A nonlinear Bismut-Elworthy formula for HJB equations with quadratic Hamiltonian in Banach spaces

We consider a Backward Stochastic Differential Equation (BSDE for short) in a Markovian framework for the pair of processes $(Y,Z)$, with generator with quadratic growth with respect to $Z$. The forward equation is an evolution equation in an abstract Banach space. We prove an analogue of the Bismut-Elworty formula when the diffusion operator has a pseudo-inverse not necessarily bounded and when the generator has quadratic growth with respect to $Z$. In particular, our model covers the case of the heat equation in space dimension greater than or equal to 2. We apply these results to solve semilinear Kolmogorov equations for the unknown $v$, with nonlinear term with quadratic growth with respect to $\nabla v$ and final condition only bounded and continuous, and to solve stochastic optimal control problems with quadratic growth

The role of culture in long-term care arrangement decisions

In this paper, we show how and to what extent cultural factors may influence the LTC market and elderly living arrangements. Using a spatial regression discontinuity design, we exploit the within-state variation in language groups in Switzerland to provide evidence about cultural differences in LTC use. We show that elderly people residing in regions speaking a Latin language (French, Italian and Romansh) enter nursing homes in worse health conditions and rely more on home-based care compared to elderly people residing in the neighboring German regions. Differences in the strength of family ties across linguistic groups represent the most reasonable explanation for such differences

The role of culture in long-term care

The aim of this paper is to assess the role of culture in shaping individual preferences to- wards different long-term care (LTC) arrangements. The analysis uses Swiss data from two administrative databases covering the universe of formal LTC providers between 2007 and 2013. Switzerland is a multi-cultural confederation where state administrative borders do not always coincide with cultural groups. For this reason, we exploit the within-state variation in cultural groups to show evidence about cultural differences in LTC use. In particular, we use spatial regression discontinuity design (RDD) at the language border between French-speaking and German-speaking individuals living in bilingual cantons to provide causal interpretation of the differences in formal LTC use between these two main cultural groups. Our results suggest a strong role of culture in shaping household decisions about formal LTC use. In particular, elderly people residing in regions speaking a Latin language (French, Italian and Romansh) use home-based care services more intensely and enter in nursing homes at older ages and in worse health conditions with respect to elderly people in German regions. This difference across the two cultural groups are driven by different preferences towards LTC arrangement

Il restauro della cattedrale di Reggio Emilia: indagini su aspetti storici e litologici.

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Evidenza del coinvolgimento di geni nell'insorgenza delle schisi labio-palatine

The CL/P are the most common and easily recognizable craniofacial malformations with a complex etiology that requires the involvement of genetic and environmental components. The analysis of the genetic component shows more than 14 loci and genes involved in the onset of the disease. I’ve selected and investigated some of the possible candidate genes for CL/P. MYH14 gene, that maps on chromosome 19, on the OFC3 locus, and shows a strong homology with MYH9 gene. I’ve also investigated TP63 and MID1 genes, that are responsible respectively for EEC syndrome and Opitz syndrome, both of them presenting cleft. I’ve also decided to investigate JAG2 because TP63 product regulates the this gene, and both of them are component of the Notch signalling pathway. I’ve, also, studied the MKX and LMO4 genes. MKX is an important development regulator that is highly expressed in palatal mesenchyme, and map in the region responsible for Twirler mutation that cause cleft in mouse. LMO4 is necessary for neural tube development and cooperating with Grhl3, promotes cellular migration during morphogenetic events like “in utero” cleft healing. Low folate levels and high levels of homocysteine increase the risk of cleft, genes involved in their metabolism may be of interest in cleft occurrence. I’ve decided to investigate BHMT and CBS genes coding for enzymes involved in homocysteine metabolism. I’ve also investigated BHMT2 gene that maps close to BHMT and presents with him a 73% of homology. I’ve performed a linkage analysis using SNPs mapping in the genes and their boundaries, for each gene, for MKX and LMO4 I’ve also performed a sequencing analysis. My results for MID1 and CBS genes support the hypothesis of a possible role of these genes in cleft. I’ve found borderline association values for JAG2, MKX and LMO4 genes

Hidden secrets of the Northern Adriatic: "Tegnúe", peculiar reefs

Abstract Research carried out over the last 40 years has underlined the scientific importance of the rocky outcrops scattered on the Northern Adriatic Sea bed sometimes referred to as "tegnúe". The zoobenthic biocenoses developing over these peculiar geological formations are as extraordinary as they are unique. A study carried out for an entire year in two sampling stations, at different distances from the coast, revealed a very high number of zoobenthic species, including those which have now become rare and are therefore protected in Italian seas. The water turbidity of the northern Adriatic Sea greatly reduces the quantity of light reaching these outcrops, limiting the activity of autotrophic organisms only to sciaphilous genera. Thus, the most represented trophic categories of zoobenthos are suspension, especially filter feeders. Biodiversity values calculated for the communities of these particular reefs are far higher than normally found in the soft seabed in nearby areas, but even higher than in other coralligenous outcrops in other marine ecosystem in the world. The ecological role played by the tegnúe in the Northern Adriatic is extraordinary because as well as being true oases of biodiversity, they are areas naturally protected against bottom trawl-fishing. Thus, they offer shelter and reproduction sites for a number of fish and invertebrate species, including some under stress due to severe fishing pressure

