437 research outputs found
Predictability of oppositional defiant disorder and symptom dimensions in children and adolescents with ADHD combined type
Background Oppositional defiant disorder (ODD) is frequently co-occurring with attention deficit hyperactivity disorder (ADHD) in children and adolescents. Because ODD is a precursor of later conduct disorder (CD) and affective disorders, early diagnostic identification is warranted. Furthermore, the predictability of three recently confirmed ODD dimensions (ODD-irritable, ODD-headstrong and ODD-hurtful) may assist clinical decision making. Method Receiver-operating characteristic (ROC) analysis was used in order to test the diagnostic accuracy of the Conners' Parent Rating Scale revised (CPRS-R) and the parent version of the Strength and Difficulties Questionnaire (PSDQ) in the prediction of ODD in a transnational sample of 1093 subjects aged 5-17 years from the International Multicentre ADHD Genetics study. In a second step, the prediction of three ODD dimensions by the same parent rating scales was assessed by backward linear regression analyses. Results ROC analyses showed adequate diagnostic accuracy of the CPRS-R and the PSDQ in predicting ODD in this ADHD sample. Furthermore, the three-dimensional structure of ODD was confirmed by confirmatory factor analysis and the CPRS-R emotional lability scale significantly predicted the ODD irritable dimension. Conclusions The PSDQ and the CPRS-R are both suitable screening instruments in the identification of ODD. The emotional lability scale of the CPRS-R is an adequate predictor of irritability in youth referred for ADH
Confirmation that a specific haplotype of the dopamine transporter gene is associated with Combined-Type ADHD
Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required. <br/
Modern optical astronomy: technology and impact of interferometry
The present `state of the art' and the path to future progress in high
spatial resolution imaging interferometry is reviewed. The review begins with a
treatment of the fundamentals of stellar optical interferometry, the origin,
properties, optical effects of turbulence in the Earth's atmosphere, the
passive methods that are applied on a single telescope to overcome atmospheric
image degradation such as speckle interferometry, and various other techniques.
These topics include differential speckle interferometry, speckle spectroscopy
and polarimetry, phase diversity, wavefront shearing interferometry,
phase-closure methods, dark speckle imaging, as well as the limitations imposed
by the detectors on the performance of speckle imaging. A brief account is
given of the technological innovation of adaptive-optics (AO) to compensate
such atmospheric effects on the image in real time. A major advancement
involves the transition from single-aperture to the dilute-aperture
interferometry using multiple telescopes. Therefore, the review deals with
recent developments involving ground-based, and space-based optical arrays.
Emphasis is placed on the problems specific to delay-lines, beam recombination,
polarization, dispersion, fringe-tracking, bootstrapping, coherencing and
cophasing, and recovery of the visibility functions. The role of AO in
enhancing visibilities is also discussed. The applications of interferometry,
such as imaging, astrometry, and nulling are described. The mathematical
intricacies of the various `post-detection' image-processing techniques are
examined critically. The review concludes with a discussion of the
astrophysical importance and the perspectives of interferometry.Comment: 65 pages LaTeX file including 23 figures. Reviews of Modern Physics,
2002, to appear in April issu
Optical Intensity Interferometry with the Cherenkov Telescope Array
With its unprecedented light-collecting area for night-sky observations, the
Cherenkov Telescope Array (CTA) holds great potential for also optical stellar
astronomy, in particular as a multi-element intensity interferometer for
realizing imaging with sub-milliarcsecond angular resolution. Such an
order-of-magnitude increase of the spatial resolution achieved in optical
astronomy will reveal the surfaces of rotationally flattened stars with
structures in their circumstellar disks and winds, or the gas flows between
close binaries. Image reconstruction is feasible from the second-order
coherence of light, measured as the temporal correlations of arrival times
between photons recorded in different telescopes. This technique (once
pioneered by Hanbury Brown and Twiss) connects telescopes only with electronic
signals and is practically insensitive to atmospheric turbulence and to
imperfections in telescope optics. Detector and telescope requirements are very
similar to those for imaging air Cherenkov observatories, the main difference
being the signal processing (calculating cross correlations between single
camera pixels in pairs of telescopes). Observations of brighter stars are not
limited by sky brightness, permitting efficient CTA use during also bright-Moon
periods. While other concepts have been proposed to realize kilometer-scale
optical interferometers of conventional amplitude (phase-) type, both in space
and on the ground, their complexity places them much further into the future
than CTA, which thus could become the first kilometer-scale optical imager in
astronomy.Comment: Astroparticle Physics, in press; 47 pages, 10 figures, 124 reference
Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes
Proteasome-catalyzed peptide splicing represents an additional catalytic
activity of proteasomes contributing to the pool of MHC-class I-presented
