Contratos de intermediacion en las exportaciones de frutas

39 p.La investigación realizada constituye un esfuerzo por reflexionar acerca de la aplicabilidad de algunos contratos usualmente utilizados en las exportaciones de frutas realizadas desde nuestro país hacia el extranjero, teniendo en consideración los aspectos más relevantes de cada una de las figuras jurídicas comúnmente aplicadas a los supuestos de intermediación entre importadores y exportadores. Se aborda principalmente el contrato de compraventa internacional de mercaderías en virtud de la Convención de Viena de 1980 sobre Compraventa Internacional de Mercaderías, relacionando las normas contenidas en aquella Convención con las normativas de Derecho nacional chileno, con el fin de establecer ciertas diferencias entre ambas realidades normativas, y de determinar algunas ventajas y desventajas en relación a la aplicación de la Convención, como medio idóneo para realizar exportaciones de frutas. Asimismo se abordan, en forma muy general, los contratos de comisión y agencia./ ABSTRACT The research executed constitute an effort to reflect about the applicability of some contracts usually used in the exports of fruits executed from our country to the abroad, taking into consideration the most outstanding aspects of each of the contracts usually applied on the scenarios of the exports between importers and exporters. It`s raised mainly the contract of international sale of goods according to the United Nations Convention on Contract for the International sale of goods of 1980, relating his rules with the chilean regulation, for establish some diferences between bouth legal realities and determine some advantages and disadvantages related with the application of the Convention, like suitable way for realize exports of fruits. In the same way it`s raised in general way the contracts of commission and agency

Secalharidade como ética e como modo de vida: o projeto AND_Lab e a investigação das práticas de encontro e de manuseamento coletivo do viver juntos

Partilhamos aqui dois extratos do discurso que sustenta o projeto AND_Lab, um laboratório de investigação que emergiu do encontro não-marcado entre um coreógrafo e uma antropóloga: 1) um trecho do manifesto que escrevemos juntos na inauguração do AND_Lab e 2) uma parte da conferência-performance “Secalharidade”, conceito que nomeia, justamente, o modo de operar e habitar paisagens comuns que se desenhou na contaminação recíproca entre nossos conceitos e procedimentos

Forecasting high waters at Venice Lagoon using chaotic time series analysis and nonlinear neural networks

Time series analysis using nonlinear dynamics systems theory and multilayer neural networks models have been applied to the time sequence of water level data recorded every hour at 'Punta della Salute' from Venice Lagoon during the years 1980–1994. The first method is based on the reconstruction of the state space attractor using time delay embedding vectors and on the characterisation of invariant properties which define its dynamics. The results suggest the existence of a low dimensional chaotic attractor with a Lyapunov dimension, DL, of around 6.6 and a predictability between 8 and 13 hours ahead. Furthermore, once the attractor has been reconstructed it is possible to make predictions by mapping local-neighbourhood to local-neighbourhood in the reconstructed phase space. To compare the prediction results with another nonlinear method, two nonlinear autoregressive models (NAR) based on multilayer feedforward neural networks have been developed. From the study, it can be observed that nonlinear forecasting produces adequate results for the 'normal' dynamic behaviour of the water level of Venice Lagoon, outperforming linear algorithms, however, both methods fail to forecast the 'high water' phenomenon more than 2–3 hours ahead

Predicting Proteome-Early Drug Induced Cardiac Toxicity Relationships (Pro-EDICToRs) with Node Overlapping Parameters (NOPs) of a new class of Blood Mass-Spectra graphs

