Science Hackathons for Cyberphysical System Security Research: Putting CPS testbed platforms to good use

A challenge is to develop cyber-physical system scenarios that reflect the diversity and complexity of real-life cyber-physical systems in the research questions that they address. Time-bounded collaborative events, such as hackathons, jams and sprints, are increasingly used as a means of bringing groups of individuals together, in order to explore challenges and develop solutions. This paper describes our experiences, using a science hackathon to bring individual researchers together, in order to develop a common use-case implemented on a shared CPS testbed platform that embodies the diversity in their own security research questions. A qualitative study of the event was conducted, in order to evaluate the success of the process, with a view to improving future similar events

Ethyl anthracene-9-carboxyl­ate

In the title compound, C17H14O2, the COO group and the anthracene fragment form a dihedral angle of 76.00 (19)°. The torsion angle around the O—Csp 3 bond of the ester group is 108.52 (18)°. The crystal structure is stabilized by C—H⋯O inter­actions and edge-to-face arene inter­actions with C—H⋯(ring centroid) distances in the range 2.75–2.84 Å

Personality predictors of the time course for lung cancer onset

Numerous findings suggest that personality is linked to the incidence and experience of negative health outcomes. More specifically, trait negative affect is negatively related to a number of health outcomes. The current study expands our understanding of the link between personality and disease by examining the time course for lung cancer onset. In a sample of patients who had recently undergone surgical resection for lung cancer, a variety of negative affect-related personality variables were assessed to determine their relationship with age at surgery. After controlling for smoking behavior, it was found that trait negative affect was associated with time course for lung cancer onset, such that those with higher (vs. lower) levels of trait negative affect manifested lung cancer earlier in their lives. Thus, trait negative affect represents an independent risk factor among those prone to lung cancer (i.e. smokers)

The CHeriScape project, 2014-2016 : key messages from CHeriScape : cultural solutions for cultural problems

publishedVersio

The human phosphotyrosine signaling network: Evolution and hotspots of hijacking in cancer

Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment interactions, has been considered to be an evolutionary innovation in multicellular metazoans. However, neither the emergence nor the evolution of the human pTyr signaling system is currently understood. Tyrosine kinase (TK) circuits, each of which consists of a TK writer, a kinase substrate, and a related reader, such as Src homology (SH) 2 domains and pTyr-binding (PTB) domains, comprise the core machinery of the pTyr signaling network. In this study, we analyzed the evolutionary trajectories of 583 literature-derived and 50,000 computationally predicted human TK circuits in 19 representative eukaryotic species and assigned their evolutionary origins. We found that human TK circuits for intracellular pTyr signaling originated largely from primitive organisms, whereas the inter- or extracellular signaling circuits experienced significant expansion in the bilaterian lineage through the back- wiring of newly evolved kinases to primitive substrates and SH2/PTB domains. Conversely, the TK circuits that are involved in tissue-specific signaling evolved mainly in vertebrates by the back-wiring of vertebrate substrates to primitive kinases and SH2/PTB domains. Importantly, we found that cancer signaling preferentially employs the pTyr sites, which are linked to more TK circuits. Our work provides insights into the evolutionary paths of the human pTyr signaling circuits and suggests the use of a network approach for cancer intervention through the targeting of key pTyr sites and their associated signaling hubs in the network. © 2012, Published by Cold Spring Harbor Laboratory Press

Vibrational spectra, assignments and normal coordinate analyses for crystalline zirconium tetrachloride and tetrabromide

Raman and far-IR spectra have been obtained of crystalline ZrCl4 and ZrBr4. The observed frequencies have been interpreted on the basis of the C2h symmetry of the Bravais unit cell and have been subjected to a normal coordinate analysis. The interpretation and results are satisfactorily in accord with the X-ray structure.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24546/1/0000826.pd

A Far-ultraviolet Atlas of Low-resolution Hubble Space Telescope Spectra of T Tauri Stars

We present a far-ultraviolet (FUV) spectral atlas consisting of spectra of 91 pre-main sequence stars. Most stars in this sample were observed with the Space Telescope Imaging Spectrograph (STIS) and Advanced Camera for Surveys (ACS) on the \emph{Hubble Space Telescope} (\emph{HST}). We find strong correlations among the \ion{O}{1} $\lambda$1304 triplet, %\ion{C}{2} $\lambda$1335, the \ion{Si}{4} $\lambda\lambda$1394/1403 doublet, the \ion{C}{4} $\lambda$1549 doublet, and the \ion{He}{2} $\lambda$1640 line luminosities. For classical T Tauri stars (CTTSs), we also find strong correlations between these lines and the accretion luminosity, suggesting that these lines form in processes related to accretion. These FUV line fluxes and X-ray luminosity correlate loosely with large scatters. The FUV emission also correlates well with H$\alpha$, H$\beta$, and \ion{Ca}{2} K line luminosities. These correlations between FUV and optical diagostics can be used to obtain rough estimates of FUV line fluxes from optical observations. Molecular hydrogen (H$_{2}$) emission is generally present in the spectra of actively accreting CTTSs but not the weak-lined T Tauri stars (WTTSs) that are not accreting. The presence of H$_2$ emission in the spectrum of HD 98800 N suggests that the disk should be classified as actively accreting rather than a debris disk. The spectra in the atlas are available at http://archive.stsci.edu/prepds/ttauriatlas.Comment: 89 pages, 30 figures, published in Ap

Hydrogen Molecules In Superstrong Magnetic Field: II. Excitation Levels

We study the energy levels of H$_2$ molecules in a superstrong magnetic field (B\go 10^{12} G), typically found on the surfaces of neutron stars. The interatomic interaction potentials are calculated by a Hartree-Fock method with multi-configurations assuming electrons are in the ground Landau state. Both the aligned configurations and arbitrary orientations of the molecular axis with respect to the magnetic field axis are considered. Different types of molecular excitations are then studied: electronic excitations, aligned (along the magnetic axis) vibrational excitations, transverse vibrational excitations (a constrained rotation of the molecular axis around the magnetic field line). Similar results for the molecular ion H$_2^+$ are also obtained and compared with previous variational calculations. Both numerical results and analytical fitting formulae are given for a wide range of field strengths. In contrast to the zero-field case, it is found that the transverse vibrational excitation energies can be larger than the aligned vibration excitation, and they both can be comparable or larger than the electronic excitations. For B\go B_{crit}=4.23\times 10^{13} G, the Landau energy of proton is appreciable and there is some controversy regarding the dissociation energy of H$_2$. We show that H$_2$ is bound even for $B>>B_{crit}$ and that neither proton has a Landau excitation in the ground molecular state.Comment: Revtex (45 pages), 3 postscript figures; Phys. Rev. A in pres

CXCL8 Chemokines in Teleost Fish: Two Lineages with Distinct Expression Profiles during Early Phases of Inflammation

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