Visualising transformative spaces for education: a focus on lecture halls, computer rooms and studios

One room, three learning spaces for creative education. This image-led investigation shows how a standard blank room can be effectively transformed into three different kinds of learning environments: a lecture hall, a computer room and a studio. Research has shown that effective design of teaching spaces is beneficial to the learning experience and contributes to creating a more engaging relationship between teachers and learners. On the other hand, few visual resources have been produced to support this in the UK. This article seeks to fill this gap. The design of these classrooms applies Basye’s idea of campfire to stimulate and support interaction between teachers and learners. In particular, these visuals show how technology can improve the students’ experience of the lecture hall, provide adequate lighting, personal space and drawing devices in the computer room, and finally how gathering in a circle may replicate the benefits of campfires in the studio

Anomalous Rotational Relaxation: A Fractional Fokker-Planck Equation Approach

In this study we obtained analytically relaxation function in terms of rotational correlation functions based on Brownian motion for complex disordered systems in a stochastic framework. We found out that rotational relaxation function has a fractional form for complex disordered systems, which indicates relaxation has non-exponential character obeys to Kohlrausch-William-Watts law, following the Mittag-Leffler decay.Comment: Revtex4, 9 pages. Paper was revised. References adde

How do supply chain management and information systems practices influence operational performance?:Evidence from emerging country SMEs

This study first provides a comparative analysis of the impact of supply chain management (SCM) and information systems (IS) practices on operational performance (OPER) of small- and medium-sized enterprises (SMEs) operating in two neighbouring emerging country markets of Turkey and Bulgaria. Then, we investigate moderating effects of both SCM–IS-linked enablers and inhibitors on the links between SCM and IS practices and OPER of SMEs. To this end, we first empirically identify the underlying dimensions of SCM and IS practices, and SCM–IS-related enabling and inhibiting factors. Second, a series of regression analyses are undertaken to estimate the impact of the study's constructs on OPER of SMEs. The results are discussed comparatively within the contexts of both Turkish and Bulgarian SMEs and beyond. The study makes a significant contribution to the extant literature through obtaining and analysing cross-national survey data of SCM and IS practices in emerging country markets

The role of KIBRA in reconstructive episodic memory

In order to retrieve episodic past events, the missing information needs to be reconstructed using information stored in semantic memory. Failures in these reconstructive processes are expressed as false memories. KIBRA single nucleotide polymorphism (rs17070145) has been linked to episodic memory performance as well as an increased risk of Alzheimer’s disease and post-traumatic stress disorder (PTSD). Here, the role of KIBRA rs17070145 polymorphism (male and female CC vs. CT/TT carriers) in reconstructive episodic memory in the Deese-Roediger-McDermott (DRM) paradigm was investigated in N = 219 healthy individuals. Female participants outperformed males in the free recall condition. Furthermore, a trend towards a gender x genotype interaction was found for false recognition rates. Female CT/TT carriers exhibited a lower proportion of false recognition rates for associated critical lures as compared to male CT/TT. Additionally, an association between KIBRA rs17070145 genotype, familiarity and recollection based recognition performance was found. In trials with correct recognition of listed items CT/TT carriers showed more “remember”, but fewer “know” responses as compared to CC carriers. Our findings suggest that the T-allele of KIBRA rs17070145 supports recollection based episodic memory retrieval and contributes to memory accuracy in a gender dependent manner. Findings are discussed in the context of the specific contribution of KIBRA related SNPs to reconstructive episodic memory and its implications for cognitive and emotional symptoms in dementia and PTS

Уровень провоспалительных цитокинов внутриматочных смывов при гиперплазиях эндометрия

