9 research outputs found
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir
- Author
- Aslam Saima
- Benner Sarah E.
- Blumberg Emily A.
- Desai Niraj M.
- Doby Brianna L.
- Durand Christine M.
- Eby Yolanda
- Elias Nahel
- Fernandez Reinaldo E.
- Florman Sander
- Friedman-Moraco Rachel
- Gilbert Alexander
- Habtehyimer Feben
- Hussain Sarah
- Husson Jennifer
- Kirby Charles S.
- Laird Gregory M.
- Malinis Maricar
- Massie Allan B.
- Mehta Sapna A.
- Mehta Shikha
- Morris Michele I.
- Odim Jonah
- Ostrander Darin
- Patel Eshan U.
- Pereira Marcus R.
- Quinn Thomas C.
- Rana Meenakshi M.
- Ranganna Karthik
- Redd Andrew D.
- Ruff Jessica E.
- Santos Carlos A.Q.
- Schmidt Haley A.
- Segev Dorry L.
- Siliciano Robert F.
- Small Catherine B.
- Smith Melissa L.
- Stock Peter
- Stosor Valentina
- Tobian Aaron A.R.
- Zhu Xianming
- Publication venue
- American Society for Clinical Investigation
- Publication date
- 08/11/2022
- Field of study
The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evaluated the LVR and T cell receptor repertoire in HIV-infected kidney transplant recipients using intact proviral DNA assay and T cell receptor sequencing in patients receiving lymphocyte-depleting or lymphocyte-nondepleting immunosuppression induction therapy. CD4
+
T cells and intact and defective provirus frequencies decreased following lymphocyte-depleting induction therapy but rebounded to near baseline levels within 1 year after induction. In contrast, these biomarkers were relatively stable over time in the lymphocyte-nondepleting group. The lymphocyte-depleting group had early TCRβ repertoire turnover and newly detected and expanded clones compared with the lymphocyte-nondepleting group. No differences were observed in TCRβ clonality and repertoire richness between groups. These findings suggest that, even with significant decreases in the overall size of the circulating LVR, the reservoir can be reconstituted in a relatively short period of time. These results, while from a relatively unique population, suggest that curative strategies aimed at depleting the HIV LVR will need to achieve specific and durable levels of HIV-infected T cell depletion
Practice change toward better adherence to evidence-based treatment of early dental decay in the National Dental PBRN
- Author
- A Voinea-Griffin
- Andrew M Schmidt
- BP Yawn
- CW Leach
- D Bonetti
- DE Nease Jr
- Donald Brad Rindal
- E Friedson
- Emily U Durand
- GH Gilbert
- GH Gilbert
- GH Gilbert
- GH Gilbert
- Gregg H Gilbert
- J Beauchamp
- JL Riley III
- JM Grimshaw
- LA Bero
- M Bahrami
- M Eccles
- M Haines
- MA Van Wijk
- MM Nascimento
- MT Botello-Harbaum
- Olga V Godlevsky
- R Rhyne
- RG Tabak
- RJ Weyant
- TG Mettes
- Thomas J Flottemesch
- VV Gordan
- WE Norton
- WJ van der Sanden
- WJ Van der Sanden
