Briefing Book: Tort Litigation by the Numbers. Center for Justice and Democracy

The Center for Justice & Democracy at New York Law School released its new briefing book, TORT LITIGATION: BY THE NUMBERS. The book highlights the latest information and statistics on tort (personal injury) suits across the country, based largely on recent statistics from the National Center for State Courts (NCSC),[1] the U.S. Department of Justice and other research institutions. Principal authors of the briefing book are Emily Gottlieb, CJ&D’s Deputy Director for Law and Policy, and Joanne Doroshow, CJ&D Executive Director. Said Doroshow, “This briefing book shows that injured Americans hardly ever sue wrongdoers for their injuries, and when they do, their recoveries are extremely modest. Personal injury or ‘tort’ lawsuits comprise only a tiny percentage of civil cases. The only ‘sue-happy’ entities in this country are banks and debt collectors.” Among the many research findings in this volume are: Tort suits represent only seven percent (7%) of all civil cases in state courts. The biggest chunk of those (40%) are car accidents. Judges and juries dispose of only 15 percent of tort cases. 80% of civil cases involve contracts and small claims. But harmed consumers aren’t bringing these cases - they’re the ones being sued. Specifically, contract caseloads consist “primarily of debt collection (37%), landlord/tenant (29%), and foreclosure (17%) cases.” And these cases are increasing while tort filings are falling! 75% of tort judgments are less than $12,200. As to juries specifically, NCSC found that “50 percent of jury awards in tort cases were$30,000 or less, and 75 percent of jury awards in tort cases were less than $152,000. Jury awards exceeded$500,000 in only 17 cases (3% of cases in which judgment exceeded zero), and exceeded $1 million in only 13 cases (2%).” High profile medical malpractice and product liability cases “often generate a great deal of attention and criticism, they comprise…less than 1% of the total civil caseload....” In addition, notes NSCS, among the “more likely explanation[s]” for our distorted perceptions of the tort system “is the focus on high-value and complex litigation by the media (especially business reports), much of which is filed in federal rather than state courts. Lower-value debt collections, landlord/tenant cases, and automobile torts involving property damage and soft-tissue injuries are rarely newsworthy.

Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we use single cell RNA-seq analysis to characterize latency in monocytes and hematopoietic stem and progenitor cells (HSPCs). In monocytes, we identify host cell surface markers that enable enrichment of latent cells harboring higher viral transcript levels, which can reactivate more efficiently, and are characterized by reduced intrinsic immune response that is important for viral gene expression. Significantly, in latent HSPCs, viral transcripts could be detected only in monocyte progenitors and were also associated with reduced immune-response. Overall, our work indicates that regardless of the developmental stage in which HCMV infects, HCMV drives hematopoietic cells towards a weaker immune-responsive monocyte state and that this anergic-like state is crucial for the virus ability to express its transcripts and to eventually reactivate

Whole-genome approach to assessing human cytomegalovirus dynamics in transplant patients undergoing antiviral therapy

Human cytomegalovirus (HCMV) is the most frequent cause of opportunistic viral infection following transplantation. Viral factors of potential clinical importance include the selection of mutants resistant to antiviral drugs and the occurrence of infections involving multiple HCMV strains. These factors are typically addressed by analyzing relevant HCMV genes by PCR and Sanger sequencing, which involves independent assays of limited sensitivity. To assess the dynamics of viral populations with high sensitivity, we applied high-throughput sequencing coupled with HCMV-adapted target enrichment to samples collected longitudinally from 11 transplant recipients (solid organ, n=9, and allogeneic hematopoietic stem cell, n=2). Only the latter presented multiple-strain infections. Four cases presented resistance mutations (n=6), two (A594V and L595S) at high (100%) and four (V715M, 32 V781I, A809V and T838A) at low (<25%) frequency. One allogeneic hematopoietic stem cell transplant recipient presented up to four resistance mutations, each at low frequency. The use of high throughput sequencing to monitor mutations and strain composition in people at risk of HCMV disease is of potential value in helping clinicians implement the most appropriate therapy

Leveraging the Power of SAR Observations for Forest Monitoring Systems

Earth observations from Synthetic Aperture Radar (SAR) can provide unique information related to forest structure and condition. Despite the many advantages of SAR, particularly where clouds impede optical observations, a knowledge gap has prevented the applied remote sensing community from harnessing its full potential. Here, we discuss the results of a collaboration between SERVIR, a joint program between NASA and the U.S. Agency for International Development (USAID), and SilvaCarbon, the United States' contribution to the Global Forest Observation Initiative, to build global capacity in using SAR for forest monitoring and biomass estimation. This includes primarily the creation of 1) The SAR Handbook: Comprehensive Methodologies for Forest Monitoring and Biomass Estimation, 2) a series of international hands-on trainings and training materials, 3) quick-reference guides illustrating SAR concepts, and 4) animated videos explaining how SAR works. The SERVIR-Global community joined efforts to develop a hands-on guide to support decision-makers in the forestry community to leverage the power of SAR technology to better protect and manage forest resources. We worked with world-renowned SAR experts to provide targeted trainings and develop the SAR Handbook. This handbook consists of approachable theoretical background and applied content that contributes to filling the knowledge gap in the applied use of SAR technology for forestry applications. We hope that forest managers and remote sensing specialists will use these materials to benefit from currently available SAR datasets, as well as prepare for future SAR missions, such as NISAR and BIOMASS. Since its release on April 11, 2019, the SAR Handbook has been accessed more than 100,000 times in less than a month, demonstrating the remote sensing community's urgent need and interest to learn and use SAR

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. METHODS: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis. RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P  =  5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P  =  2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively. CONCLUSIONS: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function