The 11th International Electronic Conference on Synthetic Organic Chemistry session Computational ChemistryBlood Serum Proteome-Mass Spectra (SP-MS) may allow detecting Proteome-Early Drug Induced Cardiac Toxicity Relationships (called here Pro-EDICToRs). However, due to the thousands of proteins in the SP identifying general Pro-EDICToRs patterns instead of a single protein marker may represents a more realistic alternative. In this sense, first we introduced a novel Cartesian 2D spectrum graph for SP-MS. Next, we introduced the graph node-overlapping parameters (nopk) to numerically characterize SP-MS using them as inputs to seek a Quantitative Proteome-Toxicity Relationship (QPTR) classifier for Pro-EDICToRs with accuracy higher than 80%. Principal Component Analysis (PCA) on the nopk values present in the QPTR model explains with one factor (F1) the 82.7% of variance. Next, these nopk values were used to construct by the first time a Pro-EDICToRs Complex Network having nodes (samples) linked by edges (similarity between two samples). We compared the topology of two sub-networks (cardiac toxicity and control samples); finding extreme relative differences for the re-linking (P) and Zagreb (M2) indices (9.5 and 54.2 % respectively) out of 11 parameters. We also compared subnetworks with well known ideal random networks including Barabasi-Albert, Kleinberg Small World, Erdos-Renyi, and Epsstein Power Law models. Finally, we proposed Partial Order (PO) schemes of the 115 samples based on LDA-probabilities, F1-scores and/or network node degrees. PCA-CN and LDA-PCA based POs with Tanimoto’s coefficients equal or higher than 0.75 are promising for the study of Pro-EDICToRs. These results shows that simple QPTRs models based on MS graph numerical parameters are an interesting tool for proteome researchThe authors thank projects funded by the Xunta de Galicia (PXIB20304PR and BTF20302PR) and the Ministerio de Sanidad y Consumo (PI061457). González-Díaz H. acknowledges tenure track research position funded by the Program Isidro Parga Pondal, Xunta de Galici

From Complex Networks to Time Series Analysis and Viceversa: Application to Metabolic Networks

In this work we present a simple and fast approach to generate network structures based on time series recurrence plots and viceversa. In addition, we discuss the application of the different analysis techniques developed in both fields, i.e. complex networks and time series analysis. Concerning the transformation from time series to networks, we propose a deterministic growth procedure which produces a new types of complex network structures that have some interesting features. This simple and fast approach is able to generate deterministic network structures based on time series recurrence plots. The generated networks contain several properties of the original time series. In this case, networks generated from chaotic attractors display interesting features from the point of view of robustness which could help in designing systems with high tolerance against errors and transfer of information. Chaotic networks based on the Lorenz attractor show that they are highly tolerant against attacks and they have a high ability for the transfer of information or on the contrary they are able to transmit infections faster. It is still necessary to investigate if such chaotic networks exist already in natural or man-made systems or, if possible, to construct such networks and test their properties. On the other hand, the transformation from networks to time series presents some problems concerning the selection of the initial time or in our case the initial node and the way in which the nodes are visited. If a network has been generated following a certain growth law it seems logical to choose the first node as the origin and then proceed following the network growth pattern. However, the situation is not so clear for example with metabolic networks, where it is difficult to select which is the first metabolite. Similar concerns would apply to other types of biological networks. In this case several alternatives could be considered, e.g. ordering using the number of connections. However, we have still to find if there are some invariant/preserved properties in the generated time series from the same network. We have found that rescaled range analysis does not preserve the fractal structure in the time series. In any case, if time series parameters would be invariant against the initial node selection, then they could be used to analyze the networks that have generated said time series. Our future work will continue along these lines.JRC.I.6-Systems toxicolog

Introdução: a operacionalidade do jogo

A chamada para artigos deste dossiê pretende discutir o conceito de jogo na sua operacionalidade nomeadamente como o jogo serve de laboratório experimental de procedimentos, como o jogo é posto em prática e que consequências este fazer proporciona, contribuindo para uma heurística da análise sociocultural. O foco elenca então a articulação de vários “comos”: 1) a forma como o jogo se faz dispositivo (ou contra-dispositivo do senso comum) para a invenção coletiva e dissensual do comum, permitindo desvincular a prática da comunidade dos mecanismos identitários da pertença e da reprodução, bem como re-situar o seu entendimento enquanto processo de vinculação sempre em aberto: nem essência nem substância, mas potência de relação que está sempre por ser efetuada a cada vez; 2) a forma como o jogo está a ser ativado, em diferentes áreas, enquanto prática exploratória – explicitando o que um corpo pode e contribuindo para a reimaginação da corporeidade e dos modos de estar no mundo; 3) a forma como o jogo pode funcionar como plano de re-performance e/ou como chave analítica para dar a ver as complexas relações éticas, estéticas e políticas implicadas na constante negociação social dos lugares de fala, das representações e das formações subjetivas; 4) a forma como o jogo é usado para a reinvenção de práticas pedagógicas e de práticas metodológicas; 5) a forma como o jogo, nas suas engrenagens e de dinâmica processual, se relaciona com a utopia ou com a vanguarda e se pode concretizar enquanto heterotopia.SFRH/BPD/100647/2014info:eu-repo/semantics/publishedVersio

Espanhol como língua estrangeira em tempos de pandemia: Atividades síncronas que apenas o ensino remoto proporciona