- WR Carpenter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance
- Author
- A Hagiwara
- A Nicolli
- A Takahashi
- AC Schinzel
- Alain Lacampagne
- Amélie Bravard
- Annie Durand
- AP Arruda
- AR Vliet van
- Birke Bartosch
- C Betz
- C Cardenas
- C Giorgi
- C Zhang
- D Sebastian
- E Tubbs
- Elise Belaidi
- Emilie Blond
- Emily Tubbs
- Fabien Zoulim
- G Csordas
- G Quarato
- G Szabadkai
- Geoffrey Teixeira
- Guillaume Vial
- H Li
- Hubert Vidal
- J Ning
- Jennifer Rieusset
- Jeremy Fauconnier
- K Woodfield
- L Ozcan
- Ludovic Gomez
- M Paillard
- Marie Demion
- Marie-Agnès Chauvin
- Maud Michelet
- Melanie Paillard
- Michel Ovize
- MJ Jurczak
- MN Berry
- N Kumashiro
- OM Brito de
- Pierre Theurey
- Q Zhao
- R Bravo
- R Rizzuto
- R Ye
- T Simmen
- U Ozcan
- Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
ASIRI: An Ocean–Atmosphere Initiative for Bay of Bengal
- Author
- Alling
- Amala Mahadevan
- Amit Tandon
- Amy F. Waterhouse
- Andrew J. Lucas
- Andrews
- Antony
- Arnold L. Gordon
- Arobone
- Bhat
- Boccaletti
- Booij
- Caitlin B. Whalen
- Chen
- Chen
- Cheng
- Craig M. Lee
- Daniel L. Rudnick
- David W. Wang
- De Silva
- Debasis Sengupta
- Durand
- D’Asaro
- Emily Shroyer
- Ewa Jarosz
- Fox-Kemper
- G. S. Bhat
- Gadgil
- Garrett
- Girishkumar
- Gordon
- Harindra J. S. Fernando
- Harper Simmons
- Hemantha W. Wijesekera
- Hieu Pham
- Hodur
- Iossif Lozovatsky
- J. Thomas Farrar
- Jackson
- Jared Buckley
- Jennifer Mackinnon
- Jensen
- Jensen
- Jensen
- Jonathan Nash
- K. Arulananthan
- Karan Venayagamoorthy
- Kathleen M. Stafford
- Kurien
- Lagerloef
- Laura S. Leo
- Levine
- Louis St. Laurent
- Luc Rainville
- Luca Centurioni
- Lucas
- M. Ravichandran
- Madden
- Mahadevan
- Mahadevan
- Mark Baumgartner
- Martin
- Matthias Lankhorst
- McCreary
- McPhaden
- Melissa M. Omand
- Moum
- Mukherjee
- Murty
- Murty
- Neeraj Agrawal
- Niiler
- Osborne
- Patrick Conry
- Perry
- Pham
- Pinkel
- Potemra
- Rainville
- Ramachandran
- Ramasamy Venkatesan
- Rao
- Rao
- Rashmi Sharma
- Robert Pinkel
- Robert Weller
- S. U. P. Jinadasa
- Sanjiv Ramachandran
- Schott
- Schott
- Sengupta
- Shankar
- Shaun Johnston
- Shenoi
- Shetye
- Strang
- Sutanu Sarkar
- Tommy G. Jensen
- Uwe Send
- Verena Hormann
- Vialard
- Vinayachandran
- Vinayachandran
- Vinayachandran
- Wallace
- Webster
- Wheeler
- Wijeratne
- Wijesekera
- William J. Teague
- Yamamoto
- Yu
- Yu
- Publication venue
- 'American Meteorological Society'
- Publication date
- Field of study
Systemic Diseases Associated with Retinal Dystrophies
- Author
- Adams NA
- Ala-Mello S
- Alexiev BA
- Arts HH
- Beales PL
- Bennett MJ
- Berger W
- Blacque OE
- Branham K
- Campo RV
- Caruso RC
- Chowers I
- Cohen BH
- Deveault C
- DiMauro S
- Eldjarn L
- Emily M. Place
- Eric A. Pierce
- Fahnehjelm KT
- Filocamo M
- Filosto M
- Flament-Durand J