epitopes. We here biochemically and functionally characterized a new melanoma
gp100 derived spliced epitope. We demonstrate that the gp100mel47–52/40–42
antigenic peptide is generated in vitro and in cellulo by a not yet described
proteasomal condensation reaction. gp100mel47–52/40–42 generation is enhanced
in the presence of the β5i/LMP7 proteasome-subunit and elicits a peptide-
specific CD8+ T cell response. Importantly, we demonstrate that different
gp100mel-derived spliced epitopes are generated and presented to CD8+ T cells
with efficacies comparable to non-spliced canonical tumor epitopes and that
gp100mel-derived spliced epitopes trigger activation of CD8+ T cells found in
peripheral blood of half of the melanoma patients tested. Our data suggest
that both transpeptidation and condensation reactions contribute to the
frequent generation of spliced epitopes also in vivo and that their immune
relevance may be comparable to non-spliced epitopes
Avpr1a variant associated with preschoolers' lower altruistic behavior
10.1371/journal.pone.0025274PLoS ONE69
Stellar Intensity Interferometry: Prospects for sub-milliarcsecond optical imaging
Using kilometric arrays of air Cherenkov telescopes, intensity interferometry
may increase the spatial resolution in optical astronomy by an order of
magnitude, enabling images of rapidly rotating stars with structures in their
circumstellar disks and winds, or mapping out patterns of nonradial pulsations
across stellar surfaces. Intensity interferometry (pioneered by Hanbury Brown
and Twiss) connects telescopes only electronically, and is practically
insensitive to atmospheric turbulence and optical imperfections, permitting
observations over long baselines and through large airmasses, also at short
optical wavelengths. The required large telescopes with very fast detectors are
becoming available as arrays of air Cherenkov telescopes, distributed over a
few square km. Digital signal handling enables very many baselines to be
synthesized, while stars are tracked with electronic time delays, thus
synthesizing an optical interferometer in software. Simulated observations
indicate limiting magnitudes around m(v)=8, reaching resolutions ~30
microarcsec in the violet. The signal-to-noise ratio favors high-temperature
sources and emission-line structures, and is independent of the optical
passband, be it a single spectral line or the broad spectral continuum.
Intensity interferometry provides the modulus (but not phase) of any spatial
frequency component of the source image; for this reason image reconstruction
requires phase retrieval techniques, feasible if sufficient coverage of the
interferometric (u,v)-plane is available. Experiments are in progress; test
telescopes have been erected, and trials in connecting large Cherenkov
telescopes have been carried out. This paper reviews this interferometric
method in view of the new possibilities offered by arrays of air Cherenkov
telescopes, and outlines observational programs that should become realistic
already in the rather near future.Comment: New Astronomy Reviews, in press; 101 pages, 11 figures, 185
reference
U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game
10.1371/journal.pone.0051095PLoS ONE712
Differential Genetic Susceptibility to Child Risk at Birth in Predicting Observed Maternal Behavior
This study examined parenting as a function of child medical risks at birth and parental genotype (dopamine D4 receptor; DRD4). Our hypothesis was that the relation between child risks and later maternal sensitivity would depend on the presence/absence of a genetic variant in the mothers, thus revealing a gene by environment interaction (GXE). Risk at birth was defined by combining risk indices of children's gestational age at birth, birth weight, and admission to the neonatal intensive care unit. The DRD4-III 7-repeat allele was chosen as a relevant genotype as it was recently shown to moderate the effect of environmental stress on parental sensitivity. Mothers of 104 twin pairs provided DNA samples and were observed with their children in a laboratory play session when the children were 3.5 years old. Results indicate that higher levels of risk at birth were associated with less sensitive parenting only among mothers carrying the 7-repeat allele, but not among mothers carrying shorter alleles. Moreover, mothers who are carriers of the 7-repeat allele and whose children scored low on the risk index were observed to have the highest levels of sensitivity. These findings provide evidence for the interactive effects of genes and environment (in this study, children born at higher risk) on parenting, and are consistent with a genetic differential susceptibility model of parenting by demonstrating that some parents are inherently more susceptible to environmental influences, both good and bad, than are others
Genetic Determinants of Financial Risk Taking
Individuals vary in their willingness to take financial risks. Here we show that variants of two genes that regulate dopamine and serotonin neurotransmission and have been previously linked to emotional behavior, anxiety and addiction (5-HTTLPR and DRD4) are significant determinants of risk taking in investment decisions. We find that the 5-HTTLPR s/s allele carriers take 28% less risk than those carrying the s/l or l/l alleles of the gene. DRD4 7-repeat allele carriers take 25% more risk than individuals without the 7-repeat allele. These findings contribute to the emerging literature on the genetic determinants of economic behavior
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