1068 Museum

THE SEMESTER BEGAN WITH APPLYING OUR UNDERSTANDING AND KNOWLEDGE OF PUBLIC AND PRIVATE SPACES. MY KNOWLEDGE AND UNDERSTANDING CORRELATED TO WHAT IS EXPOSED AS TO WHAT IS BUILTIN THE PROJECT. THE PUBLIC SPACES ARE OPEN WITH NO DISCIPLINE AND NO CONTAINMENT; AS OPPOSED TO THE PRIVATE SPACES WHICH ARE FORTIFIED AND SECLUDED FROM ITS CONTEXT AND ITS ENVIRONMENT. THE DEFINTION OF TERMS DROVE THE PROJECT AND TRANSLATED INTO ITS FORMS, SPACES, AND LANGUAGES. I ULTIMATELY DESIGNED A MUSEUM FOR THE ARTISTIC AND INDUSTRIAL LONG ISLAND CITY IN QUEENS. THE PROJECT\u27S SITE IS ON A BLOCK THAT SHARES SPACE WITH APARTMENT TOWN HOUSES, A BANK AND A DRIVING SCHOOL WITH THE RELATIONSHIP OF AN ADJACENT ELEVATED RAILWAY ON THE WEST SIDE. THE CENSUS BLOCK IS 1068, BIRTHING THE NAME OF THE MUSEUM. THE BUILDING FOLLOWS THE FACE OF ITS NEIGHBORS BUT ITS FACADE DOES NOT CONFORM TO THE AREA. IT REIMAGINES THE PAST INDUSRIAL APPEARANCES AND CONDITIONS WITH THE DIAMOND CAGE. UNDERNEATH THIS FACADE IS A MULLION THAT SHOOTS OUT AT THE ENDS OF THE MUSEUM TO CREATE A MOVEMENT AS YOU APPROACH THE BUILDING. LASTLY, ITS ANCHOR AND ITS BASE ARE GLASS WALLS TO CREATE MOMENTS OF LIGHT STUDIES WITHIN THE INTERIOR AND OPPORTUNITIES FOR PUBLIC AND PRIVATE MOMENTS VIEWED FROM THE EXTERIOR OR INTERIOR OF THE MUSEUM. I ENVISIONED THE BUILDING WOULD FLOAT SO THERE COULD BE AN UBRAN GESTURE OF THE BLOCK BEING ACCESSIBLE. THEREFORE, THE MUSEUM DOES NOT BECOME DISPENSABLE AS THIS CREATES EXPERIENCES SHARED WITH THE PUBLIC. ENTRANCES TO THE MUSEUM ARE THE INVITING GRAND STAIRS FACING THE EAST SIDE AS THEY WIND DOWN TO THE GROUND FLOOR AND ELEVATOR CORES ON THE WEST SIDE. SUPPORTS TO THE BUILDING ARE WEIGHTED DOWN TO CREATE AN ILLUSION THAT THE MUSEUM IS SECURE EVEN THOUGH THE BUILDING FOOTPRINT IS NOT PLANTED ON THE STREET LEVEL. CIRCULATION OF THE BUILDING IS DIRECT AS IT IS PRIMARILY ESCALTORS AND ELEVATORS THAT TAKE YOU THROUGH THE MUSEUM. I ATTEMPTED TO CREATE A LANGUAGE THAT CAN SHOW THE HISTORY OF PAST, PRESENT, AND FUTURE IN PHYSICAL WAYS WITH TRADITIONAL, STACKED FLOOR PLATES OF EXHIBITION HALLS THAT CAN DISPLAY AND ART THROUGH DIFFERENT MEDIUMS WHICH ALSO EDUCATES ON WHAT QUEENS WAS AND CAN BE. WHAT CONNECTS TO ITS END ARE THE UNORTHODOX FORMS OF DWELLINGS WHICH BECOMES IRONIC AS ITS SPACES ARE MEANT TO BE SECLUDED FOR MEDITATION AND THOUGHT; ASIDES FROM THOSE THAT HAVE A DUALITY TO SERVE AS SPACES FOR ACOUSTICS AND PERFORMANCES, WHICH CALL FOR GATHERINGS. THE CONNECTIONS BETWEEN SPACES ARE NOT SOLID CORRELATIONS, AS THE LINK BETWEEN PAST AND FUTURE ARE UNPREDICTABLE. 1068 MUSEUM PROPOSES SPACES THAT CAN ENHANCE EXCLUSIVE EXPERIENCES TO THE PUBLIC WHILE ALSO OFFERING THE CHOICE TO SUBMERGE YOURSELF OR NOT IN THE SPACES CONTAINED AND CONTROLLED WITHIN THE INTERIOR AND THE EXTERIOR

