Investigation of the relationship between mean platelet volume and obstructive sleep apnea syndrome

Objective: Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent upper airway obstruction and intermittent hypoxia during sleep. Intermittent hypoxia and increased inflammatory activity plays a role in increased risk of cardiovascular disease in the OSAS. OSAS is an important cause of morbidity and mortality and cardiovascular disorders are the most important complications of OSAS. Mean platelet volume (MPV) is a marker of platelet activation and function, and increased platelet volume is associated with increased platelet activity. Different diseases related with inflammation, hypoxia, vascular injury, thrombosis and atherosclerosis were found to be associated with MPV. In this study, we aimed to investigate the relationship between OSAS and MPV. Methods: In this retrospective study, data of sex and age matched 33 patients with moderate OSAS, 34 patients with severe OSAS and 30 healthy subjects were evaluated. Results: The mean MPV was found in control, moderate OSAS and severe OSAS groups as 7.83±1.00, 8.26±1.40 and 8.94±1.20 (fL) respectively. The mean MPV value was significantly higher in severe OSAS group than control subjects (p=0.001). In correlation analysis, there were positive correlation between MPV with apnea-hypopnea index and total sleep time, and negative correlation between MPV with platelet count and minimum oxygen saturation (Respectively, p=0.003 / R=0.295, p=0.030 / R=0.221, p=0.011 / R= -0.257, p=0.019 / R= -0.238). Conclusion: In this study, the increased MPV was associated with severe OSAS and the results of this study suggest that the platelet activation is increased in OSAS. Hypoxia caused by OSAS, due to the activated platelets, may play a role in the development of cardiovascular diseases which is an important cause of morbidity and mortality in OSAS. J Clin Exp Invest 2013; 4 (4): 492-49

Fracture Resistance Of Endodontically Treated Teeth Restored With Or Without Post Systems

Background/purpose: The aim of this study was to determine and compare the fracture resistance of endodontically treated teeth restored with or without posts. Materials and methods: Undamaged, extracted human premolar teeth (48 in total) were randomly divided into four groups of 12 each. Clinical crowns of the teeth were cut 3 mm coronal to the cementoenamel junction. Root canals were enlarged using rotary canal instruments (Dentsply) and filled with gutta-percha (Dentsply) as well as a sealer (AH 26, De Trey). In all groups, gutta-percha was removed, and the post space was prepared using tapered drills (FRC Postec post kit, Ivoclar Vivadent). The first group of fiber-reinforced composite posts (FRC Postec Plus, Ivoclar Vivadent) and the second group of Ever Stick posts (Stick Tech) were luted into the root canals using dual curing resin cement (Variolink II, Ivoclar Vivadent). In the third group, post spaces were filled using a hybrid resin composite (Tetric Evo Ceram, Ivoclar Vivadent). The fourth group served as a control with direct resin composite core reconstruction formed without a post. Composite cores were constructed with a hybrid resin composite (Tetric Evo Ceram, Ivoclar Vivadent) in all groups. Fracture loading was accomplished using an universal testing machine at a crosshead speed of 1 mm/min in compression mode. Results: There were no statistically significant differences between the fracture resistance values for the four experimental groups (P > 0.05). Conclusions: Fiber-reinforced posts can be used as a core material in endodontically treated teeth as well as composite core reconstructions. Copyright (C) 2012, Association for Dental Sciences of the Republic of China. Published by Elsevier Taiwan LLC. All rights reserved.WoSScopu

BARYUM ASPİRASYONU: OLGU SUNUMU

ÖzetBaryumlu grafilerin çekimi sırasında baryum aspirasyonu nadir görülmekte olup, baryum aspire eden hastalar asemptomatik olabileceği gibi ölümle sonuçlanan vakalarda bildirilmiştir. Biz burada yutma güçlüğü nedeniyle baryumlu özefagus grafisi çekimi sırasında baryum aspire eden bir olgu sunuyoruz. 77 yaşında erkek hasta baryumlu özefagus grafisi çekimi sırasında gelişen öksürük, nefes darlığı şikayetleri ile acil servise başvurdu. Akciğer grafisinde; her iki ana bronşta ve sol akciğer alt zon medial bölümündeki bronşlarda opak madde izlendi. Hasta göğüs hastalıkları kliniğine baryum aspirasyonu tanısı ile yatırıldı. Toraks BT’de; özefagus proksimal kısmında trakeaya bası ve invazyon oluşturan kitle lezyonu izlendi. Bronkoskopi’de trakea arka duvarda dıştan bası ile daralma, mukozada infiltrasyon, ana karinada küntleşme izlendi. Trakea, ana karina düzeyinden punch biyopsi yapıldı. Biyopsi sonucu; yassı hücreli karsinom olarak raporlandı. Onkoloji kliniğiyle konsülte edilen hasta bu kliniğe devredildi.Anahtar Kelimeler: Baryum sülfat, Özefagus karsinomu, Solunumla aspirasyo

Aortic valve replacement with on-pump beating heart technique

Background: The aim of this study was to assess the efficacy and applicability of on-pump beating heart aortic valve replacement with retrograde coronary sinus (CS) warm blood perfusion. Methods: The prospective study included 14 consecutive patients who underwent aortic valve replacement with mechanical prosthesis using retrograde CS perfusion. The operative variables and early outcome of this procedure are presented. Results: Retrograde CS perfusion and venting the heart from the pulmonary vein provided good visualization of the operative field and performance of the operations without any difficulty. Partial oxygen pressures of CS perfusion blood and the returning blood from the coronary ostia were 288.5 +/- 34.4 and 39.6 +/- 4.6 mmHg, respectively. Postoperative peak creatine kinase-MB and troponin T values were mean 77.0 +/- 63.6 IU/L and mean 0.8 +/- 0.7 ng/mL, respectively. No mortality or major complication was observed and all the patients were discharged from the hospital in good condition. Conclusions: On-pump beating heart aortic valve replacement with retrograde CS warm blood perfusion is a good surgical option, and has the advantage of maintaining physiologic condition of the heart throughout the procedure