Thermal properties of highly structured composite and aluminium sheets in an aerodynamic tunnel

This article deals with the thermodynamic behaviour of heat shields - structured metal and composite plates. Experiments have been carried out in a wind tunnel with an additional heating, which simulates the heat source from engine or exhaust pipe and simultaneously the airflow generated during a car movement. The tested sheets with hexagonal structure were a standard commercial made of aluminium and a second manufactured by replication (lamination, diffusion) from glass fabric. The airflow in a parallel way along the sheets was analysed experimentally in order to determine the heat transfer efficiency between surfaces of sheets and surrounding airflow. The temperature on the sheets was chosen to observe the effects of different sheets material, various heat power and airflow velocity. During the experiment a thermal input below the sheets and airflow velocity through the tunnel have been changed. The thermal field distribution on the metal sheet is different than in case of composite sheet. For the composite material the thermal field distribution was more homogeneous. This article describe briefly also methods of obtaining real composite geometry based on scanned data and their reconstruction for using in some future numerical models

DIMETHOXYFLAVONE ISOLATED FROM THE STEM BARK OF STEREOSPERMUM KUNTHIANUM POSSESSES ANTIDIARRHOEAL ACTIVITY IN RODENTS

This study was undertaken to evaluate the antidiarrhoeal activity of 3, 7, 4/-trihydroxy-3/-(8//-acetoxy-7//-methyloctyl)-5, 6-dimethoxyflavone, a flavonoid isolated from the stem bark of Stereospermum kunthianum. The antidiarrhoeal activity was evaluated using rodent models with diarrhoea. The normal intestinal transit, castor oil-induced intestinal transit and castor oil-induced diarrhoea tests in mice as well as castor oil-induced intestinal fluid accumulation in rats were employed in the study. The animals were pretreated with distilled water (10 ml/kg for mice, 5 ml/kg for rats), dimethoxyflavone (25 mg/kg or 50 mg/kg), morphine (10 mg/kg), or indomethacin (10 mg/kg) before induction of diarrhoea with castor oil (0.2ml for mice and 2ml for rats). Dimethoxyflavone dose dependently and significantly reduced (

Novel photon detection based on electronically-induced stress in silicon

The feasibility of microcantilever-based optical detection is demonstrated. Specifically, the authors report here on an evaluation of laboratory prototypes that are based on commercially available microcantilevers. In this work, optical transduction techniques were used to measure microcantilever response to photons and study the electronic stress in silicon microcantilevers, and their temporal and photometric response. The photo-generation of free charge carriers (electrons, holes) in a semiconductor gives rise to photo-induced (electronic) mechanical strain. The excess charge carriers responsible for the photo-induced stress, were produced via photon irradiation from a diode laser with wavelength {lambda} = 780 nm. The authors found that for silicon, the photo-induced stress results in a contraction of the crystal lattice due to the presence of excess electron-hole-pairs. In addition, the photo-induced stress is of opposite direction and about four times larger than the stress resulting from direct thermal excitation. When charge carriers are generated in a short time, a very rapid deflection of the microcantilever is observed (response time {approximately} {micro}s)

Hardy's inequality for functions vanishing on a part of the boundary

We develop a geometric framework for Hardy's inequality on a bounded domain when the functions do vanish only on a closed portion of the boundary.Comment: 26 pages, 2 figures, includes several improvements in Sections 6-8 allowing to relax the assumptions in the main results. Final version published at http://link.springer.com/article/10.1007%2Fs11118-015-9463-

The role of biofactors in the prevention and treatment of age‐related diseases

The present demographic changes toward an aging society caused a rise in the number of senior citizens and the incidence and burden of age‐related diseases (such as cardiovascular diseases [CVD], cancer, nonalcoholic fatty liver disease [NAFLD], diabetes mellitus, and dementia), of which nearly half is attributable to the population ≥60 years of age. Deficiencies in individual nutrients have been associated with increased risks for age‐related diseases and high intakes and/or blood concentrations with risk reduction. Nutrition in general and the dietary intake of essential and nonessential biofactors is a major determinant of human health, the risk to develop age‐related diseases, and ultimately of mortality in the older population. These biofactors can be a cost‐effective strategy to prevent or, in some cases, even treat age‐related diseases. Examples reviewed herein include omega‐3 fatty acids and dietary fiber for the prevention of CVD, α‐tocopherol (vitamin E) for the treatment of biopsy‐proven nonalcoholic steatohepatitis, vitamin D for the prevention of neurodegenerative diseases, thiamine and α‐lipoic acid for the treatment of diabetic neuropathy, and the role of folate in cancer epigenetics. This list of potentially helpful biofactors in the prevention and treatment of age‐related diseases, however, is not exhaustive and many more examples exist. Furthermore, since there is currently no generally accepted definition of the term biofactors , we here propose a definition that, when adopted by scientists, will enable a harmonization and consistent use of the term in the scientific literature

Kemalettin - (Mimar) [1870-1927]

Taha Toros Arşivi, Dosya No: 134-Mimar Kemalettinİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a phenotype reminiscent of NPC1 mutant cells. Here, we demonstrate that this cellular cholesterol imbalance is due to AnxA6 promoting Rab7 inactivation via TBC1D15, a Rab7-GAP. In NPC1 mutant cells, AnxA6 depletion and eventual Rab7 activation was associated with peripheral distribution and increased mobility of late endosomes. This was accompanied by an enhanced lipid accumulation in lipid droplets in an acyl-CoA:cholesterol acyltransferase (ACAT)-dependent manner. Moreover, in AnxA6-deficient NPC1 mutant cells, Rab7-mediated rescue of late endosome-cholesterol export required the StAR-related lipid transfer domain-3 (StARD3) protein. Electron microscopy revealed a significant increase of membrane contact sites (MCS) between late endosomes and ER in NPC1 mutant cells lacking AnxA6, suggesting late endosome-cholesterol transfer to the ER via Rab7 and StARD3-dependent MCS formation. This study identifies AnxA6 as a novel gatekeeper that controls cellular distribution of late endosome-cholesterol via regulation of a Rab7-GAP and MCS formation

Worker remittances and the global preconditions of ‘smart development’

With the growing environmental crisis affecting our globe, ideas to weigh economic or social progress by the ‘energy input’ necessary to achieve it are increasingly gaining acceptance. This question is intriguing and is being dealt with by a growing number of studies, focusing on the environmental price of human progress. Even more intriguing, however, is the question of which factors of social organization contribute to a responsible use of the resources of our planet to achieve a given social result (‘smart development’). In this essay, we present the first systematic study on how migration – or rather, more concretely, received worker remittances per GDP – helps the nations of our globe to enjoy social and economic progress at a relatively small environmental price. We look at the effects of migration on the balance sheets of societal accounting, based on the ‘ecological price’ of the combined performance of democracy, economic growth, gender equality, human development, research and development, and social cohesion. Feminism in power, economic freedom, population density, the UNDP education index as well as the receipt of worker remittances all significantly contribute towards a ‘smart overall development’, while high military expenditures and a high world economic openness are a bottleneck for ‘smart overall development’