Role Playing Next Generation 9-1-1: Sensemaking with Social Media in Public-Safety Answering Points

For over a decade, research has suggested that social media can enhance the situational awareness of emergency responders during a crisis. Rarely, however, do studies examine the sensemaking processes of emergency responders by which situational awareness is achieved. We examine sensemaking in a Public-Safety Answering Point (PSAP) through role plays with 9-1-1 telecommunicators that imagine how social media analysts can contribute to sensemaking processes among 9-1-1 call takers, dispatchers, and emergency responders. These role plays suggest social media can address information gaps that emerge when 9-1-1 callers fail to provide critical information and vice versa, suggesting social media enhances situational awareness only when integrated into sensemaking processes that synthesize information across multiple, incomplete, but complementary data sources. This synthesis, however, requires cooperative information gathering and sharing among call takers, dispatchers, and social media analysts that PSAPs can coordinate using common interpretive frameworks and common information spaces

Actividades colaborativas en el aprendizaje de marcadores discursivos en estudiantes universitarios

The objective of this research work is to analyze the influence of collaborative activities on the learning of discourse markers in the students of the Language Comprehension and Production from a private university in Lima. It is an applied research with a quasi-experimental design, composed of experimental and control. For the collection of data, the Test on discourse markers was used. Likewise, a pretest measurement was carried out successively, and once the results were obtained, the workshop on collaborative activities, composed of 7 sessions, was conducted in the experimental group to then carry out the posttest measurements in both groups. The hypothesis testing was made with the Mann Whitney U test. The results showed that there was significant influence of the collaborative work on the learning of the discourse markers in the students that are object of study.El objetivo de la presente investigación es analizar la influencia de las actividades colaborativas en el aprendizaje de los marcadores discursivos en los estudiantes del curso Comprensión y Producción de Lenguaje de una universidad privada de Lima. Es una investigación aplicada con un diseño cuasi experimental, conformándose los grupos, experimental y control. Para la recolección de datos, se empleó la Prueba sobre marcadores discursivos. Asimismo, se efectuó sucesivamente una medición pre test, y obtenidos los resultados,  se aplicó el taller sobre actividades colaborativas, compuesto por 7 sesiones, en el grupo experimental, para luego efectuar las mediciones post test, en ambos grupos. La contrastación de hipótesis se efectuó con la prueba U de Mann Whitney. Los resultados mostraron que hubo influencia significativa del trabajo colaborativo sobre el aprendizaje de los marcadores discursivos en los estudiantes objeto de estudio

Inference of Convergent Gene Acquisition Among Pseudomonas syringae Strains Isolated From Watermelon, Cantaloupe, and Squash

Pseudomonas syringae sensu strict , (phylogroup 2; referred to as P. syringae) consists of an environmentally ubiquitous bacterial population associated with diseases of numerous plant species. Recent studies using multilocus sequence analysis have indicated the clonal expansion of several P. syringae lineages, located in phylogroups 2a and 2b, in association with outbreaks of bacterial spot disease of watermelon, cantaloupe, and squash in the United States. To investigate the evolutionary processes that led to the emergence of these epidemic lineages, we sequenced the genomes of six P. syringae strains that were isolated from cucurbits grown in the United States, Europe, and China over a period of more than a decade, as well as eight strains that were isolated from watermelon and squash grown in six different Florida counties during the 2013 and 2014 seasons. These data were subjected to comparative analyses along with 42 previously sequenced genomes of P. syringae stains collected from diverse plant species and environments available from GenBank. Maximum likelihood reconstruction of the P. syringae core genome revealed the presence of a hybrid phylogenetic group, comprised of cucurbit strains collected in Florida, Italy, Serbia, and France, which emerged through genome-wide homologous recombination between phylogroups 2a and 2b. Functional analysis of the recombinant core genome showed that pathways involved in the ATP-dependent transport and metabolism of amino acids, bacterial motility, and secretion systems were enriched for recombination. A survey of described virulence factors indicated the convergent acquisition of several accessory type 3 secreted effectors (T3SEs) among phylogenetically distinct lineages through integrative and conjugative element and plasmid loci. Finally, pathogenicity assays on watermelon and squash showed qualitative differences in virulence between strains of the same clonal lineage, which correlated with T3SEs acquired through various mechanisms of horizontal gene transfer (HGT). This study provides novel insights into the interplay of homologous recombination and HGT toward pathogen emergence and highlights the dynamic nature of P. syringae sensu lato genomes

Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer.

BackgroundIn the Prostate Cancer Prevention Trial, finasteride selectively suppressed low-grade prostate cancer and significantly reduced the incidence of prostate cancer in men treated with finasteride compared with placebo. However, an apparent increase in high-grade disease was also observed among men randomized to finasteride. We aimed to determine why and hypothesized that there is a grade-dependent response to finasteride.MethodsFrom 2007 to 2012, we randomized dynamically by intranet-accessible software 183 men with localized prostate cancer to receive 5mg finasteride or placebo daily in a double-blind study during the 4-6weeks preceding prostatectomy. As the primary end point, the expression of a predefined molecular signature (ERβ, UBE2C, SRD5A2, and VEGF) differentiating high- and low-grade tumors in Gleason grade (GG) 3 areas of finasteride-exposed tumors from those in GG3 areas of placebo-exposed tumors, adjusted for Gleason score (GS) at prostatectomy, was compared. We also determined androgen receptor (AR) levels, Ki-67, and cleaved caspase 3 to evaluate the effects of finasteride on the expression of its downstream target, cell proliferation, and apoptosis, respectively. The expression of these markers was also compared across grades between and within treatment groups. Logistic regression was used to assess the expression of markers.FindingsWe found that the predetermined molecular signature did not distinguish GG3 from GG4 areas in the placebo group. However, AR expression was significantly lower in the GG4 areas of the finasteride group than in those of the placebo group. Within the finasteride group, AR expression was also lower in GG4 than in GG3 areas, but not significantly. Expression of cleaved caspase 3 was significantly increased in both GG3 and GG4 areas in the finasteride group compared to the placebo group, although it was lower in GG4 than in GG3 areas in both groups.InterpretationWe showed that finasteride's effect on apoptosis and AR expression is tumor grade dependent after short-term intervention. This may explain finasteride's selective suppression of low-grade tumors observed in the PCPT

A Chandra ACIS Study of the Young Star Cluster Trumpler 15 in Carina and Correlation with Near-infrared Sources

Using the highest-resolution X-ray observation of the Trumpler 15 star cluster taken by the Chandra X-ray Observatory, we estimate the total size of its stellar population by comparing the X-ray luminosity function of the detected sources to a calibrator cluster, and identify for the first time a significant fraction (~14%) of its individual members. The highest-resolution near-IR observation of Trumpler 15 (taken by the HAWK-I instrument on the VLT) was found to detect most of our X-ray selected sample of cluster members, with a K-excess disk frequency of 3.8+-0.7%. The near-IR data, X-ray luminosity function, and published spectral types of the brightest members support a cluster age estimate (5-10 Myr) that is older than those for the nearby Trumpler 14 and Trumpler 16 clusters, and suggest that high-mass members may have already exploded as supernovae. The morphology of the inner ~0.7 pc core of the cluster is found to be spherical. However, the outer regions (beyond 2 pc) are elongated, forming an `envelope' of stars that, in projection, appears to connect Trumpler 15 to Trumpler 14; this morphology supports the view that these clusters are physically associated. Clear evidence of mass segregation is seen. This study appears in a Special Issue of the ApJS devoted to the Chandra Carina Complex Project (CCCP), a 1.42 square degree Chandra X-ray survey of the Great Nebula in Carina.Comment: Accepted for the ApJS Special Issue on the Chandra Carina Complex Project (CCCP), scheduled for publication in May 2011. All 16 CCCP Special Issue papers are available at http://cochise.astro.psu.edu/Carina_public/special_issue.html through 2011 at least. 30 pages; 8 figures; 3 table