BRAF and TERT mutations in papillary thyroid cancer patients of Latino ancestry.

Papillary thyroid cancer (PTC) is the second most commonly diagnosed malignancy in U.S. Latinas and in Colombian women. Studies in non-Latinos indicate that BRAF and TERT mutations are PTC prognostic markers. This study aimed to determine the prevalence and clinical associations of BRAF and TERT mutations in PTC Latino patients from Colombia. We analyzed mutations of BRAF (V600E) and TERT promoter (C228T, C250T) in tumor DNA from 141 patients (75 with classical variant PTC, CVPTC; 66 with follicular variant PTC, FVPTC) recruited through a multi-center study. Associations between mutations and clinical variables were evaluated with Fisher exact tests. Survival was evaluated with Kaplan-Meier plots. Double-mutant tumors (BRAF+/TERT+, n = 14 patients) were more common in CVPTC (P = 0.02). Relative to patients without mutations (n = 48), double mutations were more common in patients with large tumors (P = 0.03), lymph node metastasis (P = 0.01), extra-thyroid extension (P = 0.03), and advanced stage (P = 6.0 × 10-5). In older patients, TERT mutations were more frequent (mean age 51 years vs 45 years for wild type TERT, P = 0.04) and survival was lower (HR = 1.20; P = 0.017); however, given the small sample size, the decrease in survival was not statically significant between genotypes. Comparisons with published data in US whites revealed that Colombian patients had a higher prevalence of severe pathological features and of double-mutant tumors (10 vs 6%, P = 0.001). Mutations in both oncogenes show prognostic associations in Latinos from Colombia. Our study is important to advance Latino PTC precision medicine and replicates previous prognostic associations between BRAF and TERT in this population

Retrospective study of the clinical evolution of three clinical cases of benign prostatic hyperplasia in dogs.

Se expone un estudio comparativo de la evolución clínica de tres pacientes caninos (un Basset Hound de nueve años y dos Bóxer de seis y ocho años, respectivamente), los cuales presentaban antecedentes de hematuria y/o secreción uretral sanguinolenta en ausencia de micción. Una vez realizado el examen físico y los exámenes paraclínicos, el diagnóstico fue de Hiperplasia Prostática Benigna (HPB). Esta enfermedad es un cambio normal del envejecimiento y es la patología más común de la próstata canina. Las potenciales etiologías de esta enfermedad comprenden una proporción anormal de andrógenos y estrógenos, un incremento en el número de receptores androgénicos y sensibilidad tisular a los andrógenos; siendo la dihidrotestosterona el principal promotor de la HPB. El tratamiento principal de esta enfermedad es la orquiectomía y/o la medicación con hormonas anti-androgénicas.ABSTRACT. A comparative study of the clinical evolution of three canine patients (one nine years old Basset Hound and two Boxer –six and eight years old), who were taken to medical attention due to hematuria and urethral bloody secretion in absence of urination, is exposed. Once the physical examination and the paraclinical test were carried out, a Complex Benign Prostatic Hyperplasia (CBPH) was diagnosed. This pathology is a normal change of aging and the commonest pathology of the canine prostate. The potential etiologies of this disease comprise an abnormal proportion of androgens and estrogens, increase in the number of androgenics receptors and increase of tissue sensitivity to androgens; which are mainly promoted by dihidrotestosterone. The main treatment of CBPH is the orchiectomy and/or the treatment with antiandrogenics hormones

Subcapsular hepatic hematoma post-endoscopic retrograde cholangiopancreatography: a case report and literature review

A 23-year-old female with a history of long-standing obesity, recently was diagnosed with cholelithiasis, along with a 15 day development of jaundice. An ERCP (endoscopic retrograde cholangiopancreatography) was performed, during which resulted an unsuccessful sphincterotomy, this was followed by placing a 7-centimeter, 10 French Amsterdam-type stent, subsequently she experienced sudden abdominal pain, and a CT scan revealed a subcapsular hepatic hematoma, which required surgical management. The objective was to describe a clinical case of subcapsular hepatic hematoma, clinical presentation, and therapeutic conduct. The treatment of subcapsular hepatic hematoma will depend on the patient's hemodynamic stability. However, survival is uncertain due to its rarity, making it crucial to recognize its early signs and symptoms and act promptly.

Cromatosis de los bovinos o vaca morada en Colombia: (1. Pt.).

Se describen estudios clínicos, morfológicos, patológicos, epidemiológicos, toxicológicos y experimentales de una entidad patológica conocida como cromatosis, la cual afecta a los bovinos y ovinos de los departamentos del Huila y Tolima en Colombia. La entidad se presenta en climas cálidos, con temperaturas de 27 a 29 grados centígrados, en zonas localizadas entre 500 y 700 m.s.n.m., pobres en material vegetal y suelos de tipo volcánico en donde predomina el pasto Teatino, y en clima frío, con temperatura de 14 grados centígrados en la zona de Roncesvalles (Tolima), a 2.600 m.s.n.m., con suelos ondulados cubiertos en su mayoría por pasto kikuyo. El síndrome se caracteriza por la pigmentación rosada o violeta que toman los dientes, mucosas, tejidos elásticos, subcutáneos, musculares y óseos, igual que la orina y algunas veces la leche. La prevalencia instantánea en las fincas problema de clima cálido fue de 11,5 por ciento. La cromatosis de clima cálido fue reproducida experimentalmente en conejos, ovinos y bovinos, suministrándoles la planta mamei-tomatillo. La cromatosis de clima frío se reprodujo en conejos suministrándoles la planta mamei de tierra fría. Las pérdidas originadas por esta enfermedad son debidas a la baja de peso, decomiso de canales y muertes que se producen en el campo. De la Bunchosia pseudonitida, se aisló un alcaloide que al exponerse a la luz del sol y al aire, se torna violáceo, por lo cual se cree pueda ser el responsable de producir la cromatosisPastos y forraje

