O le fa’asolo a Mānaia : the implementation of a junior Samoan language class in a New Zealand secondary school with a small and diverse Pasifika student community.

While there is a significant number of Pasifika secondary students in Auckland, there are also over 100 secondary schools across New Zealand which have Pasifika student populations of between 5-10% and / or between 30-70 Pasifika students. Equally, these populations can be diverse with a range of Pasifika ethnicities represented. Increasingly there are students carrying more than one Pacific ethnicity or other ethnicities. The Pasifika Education Plans since 2001 have highlighted the role of schools to support Pasifika students to maintain their languages and cultures. Nationally, supporting Pasifika languages in secondary schools has mostly focused on where there are larger Pasifika populations, rather than smaller groups of Pasifika students. The thesis responds to the Pasifika Education Plan by implementing a junior Samoan language class in a secondary school with a small and diverse Pasifika population. It explores culturally responsive practice through reflective and reflexive practitioner research. Teu le va (to value and nurture) was used as a pedagogy and methodology. This was the approach used to support relationships and reciprocity with the research participants. The overall methodology used was action research with a focus on practitioner research. The findings are shared using the metaphor of O le fa’asolo a Mānaia. Each of the findings’ chapters builds the metaphor and examines the supports, challenges, and effects of the implementation. The project was three years from 2015 to 2018. There were three phases: the Initial Phase, Evolving Phase and New Model Phase. The main outcome was the junior Samoan language class evolved to create a new multilingual and multilevel Pasifika languages space (va). The findings do not categorise themselves precisely into supports, challenges and effects hence the findings are presented under the themes of the collaboration of schools; linguistic and cultural development; parents’ support and engagement; effective bi-cultural teacher and student leadership collaboration and professional development; diversity; funding uncertainty, class size justifications and time constraints; a transformative paradigm; and the evolution into a new teaching and learning space

Investigating the Roles of Aquaporin 4 in Intracellular and Extracellular Vesicles in Models of Traumatic Injury

Recent findings indicate that Aquaporins (AQP) play important roles in intracellular and extracellular Vesicles (EV). Intracellular vesicular trafficking of vesicles causes increased AQP concentration in the plasma membrane and increased water uptake by cells. It has recently been shown that AQP are released in EV, multiple roles for AQP in EV have been suggested, such as volumetric control of cells, uptake of AQP by recipient cells, and more. Both mechanisms have been identified in cells expressing AQP4 and have been linked to the pathological uptake and accumulation of water (oedema) in the central nervous system following injury. This study aims to understand the role of AQP4 in intracellular and extracellular vesicles. We ask: 1) Does AQP4 traffic to the endfeet of astrocytes following injury? 2) Does extracellular hypotonicity (as seen in CNS oedema) promote EV release? 3) Is AQP4 present in these EV? and 4) what is the role of AQP4 in these EV? A rat spinal crush injury model was used to investigate the role of calmodulin (CaM) and protein kinase A (PKA) in AQP4 trafficking to astrocytic endfeet in vivo, a mechanism previously only investigated in an in vitro model. Inhibition of CaM and PKA reduced AQP4 expression and trafficking to endfeet. An EV release model was developed to produced AQP4-positive EV in vitro, using stably transfected cell lines expressing AQP4, changes in extracellular tonicity impacted both EV release and EV cargo. Changes in EV populations were measured using ultraviolet side scatter flow cytometry and western blotting. These results indicate that AQP4 plays an important role in astrocytic vesicles and could be a therapeutic target to cerebral oedema

The Effect of Galactic Properties on the Escape Fraction of Ionizing Photons

The escape fraction, fesc, of ionizing photons from early galaxies is a crucial parameter for determining whether the observed galaxies at z > 6 are able to reionize the high-redshift intergalactic medium. Previous attempts to measure fesc have found a wide range of values, varying from less than 0.01 to nearly 1. Rather than finding a single value of fesc, we clarify through modeling how internal properties of galaxies affect fesc through the density and distribution of neutral hydrogen within the galaxy, along with the rate of ionizing photons production. We find that the escape fraction depends sensitively on the covering factor of clumps, along with the density of the clumped and interclump medium. One must therefore be cautious when dealing with an inhomogeneous medium. Fewer, high-density clumps lead to a greater escape fraction than more numerous low-density clumps. When more ionizing photons are produced in a starburst, fesc increases, as photons escape more readily from the gas layers. Large variations in the predicted escape fraction, caused by differences in the hydrogen distribution, may explain the large observed differences in fesc among galaxies. Values of fesc must also be consistent with the reionization history. High-mass galaxies alone are unable to reionize the universe, because fesc > 1 would be required. Small galaxies are needed to achieve reionization, with greater mean escape fraction in the past.Comment: 27 pages, 8 figures. Accepted to ApJ. v2: Improvements based on referee's comment

