Forestomach pH in hunted roe deer ( Capreolus capreolus ) in relation to forestomach region, time of measurement and supplemental feeding and comparison among wild ruminant species

There is a debate whether supplemental feeding of deer bears the risk of inducing health problems, in particular acidosis. Here, the pH values of forestomach contents of free-ranging roe deer (Capreolus capreolus) shot in areas with and without supplemental winter feeding were compared. pH was similar in the dorsal and ventral rumen, but lower at these sites than in the Atrium ruminis, where it was again lower than in the reticulum; this pattern corresponds to expectations based on differences in the presence of saliva at the different sites of the forestomach. pH was lower with increasing time that elapsed between death of the animal and measuring pH in unsupplemented animals and was lower in unsupplemented animals in May/June than later in the year. Animals with supplemental winter feeding had significantly lower rumen pH (5.5) than animals without food supplementation (5.7). These data suggest that supplemental feeding of roe deer has the potential to lower forestomach pH. Although pH values measured in supplemented animals in this study would be considered indicative of rumen acidosis in domestic cattle, they are within the range previously measured in various free-ranging Odocoilid species, including roe deer; were of a similar magnitude as the May/June values of unsupplemented roe deer in this study; and must be considered with respect to potentially rapid declines in pH between death of the animal and pH measurement. Given methodological problems, analyses of literature data from free-ranging wild ruminants provide little evidence for a systematic variation of rumen pH with feeding type and body mass, but lead to the hypothesis that some New World cervids, including the roe deer, might either naturally have lower pH values than other ruminants or rumen contents whose pH drops rapidly after deat

Electronic and vibrational states of single tin-phthalocyanine molecules in double layers on Ag(111)

Electronic and vibrational properties of the two stable molecular configurations of Sn-phthalocyanine adsorbed on an ultrathin Sn-phthalocyanine buffer film on Ag(111) have been investigated with scanning tunneling microscopy and density functional calculations. Complex submolecular patterns are experimentally observed in unoccupied states images. The calculations show that they result from a superposition of Sn p orbitals. Furthermore, the characteristic features in spectra of the differential conductance are reproduced by the calculations together with a remarkable difference between the two configurations. First-principles calculations show that rather than a single vibrational mode and its higher harmonics the excitations of different molecular vibrational quanta induce replica of orbital spectroscopic signatures. The replicated orbital features appear for the configuration with a low molecule-surface coupling. To model spectra of molecules with a larger coupling to the surface it is sufficient to consider elastic tunneling to orbital resonances alone

Sparsity in the Delay-Doppler Domain for Measured 60 GHz Vehicle-to-Infrastructure Communication Channels

We report results from millimeter wave vehicle-to-infrastructure (V2I) channel measurements conducted on Sept. 25, 2018 in an urban street environment, down-town Vienna, Austria. Measurements of a frequency-division multiplexed multiple-input single-output channel have been acquired with a time-domain channel sounder at 60 GHz with a bandwidth of 100 MHz and a frequency resolution of 5 MHz. Two horn antennas were used on a moving transmitter vehicle: one horn emitted a beam towards the horizon and the second horn emitted an elevated beam at 15-degrees up-tilt. This configuration was chosen to assess the impact of beam elevation on V2I communication channel characteristics: propagation loss and sparsity of the local scattering function in the delay-Doppler domain. The measurement results within urban speed limits show high sparsity in the delay-Doppler domain.Comment: submitted to IEEE International Conference on Communication

100 kW Nested Hall Thruster System Development

Large scale cargo transportation to support human missions to the Moon and Mars will require very high power Solar Electric Propulsion (SEP) systems operating between 200 and 400 kW. Aerojet Rocketdyne's NextSTEP program is developing and demonstrating a 100 kW EP system, the XR-100, using a Nested Hall Thruster (NHT) designed for powers up to 200 kW, a modular power processor and a modular flow controller. The three year program objective is to operate the integrated EP system continuously at 100 kW for 100 h, advancing this very high power Electric Propulsion (EP) system to Technology Readiness Level (TRL) 5. With our University of Michigan, Jet Propulsion Laboratory and NASA Glenn Research Center teammates, Aerojet Rocketdyne has completed the initial phase of the program, including operating the thruster at up to 30 kW to validate the thermal models and developing and operating multiple power processor modules in the required seriesparallel configuration. The current phase includes completing a TRL 4 integrated system test at reduced power to validate all system operating phases. Design upgrades to demonstrate the TRL 5 capabilities are underway. This paper will present the high power XR-100 capabilities, overall program and design approach and the latest test results for the 100 kW EP system demonstration program