Em 2020, a pandemia do Covid-19 atingiu todo o planeta e modificou completamente as formas de interação social. Diversos setores foram comprometidos, assim como a Educação, e todos precisaram se adaptar. Portanto, no momento atual, a reinvenção e a (re)aprendizagem são essenciais para que se possa construir novas alternativas de ensino, e no FIVU-UFPR (Formação em Idiomas para a Vida Universitária — Universidade Federal do Paraná) não foi diferente. Pensando nisso, o projeto abriu espaço para estudantes do curso de Letras da UFPR desenvolverem seus estágios obrigatórios com a criação de um curso montado integralmente no formato online para estudantes da pós-graduação em Educação. Porém, pensando em tornar as aulas mais atrativas e dinâmicas, metodologias, atividades e interações tiveram que ser adaptadas. Sendo assim, além do aprimoramento como professores, através desse estágio obrigatório, houve a oportunidade de aprender mais sobre a área tecnológica. Por integrarmos a equipe de professores em formação nesse projeto, apresentamos, neste artigo, alguns exemplos de atividades que foram pensadas para essa nova modalidade de ensino e que tiveram um resultado positivo no processo de ensino/aprendizagem

Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiological Hallmarks

Alzheimer disease (AD) is the most common neurodegenerative disease featuring progressive and degenerative neurological impairments resulting in memory loss and cognitive decline. The specific mechanisms underlying AD are still poorly understood, but it is suggested that a deficiency in the brain neurotransmitter acetylcholine, the deposition of insoluble aggregates of fibrillar β-amyloid 1–42 (Aβ42), and iron and glutamate accumulation play an important role in the disease progress. Despite the existence of approved cholinergic drugs, none of them demonstrated effectiveness in modifying disease progression. Accordingly, the development of new chemical entities acting on more than one target is attracting progressively more attention as they can tackle intricate network targets and modulate their effects. Within this endeavor, a series of mitochondriotropic antioxidants inspired on hydroxycinnamic (HCA’s) scaffold were synthesized, screened toward cholinesterases and evaluated as neuroprotectors in a differentiated human SH-SY5Y cell line. From the series, compounds 7 and 11 with a 10-carbon chain can be viewed as multi-target leads for the treatment of AD, as they act as dual and bifunctional cholinesterase inhibitors and prevent the neuronal damage caused by diverse aggressors related to protein misfolding and aggregation, iron accumulation and excitotoxicityThis work was funded by FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and national funds by FCT-Foundation for Science and Technology under research grants (UID/QUI/00081, NORTE-01-0145-FEDER-000028, PTDC/DTP-FTO/2433/2014, PTDC/BIA-MOL/28607/2017, POCI-01-0145-FEDER-028607). S. Benfeito and C. Fernandes grants are supported by FCT, POPH and QREN. The authors also thank the COST action CA15135 for supportS

La cueva de Gabasa revisada 15 años después: un cubil para las hienas y un cazadero para los Neandertales

Parafraseando el conocido artículo de F. Bordes (1981) sobre el complejo musteriense, aprovechamos la ocasión para revisar (“revisitar”) los datos generales de la Cueva de Gabasa 15 años después de la última campaña de excavación desarrollada en 1994. Nuevas determinaciones cronológicas realizadas por T. Torres y J.E. Ortiz sobre el nivel h, nos llevan a replantear las hipó- tesis generales sobre cronología y reconstrucción ambiental de este importante depósito. Por ello la destacada presencia de hienas y otros carnívoros en el conjunto material de este sitio, puede ser ahora enfocada bajo nuevas premisas cronológicas y en parte, taxonómicas

Alternative Methodologies for the Synthesis of Substituted 3-arylcoumarins: Perkin Reactions and Palladium-Catalyzed Synthesis

With the aim to find out the best methodology to prepare different series of substituted coumarins, thinking on their pharmacological evaluation, in the present communication we report the synthesis of 3-phenylcoumarin with different number and position of substituent groups in both 3-phenyl and coumarin rings. The substituents in this new scaffold were introduced in the 6 and 8 positions of the coumarin moiety and in 3'and 4' positions of the 3-phenyl ring. The synthesized compounds 1-7, 8 and 9-11 were prepared and characterized by different methodologies. Perkin modified reaction (method A and B) and Palladium-catalyzed synthesis (method C) were the methodologies described in this communicationWe are grateful to the Spanish Ministerio de Sanidad y Consumo (PS09/00501) and to Xunta da Galicia (CSA030203PR). M.J.M. also thanks Fundação de Ciência e Tecnologia for a PhD gran