Social and technological innovations in forestry

In Europe, when referring to innovation in forestry, the dominant discourses mostly deal with technological innovation based on large-scale industrial investments. \u201cInnovation is rather often used synonymously with technological innovation (Kubeczko et al. 2006:706)\u201d. This is supported by a biased (limited) interpretation of the bioeconomy strategies, where attention is almost completely focused on the development of bio-refineries, i.e. on innovative plants that produce power, heat, a potentially large set of bio-chemicals and in some cases pulp, normally using huge amounts of low-value biomasses from agriculture, forestry or organic wastes (McCormick and Kautto 2013; Scarlat et al. 2015; Fund et al. 2015.). Also in the case of plants producing just bio-energy, the needs for industrial scale economies are creating a demand for woody biomass that is frequently not covered by the potential local supply, so industrial plants are located in proximity to port facilities with a process of internationalization not only of the investment capital, but also wood procurement (P\ufclzl et al. 2017). Moreover, although it has been pointed out \u201cthe need to focus on innovation as a socially embedded phenomenon that should stretch across all economic sectors, [this concept] has mostly been applied in policy practice in high-tech fields, often with a technological focus or bias (EU 2003; von Tunzelmann and Acha 2003)\u201d, rather than in forestry (Rametsteiner and Weiss 2003: 692). Other emerging and innovative initiatives, like for example the creation of nature-based businesses connected with the establishment of payment schemes for ecosystem (or environmental) services (PES) that try to obtain value from the management of public goods such as water, biodiversity, human wellbeing and others (e.g., Wunder 2005), are often not considered as strategic choices to be invested in for the development of national economies , despite their potential in rural development (e.g., by means of income generation and employment creation) and innovation (Matilainen et al. 2011; Slee 2011; O\u2019Driscoll et al. 2017; Tyrv\ue4inen et al. 2017). However, it was recently stressed that a new policy narrative is needed, that \u201cshould emphasise a sustainable and socially inclusive forest-based bioeconomy (Winkel 2017:153)\u201d, i.e. a holistic bioeconomy [\u2026] \u201cthat recognises and mobilises the entire spectrum of ecosystem services that Europe\u2019s forests can provide for the benefit of Europe\u2019s societies (Winkel 2017)\u201d. This chapter introduces and discusses the various implications of social and technological innovation on the forestry sector, especially in Europe. In the first section, links are made with the various components of globalization. In the second, both approaches are presented based on commonly used definitions. In the third, the two approaches are illustrated by means of concrete examples, while their pros and cons (in terms of positive and negative consequences) are pointed out and briefly compared. In the fourth section, insights into how to integrate the two approaches are proposed and discussed in relation to the current perspectives of globalization and future development. The special role that information technologies can play in the two cases is highlighted

The role of detraining in tendon mechanobiology

INTRODUCTION: Several conditions such as training, aging, estrogen deficiency and drugs could affect the biological and anatomo-physiological characteristics of the tendon. Additionally, recent preclinical and clinical studies examined the effect of detraining on tendon, showing alterations in its structure and morphology and in tenocyte mechanobiology. However, few data evaluated the importance that cessation of training might have on tendon. Basically, we do not fully understand how tendons react to a phase of training followed by sudden detraining. Therefore, within this review, we summarize the studies where tendon detraining was examined. MATERIALS AND METHODS: A descriptive systematic literature review was carried out by searching three databases (PubMed, Scopus and Web of Knowledge) on tendon detraining. Original articles in English from 2000 to 2015 were included. In addition, the search was extended to the reference lists of the selected articles. A public reference manager (www.mendeley.com) was adopted to remove duplicate articles. RESULTS: An initial literature search yielded 134 references (www.pubmed.org: 53; www.scopus.com: 11; www.webofknowledge.com: 70). Fifteen publications were extracted based on the title for further analysis by two independent reviewers. Abstracts and complete articles were after that reviewed to evaluate if they met inclusion criteria. CONCLUSIONS: The revised literature comprised four clinical studies and an in vitro and three in vivo reports. Overall, the results showed that tendon structure and properties after detraining are compromised, with an alteration in the tissue structural organization and mechanical properties. Clinical studies usually showed a lesser extent of tendon alterations, probably because preclinical studies permit an in-depth evaluation of tendon modifications, which is hard to perform in human subjects. In conclusion, after a period of sudden detraining (e.g., after an injury), physical activity should be taken with caution, following a targeted rehabilitation program. However, further research should be performed to fully understand the effect of sudden detraining on tendons

Social Innovation in the Mediterranean and how it can help to manage Mediterranean forests

This presentation specifies how social innovation initiatives can be promoted in Mediterranean forests. Furthermore, it presents the evaluation methodology proposed for analyzing these initiatives. Preliminary results are also identified and some concluding remarks proposed

Functional Echomyography: thickness, ecogenicity, contraction and perfusion of the LMN denervated human muscle before and during h-bFES

Permanent denervated muscles were evaluated by ultrasound to monitor changes in morphology, thickness, contraction-relaxation kinetics and perfusion due to the electrical stimulation program of the Rise2-Italy project. In a case of monolateral lesion, morphology and ultrasonographic structure of the denervated muscles changed during the period of stimulation from a pattern typical of complete denervation-induced muscle atrophy to a pattern which might be considered “normal” when detected in an old patient. Thickness improved significantly more in the middle third of the denervated muscle, reaching the same value as the contralateral innervated muscle. Contraction-relaxation kinetics, measured by recording the muscle movements during electrical stimulation, showed an abnormal behavior of the chronically denervated muscle during the relaxation phase, which resulted to be significantly longer than in normal muscle. The long-term denervated muscles analyzed with Echo Doppler showed at rest a low resistance arterial flow that became pulsed during and after electrical stimulation. As expected, the ultra sound measured electrical stimulation-induced hyperemia lasted longer than the stimulation period. The higher than normal energy of the delivered electrical stimuli of the Vienna home-based Functional Electrical Stimulation strategy (h-b FES) demonstrate that the explored muscles were still almost completely denervated during the one-year of training. In conclusion, this pilot study confirms the usefulness of Functional Echomyography in the follow-up and the positive effects of h-b FES of denervated muscles