An Explainable-AI approach for Diagnosis of COVID-19 using MALDI-ToF Mass Spectrometry

The severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) caused a global pandemic and imposed immense effects on the global economy. Accurate, cost-effective, and quick tests have proven substantial in identifying infected people and mitigating the spread. Recently, multiple alternative platforms for testing coronavirus disease 2019 (COVID-19) have been published that show high agreement with current gold standard real-time polymerase chain reaction (RT-PCR) results. These new methods do away with nasopharyngeal (NP) swabs, eliminate the need for complicated reagents, and reduce the burden on RT-PCR test reagent supply. In the present work, we have designed an artificial intelligence-based (AI) testing method to provide confidence in the results. Current AI applications to COVID-19 studies often lack a biological foundation in the decision-making process, and our AI approach is one of the earliest to leverage explainable-AI (X-AI) algorithms for COVID-19 diagnosis using mass spectrometry. Here, we have employed X-AI to explain the decision-making process on a local (per-sample) and global (all samples) basis underscored by biologically relevant features. We evaluated our technique with data extracted from human gargle samples and achieved a testing accuracy of 94.44%. Such techniques would strengthen the relationship between AI and clinical diagnostics by providing biomedical researchers and healthcare workers with trustworthy and, most importantly, explainable test results

Knowledge Translation Task Force for Core Measures Clinical Practice Guideline: A Short Report on the Process and Utilization

Background As part of the 2018 Clinical Practice Guideline (CPG): A Core Set of Outcome Measures for Adults with Neurologic Conditions Undergoing Rehabilitation, a Knowledge Translation (KT) Task Force was convened. The purpose of this short report was to (1) demonstrate the potential impact of a CPG KT Task Force through a practical example of efforts to implement a CPG into neurologic physical therapy practice and (2) describe the process to convene a KT Task Force and develop products (KT Toolkit) to facilitate implementation of the CPG. Methods To describe the process used by the KT Task Force to develop and review a KT Toolkit for implementation of the CPG. Results Utilizing the Knowledge-To-Action Cycle framework, eight tools were developed as part of the KT Toolkit and are available with open access to the public. Findings indicate that the Core Outcome Measures Homepage, which houses the KT Toolkit, has had greater than 70,000 views since its publication. Conclusions This short report serves as an example of the efforts made to implement a CPG into physical therapy practice. The processes to facilitate KT and the tools developed can inform future implementation efforts and underscore the importance of having a KT Task Force to implement a CPG. Moving forward, KT Task Forces should be convened to implement new or revised guidelines

H-ATLAS/GAMA and HeViCS - dusty early-type galaxies in different environments

NKA acknowledges the support of the Science and Technology Facilities Council. LD, RJI and SJM acknowledge support from the European Research Council Advanced Grant COSMICISM. IDL gratefully acknowledges the support of the Flemish Fund for Scientific Research (FWO-Vlaanderen). KR acknowledges support from the European Research Council Starting Grant SEDmorph (P.I. V. Wild). Date of acceptance: 22/05/2015The Herschel Space Observatory has had a tremendous impact on the study of extragalactic dust. Specifically, early-type galaxies (ETG) have been the focus of several studies. In this paper, we combine results from two Herschel studies -a Virgo cluster study Herschel Virgo Cluster Survey (HeViCS) and a broader, low-redshift Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS)/Galaxy and Mass Assembly (GAMA) study -and contrast the dust and associated properties for similar mass galaxies. This comparison is motivated by differences in results exhibited between multiple Herschel studies of ETG. A comparison between consistent modified blackbody derived dust mass is carried out, revealing strong differences between the two samples in both dust mass and dust-to-stellar mass ratio. In particular, the HeViCS sample lacks massive ETG with as high a specific dust content as found in H-ATLAS. This is most likely connected with the difference in environment for the two samples. We calculate nearest neighbour environment densities in a consistent way, showing that H-ATLAS ETG occupy sparser regions of the local Universe, whereas HeViCS ETG occupy dense regions. This is also true for ETG that are not Herschel-detected but are in the Virgo and GAMA parent samples. Spectral energy distributions are fit to the panchromatic data. From these, we find that in H-ATLAS the specific star formation rate anticorrelates with stellar mass and reaches values as high as in our Galaxy. On the other hand HeViCS ETG appear to have little star formation. Based on the trends found here, H-ATLAS ETG are thought to have more extended star formation histories and a younger stellar population than HeViCS ETG.Publisher PDFPeer reviewe

Argos - III. Stellar populations in the galactic bulge of the milky way

We present the metallicity results from the ARGOS spectroscopic survey of the Galactic bulge. Our aim is to understand the formation of the Galactic bulge: did it form via mergers, as expected from Λ cold dark matter theory, or from disc instabilities,

ARGOS - IV. The kinematics of the Milky Way bulge

We present the kinematic results from our ARGOS spectroscopic survey of the Galactic bulge of the Milky Way. Our aim is to understand the formation of the Galactic bulge. We examine the kinematics of about 17 400 stars in the bulge located within 3.5 kp

Is measurement error altered by participation in a physical activity intervention?