Situación y Perspectivas Económicas 2009 -2010

Gestión del ConocimientoConsideraciones aportadas por el Doctor Juan Carlos Echeverry sobre las consecuencias de la crisis económica internacional en la económica nacional.Competitivida

Panorama mundial y su efecto en Colombia

Gestión del ConocimientoConsideraciones sobre las causas y consecuencias de la crisis económica internacional en la económica Colombiana.Competitivida

Transient spatiotemporal chaos in the complex Ginzburg-Landau equation on long domains

Numerical simulations of the complex Ginzburg-Landau equation in one spatial dimension on periodic domains with sufficiently large spatial period reveal persistent chaotic dynamics in large parts of parameter space that extend into the Benjamin-Feir stable regime. This situation changes when nonperiodic boundary conditions are imposed, and in the Benjamin-Feir stable regime chaos takes the form of a long-lived transient decaying to a spatially uniform oscillatory state. The lifetime of the transient has Poisson statistics and no domain length is found sufficient for persistent chaos

Evaluación de híbridos y clones de plátano y banano tolerantes a la sigatoka negra en el Centro-Sur del departamento del Tolima, Colombia.

El plátano y el banano (Musa AAB y AAA) ocupan un lugar de importancia en la agricultura del Centro-Sur del departamento del Tolima en Colombia, sobre todo en áreas de economía social rural campesina, tanto en términos de área cultivada (6.000 ha en plátano y 1.500 ha en banano) como en producción (40.000 t de plátano y 3.000 t de banano). El objetivo de este experimento fue evaluar algunos híbridos y cultivares de referencia de plátano y banano resistentes a la sigatoka negra para probar en campo su relación con la enfermedad en términos de severidad. Los FHIA-01 y FHIA-02 se destacaron altamente resistentes a la sigatoka negra y los FHIA-03 y FHIA-21 como resistentes, así como el cultivar de referencia Cachaco común. El FHIA-21 superó en 105 por ciento el rendimiento de los demás cultivares. El FHIA-03 tuvo buena aceptación en el mercado y sus características semejantes al Cachaco común lo convierten en buena alternativa de producción. FHIA-01 y FHIA-02, no obstante presentar buena precocidad, no fueron aceptados en el mercado. FHIA-01 y FHIA-02 presentaron los mejores rendimientos frente a los cultivares de referencia, con promedios de 26,1 t/ha y 27,4 t/ha, respectivamente. Por precocidad se destacaron FHIA-02, Hartón seudotallo rojo, Hartón enano, FHIA-03, Hartón Costa y Hartón liberalPlátano-Musa sapientumBanano- Musa acuminata - Musa paradisiac

The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics.

Familial nonmedullary thyroid cancer (NMTC) has not been clearly linked to causal germline variants, despite the large role that genetic factors play in risk. Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC. We have previously shown that the HABP2 G534E variant is not associated with TC risk in patients from the British Isles. Hispanics are the largest and the youngest minority in the United States and NMTC is now the second most common malignancy in women from this population. In order to determine if the HABP2 G534E variant played a role in NMTC risk among Hispanic populations, we analyzed 281 cases and 1105 population-matched controls from a multicenter study in Colombia, evaluating the association through logistic regression. We found that the HABP2 G534E variant was not significantly associated with NMTC risk (P=0.843) in this Hispanic group. We also stratified available clinical data by multiple available clinicopathological variables and further analyzed the effect of HABP2 on NMTC presentation. However, we failed to detect associations between HABP2 G534E and NMTC risk, regardless of disease presentation (P≥0.273 for all cases). Therefore, without any significant associations between the HABP2 G534E variant and NMTC risk, we conclude that the variant is not causal of NMTC in this Hispanic population

Magnetic effect in viscosity of magnetorheological fluids

ABSTRACT: In this work the study of viscosity is presented for a magnetorheological fluid made from iron oxides micrometre, under an external magnetic field. The material was characterized by magnetic loops in a vibrating sample magnetometer and its crystal structure by X-ray diffraction. The results show that saturation magnetization and coercive field have dependence with the powder size. The material has different crystal structure which lattice parameters were determined by Rietveld refinement. The viscosity of the magnetorheological fluid was measured by a viscometer with rotational symmetry with and without external field. This result evidence a dependency on the size, percentage iron oxide and the applied magnetic field, it is due to the hydrodynamic volume of iron oxide interacts with the external magnetic field, increasing the flow resistance