- Folz SJ
- Gibberd FB
- Gilissen C
- Gleeson JG
- Green JS
- Haas RH
- Heckenlively JR
- Hildebrandt F
- Iannaccone A
- Imhoff O
- Jansen GA
- Jansen GA
- Keppler-Noreuil KM
- Kim SK
- Leys D
- Li G
- Liu Q
- Ma C
- Makela-Bengs P
- Marshall JD
- Medhioub M
- Mockel A
- Moraes CT
- Moser HW
- Mykytyn K
- Nachury MV
- Neufeld EF
- Novarino G
- Ortiz RG
- Pazour GJ
- Pfeffer G
- Plant GR
- Puddu P
- Refsum S
- Refsum S
- Riise R
- Russell-Eggitt IM
- Samie MA
- Sang L
- Schuchman EH
- Scotto JM
- Seo S
- Siintola E
- Steele BT
- Steinberg SJ
- Tatuch Y
- Thomas GH
- Toussaint D
- Travaglini L
- van den Brink DM
- van Reeuwijk J
- Warrier V
- Wheatley DN
- Wiggs JL
- Williams RE
- Wolfrum U
- Wungjiranirun M
- Xiang Q. Werdich
- Zeman W
- Zeviani M
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke
- Author
- AJ Ferreira
- AJ Ferreira
- AJ Ferreira
- AJ Roks
- AM Souza De
- AP Mecca
- AY Chang
- AZ El-Hashim
- B Rentzsch
- C Iadecola
- C Peiro
- C Sumners
- CA McCarthy
- CA McCarthy
- CH Castro
- Colin Sumners
- DA Greenberg
- DG Passos-Silva
- DM Silva
- Douglas M. Bennion
- E Deliu
- E Karip
- E Kostenis
- EA Tallant
- EC Jauch
- ED Moore
- Emily Haltigan
- F Gembardt
- F Zhang
- G Gorelik
- G Li
- G Raffai
- G Wiemer
- H Heitsch
- HT Ong
- I Makino
- J Chen
- J Chen
- J Grobe
- J Li
- J Lu
- J Lu
- J Zheng
- JF Giani
- JL Grobe
- JL Zheng
- JP Joseph
- K Ohshima
- KB Brosnihan
- KD Silveira da
- L Hunyady
- LJ Min
- LV Kulemina
- M Dharmani
- M Fisher
- M Miyoshi
- M Mogi
- M Waldhoer
- MA Costa
- MC Chappell
- MD Ginsberg
- MJ Durand
- MJ Huentelman
- MM Muthalif
- MR Bigio Del
- N Jaiswal
- P Gelosa
- P Xu
- PE Gallagher
- PE Walters
- PM Abadir
- RA Fraga-Silva
- RA Pena Silva
- RA Santos
- RM Wosten-van Asperen
- Robert W. Regenhardt
- RW Regenhardt
- RW Regenhardt
- RW Regenhardt
- S AbdAlla
- S Bosnyak
- S Kuriakose
- S Lara Lda
- S Lee
- S Tesanovic
- SC Smith Jr
- SH Santos
- SP Bagby
- SV Pinheiro
- T Jiang
- T Jiang
- T Jiang
- T Jiang
- T Kagiyama
- T Kagiyama
- TV Lanz
- U. Muscha Steckelings
- V Koka
- V Shenoy
- VB Patel
- VS Lemos
- W Dai
- WJ Petty
- Y Meng
- Y Wang
- Y Zhang
- YB Sui
- Z Lenkei
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference
- Author
- Abdi Zakee
- Abt Peter
- Adams Megan
- Ahn Chul-Soo
- Akamatsu Nobuhisa
- Alconchel Felipe
- Alradhawi Mohammad
- Aluvihare Varuna
- Andacoglu Oya
- Armstrong Matthew
- Arulrajan Sithhipratha
- Ascher Nancy
- Auzinger Georg
- Badenoch Adam
- Balci Deniz
- Barth Rolf
- Bartoszko Justyna
- Belghiti Jacques
- Berenguer Marina
- Berlakovich Gabriela
- Berzigotti Annalisa
- Bezinover Dmitri
- Bhangui Pooja
- Bhangui Prashant
- Bhat Mamatha
- Biancofiore Gianni
- Blakemore Timon
- Blasi Annabel
- Blumberg Emily
- Boehly Jennifer
- Bogan Stephanie
- Borakati Aditya
- Briggs Tim
- Broering Dieter
