The Cultural Evolution of Democracy: Saltational Changes in A Political Regime Landscape

Transitions to democracy are most often considered the outcome of historical modernization processes. Socio-economic changes, such as increases in per capita GNP, education levels, urbanization and communication, have traditionally been found to be correlates or ‘requisites’ of democratic reform. However, transition times and the number of reform steps have not been studied comprehensively. Here we show that historically, transitions to democracy have mainly occurred through rapid leaps rather than slow and incremental transition steps, with a median time from autocracy to democracy of 2.4 years, and overnight in the reverse direction. Our results show that autocracy and democracy have acted as peaks in an evolutionary landscape of possible modes of institutional arrangements. Only scarcely have there been slow incremental transitions. We discuss our results in relation to the application of phylogenetic comparative methods in cultural evolution and point out that the evolving unit in this system is the institutional arrangement, not the individual country which is instead better regarded as the ‘host’ for the political system

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development.

Auxin phytohormones control most aspects of plant development through a complex and interconnected signaling network. In the presence of auxin, AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) transcriptional repressors are targeted for degradation by the SKP1-CULLIN1-F-BOX (SCF) ubiquitin-protein ligases containing TRANSPORT INHIBITOR RESISTANT 1/AUXIN SIGNALING F-BOX (TIR1/AFB). CULLIN1-neddylation is required for SCFTIR1/AFB functionality, as exemplified by mutants deficient in the NEDD8-activating enzyme subunit AUXIN-RESISTANT 1 (AXR1). Here, we report a chemical biology screen that identifies small molecules requiring AXR1 to modulate plant development. We selected four molecules of interest, RubNeddin 1 to 4 (RN1 to -4), among which RN3 and RN4 trigger selective auxin responses at transcriptional, biochemical, and morphological levels. This selective activity is explained by their ability to consistently promote the interaction between TIR1 and a specific subset of AUX/IAA proteins, stimulating the degradation of particular AUX/IAA combinations. Finally, we performed a genetic screen using RN4, the RN with the greatest potential for dissecting auxin perception, which revealed that the chromatin remodeling ATPase BRAHMA is implicated in auxin-mediated apical hook development. These results demonstrate the power of selective auxin agonists to dissect auxin perception for plant developmental functions, as well as offering opportunities to discover new molecular players involved in auxin responses

Spelar den gynsamma psykosociala arbetsmiljön någon roll? : En kvantitativ enkätundersökning om psykosocial arbetsmiljö och stress hos kontorsarbetare

Bakgrund: Antalet fall av utmattningssyndrom i Sverige har ökat sedan 1980 och en orsak till ökningen är höga krav i relation till låg kontroll och lågt stöd på arbetsplatsen. Krav-kontroll-stöd-modellen kan identifiera förekomsten av psykosocial arbetsmiljö och dess påverkan på arbetares stressnivåerna. Syfte: Att undersöka eventuella samband mellan kontorsarbetares psykosociala arbetsmiljö och stress på arbetsplatsen. Metod: En kvantitativ tvärsnittsstudie genomfördes med en enkätundersökning för att besvara uppsatsen syfte. Totalt svarade 109 respondenter och data analyserades i SPSS med korrelationsanalyser och Fisher’s exact test. Resultat: Kontorsarbetare skattar höga nivåer av krav, kontroll och stöd. Ungefär 57% av 101 kontorsarbetare skattar att de har en hög stressnivå och ungefär 86% befinner sig i en gynnsam psykosocial arbetsmiljö. Det förekommer en svag till medelstark korrelation mellan krav, kontroll och stöd i samband med stress. Slutsatser: Majoriteten av kontorsarbetare har höga krav, hög kontroll och högt stöd på deras arbetsplats men lite mer än hälften av alla kontorsarbetare har en hög stressnivå. Det förekommer ingen skillnad mellan en gynnsam- och en ogynnsam psykosocial arbetsmiljö i samband med stress

An L ∞ Approach to Structure and Motion Problems in 1D-Vision

The structure and motion problem of multiple onedimensional projections of a two-dimensional environment is studied. One-dimensional cameras have proven useful in several different applications, most prominently for autonomous guided vehicles, but also in ordinary vision for analysing planar motion and the projection of lines. Previous results on one-dimensional vision are limited to classifying and solving minimal cases, bundle adjustment for finding local minima to the structure and motion problem and linear algorithms based on algebraic cost functions. In this paper, we present a method for finding the global minimum to the structure and motion problem using the max norm of reprojection errors. We show how the optimal solution can be computed efficiently using simple linear programming techniques. The algorithms have been tested on a variety of different scenarios, both real and synthetic, with good performance. In addition, we show how to solve the multiview triangulation problem, the camera pose problem and how to dualize the algorithm in the Carlsson duality sense, all within the same framework. 1

Modelling cultural systems and selective filters

A specific goal of the field of cultural evolution is to understand how processes of transmission and selection at the individual level lead to population-wide patterns of cultural diversity and change. Models of cultural evolution have typically assumed that traits are independent of one another and essentially exchangeable. But culture has a structure: traits bear relationships to one another that affect the transmission and selection process itself. Here we introduce a modelling framework to explore the effect of cultural structure on the process of learning. Through simulations, we find that introducing this simple structure changes the cultural dynamics. Based on a basic filtering mechanism for parsing these relationships, more elaborate cultural filters emerge. In a mostly incompatible cultural domain of traits, these filters organise culture into mostly (but not fully) consistent and stable systems. Incompatible domains produce small homogeneous cultures, while more compatibility increases size, diversity, and group divergence. When individuals copy based on a trait's features (here, its compatibility relationships) they produce more homogeneous cultures than when they copy based on the agent carrying the cultural trait. We discuss the implications of considering cultural systems and filters in the dynamics of cultural change

Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis.

Upon sustained insult, kinins are released and many kinin responses, such as inflammatory pain, adapt from a B2 receptor (B2R) type in the acute phase to a B1 receptor (B1R) type in the chronic phase. In this study, we show that kinins modulate receptor endocytosis to rapidly decrease B2R and increase B1R on the cell surface. B2Rs, which require agonist for activity, are stable plasma membrane components without agonist but recruit beta-arrestin 2, internalize in a clathrin-dependent manner, and recycle rapidly upon agonist treatment. In contrast, B1Rs, which are inducible and constitutively active, constitutively internalize without agonist via a clathrin-dependent pathway, do not recruit beta-arrestin 2, bind G protein-coupled receptor sorting protein, and target lysosomes for degradation. Agonist delays B1R endocytosis, thus transiently stabilizing the receptor. Most of the receptor trafficking phenotypes are transplantable from one receptor to the other through exchange of the C-terminal receptor tails, indicating that the tails contain epitopes that are important for the binding of protein partners that participate in the endocytic and postendocytic receptor choices. It is noteworthy that the agonist delay of B1R endocytosis is not transplanted to the B2R via the B1R tail, suggesting that this property of the B1R requires another domain. These events provide a rapid kinin-dependent mechanism for 1) regulating the constitutive B1R activity and 2) shifting the balance of accessible receptors in favor of B1R