13kW Advanced Electric Propulsion Flight System Development and Qualification

The next phase of robotic and human deep space exploration missions is enhanced by high performance, high power solar electric propulsion systems for large-scale science missions and cargo transportation. Aerojet Rocketdynes Advanced Electric Propulsion System (AEPS) program is completing development, qualification and delivery of five flight 13.3kW EP systems to NASA. The flight AEPS includes a magnetically-shielded, long-life Hall thruster, power processing unit (PPU), xenon flow controller (XFC), and intrasystem harnesses. The Hall thruster, originally developed and demonstrated by NASAs Glenn Research Center and the Jet Propulsion Laboratory, operates at input powers up to 12.5kW while providing a specific impulse over 2600s at an input voltage of 600V. The power processor is designed to accommodate an input voltage range of 95 to 140V, consistent with operation beyond the orbit of Mars. The integrated system is continuously throttleable between 3 and 13.3kW. The program has completed the system requirement review; the system, thruster, PPU and XFC preliminary design reviews; development of engineering models, and initial system integration testing. This paper will present the high power AEPS capabilities, overall program and design status and the latest test results for the 13.3kW flight system development and qualification program

Genomics of Divergence along a Continuum of Parapatric Population Differentiation

MM received funding from the Max Planck innovation funds for this project. PGDF was supported by a Marie Curie European Reintegration Grant (proposal nr 270891). CE was supported by German Science Foundation grants (DFG, EI 841/4-1 and EI 841/6-1)

Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas

Most genome-wide association studies (GWAS) were analyzed using single marker tests in combination with stringent correction procedures for multiple testing. Thus, a substantial proportion of associated single nucleotide polymorphisms (SNPs) remained undetected and may account for missing heritability in complex traits. Model selection procedures present a powerful alternative to identify associated SNPs in high-dimensional settings. In this GWAS including 1060 colorectal cancer cases, 689 cases of advanced colorectal adenomas and 4367 controls we pursued a dual approach to investigate genome-wide associations with disease risk applying both, single marker analysis and model selection based on the modified Bayesian information criterion, mBIC2, implemented in the software package MOSGWA. For different case-control comparisons, we report models including between 1-14 candidate SNPs. A genome-wide significant association of rs17659990 (P=5.43x10(-9), DOCK3, chromosome 3p21.2) with colorectal cancer risk was observed. Furthermore, 56 SNPs known to influence susceptibility to colorectal cancer and advanced adenoma were tested in a hypothesis-driven approach and several of them were found to be relevant in our Austrian cohort. After correction for multiple testing (alpha=8.9x10(-4)), the most significant associations were observed for SNPs rs10505477 (P=6.08x10(-4)) and rs6983267 (P=7.35x10(-4)) of CASC8, rs3802842 (P=8.98x10(-5), COLCA1,2), and rs12953717 (P=4.64x10(-4), SMAD7). All previously unreported SNPs demand replication in additional samples. Reanalysis of existing GWAS datasets using model selection as tool to detect SNPs associated with a complex trait may present a promising resource to identify further genetic risk variants not only for colorectal cancer

An overview of the first decade of PollyNET: An emerging network of automated Raman-polarization lidars for continuous aerosol profiling

A global vertically resolved aerosol data set covering more than 10 years of observations at more than 20 measurement sites distributed from 63° N to 52° S and 72° W to 124° E has been achieved within the Raman and polarization lidar network PollyNET. This network consists of portable, remote-controlled multiwavelength-polarization-Raman lidars (Polly) for automated and continuous 24/7 observations of clouds and aerosols. PollyNET is an independent, voluntary, and scientific network. All Polly lidars feature a standardized instrument design with different capabilities ranging from single wavelength to multiwavelength systems, and now apply unified calibration, quality control, and data analysis. The observations are processed in near-real time without manual intervention, and are presented online at http://polly.tropos.de/. The paper gives an overview of the observations on four continents and two research vessels obtained with eight Polly systems. The specific aerosol types at these locations (mineral dust, smoke, dust-smoke and other dusty mixtures, urban haze, and volcanic ash) are identified by their Ångström exponent, lidar ratio, and depolarization ratio. The vertical aerosol distribution at the PollyNET locations is discussed on the basis of more than 55 000 automatically retrieved 30 min particle backscatter coefficient profiles at 532 nm as this operating wavelength is available for all Polly lidar systems. A seasonal analysis of measurements at selected sites revealed typical and extraordinary aerosol conditions as well as seasonal differences. These studies show the potential of PollyNET to support the establishment of a global aerosol climatology that covers the entire troposphere

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation. Functional analysis in mice showed that NSM controls alcohol consumption, affective behaviour, and their interaction by regulating hippocampal volume, cortical connectivity, and monoaminergic responses. Furthermore, NSM controlled bone–brain communication by enhancing osteocalcin signalling, which can independently supress alcohol consumption and reduce depressive behaviour. Altogether, we identified a single gene source for multiple pathways originating in the brain and bone, which interlink disorders of a mental–physical co-morbidity trias of alcohol abuse—depression/anxiety—bone disorder. Targeting NSM and osteocalcin signalling may, thus, provide a new systems approach in the treatment of a mental–physical co-morbidity trias