429 research outputs found
A theoretical analysis of the free vibration of discretely stiffened cylindrical shells with arbitrary end conditions
Theoretical analysis of free vibration of discretely stiffened cylindrical shells with arbitrary end condition
The influence of changing end conditions on the resonant response of beams and plates
Approximation method for structural beam and plate resonances at elastic edge excitation
An approximate theory for transverse shear deformation and rotatory inertia effects in vibrating beams
Transverse shear deformation and rotary inertia effects in vibrating beam
Threshold production in nucleon-nucleon collisions
We analyze production in nucleon-nucleon collisions near threshold
in the framework of a general model independent formalism, which can be applied
to any reaction , where , , or . Such
reactions show large isotopic effects: a large difference for - and
-collisions, which is due to the different spin structure of the
corresponding matrix elements. The analysis of the spin structure and of the
polarization observables is based on symmetry properties of the strong
interaction. Using existing experimental data on the different decays of
meson, we suggest a model for , based on
channel -exchanges. We predict polarization phenomena for the
-reaction and the ratio of cross sections for and
-collisions. For the processes we apply two
different approaches: vector meson exchange and local four-particle
interaction. In both cases we find larger -production in
-collisions, with respect to -collisions.Comment: 17 pages, 6 figure
Neutrophil to Lymphocyte Ratio: A Prognostic Indicator for Astronaut Health
Short-term and long-term spaceflight missions can cause immune system dysfunction in astronauts. Recent studies indicate elevated white blood cells (WBC) and polymorphonuclear neutrophils (PMN) in astronaut blood, along with unchanged or reduced lymphocyte counts, and reduced T cell function, during short-(days) and long-(months) term spaceflight. A high PMN to lymphocyte ratio (NLR) can acts as a strong predictor of poor prognosis in cancer, and as a biomarker for subclinical inflammation in humans and chronic stress in mouse models, however, the NLR has not yet been identified as a predictor of astronaut health during spaceflight. For this, complete blood cell count data collected from astronauts and rodents that have flown for short- and long-term missions on board the International Space Station (ISS) was repurposed to determine the NLR pre-, in-, and post-flight. The results displayed that the NLR progressively increased during spaceflight in both human and mice, while a spike in the NLR was observed at post-flight landing, suggesting stress-induced factors may be involved. In addition, the ground-based chronic microgravity analog, hindlimb unloading in mice, indicated an increased NLR, along with induced myeloperoxidase expression, as measured by quantitative (q)PCR. The mechanism for increased NLR was further assessed in vitro using the NASA-developed rotating wall vessel (RWV) cell culture suspension system with human WBCs. The results indicated that simulated microgravity led to increased mature PMN counts, NLR profiles, and production of reactive oxygen species (ROS). Collectively, these studies show that an increased NLR is observed in spaceflight missions, and in chronic microgravity-analog simulation in mice, and that this effect may be potentiated by the oxidative stress response in blood cells under microgravity conditions. Furthermore, these results suggest that a disrupted NLR profile in spaceflight may further disrupt immune homeostasis, potentially causing chronic immune-mediated inflammatory diseases. Thus, we propose that the health status of astronauts during short- and long-term space missions can be monitored by their NLR profile, in addition to utilizing this measurement as a tool for interventions and countermeasure development to restore homeostatic immunity
Neutrophil-to-Lymphocyte Ratio: A Biomarker to Monitor the Immune Status of Astronauts
A comprehensive understanding of spaceflight factors involved in immune dysfunction and the evaluation of biomarkers to assess in-flight astronaut health are essential goals for NASA. An elevated neutrophil-to-lymphocyte ratio (NLR) is a potential biomarker candidate, as leukocyte differentials are altered during spaceflight. In the reduced gravity environment of space, rodents and astronauts displayed elevated NLR and granulocyte-to-lymphocyte ratios (GLR), respectively. To simulate microgravity using two well-established ground-based models, we cultured human whole blood-leukocytes in high-aspect rotating wall vessels (HARV-RWV) and used hindlimb unloaded (HU) mice. Both HARV-RWV simulation of leukocytes and HU-exposed mice showed elevated NLR profiles comparable to spaceflight exposed samples. To assess mechanisms involved, we found the simulated microgravity HARV-RWV model resulted in an imbalance of redox processes and activation of myeloperoxidase-producing inflammatory neutrophils, while antioxidant treatment reversed these effects. In the simulated microgravity HU model, mitochondrial catalase-transgenic mice that have reduced oxidative stress responses showed reduced neutrophil counts, NLR, and a dampened release of selective inflammatory cytokines compared to wildtype HU mice, suggesting simulated microgravity induced oxidative stress responses that triggered inflammation. In brief, both spaceflight and simulated microgravity models caused elevated NLR, indicating this as a potential biomarker for future in-flight immune health monitoring
The X-ray Telescope of CAST
The Cern Axion Solar Telescope (CAST) is in operation and taking data since
2003. The main objective of the CAST experiment is to search for a hypothetical
pseudoscalar boson, the axion, which might be produced in the core of the sun.