WINKLER, E., L. WATERS, E. EAKIN, B. FJELDSOE, N. OWEN, and M. REEVES. Is Measurement Error Altered by Participation in a Physical Activity Intervention? Med. Sci. Sports Exerc., Vol. 45, No. 5, pp. 1004-1011, 2013. Purpose: There is no "gold standard" measure for moderate to vigorous physical activity (MVPA); some error is inherent to self-report and device-based measures. Few studies have examined agreement between self-report and device-based measures in the intervention trial context or whether the difference between measures is influenced by intervention participation. Methods: MVPA was measured at baseline and after 6 months by Active Australia Survey (AAS) and by the GT1M accelerometer (>= 1952 counts per minute) in the intervention (n = 135) and usual care control (n = 141) participants of a randomized trial targeting weight loss by MVPA increases and energy intake reductions in adults with type 2 diabetes. Agreement (for each group at each assessment) was examined using the Bland-Altman approach and regression-based modeling. Because the differences between MVPA measures varied with average values ([AAS + GT1M]/2), they were examined as a percentage of average physical activity. t-tests were used to assess unadjusted group differences and changes over time. ANCOVA models tested intervention effects on measurement error at follow-up, adjusted for baseline. Results: Agreement worsened, and variability in the difference measures became greater, as the average amount of MVPA increased. Measurement error differed significantly between groups at follow-up (P = 0.010) but not at baseline (P = 0.157) and changed significantly within the intervention group (P = 0.001) but not the control group (P = 0.164). There was a statistically significant effect of the intervention on measurement error (P = 0.026). Conclusions: Measurement error of self-report relative to the accelerometer appeared to be affected by intervention. Because measurement error cannot be definitively attributed to self-report or accelerometer, it would be prudent to measure both in future studies

Measuring older adults' sedentary time: Reliability, validity, and responsiveness

GARDINER, P. A., B. K. CLARK, G. N. HEALY, E. G. EAKIN, E. A. H. WINKLER, and N. OWEN. Measuring Older Adults' Sedentary Time: Reliability, Validity, and Responsiveness. Med. Sci. Sports Exerc., Vol. 43, No. 11, pp. 2127-2133, 2011. Purpose: With evidence that prolonged sitting has deleterious health consequences, decreasing sedentary time is a potentially important preventive health target. High-quality measures, particularly for use with older adults, who are the most sedentary population group, are needed to evaluate the effect of sedentary behavior interventions. We examined the reliability, validity, and responsiveness to change of a self-report sedentary behavior questionnaire that assessed time spent in behaviors common among older adults: watching television, computer use, reading, socializing, transport and hobbies, and a summary measure (total sedentary time). Methods: In the context of a sedentary behavior intervention, nonworking older adults (n = 48, age = 73 +/- 8 yr (mean +/- SD)) completed the questionnaire on three occasions during a 2-wk period (7 d between administrations) and wore an accelerometer (ActiGraph model GT1M) for two periods of 6 d. Test-retest reliability (for the individual items and the summary measure) and validity (self-reported total sedentary time compared with accelerometer-derived sedentary time) were assessed during the 1-wk preintervention period, using Spearman (rho) correlations and 95% confidence intervals (CI). Responsiveness to change after the intervention was assessed using the responsiveness statistic (RS). Results: Test-retest reliability was excellent for television viewing time (rho (95% CI) = 0.78 (0.63-0.89)), computer use (rho (95% CI) = 0.90 (0.83-0.94)), and reading (rho (95% CI) = 0.77 (0.62-0.86)); acceptable for hobbies (rho (95% CI) = 0.61 (0.39-0.76)); and poor for socializing and transport (rho < 0.45). Total sedentary time had acceptable test-retest reliability (rho (95% CI) = 0.52 (0.27-0.70)) and validity (rho (95% CI) = 0.30 (0.02-0.54)). Self-report total sedentary time was similarly responsive to change (RS = 0.47) as accelerometer-derived sedentary time (RS = 0.39). Conclusions: The summary measure of total sedentary time has good repeatability and modest validity and is sufficiently responsive to change suggesting that it is suitable for use in interventions with older adults