Zinc and cobalt complexes based on tripodal ligands: synthesis, structure and reactivity toward lactide.

International audienceThe coordination chemistry of a series of pro-ligands ([L¹]-[L⁶]) with cobalt and zinc derivatives has been studied. All complexes have been characterized by multinuclear NMR, elemental analysis, and by single-crystal X-ray diffraction studies. Polymerization of rac-lactide takes place at 130 °C in the presence of cobalt and zinc complexes to yield polymers under solvent free conditions with controlled molecular masses and narrow polydispersities

Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives

International audienceWith the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side chain was clearly shown to improve the biological activity of most of their corresponding organic curcuminoid analogues

Microstructurally controlled polymers of rac-lactide by lithium complexes

International audienceA series of polylactides was prepared by stereoselective ring-opening polymerization of rac-lactid