Dynamic symptom networks across different at-risk stages for psychosis:An individual and transdiagnostic perspective

The clinical staging model distinguishes different stages of mental illness. Early stages, are suggested to be more mild, diffuse and volatile in terms of expression of psychopathology than later stages. This study aimed to compare individual transdiagnostic symptom networks based on intensive longitudinal data between individuals in different early clinical stages for psychosis. It was hypothesized that with increasing clinical stage (i) density of symptom networks would increase and (ii) psychotic experiences would be more central in the symptom networks. Data came from a 90-day diary study, resulting in 8640 observations within N = 96 individuals, divided over four subgroups representing different early clinical stages (n1 = 25, n2 = 27, n3 = 24, n4 = 20). Sparse Time Series Chain Graphical Models were used to create individual contemporaneous and temporal symptom networks based on 10 items concerning symptoms of depression, anxiety, psychosis, non-specific and vulnerability domains. Network density and symptom centrality (strength) were calculated individually and compared between and within the four subgroups. Level of psychopathology increased with clinical stage. The symptom networks showed large between-individual variation, but neither network density not psychotic symptom strength differed between the subgroups in the contemporaneous (pdensity = 0.59, pstrength > 0.51) and temporal (pdensity = 0.75, pstrength > 0.35) networks. No support was found for our hypothesis that higher clinical stage comes with higher symptom network density or a more central role for psychotic symptoms. Based on the high inter-individual variability, our results highlight the importance of individualized assessment of symptom networks

Guidelines For The Standardization Of Preanalytic Variables For Blood-based Biomarker Studies In Alzheimer\u27s Disease Research

The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer\u27s disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field to foster cross-validation across cohorts and laboratorie

Large pore REE/Al pillared bentonites: Preparation, structural aspects and catalytic properties

Ce/Al and La/Al pillared bentonites were prepared by cation-exchange of different bentonites with hydrothermally treated (130-160°C for 16-136 h) solutions containing mixtures of aluminiumchlorohydrate (ACH) and REE (Ce and La)-salts. After calcination at 500°C the pillared clays are characterised by basal spacings of 24.8-25.7 A, and have BET surface areas of approximately 430 m/g. The pillared products are hydrothermally stable to at least 500°C. The large basal spacings and surface areas are due to the formation of large REE/Al containing polyoxycations. The formation of this cation is favoured by high initial Al concentrations (≥ 3.7 M) and an OH/Al molar ratio of approximately 2.5. Ce/Al or La/Al ratios can be as low as 1/30. Hydroconversion of n-heptane indicated that the activity of these materials is higher than that of a conventional Pt loaded amorphous silica alumina (ASA) reference catalyst. The selectivity is strongly dependant on the type of starting clay. In industrial hydrocracking of normal feedstock, a Ni/W loaded REE/Al pillared clay catalyst showed slightly higher initial activity than the ASA reference catalyst. However, the pillared clay catalyst showed rapid deactivation due to coke-formation, which reduced the surface area and pore volume. Additionally coke formation may be facilitated by the relatively high iron content of the pillared bentonite (3.43 wt%)

Preparation, structural characteristics and catalytic properties of large-pore rare earth element (Ce, La)/Al-pillared smectites

Ce/Al- and La/Al-pillared smectites were prepared by cation exchange of bentonite, saponite and laponne with hydrothermally treated (130-160 °C for 16-136 h) solutions containing mixtures of aluminumchlorohydrate (ACH) and Ce-/and La-salts. After calcination at 500 °C, the pillared products are characterized by basal spacings between 24.8 and 25.7 Å and surface areas of approximately 430 m g. The products are hydrothermally stable at 500 °C after 2 h in steam. The large basal spacings are due to the formation of a large Ce/La-bearing Al-polyoxocation, whose formation is favored by initially high Al concentrations ≥3.7 M and an OH/Al molar ratio of approximately 2.5. The Ce/Al or La/Al molar ratios can be as low as 1/30. Al nuclear magnetic resonance (NMR) spectroscopy has shown that the polyoxocation has a higher Al/Al ratio than the Keggin structure Al, which may partly explain the higher stability compared to normal Al-pillared clays. Hydroconversion of n-heptane indicated that the activity of the Pt-loaded pillared products is higher than that of a conventional Pt-loaded amorphous silica-alumina catalyst. Selectivity is strongly dependent on the type of starting clay and its acidity In industrial hydrocracking of normal feedstock, a Ni/W-loaded Ce/Al-pillared bentonite catalyst showed rapid deactivation due to coke-formation reducing the surface area and the pore volume. Additionally coke-formation is facilitated by the relatively high iron content of the pillared bentonite (3.43 wt% FeO)

Ascending and Descending VPs in English

We argue that English allows both rightward-descending VP shell structures and more traditional rightward-ascending VPs. The choice between these depends on case theory and economy. Case theory triggers VP shell formation whenever the verb is merged with a DP object after it has been merged with some other category. The reason is that VP shell formation allows verb and object to surface in adjacent positions, a prerequisite for case licensing in English. Economy has the effect that in all other circumstances, VP shell formation is blocked. Our argument is based on a range of intricate data, many of which involve the distribution of object-oriented floating quantifiers. We end with a discussion of the binding data that are often taken to support a uniformly descending structure—incorrectly, in our view

Social brains on drugs: tools for neuromodulation in social neuroscience

Neuromodulators such as serotonin, oxytocin, and testosterone play an important role in social behavior. Studies examining the effects of these neuromodulators and others on social cognition and behavior, and their neural underpinnings, are becoming increasingly common. Here, we provide an overview of methodological considerations for those wishing to evaluate or conduct empirical studies of neuromodulation in social neuroscience