- Brombosz Elizabeth
- Brown Robert
- Brustia Raffaele
- Burra Patrizia
- Busuttil Ronald
- Caicedo Juan
- Campos-Varela Isabel
- Cattral Mark
- Chadha Ryan
- Chan Albert
- Chaudhary Abhideep
- Cheah Yee Lee
- Cherqui Daniel
- Chieh Alfred Kow Wei
- Chinnakotla Srinath
- Chok Kenneth Siu Ho
- Ciria Rubén
- Crespo Gonzalo
- Crouch Cara
- Davidson Brian
- de Jonge Jeroen
- De Martin Eleonora
- de Santibañes Martin
- Denehy Linda
- DeWolf Andre
- Dharancy Sebastien
- Dimitrokallis Nikolaos
- Dominguez Beatriz
- Durand Francois
- Dutkowski Philipp
- Eason James
- Egawa Hiroto
- Eghtesad Bijan
- Eguchi Susumu
- Elnagar Mohamed
- Emamaullee Juliet Ann
- Emond Jean
- Enoch Mary Anne
- Fan Ka Hay
- Fan Ka Siu
- Farrer Giselle
- Fernandez Thomas
- Findlay James
- Florman Sander
- Forbes Stuart J
- Forkin Katherine T.
- Fraser Kyra
- Friend Peter
- Fritche Dominic
- Frola Carlo
- Fung John
- Genyk Yuri
- Ghani Shahi Abdul
- Ghobrial Mark
- Giorgio Patricia
- Gitman Marina
- Goldaracena Nicholas
- Gorvin Lucy
- Guarrera James
- Gustar Adrian
- Hannon Vivienne
- Healy Pamela
- Heimbach Julie
- Hernandez-Alejandro Roberto
- Hessheimer Amelia
- Hidalgo Camila
- Hillingsø Jens G
- Hogan Brian
- Hong Suk Kyun
- Huda Fabia Ferdousi
- Humar Abhinav
- Hwang Shin
- Ikegami Toru
- Imber Charles
- Imventarza Oscar
- Izzy Manhal
- Jackson Whitney
- Jafarian Ali
- Jalal Arif
- Jeilani Lelia
- Kabacam Gokhan
- Kaldas Fady
- Kalisvaart Marit
- Kang Yoogoo
- Kasahara Mureo
- Kathirvel Manikandan
- Keskin Onur
- Khanal Pragalva
- Kim Dong-Sik
- Kirchner Varvara
- Klair Tarunjeet S.
- Klinck John
- Klintmalm Goran
- Kostakis Ioannis
- Kotton Camille
- Krenn Claus
- Kronish Kate
- Krzanicki Dominik
- Kwok Hiu Tat
- Kwon Choon Hyuck David
- Lai Jennifer
- Lam Walter
- Lee Kwang-Woong
- Lenti Lorenzo
- Lerut Jan
- Levstik Mark
- Liew Belle
- Lindsay Martine
- Liu Jiang
- Liu Linda
- Liying Sun
- Londoño Maria-Carlota
- Lurje Georg
- Ma Ka Wing
- Machairas Nikolaos
- Mahay Arun
- Makhdoom Shahroo
- Malik Ashish
- Maluf Daniel
- Man Nancy Kwan
- Manser Tanja
- Mas Valeria
- Matins Paulo
- Mayr Andreas
- Mazzola Alessandra
- McCaughan Geoffrey
- McCluskey Stuart
- McCormack Lucas
- McKenna Gregory
- Merritt William
- Mestre-Costa Joao
- Milan Michele Mazza
- Miller Charles
- Milliken Don
- Milliken Don
- Mina Daniel Santa
- Mohamed Ahmed
- Monbaliu Diethard
- Montano-Loza Aldo
- Montasser Iman
- Morare Nolitha
- Morkane Clare
- Morkane Clare
- Mrzljak Anna
- Muiesan Paolo
- Mukhtar Ahmed
- Muller Elmi
- Munro Annalise
- Nadalin Silvio
- Nasralla David
- Newsome Philip N
- Niemann Claus U
- Northup Patrick
- O'Farrell Bryan
- Olmos Andrea
- Olthoff Kim
- Orloff Susan
- Otti Vanessa
- Pai Sher-Lu
- Palli Graciela Martinez
- Pan Terry
- Pang Li
- Parotto Matteo
- Patel Dhupal
- Patel Madhukar S.
