Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria

This study reports the incidence of urinary tract infections (UTIs) among 80 pregnant women attending antenatal clinics at Oluyoro Catholic Hospital (OCH), Ibadan, Nigeria, as well as the isolation and identification of the pathogens responsible for the infection. A total of 80 clean voided mid-stream urine samples were collected from pregnant women between the ages of 21-40 years. The results showed that the incidence of UTIs in this study population was 47.5%, and 38 bacterial isolates were identifiedbased on colonial morphology, microscopic characteristics, and biochemical tests. The most predominant bacterium was Escherichia coli 16 (42.1%). This was followed by Staphylococcus aureus 11 (28.9%), Klebsiella aerogenes 7 (18.4%), Pseudomonas aeruginosa 2 (5.3%), and a mixed culture of K. aerogenes and Staphylococcus aureus 2 (5.3%). Urine microscopy revealed the presence of pus cells in 15 of the urine samples collected. Two urine samples, representing 2.5% of the samples, contained yeast cells, suggesting that candidiasis was also predominant. The high incidence of UTIs reported in this study should be of great concern, as not only do UTIs pose a threat to health, but they also impose an economic and social burden due to the stigma associated with these infections

Survival at 10 years following lower extremity amputations in patients with diabetic foot disease

This is an accepted manuscript of an article published by Springer in Endocrine on 12/04/2020, available online: https://doi.org/10.1007/s12020-020-02292-7 The accepted version of the publication may differ from the final published version.© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Background: Amputations are associated with markedly reduced long-term survival in patients with diabetic foot disease. However, there is paucity of long-term survival data in published literature. Methods: We searched the electronic case records and laboratory details of patients who underwent amputations between 1997 and 2006 to obtain at least 10 years of follow up data after the surgery to assess the survival rates and possible risk factors reducing survival in the year 2016. Amputation level below ankle was considered as minor and above ankle as major amputations. Results: Of the 233 cases (159 males; median age 68 years), 161 had major amputations. Of the 72 cases who had minor amputations initially, 63 needed a further amputation or contralateral amputation on follow up. One hundred seventy-seven patients (76%) were not alive after 10 years of follow up. The survival rates at 1, 3, 5, 7, and ≥10 years were 64%, 50%, 40%, 34%, and 24%, respectively. Maximum number of deaths occurred within 4 months of amputations. There was no difference between survival rates following major or minor amputations and among males or females. The only statistically significant parameter affecting lower survival rate was age ≥70 years, with each additional year of age increasing the hazard by a factor of 1.039 (95% CI: 1.024–1.054) or 3.9% (2.4–5.4%). Conclusions: Five-year and 10-year survival rates were 40% and 24%, respectively, following diabetic foot amputations. Higher age ≥70 years was associated with lower survival rate compared with younger age groups after lower extremity amputations.Published versio

Investigation of the nucleon-nucleon tensor force in the three-nucleon system

Proton-deuteron elastic scattering has been investigated at Ep =22.7 MeV by comparison of rigorous Faddeev calculations with experimental results. The observable most sensitive to the tensor force is the nucleon-nucleon polarization transfer coefficient Kyy'. The new angular distribution of Kyy' clearly favours the tensor force of the Bonn A potential, which is weaker than the one of the Paris potential.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28425/1/0000208.pd

POLARIZATION TRANSFER IN ELASTIC p-d SCATTERING AT Ep=22.7 MeV

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Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2)

Objectives: ACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization. Methods: Patients are entered into ACST-2 when revascularization is felt to be clearly indicated, when CEA and CAS are both possible, but where there is substantial uncertainty as to which is most appropriate. Trial surgeons and interventionalists are expected to use their usual techniques and CE-approved devices. We report baseline characteristics and blinded combined interim results for 30-day mortality and major morbidity for 986 patients in the ongoing trial up to September 2012. Results: A total of 986 patients (687 men, 299 women), mean age 68.7 years (SD ± 8.1) were randomized equally to CEA or CAS. Most (96%) had ipsilateral stenosis of 70-99% (median 80%) with contralateral stenoses of 50-99% in 30% and contralateral occlusion in 8%. Patients were on appropriate medical treatment. For 691 patients undergoing intervention with at least 1-month follow-up and Rankin scoring at 6 months for any stroke, the overall serious cardiovascular event rate of periprocedural (within 30 days) disabling stroke, fatal myocardial infarction, and death at 30 days was 1.0%. Conclusions: Early ACST-2 results suggest contemporary carotid intervention for asymptomatic stenosis has a low risk of serious morbidity and mortality, on par with other recent trials. The trial continues to recruit, to monitor periprocedural events and all types of stroke, aiming to randomize up to 5,000 patients to determine any differential outcomes between interventions. Clinical trial: ISRCTN21144362. © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme

Spontaneous regression of a limb AVM in a patient with Parkes Webber Syndrome. Case report.

Klippel Trenauney Syndrome (KTS) consists of the triad of venous and cutaneous capillary malformations, and tissue hypertrophy. The association with an Arterio-Venous Malformation (AVM) is known as Parkes-Weber Syndrome (PWS). We present a case of spontaneous regression of multiple small AVMs in the lower leg of a 19-year-old female with PWS. To the best of our knowledge this is the first documented case of spontaneous regression of an AVM in PWS in English literature