Evanescent incompressible strips as origin of the observed Hall resistance overshoot

In this work we provide a systematic explanation to the unusual non-monotonic behavior of the Hall resistance observed at two-dimensional electron systems. We use a semi-analytical model based on the interaction theory of the integer quantized Hall effect to investigate the existence of the anomalous, \emph{i.e} overshoot, Hall resistance $R_{H}$. The observation of the overshoot resistance at low magnetic field edge of the plateaus is elucidated by means of overlapping evanescent incompressible strips, formed due to strong magnetic fields and interactions. Utilizing a self-consistent numerical scheme we also show that, if the magnetic field is decreased the $R_{H}$ decreases to its expected value. The effects of the sample width, temperature, disorder strength and magnetic field on the overshoot peaks are investigated in detail. Based on our findings, we predict a controllable procedure to manipulate the maxima of the peaks, which can be tested experimentally. Our model does not depend on specific and intrinsic properties of the material, provided that a single particle gap exists.Comment: A theoretical follow-up paper of arXiv:1007.258

Generalized Power Pompeiu Type Inequalities for Local Fractional Integrals with Applications to Ostrowski's Inequality

WOS: 000473350600021We establish some generalizations of power Pompeiu's inequality for local fractional integral. Afterwards, these results gave some new generalized Ostrowski type inequalities. Finally, some applications of these inequalities for generalized special means are obtained

Fractional Ostrowski type inequalities for functions of bounded variaton with two variables

We first establish some fractional equalities for functions of bounded variation with two variables. Then we derive some fractional Ostrowski and Trapezoid type inequalities for functions of bounded variation with two variables. In addition, we give some Midpoint inequalities as special cases of our main results.WOS:0005415092000122-s2.0-8508947064

PERTURBED COMPANIONS OF OSTROWSKI TYPE INEQUALITIES FOR -TIMES DIFFERENTIABLE FUNCTIONS AND APPLICATIONS

We firstly examine some inequalities obtained by using sets of complex-valued functions for functions whose high order derivatives are restricted. We also give some approximations for the functions whose derivatives up to the order −1 ( ≥ 1) are continuous and whose the th derivatives are of bounded variation. So, the results provide extensions of those presented in earlier works

OSTα deficiency: A disorder with cholestasis, liver fibrosis and congenital diarrhea

Solute carrier family 51 alpha subunit (SLC51A ) encodes the alpha subunit of the heteromeric organic solute transporter alpha–beta (OSTα–OSTβ), an important contributor to intestinal bile acid (BA) reabsorption in the enterohepatic circulation.1, 2 Here, we identified the first case of OSTα deficiency in a child with unexplained elevated liver transaminases, cholestasis, and congenital diarrhea

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocytes, where 5-lipoxygenase (5-LO) translocates to the nuclear envelope to assemble a functional complex with the integral nuclear membrane protein 5-LO-activating protein (FLAP). FLAP, a MAPEG family member, facilitates AA transfer to 5-LO for efficient conversion, and LT biosynthesis critically depends on FLAP. Here we show that the novel LT biosynthesis inhibitor BRP-187 prevents the 5-LO/FLAP interaction at the nuclear envelope of human leukocytes without blocking 5-LO nuclear redistribution. BRP-187 inhibited 5-LO product formation in human monocytes and polymorphonuclear leukocytes stimulated by lipopolysaccharide plus N-formyl-methionyl-leucyl-phenylalanine (IC50=7-10nM), and upon activation by ionophore A23187 (IC50=10-60nM). Excess of exogenous AA markedly impaired the potency of BRP-187. Direct 5-LO inhibition in cell-free assays was evident only at >35-fold higher concentrations, which was reversible and not improved under reducing conditions. BRP-187 prevented A23187-induced 5-LO/FLAP complex assembly in leukocytes but failed to block 5-LO nuclear translocation, features that were shared with the FLAP inhibitor MK886. Whereas AA release, cyclooxygenases and related LOs were unaffected, BRP-187 also potently inhibited microsomal prostaglandin E2 synthase-1 (IC50=0.2μM), another MAPEG member. In vivo, BRP-187 (10mg/kg) exhibited significant effectiveness in zymosan-induced murine peritonitis, suppressing LT levels in peritoneal exudates as well as vascular permeability and neutrophil infiltration. Together, BRP-187 potently inhibits LT biosynthesis in vitro and in vivo, which seemingly is caused by preventing the 5-LO/FLAP complex assembly and warrants further preclinical evaluation