- Pericleous Stephanos
- Petrowsky Henrik
- Pirenne Jacques
- Pittau Gabriella
- Planinsic Raymond
- Pollok Joerg M
- Pomfret Elizabeth
- Pomposelli James
- Porte Robert
- Potts Jonathan
- Potts Jonathan
- Quintini Cristiano
- Rahman Suehana
- Rajakumar Akila
- Ramirez Alejandro
- Rammohan Ashwin
- Ramsay Michael
- Ramírez María Amalia Matamoros
- Rando Karina
- Raptis Dimitri A
- Reichman Trevor
- Rela Mohamed
- Reyntjens Koen
- Rizkalla Nicole
- Roberts John
- Rodríguez Gonzalo
- Roll Garrett
- Rothnie Alex
- Rubman Susan
- Rudow Dianne LaPointe
- Ruffolo Luis
- Saliba Faouzi
- Samuel Didier
- Sapisochin Gonzalo
- Satish Pranav
- Scatton Olivier
- Schizas Dimitrios
- Schofield Nick
- Scott Aneya
- Sellers Daniel
- Selzner Markus
- Selzner Markus
- Selzner Nazia
- Settmacher Utz
- Shaker Tamer Mahmoud
- Sharma Anika
- Shaw Conrad
- Shetty Amol
- Soejima Yuji
- Soin Arvinder Singh
- Song Gi-Won
- Spiro Michael
- Suh Kyung-Suk
- Tamir Noam
- Tanaka Tomohiro
- Tandon Puneeta
- Testa Giuliano
- Testa Giuliano
- Tinguely Pascale
- Tinguely Pascale
- Tokat Yaman
- Towey Jennifer
- Tschuor Christoph
- Vailas Michail
- van der Laan Luc J. W.
- Victor David
- Vij Vivek
- Villamil Federico
- Vinaixa Carmen
- Vohra Vijay
- Wagener Gebhard
- Weiss Emmanuel
- Wells Gemma
- Wey Emmanuel
- Wray Christopher
- Xia Victor
- Yagi Shintaro
- Yan Cheung Tsz
- Yeung Oscar
- Yoon Uzung
- Yoon Young-In
- Zachiotis Marinos
- Zanetto Alberto
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2023
- Field of study
The Rise of Inclusive Political Institutions and Stronger Property Rights: Time Inconsistency Vs. Opacity.