The basic physics process CAST is based on is the time inverted Primakoff
effect, by which an axion can be converted into a detectable photon in an
external electromagnetic field. The resulting X-ray photons are expected to be
thermally distributed between 1 and 7 keV. The most sensitive detector system
of CAST is a pn-CCD detector combined with a Wolter I type X-ray mirror system.
With the X-ray telescope of CAST a background reduction of more than 2 orders
off magnitude is achieved, such that for the first time the axion photon
coupling constant g_agg can be probed beyond the best astrophysical constraints
g_agg < 1 x 10^-10 GeV^-1.Comment: 19 pages, 25 figures and images, replaced by the revised version
accepted for publication in New Journal of Physic
Neutral weak currents in pion electroproduction on the nucleon
Parity violating asymmetry in inclusive scattering of longitudinally
polarized electrons by unpolarized protons with or meson
production, is calculated as a function of the momentum transfer squared
and the total energy of the -system. This asymmetry, which is
induced by the interference of the one-photon exchange amplitude with the
parity-odd part of the -exchange amplitude, is calculated for the
processes ( is a virtual photon and
a virtual Z-boson) considering the -contribution in the channel,
the standard Born contributions and vector meson ( and )
exchanges in the channel. Taking into account the known isotopic properties
of the hadron electromagnetic and neutral currents, we show that the P-odd term
is the sum of two contributions. The main term is model independent and it can
be calculated exactly in terms of fundamental constants. It is found to be
linear in . The second term is a relatively small correction which is
determined by the isoscalar component of the electromagnetic current. Near
threshold and in the -region, this isoscalar part is much smaller (in
absolute value) than the isovector one: its contribution to the asymmetry
depend on the polarization state (longitudinal or transverse) of the virtual
photon.Comment: 30 pages 9 figure
Polarization phenomena in open charm photoproduction processes
We analyze polarization effects in associative photoproduction of
pseudoscalar () charmed mesons in exclusive processes , , . Circularly polarized photons
induce nonzero polarization of the -hyperon with - and -components
(in the reaction plane) and non vanishing asymmetries and for polarized nucleon target. These polarization observables can be
predicted in model-independent way for exclusive -production processes
in collinear kinematics. The T-even -polarization and asymmetries for
non-collinear kinematics can be calculated in framework of an effective
Lagrangian approach. The depolarization coefficients , characterizing
the dependence of the -polarization on the nucleon polarization are also
calculated.Comment: 36 pages 13 figure
Gating of Long-Term Potentiation by Nicotinic Acetylcholine Receptors at the Cerebellum Input Stage
The brain needs mechanisms able to correlate plastic changes with local circuit activity and internal functional states. At the cerebellum input stage, uncontrolled induction of long-term potentiation or depression (LTP or LTD) between mossy fibres and granule cells can saturate synaptic capacity and impair cerebellar functioning, which suggests that neuromodulators are required to gate plasticity processes. Cholinergic systems innervating the cerebellum are thought to enhance procedural learning and memory. Here we show that a specific subtype of acetylcholine receptors, the α7-nAChRs, are distributed both in cerebellar mossy fibre terminals and granule cell dendrites and contribute substantially to synaptic regulation. Selective α7-nAChR activation enhances the postsynaptic calcium increase, allowing weak mossy fibre bursts, which would otherwise cause LTD, to generate robust LTP. The local microperfusion of α7-nAChR agonists could also lead to in vivo switching of LTD to LTP following sensory stimulation of the whisker pad. In the cerebellar flocculus, α7-nAChR pharmacological activation impaired vestibulo-ocular-reflex adaptation, probably because LTP was saturated, preventing the fine adjustment of synaptic weights. These results show that gating mechanisms mediated by specific subtypes of nicotinic receptors are required to control the LTD/LTP balance at the mossy fibre-granule cell relay in order to regulate cerebellar plasticity and behavioural adaptation
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