Проведено вивчення змін рівня прозапальних цитокінів ІЛ -1ß, ІЛ -6 та ФНП-α в маткових змивах у жінок з різними видами гіперплазій ендометрію. Встановлено, що формування гіперплазії ендометрію супроводжується активацією прозапальних цитокінів. Найбільш виражені зміни виявлені при комплексній гіперплазії ендометрію. Запальний процес в урогенітальної системі сприяє більш вираженому зростанню рівня цитокінів в маткових змивах. Оцінка вираженості змін в рівні цитокінів маткових змивів може використовуватися в якості додаткового критерію, що характеризує гіперплазії ендометрію, для оцінки формування запальних змін в ендометрії при його гіперплазії і для оцінки прогнозу перебігу гіперплазій.Levels of proinflammatory cytokines IL-1ß, IL-6 and TNF-α in uterine lavage fluid of women with different types of endometrial hyperplasia were studied. It is established that the formation of endometrial hyperplasia is associated with activation of proinflammatory cytokines. The most intensive changes were found in complex endometrial hyperplasia. Inflammation in the urogenital system leads to more intensive increase of cytokines level in the uterine washout. Investigation of changes in cytokines levels in uterine lavage fluid can be used as an additional criterion for characteristics of endometrial hyperplasia, to assess the formation of inflammatory changes in the endometrium and for prognosis of hyperplasia

Characterization of Reservoir Heterogenity in Carbonate-Ramp Systems, San Andres/Grayburg Permian Basin

This report summarizes research carried out by the Bureau of Economic Geology's San Andres/Grayburg Reservoir Characterization Research Laboratory (RCRL) from September 1988 through September 1990. The goal of the RCRL program was to develop advanced approaches to reservoir characterization for improved recovery of the substantial remaining mobile oil in San Andres and Grayburg reservoirs. Emphasis was placed on developing an outcrop analog for San Andres strata that could be used as (1) a guide to interpreting the regional and local geologic framework of the subsurface reservoirs and (2) a data source illustrating the scales and patterns of variability of rock-fabric facies and petrophysical properties, particularly in lateral dimensions, and on scales that cannot be studied during subsurface reservoir characterization. Areas selected for study were the San Andres exposures of the Algerita Escarpment in the northern Guadalupe Mountains and the Seminole San Andres Unit on the northern margin of the Central Basin Platform. The outcrop-analog research was emphasized because it had received little attention before this study by either industry or academe. Reports in this summary involve (1) outcrop and subsurface geological characterization of the Algerita Escarpment San Andres and the Seminole San Andres Unit (Kerans), (2) correlation of detailed outcrop mapping in order to research cored wells at Lawyer Canyon, Algerita Escarpment (Nance), (3) diagenetic/petrographic analysis of selected upper San Andres facies focusing on the origin of moldic porosity (Hovorka), (4) geologic engineering description of the upper San Andres carbonates at Lawyer Canyon and the upper producing interval at Seminole (Lucia), (5) geostatistical analysis of permeability patterns and stochastic-based finite-difference modeling of the upper San Andres parasequence window (Senger and Fogg), and (6) deterministic finite element modeling of the upper San Andres parasequence window (Kasap). Availability of basic data for these studies is summarized in the appendix.Bureau of Economic Geolog

Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rapid-onset, potentially fatal hyperinflammatory syndrome. A prompt molecular diagnosis is crucial for appropriate clinical management. Here, we validated and prospectively evaluated a targeted high-throughput sequencing approach for HLH diagnostics. Methods: A high-throughput sequencing strategy of 12 genes linked to HLH was validated in 13 patients with previously identified HLH-associated mutations and prospectively evaluated in 58 HLH patients. Moreover, 2504 healthy individuals from the 1000 Genomes project were analyzed in silico for variants in the same genes. Results: Analyses revealed a mutation detection sensitivity of 97.3 %, an average coverage per gene of 98.0 %, and adequate coverage over 98.6 % of sites previously reported as mutated in these genes. In the prospective cohort, we achieved a diagnosis in 22 out of 58 patients (38 %). Genetically undiagnosed HLH patients had a later age at onset and manifested higher frequencies of known secondary HLH triggers. Rare, putatively pathogenic monoallelic variants were identified in nine patients. However, such monoallelic variants were not enriched compared with healthy individuals. Conclusions: We have established a comprehensive high-throughput platform for genetic screening of patients with HLH. Almost all cases with reduced natural killer cell function received a diagnosis, but the majority of the prospective cases remain genetically unexplained, highlighting genetic heterogeneity and environmental impact within HLH. Moreover, in silico analyses of the genetic variation affecting HLH-related genes in the general population suggest caution with respect to interpreting causality between monoallelic mutations and HLH. A complete understanding of the genetic susceptibility to HLH thus requires further in-depth investigations, including genome sequencing and detailed immunological characterization.Peer reviewe

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

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