A Ben-Ner

A Galvan

A Grace

A Knafo

A Meyer-Lindenberg

A Smith

Ariel Knafo

C Camerer

D Cesarini

D Skuse

E Fehr

EA Hammock

F Dudbridge

F Warneken

G Caprara

Gary Bornstein

H Walum

Henry Harpending

Idan Shalev

Inga Gritsenko

J Beckmann

J Benenson

J Hirschhorn

J Moll

J Rushton

J Wigginton

L DiLalla

M Gummerum

M Nowak

M Reuter

M Thibonnier

N Eisenberg

N Laird

P Blake

R Bachner-Melman

R Ebstein

R Levin

Reut Avinun

Richard P. Ebstein

S Kim

Salomon Israel

T Wassink

Y Li

ZR Donaldson

PLoS ONE

PubMed

The genetic origins of altruism, defined here as a costly act aimed to benefit non-kin individuals, have not been examined in young children. However, previous findings concerning adults pointed at the arginine vasopressin receptor 1A (AVPR1A) gene as a possible candidate. AVPR1A has been associated with a range of behaviors including aggressive, affiliative and altruistic phenotypes, and recently a specific allele (327 bp) of one of its promoter region polymorphisms (RS3) has been singled out in particular. We modeled altruistic behavior in preschoolers using a laboratory-based economic paradigm, a modified dictator game (DG), and tested for association between DG allocations and the RS3 "target allele." Using both population and family-based analyses we show a significant link between lower allocations and the RS3 "target allele," associating it, for the first time, with a lower proclivity toward altruistic behavior in children. This finding helps further the understanding of the intricate mechanisms underlying early altruistic behavior

Richard P Ebstein

Directory of Open Access Journals

AVPR1A variant associated with preschoolers' lower altruistic behavior.

Crossref

AVPR1A Variant Associated with Preschoolers' Lower Altruistic Behavior

A (1759) The Theory of Moral Sentiments.

A comprehensive review of genetic association studies.

Altruism and aggression: The heritability of individual differences.

Altruistic helping in human infants and young chimpanzees.

Association between a vasopressin receptor AVPR1A promoter region microsatellite and eating behavior measured by a self-report questionnaire (Eating Attitudes Test) in a family-based study of a nonclinical population.

Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition.

Behavioural studies of strategic thinking in games.

Children’s altruistic behavior in the dictator game.

Copy number variants and genetic traits: closer to the resolution of phenotypic to genotypic variability.

Currency value moderates equity preference among young children.

Dopaminergic polymorphisms associated with self-report measures of human altruism: a fresh phenotype for the dopamine D4 receptor.

Dopaminergic-neuropeptide interactions in the social brain.

Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents.

Egalitarianism in young children.

Empathy in early childhood: genetic, environmental, and affective contributions.

Examination of AVPR1a as an autism susceptibility gene.

Family-based designs in the age of large-scale geneassociation studies.

Five rules for the evolution of cooperation.

Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans.

Genetic Variation in Preferences for Giving and Risk Taking.

Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans.

Heritability of children’s prosocial behavior and differential susceptibility to parenting by variation in the dopamine receptor D4 gene. Development and psychopathology 23:

Human fronto–mesolimbic networks guide decisions about charitable donation.

Hummel A

Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA. Genes, brain and behavior 7:

Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism. Social cognitive and affective neuroscience:

Knafo A

Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data.

Link between vasopressin receptor AVPR1A promoter region microsatellites and measures of social behavior in humans.

Microsatellite instability generates diversity in brain and sociobehavioral traits.

Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review.

Oxytocin, vasopressin, and the neurogenetics of sociality.

PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data.

Prosocial behavior from early to middle childhood: genetic and environmental influences on stability and change.

Prosocial development. In

Prosocial foundations of children’s academic achievement.

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors.

Share and share alike? Gender-pairing, personality, and cognitive ability as determinants of giving.

Smolen A

Study of V1-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension.

The Longitudinal Israeli Study of Twins (LIST): children’s social development as influenced by genetics, abilities, and socialization.

The nature of human altruism.

Transmission disequilibrium testing of arginine vasopressin receptor 1 A(AVPR 1 A) polymorphisms in autism.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3182215

Avpr1a variant associated with preschoolers' lower altruistic behavior

Avpr1a variant associated with preschoolers' lower altruistic behavior

Abstract

Similar works

Full text

Available Versions

Directory of Open Access Journals

Crossref