além disso, os sintomas depressivos mais graves pioram significativamente a instabilidade postural, a rigidez do tronco e os déficits motores nessa população

The CAST study protocol:A cluster randomized trial assessing the effect of circumferential casting versus plaster splinting on fracture redisplacement in reduced distal radius fractures in adults

Background There is no consensus concerning the optimal casting technique for displaced distal radius fractures (DRFs) following closed reduction. This study evaluates whether a splint or a circumferential cast is most optimal to prevent fracture redisplacement in adult patients with a reduced DRF. Additionally, the cost-effectiveness of both cast types will be calculated. Methods/design This multicenter cluster randomized controlled trial will compare initial immobilization with a circumferential below-elbow cast versus a below-elbow plaster splint in reduced DRFs. Randomization will take place on hospital-level (cluster, n = 10) with a cross-over point halfway the inclusion of the needed number of patients per hospital. Inclusion criteria comprise adult patients (≥ 18 years) with a primary displaced DRF which is treated conservatively after closed reduction. Multiple trauma patients (Injury Severity Score ≥ 16), concomitant ulnar fractures (except styloid process fractures) and patients with concomitant injury on the ipsilateral arm or inability to complete study forms will be excluded. Primary study outcome is fracture redisplacement of the initial reduced DRF. Secondary outcomes are patient-reported outcomes assessed with the Disability Arm Shoulder Hand score (DASH) and Patient-Rated Wrist Evaluation score (PRWE), comfort of the cast, quality of life assessed with the EQ-5D-5L questionnaire, analgesics use, cost-effectiveness and (serious) adverse events occurence. In total, 560 patients will be included and followed for 1 year. The estimated time required for inclusion will be 18 months. Discussion The CAST study will provide evidence whether the type of cast immobilization is of influence on fracture redisplacement in distal radius fractures. Extensive follow-up during one year concerning radiographic, functional and patient reported outcomes will give a broad view on DRF recovery. Trial registration Registered in the Dutch Trial Registry on January 14th 2020. Registration number: NL8311

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

The evolutionary conserved TOR complex 1 controls growth in response to the quality and quantity of nutrients such as carbon and amino acids. The protein kinase Sch9 is the main TORC1 effector in yeast. However, only few of its direct targets are known. In this study, we performed a genome-wide screening looking for mutants which require Sch9 function for their survival and growth. In this way, we identified multiple components of the highly conserved vacuolar proton pump (V-ATPase) which mediates the luminal acidification of multiple biosynthetic and endocytic organelles. Besides a genetic interaction, we found Sch9 also physically interacts with the V- ATPase to regulate its assembly state in response to glucose availability and TORC1 activity. Moreover, the interaction with the V-ATPase has consequences for ageing as it allowed Sch9 to control vacuolar pH and thereby trigger either lifespan extension or lifespan shortening. Hence, our results provide insights into the signaling mechanism coupling glucose availability, TORC1 signaling, pH homeostasis and longevity. As both Sch9 and the V-ATPase are highly conserved and implicated in various pathologies, these results offer fertile ground for further research in higher eukaryotes

FRESH COOLER

Hoy en día las tendencias por lo saludable están en ascenso, las circunstancias de salubridad mundial nos exigen pensar más en el bienestar propio y en las costumbres alimenticias a adoptar para reducir situaciones médicas de riesgo, es necesario adoptar una cultura de comidas saludables buscando soluciones que nos faciliten llevar a cabo actividades relacionadas a ella. El presente trabajo de investigación está basado en la elaboración de contenedores con filtros de etileno, los cuales preservan por más tiempo los alimentos perecibles (frutas y verduras); buscamos replicar y traer al mercado doméstico una experiencia real aplicada hoy en la exportación de estos productos alrededor del mundo; basados en la investigación de mercado del proyecto evidenciamos que nuestro producto facilita el almacenamiento y la conservación de dichos alimentos. Este proyecto muestra las bondades del Filtro de Etileno que alarga la vida de alimentos perecibles a través de un compuesto químico llamado Permanganato de Potasio que, gracias a su propiedad antibacterial y aplicación aprobada para alimentos, elimina las bacterias que producen la oxidación de frutas. En estos momentos donde salir de casa o comprar con frecuencia representa un riesgo para la salud consideramos que nuestro producto solucionará este problema y reducirá considerablemente las perdidas por descomposición. La empresa venderá los productos a través del canal retail, para llegar a más familias peruanas, el precio varía según el tamaño, pequeño S/22.00, mediano: S/29.00 y grande S/39.00. Los filtros de Etileno se importarán de Italia y los envases de vidrio de China.Today the trends for healthy are on the rise, the circumstances of global health require us to think more about our well-being and the eating habits to adopt to reduce risky medical situations, it is necessary to adopt a culture of healthy meals looking for solutions that facilitate us to carry out activities related to it. The present research work is based on the elaboration of containers with ethylene filters, which preserve perishable foods (fruits and vegetables) for a longer time; We seek to replicate and bring to the domestic market a real experience applied today in the export of these products around the world; Based on the project's market research, we show that our product facilitates the storage and preservation of these foods. This project shows the benefits of the Ethylene Filter that lengthens the life of perishable foods through a chemical compound called Potassium Permanganate that, thanks to its antibacterial property and approved application for food, eliminates bacteria that cause oxidation of fruits. At these times were leaving home or shopping frequently represents a health risk, we believe that our product will solve this problem and considerably reduce losses due to decomposition. The company will sell the products through the retail channel, to reach more Peruvian families, the price varies according to size, small S / 22.00, medium: S / 29.00 and large S / 39.00. Ethylene filters will be imported from Italy and glass containers from China.Trabajo de investigació