- Author
- . I = Kark
- / Mishrifeh
- = Archeosim
- = Matthews
- A Grayson
- Adelheid Otto
- Ademnes =
- Agnese Vacca
- Agnese Vacca
- Ahmad
- Al Yaqoobi
- Al-Gailani
- Al-Gailani Werr
- Al-Maqdissi
- Al-Mutawalli
- Al-Mutawalli
- Alexander Pruss
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Alfonso Archi
- Ali Ahmed
- Altaweel Mark
- Altaweel Mark
- Altorientalische Forschungen
- Amalia Catagnoti
- Amalia Catagnoti
- Amer Suleiman
- Ammon Ben-Tor
- Ammon Ben-Tor
- Ammon Ben-Tor
- Amy Styring
- Anastasio
- Anastasio
- Anastasio
- Anastasio
- Anastasio
- Anastasio
- Anastasio
- Anastasio
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- Anastasio
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- Anastasio
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- Anastasio
- Anastasio
- Anastasio
- Ancien
- Andrea Seri
- Andreas Hauptmann
- Andrew Bevan
- Andr� Parrot
- Andr� Parrot
- Andr� Parrot
- Antonio Ciccone
- Archi
- Archi
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- Archi
- Archi
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- Arch�ologiquesarch�ologiques
- Ariel M Maeir
- Ariel M Maeir
- Armen A Alchian
- Assyriologie Und Vorderasiatischen Arch�ologie
- Assyriologie Und Vorderasiatischen Arch�ologie
- Augusta Mcmahon
- Augusta Mcmahon
- Augusta Mcmahon
- Augusta Mcmahon
- Avner Greif
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- Bar-Matthews
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- Barthel Hrouda
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- Barthel Hrouda
- Barthel Hrouda
- Be Leuven
- Bechar Zuckerman
- Ben-Tor
- Benati
- Benati
- Benati
- Benati Giacomo
- Benjamin R Foster
- Benjamin R Foster
- Benjamin R Foster
- Benjamin R Foster
- Benjamin R Foster
- Berthold Einwag
- Bertrand Lafont
- Bertrand Lafont
- Bertrand Lafont
- Bevan
- Bevan
- Bjorkman
- Bonechi
- Bronze Age Globalism
- Bryce
- Bryce
- Butterlin Gallet
- C A Malibu
- C A Toronto
- Carles Boix
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- Christopher B Walker
- Christopher B Walker
- Claude F A Schaeffer
- Claudia Beuger
- Colin A Cameron
- Collon Walker
- Cooper
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- Cripps
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- Cultural Historical
- D E Berlin
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- Dan Lawrence
- Daniel C Snell
- Daniel E Fleming
- Dara Al-Yaqoobi
- Daron Acemoglu
- Daron Acemoglu
- Daron Acemoglu
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- De Boer
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- Denis Lacambre
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- Deutschen Ausgrabungen
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- Di Dal Periodo
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- Diana L Stein
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- Donald P Hansen
- Donald P Hansen
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- Early Bronze Age
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- Elizabeth C Stone
- Elizabeth C Stone
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- Elizabeth Carter
- Elizabeth Carter
- Emar Lauinger
- Emily Hammer
- Eric Chaney
- Eric Cripps
- Ernst Heinrich
- Ernst Heinrich
- Eva Strommenger
- Evangeline Cookson
- Ezer
- F A Claude
- F R Arles
- Fara
- Federico Zaina
- Federico Zaina
- Federico Zaina
- Feng He
- Fernando M Arag�n
- Fiette
- Fikri Kulako?glukulako?glu
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- Giacomo Benati
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- Giacomo Benati
- Giacomo Benati
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- Giorgio Buccellati
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- Giovanni Pettinato
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- Giuseppe Visicato
- Glenn M Schwartz
- Glenn M Schwartz
- Goddeeris
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- J Postgate
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- Kenoyer
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- Renger
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- Rey
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- Uwe Finkbeiner
- Uwe Finkbeiner
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- V = Hazor
- V = Nippur
- V Hazor
- Valentina Orsi
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Driel
- Van Koppen
- Vaughn E Crawford
- Vaughn E Crawford
- Vii = Hazor
- Vii Hazor
- Virginia R Badler
- Waetzoldt
- Waetzoldt
- Walker
- Walther Sallaberger
- Walther Sallaberger
- Walther Sallaberger
- Walther Sallaberger
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- Westenholz Goodnick
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- Wilkinson
- Wilkinson
- Wilkinson
- Wilkinson
- William J Hamblin
- Wilma Wetterstrom
- Wilson
- Wilson
- Wilson
- Wright
- Xix)
- Yoffee
- Yon
- Yon
- Yon
- Yon
- Yon
- Yoram Barzel
- Yoram Barzel
- Yves Calvet
- Yves Gallet
- Zaina
- Zaina
- Zaina
- Zainab Bahrani
- Zettler
- Zuckerman
- � Ozg��
- � Ozg��
- � Tunca
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
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- Allen Schvearn
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- Allison K.S.
- Allos R.
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- Aquino Maia
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- Arden T.
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease