Business administration as a basis for development of global entrepreneurship

The purpose of the article is to determine the role and meaning of business administration in development of global entrepreneurship. The work uses the proprietary methodology of evaluation of global competitiveness of enterprise and the proprietary methodology of evaluation of efficiency of business administration of enterprise, as well as method of correlation analysis. The authors determine the role of business administration in management of factors of development of global enterprise and offer the proprietary structural and logical model of organization of the process of business administration of global enterprise as a perspective tool for provision of global competitiveness of business and development of global entrepreneurship on the whole. The authors come to the conclusion that business administration is a basis for development of global entrepreneurship and plays an important role in this process, which consists in managing other internal and external factors of functioning of global business.peer-reviewe

Hydropower in Russia: Case Study on Hydrological Management of the Volga-Kama Cascade

The capacity of hydroelectric power plants (HPPs) in the Russian Federation (RF) exceeds 50 GW. It is about 20% of the total capacity of all power plants in the country. The Volga River basin is the biggest in Europe with the catchment area of 1 360 000 km2. It covers the most populated and most industrialized part of the European Russia. The largest cascade of reservoirs in Russia and Europe is the Volga-Kama cascade (VKC) constructed in 1930–1980. It consists of 12 great water reservoirs and HPPs with total capacity about 12 GW. The main peculiarity for the VKC management is the combination of different requirements by various economy sectors: safety, energy, navigation, water needs for domestic and industrial services, agriculture and fishery, recreation and ecological rules. These sectors often make conflicting demands for the VKC operation. The VKC management principle is to balance and satisfy all of them taking into account the changing climate and economical effectiveness. Modern decisions for the VKC management are based on two principles. First is the constant optimization of the whole VKC management rules, taking into account both climate change and the Strategy of the country development. The second is the constant technical modernization of the VKC equipment to achieve the best economical effectiveness and safety for ecosystems and population

Bag-breakup fragmentation as the dominant mechanism of sea-spray production in high winds

Peer reviewe

Phenological shifts of abiotic events, producers and consumers across a continent

Ongoing climate change can shift organism phenology in ways that vary depending on species, habitats and climate factors studied. To probe for large-scale patterns in associated phenological change, we use 70,709 observations from six decades of systematic monitoring across the former Union of Soviet Socialist Republics. Among 110 phenological events related to plants, birds, insects, amphibians and fungi, we find a mosaic of change, defying simple predictions of earlier springs, later autumns and stronger changes at higher latitudes and elevations. Site mean temperature emerged as a strong predictor of local phenology, but the magnitude and direction of change varied with trophic level and the relative timing of an event. Beyond temperature-associated variation, we uncover high variation among both sites and years, with some sites being characterized by disproportionately long seasons and others by short ones. Our findings emphasize concerns regarding ecosystem integrity and highlight the difficulty of predicting climate change outcomes. The authors use systematic monitoring across the former USSR to investigate phenological changes across taxa. The long-term mean temperature of a site emerged as a strong predictor of phenological change, with further imprints of trophic level, event timing, site, year and biotic interactions.Peer reviewe

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Medusomyces gisevii L.: cultivation, composition, and application

Tea fungus (Medusomyces gisevii L.) is a natural symbiotic consortium of yeast-like fungi and bacteria. Scientific literature provides a lot of information about the consortium, but it is largely fragmentary. We aimed to review and systematize the information on the research topic. We studied scientific publications, conference proceedings, intellectual property, regulatory documents, and Internet resources on the M. gisevii consortium using Scopus, Web of Science, e.LIBRARY.RU, and Google Academy. The methods applied included registration, grouping, classification, comparative analysis, and generalization. We described the origin and composition of tea fungus, specifying the microorganisms that make up its symbiotic community depending on the place of origin. Then, we reviewed the stages of fermentation and cultivation conditions in various nutrient media and presented the composition of the culture liquid. Finally, we analyzed the antimicrobial effect of M. gisevii on a number of microorganisms and delineated some practical uses of the fungus. The data presented in this article can be used to analyze or develop new methods for the cultivation and application of M. gisevii. We specified some possibilities for using not only the culture liquid but also the fruit body of the fungus in various industries

Simulation of the ENSO influence on the extra-tropical middle atmosphere

Abstract The impact of the El Niño Southern Oscillation (ENSO) on the Northern Hemisphere mid-winter zonal wind, temperature, and stationary planetary waves (SPWs) is evaluated using the Middle and Upper Atmosphere Model and Modern-Era Retrospective Analysis for Research and Applications (MERRA). The composites determined using simulated ensembles and MERRA winters with different ENSO phases show that the mean zonal wind in the stratosphere at higher-middle latitudes is weaker and polar region is warmer, and the activity of SPW1 is higher during El Niño events. The simulated and observed SPW2 amplitude behaves in the opposite way, and it is stronger in the stratosphere during La Niña. The observed changes of SPW1 and SPW2 amplitudes under La Niña and El Niño events should affect an efficiency of the stratosphere–troposphere coupling in different longitudinal sectors through the changes in horizontal distributions of the downward wave activity flux

PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity

Photochromic tungsten oxide (WO3) nanoparticles stabilized by polyvinylpyrrolidone (PVP) were synthesized to evaluate their potential for biomedical applications. PVP-stabilized tungsten oxide nanoparticles demonstrated a highly selective cytotoxic effect on normal and cancer cells in vitro. WO3 nanoparticles were found to induce substantial cell death in osteosarcoma cells (MNNG/HOS cell line) with a half-maximal inhibitory concentration (IC50) of 5 mg/mL, while producing no, or only minor, toxicity in healthy human mesenchymal stem cells (hMSc). WO3 nanoparticles induced intracellular oxidative stress, which led to apoptosis type cell death. The selective anti-cancer effects of WO3 nanoparticles are due to the pH sensitivity of tungsten oxide and its capability of reactive oxygen species (ROS) generation, which is expressed in the modulation of genes involved in reactive oxygen species metabolism, mitochondrial dysfunction, and apoptosis

Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances

Ionising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi treatments, the rapid development of clear phenotypes, and sensitivity to ionising radiation, combined with new genomic technologies, make planarians an outstanding tool for the discovery of potential radioprotective agents. In this work, using the well-known antioxidant N-acetylcysteine, planarians are, for the first time, shown to be an excellent model system for the fast and effective screening of novel radioprotective and radio-sensitising substances. In addition, a panel of measurable parameters that can be used for the study of radioprotective effects on this model is suggested

Manifestations of Different El Ni&ntilde;o Types in the Dynamics of the Extratropical Stratosphere

The behavior of planetary waves and their influence on the global circulation of the Northern Hemisphere during different El Ni&ntilde;o types is studied. Three sets of five boreal winters were chosen for each El Ni&ntilde;o type: Modoki I and II and canonical El Ni&ntilde;o. Based on data of the Japanese 55-year Reanalysis and the Modern-Era Retrospective Analysis for Research and Applications, the spatio-temporal structure of planetary waves and the residual mean circulation were analyzed. The results show that the canonical El Ni&ntilde;o type is characterized by the weakest wave activity in March. It is also demonstrated that warming of the polar stratosphere, accompanied by maximizing wave activity and weakening of the zonal wind, may lead to earlier stratospheric polar vortex collapse and the early spring transition under Modoki I conditions. This study is the next step in understanding of the so-called long-range teleconnections, consisting of the propagation of a signal from the tropical El Ni&ntilde;o Southern Oscillation source into the polar stratosphere